4,682
Views
42
CrossRef citations to date
0
Altmetric
Letter to the Editor

Loperamide toxicokinetics: serum concentrations in the overdose setting

, &
Pages 495-496 | Received 16 Jan 2015, Accepted 03 Mar 2015, Published online: 30 Mar 2015

References

  • Daniulaityte R, Carlson R, Falck R, Cameron D, Perera S, Chen L, Sheth A.“I just wanted to tell you that loperamide will work”: a web-based study of extra-medical use of loperamide. Drug Alcohol Depend 2013; 130:241–244.
  • Marraffa JM, Holland MG, Sullivan RW, Morgan BW, Oakes JA, Wiegand TJ, Hodgman MJ. Cardiac conduction disturbance after loperamide abuse. Clin Toxicol (Phila) 2014; 52:952–957.
  • Doser K, Meyer B, Nitsche V, Binkert-Graber P. Bioequivalence evaluation of two different oral formulations of loperamide (Diarex Lactab vs Imodium capsules). Int J Clin Pharmacol Ther 1995; 33:431–436.
  • Yu JH, Kim HJ, Lee S, Hwang SJ, Kim W, Moon CJ. LC-MS determination and bioavailability study of loperamide hydrochloride after oral administration of loperamide capsule in human volunteers. J Pharm Biomed Anal 2004; 36:421–427.
  • Streel B, Ceccato A, Klinkenberg R, Hubert P. Validation of a liquid chromatographic-tandem mass spectrometric method for the determination of loperamide in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci 2005; 814:263–273.
  • He H, Sadeque A, Erve JC, Wood AJ, Hachey DL. Quantitation of loperamide and N-demethyl-loperamide in human plasma using electrospray ionization with selected reaction ion monitoring liquid chromatography-mass spectrometry. J Chromatogr B Biomed Sci Appl 2000; 744:323–331.
  • Audi J, Layher J, Morgan B. Cardiac conduction disturbances secondary to chronic abuse of loperamide: an initial case report. Clin Toxicol 2004; 42:713–826.
  • Halcomb SE, Sivilotti ML, Goklaney A, Mullins ME. Pharmacokinetic effects of diphenhydramine or oxycodone in simulated acetaminophen overdose. Acad Emerg Med 2005; 12:169–172.
  • Reynolds IJ, Gould RJ, Snyder SH. Loperamide: blockade of calcium channels as a mechanism for antidiarrheal effects. J Pharmacol Exp Ther 1984; 231:628–632.
  • Kim KA, Chung J, Jung DH, Park JY. Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes. Eur J Clin Pharmacol 2004; 60:575–581.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.