190
Views
5
CrossRef citations to date
0
Altmetric
Research Article

The effects of fructose-1,6-diphosphate on haemodynamic parameters and survival in a rodent model of propranolol and verapamil poisoning

&
Pages 546-554 | Received 09 May 2012, Accepted 19 Jun 2012, Published online: 08 Aug 2012

References

  • Gunja N, Graudins A. Management of cardiac arrest following poisoning. Emerg Med Australas 2011; 23:16–22.
  • Bronstein AC, Spyker DA, Cantilena LR Jr., Green JL, Rumack BH, Dart RC. 2010 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 28th Annual Report. Clinical Toxicology. 2011; 49:910–941.
  • Hantson P, Beauloye C. Myocardial metabolism in toxin-induced heart failure and therapeutic implications. Clin Toxicol 2012; 50:166–171.
  • Kerns W. Management of beta-adrenergic blocker and calcium channel antagonist toxicity. Emerg Med Clin North Am 2007; 25:309–331.
  • Kirtley ME, McKay M. Fructose-1,6-bisphosphate, a regulator of metabolism. Mol Cell Biochem 1977; 18:141–149.
  • Eddy LJ, Chambers D, Honig S, Downey JM. Lack of a direct metabolic effect of fructose-1,6-diphosphate in ischemic myocardium. Am J Physiol 1981; 241:H576–;H582.
  • Farias LA, Sun J, Markov AK. Improved brain metabolism with fructose 1-6 diphosphate during insulin-induced hypoglycemic coma. Am J Med Sci 1989; 297:294–299.
  • Kuluz JW, Gregory GA, Han Y, Dietrich WD, Schleien CL. Fructose-1,6-bisphosphate reduces infarct volume after reversible middle cerebral artery occlusion in rats. Stroke 1993; 24:1576–1583.
  • Riedel BJ, Gal J, Ellis G, Marangos PJ, Fox AW, Royston D. Myocardial protection using fructose-1,6-diphosphate during coronary artery bypass graft surgery: a randomized, placebo-controlled clinical trial. Anesth Analg 2004; 98:20–29.
  • Wheeler TJ, Wiegand CB, Chien S. Fructose-1,6-bisphosphate enhances hypothermic preservation of cardiac myocytes. J Heart Lung Transplant 2005; 24:1378–1384.
  • Zhang JN, Zhang FM, Ma WS, Forrester T. Protective effect of exogenous fructose-1,6-diphosphate in cardiogenic shock. Cardiovasc Res 1988; 22:927–932.
  • Markov AK, Oglethorpe NC, Blake TM. Attenuation of digitalis toxicity with fructose-1,6-diphosphate. Clin Res 1983; 31:866A [Abstract].
  • Markov AK, Payment MF, Hume AS, Rao MR, Markov MA, Skelton TN, . Fructose-1,6-Diphosphate in the treatment of Oleander toxicity in dogs. Vet Hum Toxicol 1999; 41:9–15.
  • Gawarammana I, Mohamed F, Bowe SJ, Rathnathilake A, Narangoda SK, Azher S, . Fructose-1,6-diphosphate (FDP) as a novel antidote for yellow oleander-induced cardiac toxicity: a randomized controlled double blind study. BMC Emerg Med 2010; 10:15.
  • Graudins A, Najafi J, Perry M. Treatment of experimental verapamil poisoning with levosimendan utilizing a rodent model of drug toxicity. Clin Toxicol 2008; 46:50–56.
  • Graudins A, Wong KKL. Comparative hemodynamic effects of levosimendan alone and in conjunction with 4-aminopyridine or calcium chloride in a rodent model of severe verapamil poisoning. J Med Toxicol 2010; 6:85–93.
  • Kalam Y, Graudins A. Levosimendan infusion improves cardiac output but not blood pressure in a rodent model of severe metoprolol toxicity. Hum Exp Toxicol 2012;In Press.
  • Kalam Y, Graudins A. Levosimendan does not improve cardiac output or blood pressure in a rodent model of propranolol toxicity when administered using various dosing regimens. Int J Toxicol 2012; 31:166–174.
  • Hill MA, Larkins RG. Alterations in distribution of cardiac output in experimental diabetes in rats. Am J Physiol 1989; 257(2 Pt 2): H571–H580.
  • Najafi JM, Graudins A. Norepinephrine co-administered with levosimendan does not reverse hypotension in a rodent model experimental verapamil poisoning. Emerg Med Australas 2007; 19(Suppl1): A19–A20 [Abstract].
  • Vexler ZS, Berrios M, Ursell PC, Sola A, Ferriero DM, Gregory GA. Toxicity of fructose-1,6-bisphosphate in developing normoxic rats. Pharmacol Toxicol 1999; 84:115–121.
  • Romsi P, Kaakinen T, Kiviluoma K, Vainionpaa V, Hirvonen J, Pokela M, . Fructose-1,6-bisphosphate for improved outcome after hypothermic circulatory arrest in pigs. J Thoracic Cardiovasc Surg 2003; 125:686–698.
  • Markov AK. Hemodynamics and metabolic effects of fructose-1, 6-diphosphate in ischemia and shock—experimental and clinical observations. Ann Emerg Med 1986; 15:1470–1477.
  • Cannella DM, Kapp JP, Munschauer FE, Markov AK, Shucard DW. Cerebral resuscitation with succinate and fructose-1,6-diphosphate. Surg Neurol 1989; 31:177–182.
  • Cohen JE, Atluri P, Taylor MD, Grand TJ, Liao GP, Panlilio CM, . Fructose-1,6-diphosphate administration attenuates post-ischemic ventricular dysfunction. Heart Lung Circ 2006; 15:119–123.
  • Didlake R, Kirchner KA, Lewin J, Bower JD, Markov A. Protection from ischemic renal injury by fructose-1,6-diphosphate infusion in the rat. Circ Shock 1985; 16:205–212.
  • Markov AK, Oglethorpe NC, Blake TM, Lehan PH, Hellems HK. Hemodynamic, electrocardiographic, and metabolic effects of fructose diphosphate on acute myocardial ischemia. Am Heart J 1980; 100:639–646.
  • Sun JX, Farias LA, Markov AK. Fructose-1,6-diphosphate prevents intestinal ischemic reperfusion injury and death in rats. Gastroenterology 1990; 98:117–126.
  • Markov AK, Oglethorpe N, Young DB, Hellems HK. Irreversible hemorrhagic shock: treatment and cardiac pathophysiology. Circ Shock 1981; 8:9–19.
  • Markov AK, Turner MD, Oglethorpe N, Neely WA, Hellems HK. Fructose-1,6-diphosphate: an agent for treatment of experimental endotoxin shock. Surgery 1981; 90:482–488.
  • Hardin CD, Lazzarino G, Tavazzi B, DiPierro D, Roberts T, Giardina B, . Myocardial metabolism of exogenous FDP is consistentwith transport by a dicarboxylate transporter. Am J Physiol Heart Circ Physiol 2001; 281:H2654–;H2660.
  • Vexler ZS, Wong A, Francisco C, Manabat C, Christen S, Tauber M, . Fructose-1,6-bisphosphate preserves intracellular glutathione and protects cortical neurons against oxidative stress. Brain Res 2003; 960:90–98.
  • Buelke-Sam J, Holson JF, Bazare JJ, Young JF. Comparative stability of physiological parameters during sustained anesthesia in rats. Lab Animal Sci 1978; 28:157–162.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.