Reduced Intimal Thickening Following αvβ 3 Blockade is Associated with Smooth Muscle Cell Apoptosis

References

• Asahara T., Bauters C., Pastore C J., Kearney M., Rossow S., Bunting S., Ferrara N., Symes J. F., Isner J. M. Local delivery of vascular endothelial growth factor accelerates re-endothelialization and attenuates intimal hyperplasia in balloon-injured rat carotid artery. Circulation 1995; 91: 2793–2801
   PubMed Web of Science ®Google Scholar
• Asahara T., Chen D., Tsurumi Y., Kearney M., Rossow S., Passed J., Symes J., Isner J. Accelerated restitution of endothelial integrity and endothelium dependent function following phVEGF16s gene transfer. Circulation 1996; 94: 3291–3302
   PubMed Web of Science ®Google Scholar
• Bjornsson T. D., Dryjski M., Tluczek J., Mennie R., Ronan J., Mellin T. N., Thomas K. A. Acidic fibroblast growth factor promotes vascular repair. Proceedings of the National Academy of Science (USA) 1991; 88: 8651–8655
   PubMed Web of Science ®Google Scholar
• Bochaton-Piallat M. L., Gabbiani F, Redard M., Desmouliere A., Gabbiani G. Apoptosis participates in cellularity regulation during rat aortic intimal thickening. American Journal of Pathologv 1995; 146: 1059–1064
   PubMed Web of Science ®Google Scholar
• Breier G., Albrecht U., Sterrer S., Risau W. Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development 1992; 114: 521–532
   PubMed Web of Science ®Google Scholar
• Brooks P. C., Clark R. A.F., Cheresh D. A. Requirement of vascular integrin alpha-v-beta-3 for angiogenesis. Science 1994a; 264: 569–571
   PubMed Web of Science ®Google Scholar
• Brooks P. C., Montgomery A. M.P., Rossenfeld M., Reisfeld R. A., Hu T., Killer G., Cheresh D. A. Integrin alpha-v-beta-3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 1994b; 79: 1157–1164
   PubMed Web of Science ®Google Scholar
• Clark R. A.F., Tonnesen M. G., Gailit J., Cheresh D. A. Transient functional expression of alpha-v-beta-3 on vascular cells during wound repair. American Journal of Pathology 1996; 148: 1407–1421
   PubMed Web of Science ®Google Scholar
• Clowes A. W., Reidy M. A., Clowes M. M. Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium. Laboratory Investigation 1983; 49: 327–333
   PubMed Web of Science ®Google Scholar
• Coller B. S., Peerschke E. I., Scudder L. E., Sullivan C. A. A murine monoclonal antibody that completely blocks the binding of the fibrinogen to platelets produces a thrombasthenic-like state in normal platelets and binds to glycoproteins lib and/or Ilia. Journal of Clinical Investigation 1983; 72: 325–328
   PubMed Web of Science ®Google Scholar
• Epstein S. E., Siegall C. B., Biro S., Fu Y. M., FitzGerald D., Pastan I. Cytotoxic effects of a recombinant chimeric toxin on rapidly proliferating vascular smooth muscle cells. Circulation 1991; 84: 778–787
   PubMed Web of Science ®Google Scholar
• Feldman L. J., Steg P. G., Zheng L. P., Chen D., Kearney M., McGarr S. E., Barry J. D., Dedieu J. P., Perricaudet M., Isner J. M. Low-efficiency of percutaneous adenovirus-mediated arterial gene transfer in the atherosclerotic rabbit. Journal of Clinical Investigation 1995; 95: 2662–2671
   PubMed Web of Science ®Google Scholar
• Hoshiga M., Alpers C. E., Smith L. L., Giachelli C M., Schwartz S. M. Alpha-v-beta-3 integrin expression in normal and atherosclerotic artery. Circulation Research 1995; 11: 1129–1135
   Google Scholar
• Isner J. M., Kearney M., Bortman S., Passeri J. Apoptosis in human atherosclerosis and restenosis. Circulation 1995; 91: 2703–2711
   PubMed Web of Science ®Google Scholar
• Lefkovits J., Plow E. F., Topol E. J. Platelet glycoprotein IIb/IIIa receptors in cardiovascular medicine. New England Journal of Medicine 1995; 332: 1553–1559
   PubMed Web of Science ®Google Scholar
• Lindner V., Majack R. A., Reidy M. A. Basic fibroblast growth factor stimultaes endothelial regrowth and proliferation in denuded arteries. Journal of Clinical Investigation 1990; 85: 2004–2008
   PubMed Web of Science ®Google Scholar
• Miano J. M., Vlasic N., Tota R. R., Stemerman M. B. Smooth muscle cell immediate-early gene and growth factor activation follows vascular injury: a putative in vivo mechanism for autocrine growth. Arteriosclerosis and Thrombosis 1993; 13: 211–219
   PubMed Web of Science ®Google Scholar
• Okada Y., Copeland B. R., Hamann G. F., Koziol J. A., Cheresh D. A., del Zoppo G. J. Integrin alpha-v-beta-3 is expressed in selected microvessels after focal cerebral ischemia. American Journal of Pathology 1996; 149: 37–44
   PubMed Web of Science ®Google Scholar
• Riessen R., Isner J. M. Prospects for site-specific delivery of pharmacologic and molecular therapies. Journal of the American College of Cardiology 1994; 23: 1234–1244
   PubMed Web of Science ®Google Scholar
• Ruoslahti E., Reed J. C. Anchorage dependence, integrins, and apoptosis. Cell 1994; 11: 477–478
   Web of Science ®Google Scholar
• Schwartz S. M., Haudenschild C. C., Eddy E. M. Endothelial regeneration. I. Quantitative analysis of initial stages of endothelial regeneration in rat aortic intima. Laboratory Investigation 1978; 568–580
   PubMed Web of Science ®Google Scholar
• Skinner M. P., Raines E. W., Ross R. Dynamic expression of alpha-1-beta-1 and alpha-2-beta-l integrin receptors by human vascular smooth muscle cells: alphas-beta-1 integrin is required for chemotaxis across type I collagen-coated membranes. American Journal of Pathology 1994; 145: 1070–1081
   PubMed Web of Science ®Google Scholar
• Stromblad S., Becker J. C, Yebra M., Brooks P C, Cheresh D. A. Suppression of p53 activity and p2]WAFi cipi expression by vascular cell integrin alpha-v-beta-3 during angiogenesis. Journal of Clinical Investigation 1996; 98: 426–433
   PubMed Web of Science ®Google Scholar
• The EPIC Investigators. Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty. New England Journal of Medicine 1994; 330: 956–961
   PubMed Web of Science ®Google Scholar
• Topol E. J., Califf R. M., Weisman H. F. Randomised trial of coronary intervention with antibody against platelet IIb/IIIa integrin for reduction of clinical restenosis: results at six months. Lancet 1994; 343: 881–886
   PubMed Web of Science ®Google Scholar