1,066
Views
12
CrossRef citations to date
0
Altmetric
Brief Communication

Cardiovascular toxicity with levetiracetam overdose

, , , , &
Pages 152-154 | Received 13 Jul 2015, Accepted 27 Oct 2015, Published online: 22 Jan 2016

References

  • Lyseng-Williamson KA. Levetiracetam: a review of its use in epilepsy. Drugs. 2011;71:489–514.
  • Deshpande LS, Delorenzo RJ. Mechanisms of levetiracetam in the control of status epilepticus and epilepsy. Front Neurol. 2014;5:11.
  • Patsalos PN. Clinical pharmacokinetics of levetiracetam. Clin Pharmacokinet. 2004;43:707–724.
  • Awaad Y. Accidental overdosage of levetiracetam in two children caused no side effects. Epilepsy Behav. 2007;11:247.
  • Özkale Y, Özkale M, Saygi S, et al. Long-term accidental overdose of levetiracetam in an infant. J Child Neurol. 2014;29:959–961.
  • Larkin TM, Cohen-Oram AN, Catalano G, et al. Overdose with levetiracetam: a case report and review of the literature. J Clin Pharm Ther. 2013;38:68–70.
  • Chayasirisobhon S, Chayasirisobhon WV, Tsay CC. Acute levetiracetam overdose presented with mild adverse events. Acta Neurol Taiwan. 2010;19:292–295.
  • Miller SN, Punja M, Meggs WJ. Asymptomatic presentation of overdose of levetiracetam with highest reported serum level. Clinical Toxicol. 2014; 52: 811 (abstract).
  • Bodmer M, Monte AA, Kokko J, et al. Safety of non-therapeutic levetiracetam ingestions-a poison center based study. Pharmacoepidemiol Drug Saf. 2011;20:366–369.
  • Wills B, Reynolds P, Chu E, et al. Clinical outcomes in newer anticonvulsant overdose: a poison center observational study. J Med Toxicol. 2014;10:254–260.
  • Lewis JC, Albertson TE, Walsh MJ. An 11-year review of levetiracetam ingestions in children less than 6 years of age. Clinical Toxicol. 2014;52:964–968.
  • Brodde OE, Michel MC. Adrenergic and muscarinic receptors in the human heart. Pharmacol Rev. 1999;51:651–690
  • Oliveira AA, Nogueria CRA, Nascimento VS, et al. Evaluation of levetiracetam effects on pilocarpine-induced seizures: cholinergic muscarinic system involvement. Neurosci Lett. 2005;385:184–188.
  • Lieber CS. Medical disorders of alcoholism. N Engl J Med. 1995;333:1058–1065
  • Barrueto F Jr, Williams K, Howland MA, et al. A case of levetiracetam (Keppra) poisoning with clinical and toxicokinetic data. J Toxicol Clin Toxicol. 2002;40:881–884.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.