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Research Article

Relationships between cytokine (IL-6 and TGF-β1) gene polymorphisms and chromosomal damage in hospital workers

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Pages 314-323 | Received 20 Apr 2015, Accepted 22 Jul 2015, Published online: 03 Sep 2015

References

  • Aggarwal BB, Gadhia PK, Hopwood VL, Dave BJ, Risin S, Owen-Schaub L, Pandita R, Pathak S. 1993. Induction of chromosomal rearrangement by tumor necrosis factors produced by primary B-lymphoblastoid cells derived from cancer patients. Lymphokine Cytokine Res. 12:9–19.
  • Awad MR, El-Gamel A, Hasleton P, Turner DM, Sinnott PJ, Hutchinson IV. 1998. Genotypic variation in the TGFβ1 gene: association with transforming growth factor production, fibrotic lung disease, and graft fibrosis after lung transplantation. Transplantation 66:1014–1020.
  • Benveniste EN, Kwon WJ, Chung J, Sampson J, Pandya K, Tang LP. 1994. Differential modulation of astrocyte cytokine gene expression by TGFβ. J. Immunol. 153:5210–5221.
  • Bonassi S, Hagmar L, Strömberg U, Montagud AH, Tinnerberg H, Forni A, Heikkiliä P, Wanders S, Wilhardt P, Norppa H. 2000. Chromosomal aberrations in lymphocytes predict human cancer independently of exposure to carcinogens. Cancer Res. 60:1619–1625.
  • Bonassi S, Znaor A, Norppa H, Hagmar L. 2004. Chromosomal aberrations and risk of cancer in humans: an epidemiologic perspective. Cytogenet Genome Res. 104:376–382.
  • Carrano AV, Moore DH. 1982. The rationale and methodology for quantifying sister chromatid exchange in humans. In: Heddle JA, editor. Mutagenicity: new horizons in genetic toxicology. New York: Academic Press. p. 267–304.
  • Chapman AM, Malkin DJ, Camacho J, Schiestl RH. 2014. IL-13 over-expression in mouse lungs triggers systemic genotoxicity in peripheral blood. Mutat. Res. 769:100–107.
  • Colakogullari M, Ulukaya E, Yilmaztepe Oral A, Aymak F, Basturk B, Ursavas A, Oral HB, et al. 2008. The involvement of IL-10, IL-6, IFN-gamma, TNF-alpha and TGF-beta gene polymorphisms among Turkish lung cancer patients. Cell. Biochem. Funct. 26:283–290.
  • Donner EM, Wong BA, James RA, Preston RJ. 2010. Reciprocal translocations in somatic and germ cells of mice chronically exposed by inhalation to ethylene oxide: implications for risk assessment. Mutagenesis 25:49–55.
  • Fransman W, Vermuelen R, Kromhout H. 2004. Occupational dermal exposure to cyclo-phosphamide in Dutch hospitals: a pilot study. Ann Occup Hyg. 48:237–244.
  • Fishman D, Faulds G, Jeffery R, Mohammed-Ali V, Yudkin S, Humphries S, Woo P. 1998. The effect of novel polymorphisms in the IL-6 gene on IL-6 transcription and plasma IL-6 levels and an association with systemic-onset juvenile chronic arthritis. J Clin Invest. 102:1369–1376.
  • Garcia-Sagredo JM. 2008. Fifty years of cytogenetics: a parallel view of the evolution of cytogenetics and genotoxicology. Biochim. Biophys. Acta 1779:363–375.
  • Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ, Kagnoff MF, Karin M. 2004. Iκκβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118:285–296.
  • Guarnizo-Zuccardi P, Lopez Y, Giraldo M, Garcia N, Rodriguez L, Ramirez L, Uribe O, Garcia L, Vasquez G. 2007. Cytokine gene polymorphisms in Colombian patients with systemic lupus erythematosus. Tissue Antigens 70:376–382.
