1,027
Views
7
CrossRef citations to date
0
Altmetric
Research Article

Cimetidine enhances delayed-type hypersensitivity responses and serum interleukin (IL)-2, -10, -12, and IL-17 levels after burn injury in an animal model

, , , &
Pages 201-209 | Received 01 May 2012, Accepted 28 Jun 2012, Published online: 05 Sep 2012

References

  • Alexander, M., Daniel, T., Chaudry, I. H., Schwacha, M. G. 2005. Opiate analgesics contribute to the development of post-injury immunosuppression. J. Surg. Res. 129:161–168.
  • Arad, G., Nussinovich, R., Na’amad, M., Kaempfer, R. 1996. Dual control of human IL-2 and IFNγ gene expression by histamine: Activation and suppression. Cell. Immunol. 170:149–155.
  • Arae, K., Oboki, K., Ohno, T., Hirata, M., Nakae, S., Taguchi, H., Saito, H., Nakajima, T. 2011. Cimetidine enhances antigen-specific IgE and TH2 cytokine production. Allergol. Int. 60:339–344.
  • Awasthi, A., Kuchroo, V. K. 2009. TH17 cells: From precursors to players in inflammation and infection. Int. Immunol. 21:489–498.
  • Baker, R. A., Zeller, R. A., Klein, R. L., Thornton, R. J., Shuber, J. H., Marshall, R. E., Leibfarth, A. G., Latko, J. A. 2001. Burn wound itch control using H1 and H2 antagonists. J. Burn Care Rehab. 22:263–268.
  • Black, C. A. 1999. Delayed-type hypersensitivity: Current theories with an historic perspective. Dermatol. Online J. 5:7.
  • Butler, K. L., Ambravaneswaran, V., Agrawal, N., Bilodeau, M., Toner, M., Tompkins, R. G., Fagan, S., Irimia, D. 2010. Burn injury reduces neutrophil directional migration speed in microfluidic devices. PLoS One 5:e11921.
  • Cetinkale, O., Senel, O., Bulan, R. 1999. The effect of antioxidant therapy on cell-mediated immunity following burn injury in an animal model. Burns 25:113–118.
  • Choudhry, M. A., Mao, H., Haque, F., Khan, M., Fazal, N., Sayeed, M. M. 2002. Role of NFAT and AP-1 in PGE2-mediated T-cell suppression in burn injury. Shock 183:212–216.
  • Correia, O., Delgado, L., Roujeau, J. C., Le Cleach, L., Fleming-Torrinha, J. A. 2002. Soluble IL-2 receptor and IL-1β in toxic epidermal necrolysis: A comparative analysis of serum and blister fluid samples. Arch. Dermatol. 138:29–32.
  • de Macedo, J. L., Santos, J. B. 2005. Bacterial and fungal colonization of burn wounds. Mem. Inst. Oswaldo Cruz 100:535–539.
  • Dong, N., Yao, Y. M., Cao, Y. J., He, L. X., Yu, Y., Chai, J. K., Sheng, Z. Y. 2007. The clinical significance of changes in immunological function of T-lymphocyte in severe burn patients with sepsis. Zhonghua Shao Shang Za Zhi 23:84–87.
  • Ebtekar, M., Hassan, Z. M. 1993. Effect of immunomodulators pyrimethamine and cimetidine on immunosuppression induced by sulfur mustard in mice. Int. J. Immunopharmacol. 15:533–541.
  • Elenkov, I. J., Webster, E., Papanicolaou, D. A., Fleisher, T. A., Chrousos, G. P., Wilder, R. L. 1998. Histamine potently suppresses human IL-12 and stimulates IL-10 production via H2 receptors. J. Immunol. 161:2586–2593.
  • Fayazov, A. D., Shukurov, S. I., Shukurov, B. I., Sultanov, B. C., Namazov, A. N., Ruzimuratov, D. A. 2009. Disorders of the immune system in severely burned patients. Ann. Burns Fire Disasters 22:121–130.
