891
Views
24
CrossRef citations to date
0
Altmetric
Short report

Complete heart block and death following lamotrigine overdose

, &
Pages 330-333 | Received 17 Jan 2011, Accepted 12 Mar 2011, Published online: 12 May 2011

References

  • Fitton A, Goa KL. Lamotrigine. An update of its pharmacology and therapeutic use in epilepsy. Drugs 1995; 50:691–713.
  • Lofton AL, Klein-Schwartz W. Evaluation of lamotrigine toxicity reported to poison centers. Ann Pharmacother 2004; 38:1811–1815.
  • Mylonakis E, Vittorio CC, Hollik DA. Lamotrigine overdose presenting as anticonvulsant hypersensitivity syndrome. Ann Pharmacother 1999; 33:557–559.
  • Herold TJS. Lamotrigine as a possible cause of QRS prolongation in a patient with known seizure disorder. Can J Emerg Med 2006; 8:361–364.
  • Reimers A, Reinholt G. Acute Lamotrigine overdose in an adolescent. Ther Drug Monit 2007; 29:669–670.
  • Close BR, Banks CJ. Seizures secondary to lamotrigine toxicity in a two-year old. Ann Pharacother 2010; 44:1112–1115.
  • Wade FJ, Dang CV, Nelson L, Wasserberger J. Emergency complications of the newer anticonvulsants. J Emer Med 2010; 38:231–237.
  • Miller MA, Levsky ME. Choreiform dyskinesia following isolated lamotrigine overdose. J Child Neurol 2008; 23:243.
  • Doyon, S. Goldfrank’s Toxicologic Emergencies. 8th ed. New York: McGraw-Hill; 2006. Chapter 47, pp. 713–745.
  • Keranen T, Sorri A, Moilanen E, Ylitalo P. Effects of charcoal on the absorption and elimination of the antiepileptic drugs lamotrigine and oxcarbazepine. Arzneimittelforschung 2010; 60:421–426.
  • Rowland, A, Elliot DJ, Williams JA, Mackenzie PI, Dickinson RG, Miners JO. In vitro characterization of lamotrigine N2-glucoronidation and the lamotrigine-valproic acid interaction. Drug Metab Dispos 2006; 34:1055–1062.
  • Fillastre JP, Taburet AM, Fialaire A, Etienne I, Bidault R, Singlas E. Pharmacokinetics of lamotrigine in patients with renal impairment: influence of haemodialysis. Drugs Exp Clin Res 1993; 19:25–32.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.