References
- Adler, S., Basketter, D., Creton, S., et al. 2011. Alternative (non-animal) methods for cosmetics testing: Current status and future prospects-2010. Arch. Toxicol. 85:367–485
- Al-Tawil, N. G., Marcusson, J. A., and Moller, E. 1981. Lymphocyte transformation test in patients with nickel sensitivity: An aid to diagnosis. Acta. Derm. Venereol. 61:511–515
- Basketter, D., Crozier, J., Hubesch, B., et al. 2012. Optimized testing strategies for skin sensitization - the LLNA and beyond. Regul. Toxicol. Pharmacol. 64:9–16
- Becker, D., and Knop, J. 1993. Mechanism in allergic contact dermatitis. Exp. Dermatol. 2:63–69
- Beeler, A., Zaccaria, L., Kawabata, T., et al. 2008. CD69 up-regulation on T–cells as an in vitro marker for delayed-type drug hypersensitivity. Allergy 63:181–188
- Berard, F., Marty, J. P., and Nicolas, J. F. 2003. Allergen penetration through the skin. Eur. J. Dermatol. 13:324–330
- Bordignon, V., Palamara, F., Cordiali-Fei, P., et al. 2008. Nickel-, palladium-, and rhodium- induced IFN-gamma and IL-10 production as assessed by in vitro ELISpot-analysis in contact dermatitis patients. BMC Immunol. 9:19
- Boyman, O. 2010. Bystander activation of CD4+ T-cells. Eur. J. Immunol. 40:936–939
- Bruze, M., Isaksson, M., Edman, B., et al. 1995. A study on expert reading of patch test reactions: Inter-individual accordance. Contact Dermatitis 32:331–337
- Cavani, A., Albanesi, C., Traidl, C., et al. 2001. Effector and regulatory T-cells in allergic contact dermatitis. Trends Immunol. 22:118–120
- Cavani, A., De Pita, O., and Girolomoni, G. 2007. New aspects of the molecular basis of contact allergy. Curr. Opin. Allergy Clin. Immunol. 7:404–408
- Cavani, A., Mei, D., Guerra, E., et al. 1998. Patients with allergic contact dermatitis to nickel and non-allergic individuals display different nickel-specific T cell responses. Evidence for the presence of effector CD8+ and regulatory CD4+ T-cells. J. Invest. Dermatol. 111:621–628
- Chipinda, I., Hettick, J. M., and Siegel, P. D. 2011. Haptenation: Chemical reactivity and protein binding. J. Allergy (Cairo) 2011:839682
- Cleaver, J. E. 1967. Thymidine metabolism and cell kinetics. Amsterdam: North-Holland Publishing Co
- Coulter, E. M., Jenkinson, C., Farrell, J., et al. 2010. Measurement of CD4+ and CD8+ T-lymphocyte cytokine secretion and gene expression changes in p-phenylenediamine-allergic patients and tolerant Individuals. J. Invest. Dermatol. 130:161–174
- Coulter, E. M., Jenkinson, C., Wu, Y., et al. 2008. Activation of T-cells from allergic patients and volunteers by p-phenylenediamine and Bandrowski's base. J. Invest. Dermatol. 128:897–905
- Davis, M. D., Hylwa, S. A., and Allen, E. M. 2013. Basics of patch testing for allergic contact dermatitis. Semin. Cutan. Med. Surg. 32:158–168
- Devos, S. A., and van der Valk, P. G. 2001. The risk of active sensitization to PPD. Contact Dermatitis 44:273–275
- Devos, S. A., and van der Valk, P. G. 2002. Epicutaneous patch testing. Eur. J. Dermatol. 12:506–513
- Everness, K. M., Gawkrodger, D. J., Botham, P. A., and Hunter, J. A. 1990. The discrimination between nickel-sensitive and non-nickel-sensitive subjects by an in vitro lymphocyte transformation test. Br. J. Dermatol. 122:293–298
- Friedmann, P. S. 2007. The relationships between exposure dose and response in induction and elicitation of contact hypersensitivity in humans. Br. J. Dermatol. 157: 1093–1102
