270
Views
9
CrossRef citations to date
0
Altmetric
Rapid Communication

Acute neurotoxicity associated with recreational use of methylmethaqualone confirmed by liquid chromatography tandem mass spectrometry

, , , , , & show all
Pages 54-57 | Received 30 Oct 2012, Accepted 10 Dec 2012, Published online: 09 Jan 2013

References

  • Angelos SA, Lankin DC, Meyers JA, Raney JK. The structural identification of a methyl analog of methaqualone via 2-dimensional NMR techniques. J Forensic Sci 1993; 38:455–465.
  • Gillman MA, Harker N, Lichtigfeld FJ. Combined cannabis/methaqualone withdrawal treated with psychotropic analgesic nitrous oxide. Int J Neurosci 2006; 116:859–869.
  • Naik SR, Naik PR, Sheth UK. Involvement of gamma-amino butyric acid (GABA) in the anticonvulsant action of methaqualone. Psychopharmacology (Berl). 1978; 57:103–107.
  • van Zyl EF. A survey of reported synthesis of methaqualone and some positional and structural isomers. Forensic Sci Int 2001; 122:142–149.
  • Watanabe K. Screening colour test and specific colour test for the detection of non-barbiturate sedatives and hypnotics methaqualone and mecloqualone. United nations international drug control programme. 1996; Scitec/13.
  • Boltze KH, Dell HD, Lehwald H, Lorenz D, Rueberg-Schweer M. Substituted 4-quinazolinone derivatives as hypnotics and anticonvulsants. Arzneimittelforschung 1963; 13:688–701.
  • http://www.drugs-forum.com/forum/showthread.php?t=55413#ixzz1lKVcHbUA; last accessed on Aug 27, 2012.
  • http://eve-rave.ch/Forum/viewtopic.php?f=96&t=25618; last accessed on Aug 27, 2012.
  • Mueller DM, Duretz B, Espourteille FA, Rentsch KM. Development of a fully automated toxicological LC-MS(n) screening system in urine using online extraction with turbulent flow chromatography. Anal Bioanal Chem 2011; 400:89–100.
  • Mueller DM, Rentsch KM. Online extraction toxicological MS(n) screening system for serum and heparinized plasma and comparison of screening results between plasma and urine in the context of clinical data. J Chromatogr B Analyt Technol Biomed Life Sci 2012; 1:883–884: 189–197. Epub 2011 Aug 24.
  • Hill SL, Thomas SH. Clinical toxicology of newer recreational drugs. Clin Toxicol (Phila) 2011; 49:705–719.
  • Gibbons S, Zloh M. An analysis of the ‘legal high’ mephedrone. Bioorg Med Chem Lett. 2010; 20:4135–4139.
  • Prost F, Thormann W. Enantiomeric analysis of the five major monohydroxylated metabolites of methaqualone in human urine by chiral capillary electrophoresis. Electrophoresis 2001; 22:3270–3280.
  • Brown SS, Goenechea S. Methaqualone: metabolic, kinetic, and clinical pharmacologic observations. Clin Pharmacol Ther 1973; 14: 314–324.
  • Madden JS. A Guide to Alcohol and Drug Dependence. Bristol: John Wright & Sons; 1979.
  • Kurz RW, Hainz R, Gremmel F, Grisold W, Hruby K, Dellert P, Vycudilik W. Dangerous intoxication from extreme serum concentrations of methaqualone metabolites. Detection and quantification of biosynthesis with gas chromatography-mass spectrometry. Anaesthesist 1995; 44:863–868.
  • Abboud RT, Freedman MT, Rogers RM, Daniele RP. Methaqualone poisoning with muscular hyperactivity necessitating the use of curare. Chest 1974; 65:204–205.
  • Ionescu-Pioggia M, Bird M, Orzack MH, Benes F, Beake B, Cole JO. Methaqualone. Int Clin Psychopharmacol 1988; 3:97–109.
  • Baselt RC. Disposition of Toxic Drugs and Chemicals in Man. 6th ed. Foster City, CA: Biomedical Publications; 2002:657–659.
  • Verma R, Tiwari N. Phenytoin intoxication induced by Mandrax (methaqualone). Epilepsy Res 2012; 98:281–282.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.