Advanced search
Publication Cover
Clinical Toxicology Volume 50, 2012 - Issue 7
Submit an article Journal homepage
400
Views
13
CrossRef citations to date
0
Altmetric
Research Article

Validation of a pre-existing formula to calculate the contribution of ethanol to the osmolar gap

Alexander GarrardDepartment of Emergency Medicine, Upstate New York Poison Center at Upstate Medical University, Syracuse, NY, USACorrespondence[email protected]
,
Dawn R. SolleeFlorida/USVI Poison Information Center – Jacksonville at Shands Jacksonville, Jacksonville, FL, USA
,
Ryan C. ButterfieldCenter for Health Equity and Quality Research, University of Florida, Shands-Jacksonville, Jacksonville, FL, USA
,
Laura JohannsenShands Jacksonville Core Laboratory, University of Florida Health Science Center, Jacksonville, FL, USA
,
Adam WoodFlorida/USVI Poison Information Center – Jacksonville at Shands Jacksonville, Jacksonville, FL, USA
&
Roger L. BertholfDepartment of Pathology, University of Florida Health Science Center, Jacksonville, FL, USA
Pages 562-566 | Received 03 Apr 2012, Accepted 12 Jun 2012, Published online: 06 Jul 2012

References

  • Dorwart W, Chalmers L. Comparison of methods for calculating serum osmolality form chemical concentrations, and the prognostic value of such calculations. Clin Chem 1975 ;21:190–194.
  • Holt S, Stewart I, Dixon J, Elton R, Taylor T, Little K. Alcohol and the emergency service patient. Br Med J 1980 ;281:638–640.
  • Olson K. Emergency treatment and evaluation. In: Poisoning and Drug Overdose. 5th ed. New York: McGraw-Hill; 2007. p. 32.
  • Smith J, Quan D. Chapter 179. Alcohols. In: Tintinalli J, Stapczynski J, Cline D, Ma O, Cydulka R, Meckler G , eds. Tintinalli's Emergency Medicine: A Comprehensive Study Guide. 7th ed. New York: McGraw-Hill; 2011.
  • Purssell R, Pudek M, Brubacher J, AbuLaban R. Derivation and validation of a formula to calculate the contribution of ethanol to the osmolal gap. Ann Emerg Med 2001 ;38:653–659.
  • Clay KL, Murphy RC. On the metabolic acidosis of ethylene glycol intoxication. Toxicol Appl Pharmacol 1977 ;39:39–49.
  • Bove KE. Ethylene glycol toxicity. Am J Clin Pathol 1966 ;45:46–50.
  • Berman LB, Schreiner GE, Feys J. The nephrotoxic lesion of ethylene glycol. Ann Intern Med 1957 ;46:611–619.
  • Huber PJ. Robust regression: asymptotics, conjectures, and Monte Carlo. Ann Statist 1973 ;1:799–821.
  • Geller RJ, Spyker DA, Herold DA, Bruns DE. Serum osmolal gap and ethanol concentration: a simple and accurate formula. J Toxicol Clin Toxicol 1986 ;24:77–84.
  • Hoffman RS, Smilkstein MJ, Howland MA, Goldfrank LR. Osmol gaps revisited: normal values and limitations. J Toxicol Clin Toxicol 1993 ;31:81–93.
  • Glaser DS. Utility of the serum osmol gap in the diagnosis of methanol or ethylene glycol ingestion. Ann Emerg Med 1996 ;27:343–346.
  • Osterloh JD, Kelly TJ, Khayam-Bashi H, Romeo R. Discrepancies in osmolal gaps and calculated alcohol concentrations. Arch Pathol Lab Med 1996 ;120:637–641.
  • Steinhart B. Case report: severe ethylene glycol intoxication with normal osmolal gap – “a chilling thought”. J Emerg Med 1990 ;8:583–585.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.