Acute toxicity profile of tolperisone in overdose: Observational poison centre-based study

References

• Quasthoff S, Möckel C, Zieglgänsberger W, Schreibmayer W. Tolperisone: a typical representative of a class of centrally acting muscle relaxants with less sedative side effects. CNS Neurosci Ther 2008; 14:107–119.
   PubMed Web of Science ®Google Scholar
• Furuta Y, Yoshikawa A. Reversible adrenergic alpha-receptor blocking action of 2,4’-dimethyl-3-piperidino-propiophenone (tolperisone). Jpn J Pharmacol 1976; 26:543–550.
   PubMedGoogle Scholar
• Molnar L. Successful use of mydocalm in peripheral arterial disease. Ther Hung 1962; 10:10–12.
   PubMedGoogle Scholar
• Kocsis P, Farkas S, Fodor L, Bielik N, Thán M, Kolok S, et al. Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels. J Pharmacol Exp Ther 2005; 315:1237–1246.
   PubMed Web of Science ®Google Scholar
• Baselt R. Disposition of Toxic Drugs and Chemicals in Man. 9th ed. Foster City, California: Biomedical Publications; 2011:1697–1698.
   Google Scholar
• Ribi C, Vermeulen C, Hauser C. Anaphylactic reactions to tolperisone (Mydocalm). Swiss Med Wkly 2003; 133:369–371.
   PubMed Web of Science ®Google Scholar
• European Medicines Agency. 2013. http://www.ema.europa.eu/docs/en_GB/document_library/Referrals_document/Tolperisone_31/WC500141050.pdf. Accessed February 6, 2015.
   Google Scholar
• Dulin J, Kovács L, Ramm S, Horvath F, Ebeling L, Kohnen R. Evaluation of sedative effects of single and repeated doses of 50 mg and 150 mg tolperisone hydrochloride. Results of a prospective, randomized, double-blind, placebo-controlled trial. Pharmacopsychiatry 1998; 31:137–142.
   Google Scholar
• Wabosan. Mydocalm-Filmtabletten. February, 2010. http://www.pharmazie.com/graphic/A/36/0-14936.pdf. Accessed November 25, 2014.
   Google Scholar
• Sporkert F, Brunel C, Augsburger MP, Mangin P. Fatal tolperisone poisoning: autopsy and toxicology findings in three suicide cases. Forensic Sci Int 2012; 215:101–104.
   PubMed Web of Science ®Google Scholar
• Persson HE, Sjöberg GK, Haines JA, Pronczuk de Garbino J. Poisoning severity score. Grading of acute poisoning.J Toxicol Clin Toxicol 1998; 36:205–213.
   PubMed Web of Science ®Google Scholar
• WHO-UMC. The use of the WHO-UMC system for standardised case causality assessment, who-umc.org/Graphics/24734.pdf. Accessed February 6, 2015.
   Google Scholar
• Labatec Pharma SA, Meyrin, Switzerland (2013). Product information Mydocalm®.
   Google Scholar
• Miskolczi P, Vereczkey L, Frenkl R. Gas-liquid chromatographic method for the determination of tolperisone in human plasma: pharmacokinetic and comparative bioavailability studies. J Pharm Biomed Anal 1987; 5:695–700.
   PubMed Web of Science ®Google Scholar
• Bae JW, Kim MW, Park YS, Myung CS, Jang CG, Lee SY. Considerable interindividual variation in the pharmacokinetics of tolperisone HCL. Int J Clin Pharmacol Ther 2007; 45:110–113.
   PubMed Web of Science ®Google Scholar
• Reichert C, Reichert P, Monnet-Tschudi F, Kupferschmidt H, Ceschi A, Rauber-Lüthy C. Seizures after single-agent overdose with pharmaceutical drugs: Analysis of cases reported to a poison center. Clin Toxicol (Phila) 2014; 52:629–634.
   PubMed Web of Science ®Google Scholar
• Howland MA. Activated charcoal. In: Nelson LS, Lewin NA, Howland MA, Hoffman RS, Goldfrank LR, Flomenbaum NE, eds. Goldfrank's Toxicologic Emergencies. 19th ed. New York: McGraw-Hill Medical; 2010:108–114.
   Google Scholar
• Gregoriano C, Ceschi A, Rauber-Lüthy C, Kupferschmidt H, Banner NR, Krähenbühl S, Taegtmeyer AB. Acute thiopurine overdose: analysis of reports to a National Poison Centre 1995–2013. PLoS One 2014: 9:e86390.
   PubMedGoogle Scholar
• Ceschi A, Gregoriano C, Rauber-Lüthy C, Kupferschmidt H, Banner NR, Krähenbühl S, Taegtmeyer AB. Acute mycophenolate overdose: case series and systematic literature analysis. Expert Opin Drug Saf 2014; 13:525–534.
   PubMed Web of Science ®Google Scholar
• Tanno K, Narimatsu E, Takeyama Y, Asai Y. Infantile case of seizure induced by intoxication after accidental consumption of eperisone hydrochloride, an antispastic agent. Am J Emerg Med 2007; 25: 481–482.
   PubMed Web of Science ®Google Scholar
• Takeuchi A, Kuroki Y, Iizuka F, Iita K, Watanabe A, Hatano Y, et al. News from the Japan Poison Information Center: investigation of acute muscular relaxant poisoning based on JPIC inquiries. Chudoku Kenkyu 2011; 24:259–264.
   PubMedGoogle Scholar
• Yamagiwa T, Morita S, Amino M, Miura N, Saito T, Inokuchi S. Serum concentration of eperisone hydrochloride correlates with QT interval. Am J Emerg Med 2014; 32:75–77.
   PubMed Web of Science ®Google Scholar
• Yamagiwa T, Amino M, Morita S, Yamamoto R, Saito T, Inokuchi S. A case of torsades de pointes induced by severe QT prolongation after an overdose of eperisone and triazolam in a patient receiving nifedipine. Clin Toxicol (Phila) 2010; 48:149–152.
   PubMed Web of Science ®Google Scholar
• Fels G. Tolperisone: evaluation of the lidocaine-like activity by molecular modeling. Arch Pharm (Weinheim) 1996; 329:171–178.
   PubMed Web of Science ®Google Scholar
• Centini F, Fiore C, Riezzo I, Rossi G, Fineschi V. Suicide due to oral ingestion of lidocaine: a case report and review of the literature. Forensic Sci Int 2007; 171:57–62.
   PubMed Web of Science ®Google Scholar
• Smith M, Wolfram W, Rose R. Toxicity—seizures in an infant caused by (or related to) oral viscous lidocaine use. J Emerg Med 1992; 10:587–590.
   PubMedGoogle Scholar
• Scott DB. Evaluation of the toxicity of local anaesthetic agents in man. Br J Anaesth 1975; 47:56–61.
   PubMed Web of Science ®Google Scholar
• Englesson S, Grevsten S. The influence of acid-base changes on central nervous system toxicity of local anaesthetic agents. II. Acta Anaesthesiol Scand 1974; 18:88–103.
   PubMed Web of Science ®Google Scholar
• Hoffman RS. Understanding the limitations of retrospective analyses of poison center data. Clin Toxicol 2007; 45:943–945.
   PubMed Web of Science ®Google Scholar