- Fryauff, D. J., Mouzin, E., Church, L. W., et al. 1999. Lymphocyte response to tetanus toxin T-cell epitopes: Effects of tetanus vaccination and concurrent malaria prophylaxis. Vaccine 17:59–63
- Fulcher, D., and Wong, S. 1999. Carboxyfluorescein succinimidyl ester-based proliferative assays for assessment of T-cell function in the diagnostic laboratory. Immunol. Cell. Biol. 77:559–564
- Gamerdinger, K., Moulon, C., Karp, D. R., et al. 2003. A new type of metal recognition by human T cells: Contact residues for peptide-independent bridging of T-cell receptor and major histocompatibility complex by nickel. J. Exp. Med. 197:1345–1353
- Gaspard, I., Guinnepain, M. T., Laurent, J., et al. 2000. Il-4 and IFN-gamma mRNA induction in human peripheral lymphocytes specific for beta-lactam antibiotics in immediate or delayed hypersensitivity reactions. J. Clin. Immunol. 20:107–116
- Gerberick, G. F., and Robinson, M. K. 2000. A skin sensitization risk assessment approach for evaluation of new ingredients and products. Am. J. Contact Dermatitis 11:65–73
- Gerdes, J., Lemke, H., Baisch, H., et al. 1984. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J. Immunol. 133:1710–1715
- Gonchoroff, N. J., Katzmann, J. A., Currie, R. M., et al. 1986. S-phase detection with an antibody to bromodeoxyuridine. Role of DNase pretreatment. J. Immunol. Meth. 93:97–101
- Grabbe, S., and Schwarz, T. 1998. Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity. Immunol. Today 19:37–44
- Hanafusa, T., Azukizawa, H., Matsumura, S., and Katayama, I. 2012. The predominant drug-specific T-cell population may switch from cytotoxic T-cells to regulatory T-cells during the course of anticonvulsant-induced hypersensitivity. J. Dermatol. Sci. 65:213–219
- Humphreys, N. E., Dearman, R. J., and Kimber, I. 2003. Assessment of cumulative allergen-activated lymph node cell proliferation using flow cytometry. Toxicol. Sci. 73:80–89
- Jenkinson, C., Jenkins, R. E., Aleksic, M., et al. 2010. Characterization of p-phenylenedi-amine-albumin binding sites and T-cell responses to hapten-modified protein. J. Invest. Dermatol. 130:732–742
- Jensen, C. D., Paulsen, E., and Andersen, K. E. 2006. Retrospective evaluation of the consequence of alleged patch test sensitization. Contact Dermatitis 55:30–35
- Jensen, C. S., Lisby, S., Baadsgaard, O., et al. 2002. Decrease in nickel sensitization in a Danish schoolgirl population with ears pierced after implementation of a nickel-exposure regulation. Br. J. Dermatol. 146:636–642
- Joy, N. M., Rice, K. R., and Atwater, A. R. 2013. Stability of patch test allergens. Dermatitis 24:227–236
- Kano, Y., Hirahara, K., Mitsuyama, Y., et al. 2007. Utility of the lymphocyte transformation test in the diagnosis of drug sensitivity: Dependence on its timing and the type of drug eruption. Allergy 62:1439–1444
- Kapsenberg, M. L., Res, P., Bos, J. D., et al. 1987. Nickel-specific lymphocyte-T clones derived from allergic nickel-contact dermatitis lesions in man: Heterogeneity based on requirement of dendritic antigen-presenting cell subsets. Eur. J. Immunol. 17:861–865
- Kapsenberg, M. L., Wierenga, E. A., Stiekema, F. E., et al. 1992. TH1 lymphokine production profiles of nickel-specific CD4+T-lymphocyte clones from nickel contact allergic and non-allergic individuals. J. Invest. Dermatol. 98:59–63
- Kehren, J., Desvignes, C., Krasteva, M., et al. 1999. Cytotoxicity is mandatory for CD8+ T-cell-mediated contact hypersensitivity. J. Exp. Med. 189:779–786
