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ArticlesResearch in Toxicology

Radiolabeling and dose fixation study of oral alpha-ketoglutarate as a cyanide antidote in healthy human volunteers

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Pages 509-515 | Received 27 Mar 2010, Accepted 24 May 2010, Published online: 23 Jun 2010

References

  • Cummings TF. The treatment of cyanide poisoning. Occup Med 2004; 54:82–85.
  • Baud FJ. Cyanide: critical issues in diagnosis and treatment. Hum Exp Toxicol 2007; 26:191–201.
  • Bhattacharya R, Flora SJS. Cyanide toxicity and its treatment. In: Gupta RC, ed. Handbook of Toxicology of Chemical Warfare Agents. New York: Elsevier Inc.; 2009:255–270.
  • Rotenberg JS. Cyanide as a weapon of terror. Pediatr Ann 2003; 32:236–240.
  • Bhattacharya R. Antidotes to cyanide poisoning: present status. Indian J Pharmacol 2000; 32:94–101.
  • Baskin SL, Horowitz AM, Nealley EW. The antidotal action of sodium nitrite and sodium thiosulphate against cyanide poisoning. J Clin Pharmacol 1992; 32:368–375.
  • Van Heijst ANP, Douze JMC, Van Kesteren RG, Van Bergen J, Van Dijk A. Therapeutic problems in cyanide poisoning. Clin Toxicol 1987; 25:383–398.
  • Vick JA, Von Bredow JD. Effectiveness of intramuscularly administered cyanide antidotes on methemoglobin formation and survival. J Appl Toxicol 1998; 16:509–516.
  • Baumeister RGH, Schievelbein H, Zickgraf-Rudel G. Toxicological and clinical aspects of cyanide metabolism. Drug Res 1975; 25:1056–1063.
  • Van Heijst ANP, Meredith JJ. Antidotes for cyanide poisoning. In: Volanis GN, Sims J, Sullivan F, Turner P, eds. Basic Science in Toxicology. Brighton, UK: Taylor & Francis; 1990:558–566.
  • Hall AH, Dart R, Bogdan G. Sodim thiosulphate or hydroxocobalamin for the empiric treatment of cyanide poisoning? Ann Emerg Med 2007; 49:806–813.
  • Borron SW, Baud FJ, Megarbane B, Bismuth C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg Med 2007; 25:551–558.
  • Schwartz C, Morgan RL, Way LM, Way JL. Antagonism of cyanide intoxication with sodium pyruvate. Toxicol Appl Pharmacol 1979; 50:437–441.
  • Moore SJ, Norris JC, Ho IK, Hume AS. The efficacy of α- ketoglutaric acid in the antagonism of cyanide intoxication. Toxicol Appl Pharmacol 1986; 82:40–44.
  • Niknahad H, Khan S, Sood C, O’Brien P. Prevention of cyanide- induced cytotoxicity by nutrients in isolated rat hepatocytes. Toxicol Appl Pharmacol 1994; 128:271–279.
  • Bhattacharya R, Tulsawani RK. In vitro and in vivo evaluation of various carbonyl compounds against cyanide toxicity with particular reference to alpha-ketoglutaric acid. Drug Chem Toxicol 2008; 31:149–161.
  • Morrison RT, Boyd RN. Organic Chemistry. Boston, MA: Allyn and Bacon, Inc.; 1976:637–639.
  • Norris JC, Utley WA, Hume AS. Mechanism of antagonizing cyanide induced lethality by α-ketoglutaric acid. Toxicology 1990; 64:275–283.
  • Bhattacharya R, Vijayaraghavan R. Promising role of a-ketoglutarate in protecting the lethal effects of cyanide. Hum Exp Toxicol 2002; 21:297–303.
  • Bhattacharya R, Lakshmana Rao PV, Vijayaraghavan R. In vitro and In vivo attenuation of experimental cyanide poisoning by alpha-kotoglutarate. Toxicol Lett 2002; 128:185–195.
