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Clinical Toxicology Volume 53, 2015 - Issue 2
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Brief Communication

Use of multi-dose activated charcoal in phenytoin toxicity secondary to genetic polymorphism

Betty S. H. ChanPrince of Wales Hospital, Clinical Toxicology & Emergency Medicine, Barker St, Randwick, Sydney, AustraliaCorrespondence[email protected]
,
Kate SellorsPrince of Wales Hospital, Clinical Toxicology & Emergency Medicine, Barker St, Randwick, Sydney, Australia
,
Angela L. ChiewPrince of Wales Hospital, Clinical Toxicology & Emergency Medicine, Barker St, Randwick, Sydney, Australia
&
Nicholas A. BuckleySydney University, Pharmacology, Sydney, Australia
Pages 131-133 | Received 25 Sep 2014, Accepted 09 Dec 2014, Published online: 19 Jan 2015

References

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  • Skinner CG, Chang AS, Matthews AS, Reedy SJ, Morgan BW. Randomized controlled study on the use of multiple-dose activated charcoal in patients with supratherapeutic phenytoin levels. Clin Toxicol 2012; 50:764–769.
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  • Position statement and practice guidelines on the use of multi-dose activated charcoal in the treatment of acute poisoning. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists; European Association of Poisons Centres and Clinical Toxicologists. J Toxicol Clin Toxicol 1999; 37:731–751.
  • Rowden AM, Spoor JE, Bertino JS Jr. The effect of activated charcoal on phenytoin pharmacokinetics. Ann Emerg Med 1990; 19:1144–1147.
  • Mauro LS, Mauro VF, Brown DL, Somani P. Enhancement of phenytoin elimination by multiple-dose activated charcoal. Ann Emerg Med 1987; 16:1132–1135.
  • Howard CE, Roberts RS, Ely DS, Moye RA. Use of multiple-dose activated charcoal in phenytoin toxicity. Ann Pharmacother 1994; 28:201–203.

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