879
Views
56
CrossRef citations to date
0
Altmetric
Research Article

An assessment of the in vivo effects of intravenous lipid emulsion on blood drug concentration and haemodynamics following oro-gastric amitriptyline overdose

, , &
Pages 208-215 | Received 23 Dec 2012, Accepted 18 Feb 2013, Published online: 26 Mar 2013

References

  • Cave G, Harvey M, Graudins A. Intravenous lipid emulsion as antidote: a summary of published human experience. Emerg Med Australas 2011; 2:123–141.
  • Taftachi FF, Sanaei-Zadeh HH, Sepehrian BB, Zamani NN. Lipid emulsion improves Glasgow coma scale and decreases blood glucose level in the setting of acute non-local anesthetic drug poisoning–a randomized controlled trial. Eur Rev Med Pharmacol Sci 2012; 16:38–42.
  • Cave G, Harvey M. Intravenous lipid emulsion as antidote beyond local anesthetic toxicity: a systematic review. Acad Emerg Med 2009; 16:815–824.
  • French D, Smollin C, Ruan W, Wong A, Drasner K, Wu AHB. Partition constant and volume of distribution as predictors of clinical efficacy of lipid rescue for toxicological emergencies. Clin Toxicol (Phila) 2011; 49:801–809.
  • Edelman LB, Ripper R, Kelly K, Di Gregorio G, Weinberg GL. Metabolic context affects hemodynamic response to bupivacaine in the isolated rat heart. Chem Biol Interact 2008; 172:48–53.
  • Weinberg GL, Palmer JW, VadeBoncouer TR, Zuechner MB, Edelman G, Hoppel CL. Bupivacaine inhibits acylcarnitine exchange in cardiac mitochondria. Anesthesiology 2000; 92:523–528.
  • Gueret G, Pennec JP, Arvieux CC. Hemodynamic effects of intralipid after verapamil intoxication may be due to a direct effect of fatty acids on myocardial calcium channels. Acad Emerg Med 2007; 14:761.
  • Mottram AR, Valdivia CR, Makielski JC. Fatty acids antagonize bupivacaine – induced I(Na) blockade. Clin Toxicol (Phila) 2011; 49:729–733.
  • Buckley CD, Aronson JK. Prolonged half-life of verapamil in a case of overdose: implications for therapy. Br J Clin Pharmacol 1995; 39:680–683.
  • Graudins A, Pham HN, Salonikas C, Naidoo D, Chan B. Early presentation following overdose of modified-release paracetamol (Panadol Osteo) with biphasic and prolonged paracetamol absorption. N Z Med J 2009; 122:64–71.
  • Graudins A, Peden G, Dowsett RP. Massive overdose with controlled-release carbamazepine resulting in delayed peak serum concentrations and life-threatening toxicity. Emerg Med 2002; 14:89–94.
  • Kalam Y, Graudins A. Levosimendan does not improve cardiac output or blood pressure in a rodent model of propranolol toxicity when administered using various dosing regimens. Int J Toxicol 2012; 31: 166–174.
  • Kalam Y, Graudins A. Levosimendan infusion improves cardiac output but not blood pressure in a rodent model of severe metoprolol toxicity. Hum Exp Toxicol 2012; 31:955–963.
  • Graudins A, Wong KKL. Comparative hemodynamic effects of levosimendan alone and in conjunction with 4-aminopyridine or calcium chloride in a rodent model of severe verapamil poisoning. J Med Toxicol 2010; 6:85–93.
  • Beyer J, Woods L, George N, Gerostamoulos D, Drummer OH. Fast targeted screening of drugs and poisons in postmortem blood. Annales De Toxicologie Analytique 2009; 21:S1–7.
  • Biopharmaceutics Coordinating Committee in the Center for Drug Evaluation, Research. Guidance for Industry Bioanalytical Method Validation. U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Veterinary Medicine (CVM). 2001 April 16;1–25.
  • Alimovski Q, Beyer J, Graudins A. An in vitro assessment of the effect of intravenous lipid emulsion on total drug concentrations in human plasma utilising drugs commonly implicated in cardiovascular system poisoning. Clin Toxicol (Phila) 2012; 50:246.
  • Engels PT, Davidow JS. Intravenous fat emulsion to reverse haemodynamic instability from intentional amitriptyline overdose. Resuscitation 2010; 81:1037–1039.
  • Güloglu C, Orak M, Ustündag M, Altunci YA. Analysis of amitriptyline overdose in emergency medicine. Emerg Med J 2011; 28:296–299.
  • Boehnert MTM, Lovejoy FHF. Value of the QRS duration versus the serum drug level in predicting seizures and ventricular arrhythmias after an acute overdose of tricyclic antidepressants. N Engl J Med 1985; 313:474–479.
  • Liebelt EL, Ulrich A, Francis PD, Woolf A. Serial electrocardiogram changes in acute tricyclic antidepressant overdoses. Crit Care Med 1997; 25:1721–1726.
  • Litonius E, Niiya T, Neuvonen PJ, Rosenberg PH. No antidotal effect of intravenous lipid emulsion in experimental amitriptyline intoxication despite significant entrapment of amitriptyline. Basic Clin Pharmacol Toxicol 2012; 110:378–383.
  • Kazemi A, Harvey M, Cave G, Lahner D. The effect of lipid emulsion on depth of anaesthesia following thiopental administration to rabbits. Anaesthesia 2011; 66:373–378.
  • Dunn CC, Bird SBS, Gaspari RR. Intralipid fat emulsion decreases respiratory failure in a rat model of parathion exposure. Acad Emerg Med 2012; 19:504–509.
  • Weinberg G, Rubinstein I. Pig in a poke. Anesth Analg 2012; 114: 907–909.
  • Weinberg GG, Suresh SS. Local anesthetic systemic toxicity and animal models for rescue paradigms: can pigs fly? Paediatr Anaesth 2012; 22:121–123.
  • Buelke-Sam J, Holson JF, Bazare JJ, Young JF. Comparative stability of physiological parameters during sustained anesthesia in rats. Lab Anim Sci. 1978; 28:157–162.
  • Kalam Y, Graudins A. The effects of fructose-1,6-diphosphate on haemodynamic parameters and survival in a rodent model of propranolol and verapamil poisoning. Clin Toxicol (Phila) 2012; 50:546–554.
  • Pentel P, Benowitz N. Efficacy and mechanism of action of sodium bicarbonate in the treatment of desipramine toxicity in rats. J Pharmacol Exp Ther 1984; 230:12–19.
  • Hikal AH, Anderson CY. Pharmacokinetics of diltiazem absorption in the rat gastrointestinal tract. Arzneimittelforschung 1992; 42: 101–102.
  • Perez E, Bania TC, Medlej K, Chu J. Determining the optimal dose of intravenous fat emulsion for the treatment of severe verapamil toxicity in a rodent model. Acad Emerg Med 2008; 15:1284–1289.
  • Tebbutt S, Harvey M, Nicholson T, Cave G. Intralipid prolongs survival in a rat model of verapamil toxicity. Acad Emerg Med 2006; 13:134–139.
  • Weinberg GL, VadeBoncouer T, Ramaraju GA, Garcia-Amaro MF, Cwik MJ. Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anesthesiology 1998; 88:1071–1075.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.