  • Finnerty, C. C., Przkora, R., Herndon, D. N., Jeschke, M. G. 2009. Cytokine expression profile over time in burned mice. Cytokine 45:20–25.
  • Gauglitz, G. G., Song, J., Herndon, D. N., Finnerty, C. C., Boehning, D., Barral, J. M., Sand Jeschke, M. G., 2008. Characterization of the inflammatory response during acute and post-acute phases after severe burn. Shock 30:503–507.
  • Gharegozloo, B., Hassan, Z. M., Ardestani, A., Tavassoli, N. 2004. Effect of immunomodulator pyrimethamine and cimetidine on immunosuppression induced by burn blister fluid. Iran J. Allergy Asthma Immunol. 3:139–143.
  • Hanschen, M., Tajima, G., O’Leary, F., Ikeda, K., Lederer, J. A. 2011. Injury induces early activation of T-cell receptor signaling pathways in CD4+ regulatory T-cells. Shock 35:252–257.
  • Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., Weaver, C. T. 2005. Interleukin-17-producing CD4+ effector T-cells develop via a lineage distinct from the T-helper type 1 and 2 lineages. Nat. Immunol. 6:1123–1132.
  • Huang, W. H. 1992. Study of the abnormal plasma proteins after burn injury. Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi 8:89–92.
  • Huebinger, R. M., Rivera-Chavez, F., Chang, L. Y., Liu, M. M., Minei, J. P., Purdue, G. F., Hunt, J. L., Arnoldo, B. D., Barber, R. C. 2010. IL-10 polymorphism associated with decreased risk for mortality after burn injury. J. Surg. Res. 164:e141–145.
  • Hunt, J. P., Hunter, C. T., Brownstein, M. R., Giannopoulos, A., Hultman, C. S., deSerres, S., Bracey, L., Frelinger, J., Meyer, A. A. 1998. The effector component of the cytotoxic T-lymphocyte response has a biphasic pattern after burn injury. J. Surg. Res. 80:243–251.
  • Inatsu, A., Kogiso, M., Jeschke, M. G., Asai, A., Kobayashi, M., Herndon, D. N., Suzuki, F. 2011. Lack of TH17 cell generation in patients with severe burn injuries. J. Immunol. 187:2155–2161.
  • Ishikura, H., Fukui, H., Takeyama, N., Tanaka, T. 1999. Cimetidine activates IL-12, which enhances cellular immunity. Blood 93:1782–1783.
  • Jafarzadeh, A., Hassan, Z., Ebtekar, M., Mohaghegh-Hazrati, S., Altoriahi, T. 2010. Time-dependent changes of immunologic responses after burn injury and immunomodulation by cimetidine and pyrimethamine in an animal model. Pak. J. Pharm. Sci. 23:367–373.
  • Jager, A., Kuchroo, V. K. 2010. Effector and regulatory T-cell subsets in autoimmunity and tissue inflammation. Scand. J. Immunol. 72:173–184.
  • Jutel, M., Akdis, M., Akdis, C. A. 2009. Histamine, histamine receptors and their role in immune pathology. Clin. Exp. Allergy 39:1786–1800.
  • Jutel, M., Watanabe, T., Klunker, S., Akdis, M., Thomet, O. A., Malolepszy, J., Zak-Nejmark, T., Koga, R., Kobayashi, T., Blaser, K., Akdis, C. A. 2001. Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors. Nature 413:420–425.
  • Khoshbaten, M., Fattahi, E., Naderi, N., Khaleghian, F., Rezailashkajani, M. 2006. A comparison of oral omeprazole and intravenous cimetidine in reducing complications of duodenal peptic ulcer. BMC Gastroenterol. 6:2.
  • Kinoshita, M., Shinomiya, N., Ono, S., Tsujimoto, H., Kawabata, T., Matsumoto, A., Hiraide, H., Seki, S. 2006. Restoration of natural IgM production from liver B-cells by exogenous IL-18 improves the survival of burn-injured mice infected with Pseudomonas aeruginosa. J. Immunol. 177:4627–4635.
