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Research Article

Exploring an animal model of amodiaquine-induced liver injury in rats and mice

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Pages 694-712 | Received 10 Dec 2015, Accepted 11 Mar 2016, Published online: 14 Jul 2016

References

  • Angelucci A, Festuccia C, Gravina GL, Muzi P, Bonghi L, Vicentini C, Bologna M. 2004. Osteopontin enhances cell proliferation induced by the epidermal growth factor in human prostate cancer cells. Prostate. 59:157–166.
  • Banissi C, Ghiringhelli F, Chen L, Carpentier AF. 2009. Treg depletion with a low-dose metronomic temozolomide regimen in a rat glioma model. Cancer Immunol Immunother. 58:1627–1634.
  • Betten A, Dahlgren C, Mellqvist UH, Hermodsson S, Hellstrand K. 2004. Oxygen radical-induced natural killer cell dysfunction: Role of myeloperoxidase and regulation by serotonin. J Leukocyte Biol. 75:1111–1115.
  • Clarke JB, Maggs JL, Kitteringham NR, Park BK. 1990. Immunogenicity of amodiaquine in the rat. Int Arch Allergy Appl Immunol. 91:335–342.
  • Clarke JB, Neftel K, Kitteringham NR, Park BK. 1991. Detection of anti-drug IgG antibodies in patients with adverse drug reactions to amodiaquine. Int Arch Allergy Appl Immunol. 95:369–375.
  • Czaja MJ, Geerts A, Xu J, Schmiedeberg P, Ju Y. 1994. Monocyte chemoattractant protein (MCP)-1 expression occurs in toxic rat liver injury and human liver disease. J Leukocyte Biol. 55:120–126.
  • Diao H, Liu X, Wu Z, Kang L, Cui G, Morimoto J, Denhardt DT, Rittling S, Iwakura Y, Uede T, Li L. 2012. Osteopontin regulates IL-17 production in hepatitis. Cytokine. 60:129–137.
  • Dijkstra CD, Dopp EA, Joling P, Kraal G. 1985. The heterogeneity of mononuclear phagocytes in lymphoid organs: Distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2, and ED3. Immunology. 54:589–599.
  • Gignoux E, Azman AS, de Smet M, Azuma P, Massaquoi M, Job D, Tiffany A, Petrucci R, Sterk E, Potet J, et al. 2016. Effect of artesunate-amodiaquine on mortality related to Ebola virus disease. N Engl J Med. 374: 23–32.
  • Glick L. 1957. Fatal agranulocytosis during treatment with a amodiaquine. Br Med J. 1:932.
  • Guevart E, Aguemon A. 2009. Two cases of fulminant hepatitis during a curative treatment with an artesunate-amodiaquine combination. Med Mal Infect. 39:57–60.
  • Harrison AC, Kitteringham NR, Clarke JB, Park BK. 1992. The mechanism of bioactivation and antigen formation of amodiaquine in the rat. Biochem Pharmacol. 43:1421–1430.
  • Hirschel B. 2003. Questions about the antimalarial amodiaquine. Lancet. 361:2.
  • Kaplowitz N. 2001. Drug-induced liver disorders: Implications for drug development and regulation. Drug Safety. 24:483–490.
  • Lee WM. 2003. Drug-induced hepatotoxicity. N Engl J Med. 349:474–485.
  • Lee YS, Jeong WI. 2012. Retinoic acids and hepatic stellate cells in liver disease. J Gastroenterol Hepatol. 27:75–79.
  • Lind DE, Levi JA, Vincent PC. 1973. Amodiaquine-induced agranulocytosis: Toxic effect of amodiaquine in bone marrow cultures in vitro. Br Med J. 1:458–460.
  • Liu YJ, Zhang DQ, Sui XM, Tian W. 2009. Overexpression of human osteopontin increases cell proliferation and migration in human embryo kidney-293 cells. Cell Mol Biol Lett. 14:670–678.
  • Lobach AR, Uetrecht J. 2014. Involvement of myeloperoxidase and nadph oxidase in the covalent binding of amodiaquine and clozapine to neutrophils: implications for drug-induced agranulocytosis. Chem Res Toxicol. 27:699–709.
  • Mandrekar P, Ambade A, Lim A, Szabo G, Catalano D. 2011. An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: Regulation of pro-inflammatory cytokines and hepatic steatosis in mice. Hepatology. 54:2185–2197.
