217
Views
28
CrossRef citations to date
0
Altmetric
Original Article

Conditional Gene Targeting of Connexin43: Exploring the Consequences of Gap Junction Remodeling in the Heart

, &
Pages 345-348 | Received 01 Sep 2001, Accepted 15 Sep 2001, Published online: 11 Jul 2009

References

  • Agah R., Frenkel P. A., French B. A., Michael L. H., Overbeek P. A., Schneider M. D. Gene recombination in postmitotic cells: targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo. J. Clin. Invest. 1997; 100: 169–79
  • Chen J., Kubalak S. W., Chien K. R. Ventricular muscle-restricted targeting of the RXRα gene reveals non-cell-autonomous requirement in cardiac chamber morphogenesis. Development 1998; 125: 1943–1949
  • Gillum R. F. Epidemiology of heart failure in the United States. Am. Heart. J. 1993; 126: 1042–1047
  • Gutstein D. E., Morley G. E., Tamaddon H., Vaidya D., Schneider M. D., Chen J., Chien K. R., Stuhlmann H., Fishman G. I. Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43. Circ. Res. 2001a; 88: 333–339
  • Gutstein D. E., Morley G. E., Vaidyu D., Liu F., Chen F. L., Stuhlmann H., Fishman G. I. Heterogeneous expression of gap junction channels in the heart leads to conduction defects and ventricular dysfunction. Circulation 2001b; 104: 1194–1199
  • Kaprielian R. R., Gunning M., Dupont E., Sheppard M. N., Rothery S. M., Underwood R., Pennell D. J., Fox K., Pepper J., Poole-Wilson P. A., Severs N. J. Downregulation of immunodetectable connexin43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricle. Circulation 1998; 97: 651–660
  • Matsushita T., Oyamada M., Fujimoto K., Yasuda Y., Masuda S., Wada Y., Oka T., Takamatsu T. Remodeling of cell-cell and cell-extracellular matrix interactions at the border zone of rat myocardial infarcts. Circ. Res. 1999; 85: 1046–1055
  • Morley G. E., Vaidya D., Samie F. H., Lo C., Delmar M., Jalife J. Characterization of conduction in the ventricles of normal and heterozygous Cx43 knockout mice using optical mapping. J. Cardiovasc. Electrophysiol. 1999; 10: 1361–1375
  • Reaume A. G., de Sousa P. A., Kulkami S., Langille B. L., Zhu D., Davies T. C., Juneja S. C., Kidder G. M., Rossant J. Cardiac malformation in neonatal mice lacking connexin43. Science 1995; 267: 1831–1834
  • Sra J., Dhala A., Blank Z., Deshpande S., Cooley R., Akhtar M. Sudden cardiac death. Curr. Probl. Cardiol. 1999; 24: 461–540
  • Vaidya D., Morley G. E., Samie F. H., Jalife J. Reentry and fibrillation in the mouse heart: a challenge to the critical mass hypothesis. Circ. Res. 1999; 85: 174–181
  • Yamamoto T., Ochalski A., Hertzberg E. L., Nagy J. I. LM and EM immunolocalization of the gap junctional protein connexin 43 in rat brain. Brain. Res. 1990; 508: 313–319

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.