- Kimber, I., and Dearman, R. J. 2002. Allergic contact dermatitis: Cellular effectors. Contact Dermatitis 46:1–5
- Kimber, I., Basketter, D. A., Berthold, K., et al. 2001. Skin sensitization testing in potency and risk assessment. Toxicol. Sci. 59:198–208
- Kimber, I., Basketter, D. A., Gerberick, G. F., et al. 2011. Chemical allergy: Translating biology into hazard characterization. Toxicol. Sci. 120(Suppl 1):S238–268
- Kimber, I., Maxwell, G., Gilmour, N., et al. 2012. Allergic contact dermatitis: Commentary on the relationship between T-lymphocytes and skin sensitizing potency. Toxicology 291:18–24
- Kimber, I., Quirke, S., and Beck, M. H. 1990. Attempts to identify the causative allergen in cases of allergic contact dermatitis using an in vitro lymphocyte transformation test. Toxicol. In Vitro 4:302–306
- Kish, D. D., Gorbachev, A. V., Parameswaran, N., et al. 2012. Neutrophil expression of Fas ligand and perforin directs effector CD8 T-cell infiltration into antigen-challenged skin. J. Immunol. 189:2191–2202
- Kneilling, M., Caroli, U., Grimmel, C., et al. 2010. p-Phenylenediamine-specific lymphocyte activation test: A sensitive in vitro assay to detect p-phenylenediamine sensitization in patients with severe allergic reactions. Exp. Dermatol. 19:435–441
- Lalko, J. F., Kimber, I., Dearman, R. J., et al. 2011. Chemical reactivity measurements: Potential for characterization of respiratory chemical allergens. Toxicol. In Vitro 25:433–445
- Landsteiner, K., and Jacobs, J. 1935. Studies on the sensitization of animals with simple chemical compounds. J. Exp. Med. 61:643–656
- Mallone, R., Mannering, S. I., Brooks-Worrell, B. M., and on behalf of the Immunology of Diabetes Society, T. C. W. C. 2011. Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T-cell responses: Position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society. Clin. Exp. Immunol. 163:33–49
- Martin, S., Esser, P., Schmucker, S., et al. 2010. T-cell recognition of chemicals, protein allergens and drugs: Towards the development of in vitro assays. Cell. Mol. Life Sci. 67:4171–4184
- Martin, S., Ortmann, B., Pflugfelder, U., et al. 1992. Role of hapten-anchoring peptides in defining hapten-epitopes for MHC-restricted cytotoxic T cells. Cross-reactive TNP-determinants on different peptides. J. Immunol. 149:2569–2575
- Martin, S. F. 2004. T-lymphocyte-mediated immune responses to chemical haptens and metal ions: Implications for allergic and autoimmune disease. Int. Arch. Allergy Immunol. 134:186–198
- Martin, S. F. 2012. Allergic contact dermatitis: Xeno-inflammation of the skin. Curr. Opin. Immunol. 24:720–729
- Masjedi, K., Ahlborg, N., Gruvberger, B., et al. 2003. Methylisothiazo-linones elicit increased production of both T helper (TH)1- and TH2-like cytokines by peripheral blood mononuclear cells from contact allergic individuals. Br. J. Dermatol. 149:1172–1182
- McFadden, J. P., Yeo, L., and White, J. L. 2011. Clinical and experimental aspects of allergic contact dermatitis to p-phenylenediamine. Clinics Dermatol. 29:316–324
- Moed, H., Von Blomberg, M., Bruynzeel, D. P., et al. 2005. Improved detection of allergen-specific T-cell responses in allergic contact dermatitis through the addition of ‘cytokine cocktails'. Exp. Dermatol. 14:634–640