  • Masson MJ, Carpenter LD, Graf ML, Pohl LR. 2008. Pathogenic role of natural killer T and natural killer cells in acetaminophen-induced liver injury in mice is dependent on the presence of dimethyl sulfoxide. Hepatology. 48:889–897.
  • Metushi IG, Zhu X, Chen X., Gardam MA, Uetrecht J. 2014. Mild isoniazid-induced liver injury in humans is associated with an increase in TH17 cells and T-cells producing IL-10. Chem Res Toxicol. 27:683–689.
  • Metushi IG, Cai P, Dervovic D, Liu F, Lobach A, Nakagawa T, Uetrecht J. 2015a. Development of a novel mouse model of amodiaquine-induced liver injury with a delayed onset. J Immunotoxicol. 12:247–260.
  • Metushi IG, Hayes MA, Uetrecht J. 2015b. Treatment of PD-1 mice with amodiaquine and anti-CTLA4 leads to liver injury similar to idiosyncratic liver injury in patients. Hepatology. 61:1332–1342.
  • Millman AC, Salman M, Dayaram YK, Connell ND, Venketaraman V. 2008. Natural killer cells, glutathione, cytokines, and innate immunity against Mycobacterium tuberculosis. J Interferon Cytokine Res. 28:153–165.
  • Mizutani T, Irie Y, Nakanishi K. 1994. Styrene-induced hepatotoxicity in mice depleted of glutathione. Res Commun Mol Pathol Pharmacol. 86:361–374.
  • Mizutani T, Murakami M, Shirai M, Tanaka M, Nakanishi K. 1999. Metabolism-dependent hepatotoxicity of methimazole in mice depleted of glutathione. J Appl Toxicol. 19:193–198.
  • Mizutani T, Satoh K, Nomura H, Nakanishi K. 1991. Hepatotoxicity of eugenol in mice depleted of glutathione by treatment with DL-buthionine sulfoximine. Res Commun Chem Pathol Pharmacol. 71:219–230.
  • Nakagawa K, Miller FN, Sims DE, Lentsch AB, Miyazaki M, Edwards MJ. 1996. Mechanisms of IL-2-induced hepatic toxicity. Cancer Res. 56:507–510.
  • Papadakis KA, Prehn JL, Landers C, Han Q, Luo X, Cha SC, Wei P, Targan SR. 2004. TL1A synergizes with IL-12 and IL-18 to enhance IFNγ production in human T-cells and NK cells. J Immunol. 172:7002–7007.
  • Peraldi MN, Berrou J, Dulphy N, Seidowsky A, Haas P, Boissel N, Metivier F, Randoux C, Kossari N, Guérin A, et al. 2009. Oxidative stress mediates a reduced expression of the activating receptor NKG2D in NK cells from end-stage renal disease patients. J Immunol. 182:1696–1705.
  • Ramaiah SK, Rittling S. 2007. Role of osteopontin in regulating hepatic inflammatory responses and toxic liver injury. Expert Opin Drug Metab Toxicol. 3:519–526.
  • Shimizu S, Atsumi R, Itokawa K, Iwasaki M, Aoki T, Ono C, Izumi T, Sudo K, Okazaki O. 2009. Metabolism-dependent hepatotoxicity of amodiaquine in glutathione-depleted mice. Arch Toxicol. 83:701–707.
  • Taimr P, Higuchi H, Kocova E, Rippe RA, Friedman S, Gores GJ. 2003. Activated stellate cells express the TRAIL receptor-2/death receptor-5 and undergo TRAIL-mediated apoptosis. Hepatology. 37:87–95.
  • Taylor WR, White NJ. 2004. Anti-malarial drug toxicity: A review. Drug Safety. 27:25–61.
  • Trinchieri G. 2003. IL-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol. 3:133–146.
  • Uetrecht J. 2005. Role of animal models in the study of drug-induced hypersensitivity reactions. AAPS J. 7:E914–E921.
  • Uetrecht J. 2008. Idiosyncratic drug reactions: Past, present, and future. Chem Res Toxicol. 21:84–92.
  • Viora M, Quaranta MG, Straface E, Vari R, Masella R, Malorni W. 2001. Redox imbalance and immune functions: opposite effects of oxidized low-density lipoproteins and N-acetylcysteine. Immunology. 104:431–438.
  • White NJ, Looareesuwan S, Edwards G, Phillips RE, Karbwang J, Nicholl DD, Bunch C, Warrell DA. 1987. Pharmacokinetics of intravenous amodiaquine. Br J Clin Pharmacol. 23:127–135.

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