  • Kobayashi, K., Kaneda, K., Kasama, T., 2001. Immunopathogenesis of delayed-type hypersensitivity. Microsc. Res. Tech. 53:241–245.
  • Kovacs, E. J., Faunce, D. E., Messingham, K. A. 2004. Ethanol and burn injury: Estrogen modulation of immunity. Alcohol 33:209–216.
  • Li, M. J., Lei, J. H., Wang, T., Lu, S. J., Guan, F., Liu, W. Q., Li, Y. L. 2011. Cimetidine enhances the protective effect of GST DNA vaccine against Schistosoma japonicum. Exp. Parasitol. 128:427–432.
  • Li, X., Chaudry, I. H., Choudhry, M. A. 2009. ERK and not p38 pathway is required for IL-12 restoration of T-cell IL-2 and IFNγ in a rodent model of alcohol intoxication and burn injury. J. Immunol. 183:3955–3962.
  • MacConmara, M. P., Maung, A. A., Fujimi, S., McKenna, A. M., Delisle, A., Lapchak, P. H., Rogers, S., Lederer, J. A., Mannick, J. A. 2006. Increased CD4+CD25+ T-regulatory cell activity in trauma patients depresses protective TH1 immunity. Ann. Surg. 244:514–523.
  • MacConmara, M. P., Tajima, G., O’Leary, F., Delisle, A. J., McKenna, A. M., Stallwood, C. G., Mannick, J. A., Lederer, J. A. 2011. Regulatory T-cells suppress antigen-driven CD4 T-cell reactivity following injury. J. Leukocyte Biol. 89:137–147.
  • Miller, A. C., Rashid, R. M., Elamin, E. M. 2007. The “T” in trauma: The helper T-cell response and the role of immunomodulation in trauma and burn patients. J. Trauma 63:1407–1417.
  • Mills, K. H. 2008. Induction, function and regulation of IL-17-producing T-cells. Eur. J. Immunol. 38:2636–2649.
  • Mitsuishi, T., Iida, K., Kawana, S., 2003. Cimetidine treatment for viral warts enhances IL-2 and IFNγ expression but not IL-18 expression in lesional skin. Eur. J. Dermatol. 13:445–448.
  • Ni Choileain, N., MacConmara, M., Zang, Y., Murphy, T. J., Mannick, J. A., Lederer, J. A. 2006. Enhanced regulatory T-cell activity is an element of the host response to injury. J. Immunol. 176:225–236.
  • Oppeltz, R. F., Zhang, Q., Rani, M., Sasaki, J. R., Schwacha, M. G. 2010. Increased expression of cardiac IL-17 after burn. J. Inflamm. (London) 7:38.
  • Organ, B. C., Antonacci, A. C., Chiao, J., Chiao, J., Kumar, A., de Riesthal, H. F., Yuan, L., Black, D., Calvano, S. E. 1989. Changes in lymphocyte number and phenotype in seven lymphoid compartments after thermal injury. Ann. Surg. 210:78–89.
  • Poluektova, L. Y., Huggler, G. K., Patterson, E. B., Khan, M. M. 1999. Involvement of protein kinase A in histamine-mediated inhibition of IL-2 mRNA expression in mouse splenocytes. Immunopharmacology 41:77–87.
  • Rantfors, J., Cassuto, J. 2003. Role of histamine receptors in the regulation of edema and circulation post-burn. Burns 29:769–777.
  • Rezaei, E., Safari, H., Naderinasab, M., Aliakbarian, H. 2011. Common pathogens in burn wound and changes in their drug sensitivity. Burns 37:805–807.
  • Sabat, R., Grutz, G., Warszawska, K., Kirsch, S., Witte, E., Wolk, K., Geginat, J. 2010. Biology of IL-10. Cytokine Growth Factor Rev. 21:331–344.
  • Saito, S., Nakashima, A., Shima, T., Ito, M. 2010. TH1/TH2/TH17 and regulatory T-cell paradigm in pregnancy. Am. J. Reprod. Immunol. 63:601–610.
  • Scheinfeld, N. 2003. Cimetidine: A review of the recent developments and reports in cutaneous medicine. Dermatol. Online J. 9:4.