  • Higashimoto T, Panopoulos A, Hsieh CL, Zandi E. 2006. TNFα induces chromosomal abnormalities independent of ROS through IKK, JNK, p38, and caspase pathways. Cytokine. 34:39–50.
  • Hollegaard MV, Bidwell JL. 2006. Cytokine gene polymorphism in human disease: on-line databases, Supplement 3. Genes Immun. 7:269–276.
  • Holweg CT, Baan CC, Niesters HG, Vantrimpont PJ, Mulder PG, Maat AP, Weimar W, Balk AH. 2001. TGFβ1 gene polymorphisms in patients with end–stage heart failure. J Heart Lung Transplant. 20:979–984.
  • International Agency for Research on Cancer (IARC) (1988). Allyl compounds, aldehydes, epoxides and peroxides. In: Evaluation of the carcinogenic risk of chemicals to humans. Lyon, France: IARC 36:198–226.
  • Karaoglan I, Pehlivan S, Namiduru M, Pehlivan M, Kilinçarslan C, Balkan Y, Baydar I. 2009. TNFα, TGFβ, IL-10, IL-6, and IFNγ gene polymorphisms as risk factors for brucellosis. New Microbiol. 32:173–178.
  • Kopjar N, Garaj-Vrhocav V, Kasŭba V, Rozgaj R, Ramić S, Pavlica V, Zeljezić D. 2009. Assessment of genotoxic risks in Croatian healthcare workers occupationally exposed to cytotoxic drugs: a multi-biomarker approach. Intl. J. Hyg. Environ. Health 212:414–431.
  • Kuningas M, May L, Tamm R, van Bodegom D, van den Biggelaar AHJ, Meij JJ, Frölich M, Ziem JB, Suchiman HED, Metspalu A, et al. 2009. Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population. PLoS One 4:e7795.
  • Lazutka JR. 1996. Genetic toxicity of cytokines. Mutat. Res. 361:95–105.
  • Lorenti Garcia C, Darroudi F, Tates AD, Natarajan AT. 2001. Induction and persistence of micronuclei, sister-chromatid exchanges, and chromosomal aberrations in splenocytes and bone marrow cells of rats exposed to ethylene oxide. Mutat. Res. 492:59–67.
  • Mishra KP, Singh VK, Rani R, Yadav VS, Chandran V, Srivastava SP, Seth PK. 2003. Effect of lead exposure on the immune response of some occupationally exposed individuals. Toxicology 188:251–259.
  • Nathan I, Dizdaroglu M, Bernstein L, Junker U, Lee C, Muegge K, Durum SK. 2000. Induction of oxidative DNA damage in U937 cells by TNFα or anti-Fas stimulation. Cytokine 12:881–887.
  • Perrey C, Turner SJ, Pravica V, Howell WM, Hutchinson IV. 1999. ARMS-PCR methodologies to determine IL-10, TNFα, TNFβ, and TGFβ1 gene polymorphisms. Transplant. Immunol. 7:127–128.
  • Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S, Gutkovich-Pyest E, Urieli-Shoval S, Galun E, Ben-Neriah Y. 2004. NF-κB functions as a tumor promoter in inflammation associated cancer. Nature 431:461–466.
  • Rass U, Ahel I, West SC. 2007. Defective DNA repair and neurodegenerative disease. Cell 130:991–1004.
  • Ritchie MA, McAdams C, Fritz N. 1999. Exposure risk in the handling and administration of chemotherapy agents: a review and synthesis of the literature. Online J. Knowl. Synth. Nurs. 7:1–10.
  • Santovito A, Schilirò T, Castellano S, Cervella P, Bigatti MP, Gilli G, Bono R, Delpero M. 2011. Combined analysis of chromosomal aberrations and glutathione-S-transferase M1 and T1 polymorphisms in pathologists occupationally exposed to formaldehyde. Arch. Toxicol. 85:1295–1302.
  • Santovito A, Cervella P, Delpero M. 2014a. Chromosomal damage in peripheral blood lymphocytes from nurses occupationally exposed to chemicals. Human Exp. Toxicol. 33:897–903.