- Moulon, C., Vollmer, J., and Weltzien, H. U. 1995. Characterization of processing requirements and metal cross-reactivities in T-cell clones from patients with allergic contact dermatitis to nickel. Eur. J. Immunol. 25:3308–3315
- Mowad, C. M. 2006. Patch testing: Pitfalls and performance. Curr. Opin. Allergy Clin. Immunol. 6:340–344
- Nakano, O., Sato, M., Naito, Y., et al. 2001. Proliferative activity of intratumoral CD8+ T-lymphocytes as a prognostic factor in human renal cell carcinoma: Clinico-pathologic demonstration of antitumor immunity. Cancer. Res. 61:5132–5136
- Newman, W., Stoner, G. L., and Bloom, B. R. 1977. Primary in vitro sensitization of human T-cells. Nature 269:151–153
- Nguyen, S. H., Dang, T. P., Macpherson, C., et al. 2008. Prevalence of patch test results from 1970 to 2002 in a multi-centre population in North America (NACDG). Contact Dermatitis 58:101–106
- Nosbaum, A., Vocanson, M., Rozieres, A., et al. 2009. Allergic and irritant contact dermatitis. Eur. J. Dermatol. 19:325–332
- Novak, N., Haberstok, J., Geiger, E., and Bieber, T. 1999. Dendritic cells in allergy. Allergy 54:792–803
- Nyfeler, B., and Pichler, W. J. 1997. The lymphocyte transformation test for the diagnosis of drug allergy: Sensitivity and specificity. Clin. Exp. Allergy 27:175–181
- Ortmann, B., Martin, S., Von Bonin, A., et al. 1992. Synthetic peptides anchor T-cell-specific TNP epitopes to MHC antigens. J. Immunol. 148:1445–1450
- Pacheco, K., Barker, L., Maier, L., et al. 2013. Development of a validated blood test for nickel sensitization. J. Allergy Clin. Immunol. 132:767–769
- Pichler, W. J. 2001. Predictive drug allergy testing: An alternative viewpoint. Toxicology 158:31–41
- Pichler, W. J., and Tilch, J. 2004. The lymphocyte transformation test in the diagnosis of drug hypersensitivity. Allergy 59:809–820
- Pickard, C., Smith, A. M., Cooper, H., et al. 2007. Investigation of mechanisms underlying the T-cell response to the hapten 2,4-dinitrochlorobenzene. J. Invest. Dermatol. 127:630–637
- Porebski, G., Pecaric-Petkovic, T., Groux-Keller, M., et al. 2013. In vitro drug causality assessment in Stevens-Johnson syndrome - alternatives for lymphocyte transformation test. Clin. Exp. Allergy 43:1027–1037
- Quah, B. J., Warren, H. S., and Parish, C. R. 2007. Monitoring lymphocyte proliferation in vitro and in vivo with the intracellular fluorescent dye carboxyfluorescein diacetate succinimidyl ester. Nat. Protoc. 2:2049–2056
- Rasanen, L., and Tuomi, M. L. 1992. Diagnostic value of the lymphocyte proliferation test in nickel contact allergy and provocation in occupational coin dermatitis. Contact Dermatitis 27:250–254
- Rasanen, L., Sainio, H., Lehto, M., and Reunala, T. 1991. Lymphocyte proliferation test as a diagnostic aid in chromium contact sensitivity. Contact Dermatitis 25:25–29
- Roberts, D. W., and Aptula, A. O. 2008. Determinants of skin sensitization potential. J. Appl. Toxicol. 28:377–387
- Rustemeyer, T., Von Blomberg, B. M., Van Hoogstraten, I. M., et al. 2004. Analysis of effector and regulatory immune reactivity to nickel. Clin. Exp. Allergy. 34:1458–1466
- Saint-Mezard, P., Berard, F., Dubois, B., et al. 2004. The role of CD4+ and CD8+ T-cells in contact hypersensitivity and allergic contact dermatitis. Eur. J. Dermatol. 14:131–138
- Seldin, M. F., and Rich, R. R. 1978. Human immune responses to hapten-conjugated cells. I. Primary and secondary proliferative responses in vitro. J. Exp. Med. 147:1671–1683