  • Schwacha, M. G. 2003. Macrophages and post-burn immune dysfunction. Burns 29:1–14.
  • Schwacha, M. G., Holland, L. T., Chaudry, I. H., Messina, J. L. 2005. Genetic variability in the immune-inflammatory response after major burn injury. Shock 23:123–128.
  • Shimizu, S., Tanaka, H., Sakaki, S., Yukioka, T., Matsuda, H., Shimazaki, S. 2002. Burn depth affects dermal interstitial fluid pressure, free radical production, and serum histamine levels in rats. J. Trauma 52:683–687.
  • Steinstraesser, L., Oezdogan, Y., Wang, S. C., Steinau, H. U. 2004. Host defense peptides in burns. Burns 30:619–627.
  • Stoilova, Y. D., Haidushkal, I. A., Murdjeval, M. A., Traikov, I. Z., Popova, T. A., Kevorkyan, A. K. 2007. Immunological and microbiological investigations of patients with burn injuries. Folia Med. (Plovdiv) 49:49–58.
  • Takahashi, K., Tanaka, S., Furuta, K., Ichikawa, A. 2002. Histamine H2 receptor-mediated modulation of local cytokine expression in a mouse experimental tumor model. Biochem. Biophys. Res. Commun. 297:1205–1210.
  • Takahashi, H. K., Watanabe, T., Yokoyama, A., Iwagaki, H., Yoshino, T., Tanaka, N., Nishibori, M. 2006. Cimetidine induces IL-18 production through H2-agonist activity in monocytes. Mol. Pharmacol. 70:450–453.
  • Tang, Z., Yu, Y., Qiu, W., Zhang, J., Yang, X. 2011. Up-regulation of tim-3 expression contributes to development of burn-induced T-cell immune suppression in mice. J. Huazhong Univ. Sci. Tech. Med. Sci. 31:642–651.
  • Utsunomiya, T., Kobayashi, M., Herndon, D. N., Pollard, R. B., Suzuki, F. 2001. A mechanism of IL-12 un-responsiveness associated with thermal injury. J. Surg. Res. 96:211–217.
  • Varedi, M., Jeschke, M. G., Englander, E. W., Herndon, D. N., Barrow, R. E. 2001. Serum TGFβ in thermally-injured rats. Shock 16:380–382.
  • Walker, H. L., Mason, A. D. Jr. 1968. A standard animal burn. J. Trauma 8:1049–1051.
  • Wang, J., Su, B., Ding, Z., Du, X., Wang, B. 2008. Cimetidine enhances immune response of HBV DNA vaccination via impairment of the regulatory function of regulatory T-cells. Biochem. Biophys. Res. Commun. 372:491–496.
  • Wang, K., Wang, D. C., Feng, Y. Q., Xiang-Feng, L. 2007. Changes in cytokine levels and CD4+/CD8+ T-cells ratio in draining lymph node of burn wound. J. Burn Care Res. 28:747–753.
  • Wang, Z. P., Liang, H. P. 2007. Roles of dendritic cells in mediating decreased delayed-type hypersensitivity responses after trauma. Zhong. Yi Xue Ke Xue Yuan Xue Bao 29:501–505.
  • Yabuki, T., Takeyama, N., Tsuda, M., Saitoh, F., Tanaka, T., Noguchi, H., Nakatani, T. 2010. CpG oligonucleotides activate the immune response in burned mice. J. Surg. Res. 161:111–118.
  • Yao, Y. M., Huang, L. F. 2011. The potential role of regulatory T-cells in post-burn sepsis. Zhonghua Shao Shang Za Zhi 27:81–83.
  • Zhang, W., Wang, J., Su, B., Li, R., Ding, Z., Kang, Y., Wang, B. 2011. Cimetidine augments TH1/TH2 dual polarized immune responses to recombinant HBV antigens. Vaccine 29:4862–4868.
  • Zhu, J., Paul, W. E. 2010. Heterogeneity and plasticity of T-helper cells. Cell. Res. 20:4–12.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.