  • Santovito A, Cervella P, Delpero M. 2014b. Increased frequency of chromosomal aberrations and sister chromatid exchanges in peripheral lymphocytes of radiology technicians chronically-exposed to low levels of ionizing radiations. Environ. Toxicol. Pharmacol. 37:396–403.
  • Santovito A, Cervella P, Delpero M. 2015. Evidence of genotoxicity in lymphocytes of non-smoking alcoholics. Mol Biol Rep. 42:53–59.
  • Seidelin JB, Nielsen OH. 2005. Continuous cytokine exposure of colonic epithelial cells induces DNA damage. Eur. J. Gastroenterol. Hepatol. 17:363–369.
  • Shimoyama T, Everett SM, Fukuda S, Axon AT, Dixon MF, Crabtree JE. 2001. Influence of smoking and alcohol on gastric chemokine mRNA expression in patients with Helicobacter pylori infection. J. Clin. Pathol. 54:332–334.
  • Smith AJ, Humphries SE. 2008. Cytokine and cytokine receptor gene polymorphisms and their functionality. Cytokine Growth Factor Rev. 20:43–59.
  • Suzumura A, Sawada M, Yamamoto H, Marunouchi T. 1993. TGFβ suppresses activation and proliferation of microglia in vitro. J. Immunol. 151:2150–2158.
  • Szabo G. 1999. Consequence of alcohol consumption on host defense. Alcohol Alcohol. 34:830–841.
  • Taherkhani H, Hajilooi M, Fallah M, Khyabanchi O, Haidari M. 2009. Gene polymerphism in TGFβ codon 10 is associated with susceptibility to giardiasis. Intl. J. Immunogenet. 36:345–349.
  • Terry CF, Loukaci V, Green FR. 2000. Cooperative influence of genetic polymorphisms on IL- 6 transcriptional regulation. J. Biol. Chem 275:18138–18144.
  • Uboldi de Capei M, Dametto E, Fasano ME, Rendine S, Curtoni ES. 2003. Genotyping for cytokine polymorphisms: allele frequencies in the Italian population. Eur. J. Immunogenet. 30:5–10.
  • van Dyke AL, Cote ML, Wenzlaff AS, Land S, Schwartz AG. 2009. Cytokine SNPs: comparison of allele frequencies by race and implications for future studies. Cytokine 46:236–244.
  • Walsh PS, Metzger DA, Higuchi R. 1991. Chelex 100 as a Medium for simple extraction of DNA for PCR-based typing from forensic material. BioTechniques 10:506–13.
  • Westbrook AM, Wei B, Hacke K, Xia M, Braun J, Schiestl RH. 2012. The role of TNFα and TNF-receptor signaling in inflammation-associated systemic genotoxicity. Mutagenesis 27:77–86.
  • Wheelhouse NM, Chan YS, Gillies SE, Caldwell H, Ross JA, Harrison DJ, Prost S. 2003. TNFα-induced DNA damage in primary murine hepatocytes. Intl. J. Mol. Med. 12:889–894.
  • Xaubet A, Marin-Arguedas A, Lario S, Ancochea J, Morell F, Ruiz-Manzano J, Rodriguez-Becerra E, Rodriguez-Arias JM, Inigo P, Sanz S, et al. 2003. TGFβ1 gene polymorphisms are associated with disease progression in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 168:431–435.
  • Xing Z, Gauldie J, Cox G, Baumann H, Jordana M, Lei XF, Achong MK. 1998. IL-6 is an anti-inflammatory cytokine required for controlling local or systemic acute inflammatory responses. J. Clin. Invest. 1:311–320.
  • Yucesoy B, Turhan A, Ure M, Imir T, Karakaya A. 1997. Effects of occupational lead and cadmium exposure on some immunoregulatory cytokine levels in man. Toxicology 123:143–147.
  • Zakharyan R, Petrek M, Arakelyan A, Mrazek F, Atshemyan S, Boyajyan A. 2012. IL-6 promoter polymorphism and plasma levels in patients with schizophrenia. Tissue Antigens 80:136–142.

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