- Sherertz, E. F., Fransway, A. F., Belsito, D. V., et al. 2001. Patch testing discordance alert: False-negative findings with rubber additives and fragrances. J. Am. Acad. Dermatol. 45:313–314
- Silvennoinen-Kassinen, S. 1980. Lymphocyte transformation in nickel allergy: Amplification of T-lymphocyte responses to nickel sulphate by macrophages in vitro. Scand. J. Immunol. 12:61–65
- Soares, A., Govender, L., Hughes, J., et al. 2010. Novel application of Ki67 to quantify antigen-specific in vitro lymphoproliferation. J. Immunol. Meth. 362:43–50
- Sodomann, C. P., Rother, M., Havemann, K., and Martini, G. A. 1979. Lymphocyte proliferation to Phytohemagglutinin (PHA) in hepatitis B antigen-positive and -negative hepatitis. Res. Exp. Med. 175:95–107
- Spiewak, R., Moed, H., Von Blomberg, B. M., et al. 2007. Allergic contact dermatitis to nickel: Modified in vitro test protocols for better detection of allergen-specific response. Contact Dermatitis 56:63–69
- Sugita, K., Kabashima, K., Sawada, Y., et al. 2012. Blocking of CTLA–4 on lymphocytes improves the sensitivity of lymphocyte transformation tests in a patient with nickel allergy. Eur. J. Dermatol. 22:268–269
- Sullivan, S., Bergstresser, P. R., Tigelaar, R. E., and Streilein, J. W. 1986. Induction and regulation of contact hypersensitivity by resident, bone marrow-derived, dendritic epidermal cells: Langerhans cells and Thy-1+ epidermal cells. J. Immunol. 137:2460–2467
- Svejgaard, E., Morling, N., Svejgaard, A., and Veien, N. K. 1978. Lymphocyte transformation induced by nickel sulphate: An in vitro study of subjects with and without a positive nickel patch test. Acta. Derm. Venereol. 58:245–250
- Thepen, T., Langeveld-Wildschut, E. G., Bihari, I. C., et al. 1996. Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial TH2 response to a TH1 response in situ: An immunocytochemical study. J. Allergy Clin. Immunol. 97:828–837
- Thierse, H. J., Gamerdinger, K., Junkes, C., et al. 2005. T-cell receptor (TCR) interaction with haptens: Metal ions as non-classical haptens. Toxicology 209:101–107
- Toncic, R. J., Lipozencic, J., Martinac, I., and Greguric, S. 2011. Immunology of allergic contact dermatitis. Acta. Dermatovenerol. Croat. 19:51–68
- Tough, D. F., Borrow, P., and Sprent, J. 1996. Induction of bystander T-cell proliferation by viruses and Type I interferon in vivo. Science 272:1947–1950
- Vocanson, M., Cluzel-Tailhardat, M., Poyet, G., et al. 2008. Depletion of human peripheral blood lymphocytes in CD25+ cells allows for the sensitive in vitro screening of contact allergens. J. Invest. Dermatol. 128:2119–2122
- Vocanson, M., Hennino, A., Chavagnac, C., et al. 2005. Contribution of CD4+ and CD8+ T-cells in contact hypersensitivity and allergic contact dermatitis. Expert Rev. Clin. Immunol. 1:75–86
- Vocanson, M., Hennino, A., Cluzel-Tailhardat, M., et al. 2006. CD8+ T-cells are effector cells of contact dermatitis to common skin allergens in mice. J. Invest. Dermatol. 126:815–820
- von Blomberg-van der Flier, M., van der Burg, C. K., Pos, O., et al. 1987. In vitro studies in nickel allergy: Diagnostic value of a dual parameter analysis. J. Invest. Dermatol. 88:362–368
- Wahlberg, J. E., and Lindberg, M. 2006. Patch testing. Contact Dermatitis 4:366–390
- Werfel, T., Hentschel, M., Kapp, A., and Renz, H. 1997. Dichotomy of blood- and skin-derived IL-4-producing allergen-specific T-cells and restricted V® repertoire in nickel-mediated contact dermatitis. J. Immunol. 158:2500–2505