Intravenous lipid emulsion-augmented plasma exchange in a rabbit model of clomipramine toxicity; survival, but no sink

References

• Zimmerman J. Poisonings and overdoses in the intensive care unit: general and specific management issues. Crit Care Med 2003; 31:2794–2801.
   PubMed Web of Science ®Google Scholar
• Nenov V, Marinov P, Sabeva J, Nenov D. Current applications of plasmapheresis in clinical toxicology. Nephrol Dial Transplant 2003; 18:56–58.
   Web of Science ®Google Scholar
• Bania T, Chu J, Perez E. Hemodynamic effects of intravenous fat emulsion in an animal model of severe verapamil toxicity resuscitated with atropine, calcium, and saline. Acad Emerg Med 2007; 14:105–111.
   PubMed Web of Science ®Google Scholar
• Harvey M, Cave G. Intralipid infusion ameliorates propranolol induced hypotension in rabbits. J Med Toxicol 2008; 4:71–76.
   PubMedGoogle Scholar
• Sirianni A, Osterhoudt K, Calello D, Muller AA, Waterhouse MR, Goodkin MB, et al. Use of Intralipid in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine. Ann Emerg Med 2007; 51:412–415.
   PubMed Web of Science ®Google Scholar
• Finn S, Uncles D, Willers J, Sable N. Early treatment of a quetiapine and sertraline overdose with intralipid. Anaesthesia 2009; 64: 191–194.
   PubMed Web of Science ®Google Scholar
• Neal J, Mulroy M, Weinberg G. American society of regional anesthesia and pain medicine checklist for managing local anesthetic systemic toxicity: 2012 version. Reg Anesth Pain Med 2012; 37:16–18.
   PubMed Web of Science ®Google Scholar
• American College of Medical Toxicology. ACMT position statement: interim guidance for the use of lipid resuscitation therapy. J Med Toxicol 2011; 7:81–82.
   PubMedGoogle Scholar
• Weinberg G. Lipid resuscitation: more than a sink. Crit Care Med 2012; 40:2521–2523.
   PubMed Web of Science ®Google Scholar
• Weinberg G, VadeBoncouer T, Ramaraju G, Garcia-Amaro M, Cwik M. Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anaesthesiology 1998; 88:1071–1075.
   PubMed Web of Science ®Google Scholar
• Bania T, Chu J. Hemodynamic effect of intralipid in amitriptyline toxicity. Acad Emerg Med 2006; 13:S1:117.
   PubMedGoogle Scholar
• Harvey M, Cave G. Correlation of plasma and peritoneal diasylate clomipramine concentration with hemodynamic recovery after intralipid infusion in rabbits. Acad Em Med 2009; 16:151–156.
   PubMed Web of Science ®Google Scholar
• Bania T, Chu J, Wesolowski M. The hemodynamic effect of Intralipid on propranolol toxicity. Acad Emerg Med 2006; 13:S1:109.
   PubMedGoogle Scholar
• Niiya T, Litonius E, Petaja L, Neuvonen P, Rosenberg P. Intravenous lipid emulsion sequesters amiodarone in plasma and eliminates its hypotensive action in pigs. Ann Emerg Med 2010; 56:402–408.
   PubMed Web of Science ®Google Scholar
• Sioufi A, Pommier F, Dubois J. Simultaneous determination of clomipramine and its N-desmethyl metabolite in human whole blood by capillary gas chromatography with mass-selective detection. J Chromatogr 1988; 428:71–80.
   PubMed Web of Science ®Google Scholar
• Borg S, Ohman I. Tricyclic antidepressants. In: Dukes MNG, Aronson JK, eds. Meyler's Side Effects of Drugs. An Encyclopedia of Adverse Reactions and Interactions. 12th ed. Amsterdam: Elsevier; 1992:40–53.
   Google Scholar
• Little R. Changes in the blood volume of the rabbit with age. J Physiol 1970; 208:485–497.
   PubMed Web of Science ®Google Scholar
• Harvey M, Cave G. Intralipid outperforms sodium bicarbonate in a rabbit model of clomipramine toxicity. Ann Emerg Med 2007; 49:178–185.
   PubMed Web of Science ®Google Scholar
• Harvey M, Cave G. Case report: successful lipid resuscitation in multi-drug overdose with predominant tricyclic antidepressant toxidrome. Int J Emerg Med 2012; 5:5–8.
   PubMedGoogle Scholar
• Weinberg G, Ripper R, Murphy P, Edelman LB, Hoffman W, Strichartz G, Feinstein DL. Lipid infusion accelerates removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart. Reg Anesth Pain Med 2006; 31:296–303.
   PubMed Web of Science ®Google Scholar
• Shi K, Xia Y, Wamg Q, Wu Y, Dong X, Chen C, et al. The effect of lipid emulsion on pharmacokinetics and tissue distribution of bupivacaine in rats. Anesth Analg 2013; 116:804–809.
   PubMed Web of Science ®Google Scholar
• Fettiplace M, Ripper R, Lis K, Lin B, Lang J, Zider B, et al. Rapid cardiotonic effects of lipid emulsion infusion. Crit Care Med 2013; 41:156–162.
   PubMed Web of Science ®Google Scholar
• Partownavid P, Umar S, Li J, Rahman S, Eghbali M. Fatty acid oxidation and calcium homeostasis are involved in the rescue of bupivacaine induced cardiotoxicity by lipid emulsion in rats. Crit Care Med 2012; 40:2431–2437.
   PubMed Web of Science ®Google Scholar
• Weinbach EC, Costa JL, Nelson BD, Claggett CE, Hundal T, Bradley D, Morris SJ. Effects of tricyclic antidepressant drugs on energy-linked reactions in the mitochondria. Biochem Pharmacol 1986; 35:1445–1451.
   PubMed Web of Science ®Google Scholar
• Nadrowitz F, Stoetzer C, Foadi N, Ahrens J, Wegner F, Lampert A, et al. The distinct effects of lipid emulsions used for lipid resuscitation on gating and bupivacaine induced inhibition of the cardiac sodium channel Nav1.5. Anesth Analg 2013; 117:1101–1108. Epub ahead of print.
   PubMed Web of Science ®Google Scholar
• Dargan P, Colbridge M, Jones A. The management of tricyclic antidepressant poisoning: the role of gut decontamination, extracorporeal procedures and fab antibody fragments. Toxicol Rev 2005; 24:187–194.
   PubMedGoogle Scholar
• Harvey M, Cave G, Shaw T. Effect of intravenous lipid emulsion and octreotide on enteric thiopentone absorption; a pilot study. Clin Toxicol 2013; 51:117–118.
   PubMed Web of Science ®Google Scholar