Bisphosphonate-Induced, Hemichannel-Mediated, Anti-Apoptosis Through the Src/ERK Pathway: A Gap Junction-Independent Action of Connexin43

References

• Beyer E. C., Paul D. L., Goodenough D. A. Connexin family of gap junction proteins. J. Membr. Biol. 1990; 116: 187–194
   PubMed Web of Science ®Google Scholar
• Civitelli R., Beyer E. C., Warlow P. M., Robertson A. J., Geist S. T., Steinberg T. H. Connexin43 mediates direct intercellular communication in human osteoblastic cell networks. J. Clin. Invest. 1993; 91: 1888–1896
   PubMed Web of Science ®Google Scholar
• Davidson J. S., Baumgarten I. M. Glycyrrhetinic acid derivatives: a novel class of inhibitors of gap-junctional intercellular communication. Structure-activity relationships. J. Pharmacol. Exp. Ther. 1988; 246: 1104–1107
   PubMed Web of Science ®Google Scholar
• Homma N., Alvarado J. L., Coombs W., Stergiopoulos K., Taffet S. M., Lau A. F., Delmar M. A particle-receptor model for the insulin-induced closure of connexin43 channels. Circ. Res. 1998; 83: 27–32
   PubMed Web of Science ®Google Scholar
• Hoshi T., Zagotta W. N., Aldrich R. W. Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science 1990; 250: 533–538
   PubMed Web of Science ®Google Scholar
• John S. A., Kondo R., Wang S. Y., Goldhaber J. I., Weiss J. N. Connexin-43 hemichannels opened by metabolic inhibition. J. Biol. Chem. 1999; 274: 236–240
   PubMed Web of Science ®Google Scholar
• Kanemitsu M. Y., Loo L. W., Simon S., Lau A. F., Eckhart W. Tyrosine phosphorylation of connexin 43 by v-Src is mediated by SH2 and SH3 domain interactions. J. Biol. Chem. 1997; 272: 22824–22831
   PubMed Web of Science ®Google Scholar
• Kelsell D. P., Dunlop J., Hodgins M. B. Human diseases: clues to cracking the connexin code?. Trends Cell Biol. 2001; 11: 2–6
   PubMed Web of Science ®Google Scholar
• Klinghoffer R. A., Sachsenmaier C., Cooper J. A., Soriano P. Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J. 1999; 18: 2459–2471
   PubMed Web of Science ®Google Scholar
• Kousteni S., Bellido T., Plotkin L. I., O'Brien C. A., Bodenner D. L., Han L., Han K., Di Gregorio G. B., Katzenellenbogen J. A., Katzenellenbogen B. S., Roberson P. K., Weinstein R. S., Jilka R. L., Manolagas S. C. Sex non-specific anti-apoptotic signaling through the classical estrogen (alpha or beta) or androgen receptors: dissociation from transcriptional activity. Cell 2001; 104: 719–730
   PubMed Web of Science ®Google Scholar
• Lecanda F., Towler D. A., Ziambaras K., Cheng S. L., Koval M., Steinberg T. H., Civitelli R. Gap junctional communication modulates gene expression in osteoblastic cells. Mol. Biol. Cell 1998; 9: 2249–2258
   PubMed Web of Science ®Google Scholar
• Lecanda F., Warlow P. M., Sheikh S., Furlan F., Steinberg T. H., Civitelli R. Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction. J. Cell Biol. 2000; 151: 931–944
   PubMed Web of Science ®Google Scholar
• Manolagas S. C. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr. Rev. 2000; 21: 115–137
   PubMed Web of Science ®Google Scholar
• Marotti G., Cane V., Palazziri S., Palumbo C. Structure-function relationships in the osteocyte. Ital. J. Min. Electrol. Metab. 1990; 4: 93–106
   Google Scholar
• Martyn K. D., Kurata W. E., Warn-Cramer B. J., Burt J. M., Ten Broek E., Lau A. F. Immortalized connexin43 knockout cell lines display a subset of biological properties associated with the transformed phenotype. Cell Growth Differ. 1997; 8: 1015–1027
   PubMedGoogle Scholar
• Morley G. E., Taffet S. M., Delmar M. Intramolecular interactions mediate pH regulation of connexin43 channels. Biophys. J. 1996; 70: 1294–1302
   PubMed Web of Science ®Google Scholar
• Musil L. S., Goodenough D. A. Biochemical analysis of connexin43 intracellular transport, phosphorylation, and assembly into gap junctional plaques. J. Cell Biol. 1991; 115: 1357–1374
   PubMed Web of Science ®Google Scholar
• Plotkin L. I., Weinstein R. S., Parfitt A. M., Roberson P. K., Manolagas S. C., Bellido T. Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. J. Clin. Invest. 1999; 104: 1363–1374
   PubMed Web of Science ®Google Scholar
• Quist A. P., Rhee S. K., Lin H., Lai R. Physiological role of gap-junctional hemichannels. Extracellular calcium-dependent isosmotic volume regulation. J. Cell Biol. 2000; 148: 1063–1074
   PubMed Web of Science ®Google Scholar
• Romanello M., D'Andrea P. Dual mechanism of intercellular communication in HOBIT osteoblastic cells: a role for gap-junctional hemichannels. J. Bone Miner. Res. 2001; 16: 1465–1476
   PubMed Web of Science ®Google Scholar
• Warn-Cramer B. J., Lampe P. D., Kurata W. E., Kanemitsu M. Y., Loo L. W., Eckhart W., Lau A. F. Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein. J. Biol. Chem. 1996; 271: 3779–3786
   PubMed Web of Science ®Google Scholar
• White T. W., Paul D. L. Genetic diseases and gene knockouts reveal diverse connexin functions. Annu. Rev. Physiol. 1999; 61: 283–310
   PubMed Web of Science ®Google Scholar
• Zhou L., Kasperek E. M., Nicholson B. J. Dissection of the molecular basis of pp60(v-src) induced gating of connexin 43 gap junction channels. J. Cell Biol. 1999; 144: 1033–1045
   PubMed Web of Science ®Google Scholar