  • Bhattacharya R. α-Ketoglutarate: a promising antidote to cyanide poisoning. In: Flora SJS, Romano JA, Baskin SI, Sekhar K, eds. Pharmacological Perspectives of Toxic Chemicals and Their Antidotes. New Delhi, India: Narosa Publishing House; 2004:411–430.
  • Ballantyne B. Toxicology of cyanides. In: Ballantyne B, Marrs TC, eds. Clinical and Experimental Toxicology of Cyanides. Bristol, UK: Wright Publishers; 1987:41–126.
  • Tulsawani RK, Kumar D, Bhattacharya R. Effect of pre-treatment of α-ketoglutarate on cyanide-induced toxicity and alterations in various physiological variables in rodents. Biomed Environ Sci 2007; 20:56–63.
  • Bhattacharya R, Kumar D, Sugendran K, Pant SC, Tulsawani RK, Vijayaraghavan R. Acute toxicity studies of α-ketoglutarate: a promising antidote for cyanide poisoning. J Appl Toxicol 2001; 21:495–499.
  • Pangborn JB, Hicks JT, Chambers JR, Shahani KM, eds. A Monograph on Alpha-Ketoglutaric Acid. Lisle, IL: Bionostics, Inc.; 1990:1–3.
  • Bhavna Ahmad FJ, Mittal G, Jain GK, Malhotra G, Khar RK, Bhatnagar A. Nano-salbutamol dry powder inhalation: a new approach for treating broncho-constructive conditions. Eur J Pharm Biopharm 2009; 71:282–291.
  • Rajpal S, Mittal G, Sachdeva R, Chhillar M, Ali R, Agrawal SS, Kashyap R, Bhatnagar A. Development of atropine sulphate nasal drops and its pharmacokinetic and safety evaluation in healthy human volunteers. Environ Toxicol Pharmacol 2009; 27:206–211.
  • Davis SS, Hardy JG, Newman SP, Wilding IR. Gamma scintigraphy in the evaluation of pharmaceutical dosage forms. Eur J Nucl Med 1992; 19:971–986.
  • Wilding IR, Coupe AJ, Davis SS. The role of gamma-scintigraphy in oral drug delivery. Adv Drug Deliv Rev 2001; 46:103–124.
  • Singh AK, Bhardwaj N, Bhatnagar A. Pharmacoscintigraphy: an unexplored modality in Indian. J Pharm Sci 2004; 66:18–25.
  • Singh AK, Verma J, Bhatnagar A, Sen S, Bose M. Tc-99m Isoniazid: a specific agent for diagnosis of tuberculosis. World J Nucl Med 2003; 2:292–305.
  • Desai H. Development and method validation of analytical method for estimation of α-ketoglutarate in technical and serum by HPLC. A project report submitted by Jai Research Foundation, Valsad, India to DRDE, Gwalior. Personal communication ( Study No. 4596); 2004:1–110.
  • Cynober L. The use of a-ketoglutarate salts in clinical nutrition and metabolic care. Curr Opin Clin Nutr Metab Care 1999; 2:33–37.
  • Andrae U, Singh J, Zeigler-Skylakakis K. Pyruvate and related alpha-ketoacids protect mammalian cells in culture against hydrogen peroxide-induced cytotoxicity. Toxicol Lett 1985; 28:93–98.
  • Varma SD, Hegde KR. The effect of α-ketoglutarate against selenite cataract formation. Exp Eye Res 2004; 79:913–918.
  • Patra D. Serum kinetics study of α-ketoglutarate in Wistar rats following single oral administration. A project report submitted by Jai Research Foundation, Valsad, India to DRDE, Gwalior. Personal communication ( Study No. 1573); 2005:1–27.
  • Buddington RK, Pajor A, Buddington KK, Pierzynowski S. Absorption of alpha-ketoglutarate by the gastrointestinal tract of pigs. Comp Biochem Physiol A Mol Integr Physiol 2004; 132:215–220.
  • Lambert BD, Filip R, Stoll B, Junghans P, Derno M, Hennig U, Souffrant WB, Pierzynowski S, Burrin DG. First-pass metabolism limits the intestinal absorption of enteral alpha-ketoglutarate in young pigs. J Nutr 2006; 136:2779–2784.

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