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Commentary

How do we assess whether the QT interval is abnormal: Myths, formulae and fixed opinion

Pages 189-191 | Received 26 Jan 2015, Accepted 27 Jan 2015, Published online: 19 Feb 2015

References

  • Othong R, Devlin JP, Kazzi Z. Medical toxicologists’ practice patterns regarding drug-induced QT prolongation in overdose patients: a survey in the United States, Europe and Asia Pacific region. Clin Toxicol 2015; 53:xx.
  • Chan AS, Isbister GK, Kirkpatrick CM, Duffull SB. Assessing risk of a prolonged QT interval-a survey of emergency physicians. Int J Emerg Med 2008; 1:35–41.
  • Isbister GK, Page CB. Drug induced QT prolongation: the measurement and assessment of the QT interval in clinical practice. Br J Clin Pharmacol 2013; 76:48–57.
  • Isbister GK. Risk assessment of drug-induced QT prolongation. Australian Prescriber 2015; 38:20–24.
  • Malik M, Camm AJ. Evaluation of drug-induced QT interval prolongation: implications for drug approval and labelling. Drug Saf 2001; 24:323–351.
  • Berling I, Isbister GK, Calver L, Clunas S. Digital Holter measurement of QT prolongation in ziprasidone overdose. Clin Toxicol (Phila) 2011; 49:694–696.
  • Isbister GK, Calver L, van Gorp F, Stokes B, Page CB. Inter-rater reliability of manual QT measurement and prediction of abnormal QT, HR pairs. ClinToxicol (Phila) 2009; 47:884–888.
  • Malik M, Camm AJ. Evaluation of drug-induced QT interval prolongation: implications for drug approval and labelling. Drug Saf 2001; 24:323–351.
  • Hunt AC. Accuracy of popular automatic QT interval algorithms assessed by a ‘gold standard’ and comparison with a Novel method: computer simulation study. BMC Cardiovasc Disord 2005; 5:29.
  • Batchvarov V, Malik M. Individual patterns of QT/RR relationship. Card Electrophysiol Rev 2002; 6:282–288.
  • Friberg LE, Isbister GK, Duffull SB. Pharmacokinetic- pharmacodynamic modelling of QT interval prolongation following citalopram overdoses. Br J Clin Pharmacol 2006; 61:177–190.
  • Piotrovsky V. Pharmacokinetic-pharmacodynamic modeling in the data analysis and interpretation of drug-induced QT/QTc prolongation. AAPS J 2005; 7:E609–E24.
  • Chan A, Isbister GK, Kirkpatrick CM, Dufful SB. Drug-induced QT prolongation and torsades de pointes: evaluation of a QT nomogram. QJM 2007; 100:609–615.
  • Isbister GK, Balit CR, Macleod D, Duffull SB. Amisulpride overdose is frequently associated with QT prolongation and torsades de pointes. J Clin Psychopharmacol 2010; 30:391–395.
  • Isbister GK, Duffull SB. Quetiapine overdose: predicting intubation, duration of ventilation, cardiac monitoring and the effect of activated charcoal. Int Clin Psychopharmacol 2009; 24: 174–180.
  • van Gorp F, Whyte IM, Isbister GK. Clinical and ECG effects of escitalopram overdose. Ann Emerg Med 2009; 54:404–408.
  • Waring WS, Graham A, Gray J, Wilson AD, Howell C, Bateman DN. Evaluation of a QT nomogram for risk assessment after antidepressant overdose. Br J Clin Pharmacol 2010; 70:881–885.
  • Berling I, Isbister GK. Prolonged QT risk assessment in antipsychotic overdose using the QT nomogram. Ann Emerg Med 2015; 65: pii: S0196-0644(14)01573-X. doi: 10.1016/j.annemergmed.2014.12.005.

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