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Research Article

Simplification of the standard three-bag intravenous acetylcysteine regimen for paracetamol poisoning results in a lower incidence of adverse drug reactions

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Pages 115-119 | Received 17 Aug 2015, Accepted 27 Oct 2015, Published online: 23 Nov 2015

References

  • National Poisons Information Service UK. Annual Reports; [cited 2015 Jul 27]. Available from: http://www.hpa.org.uk/Publications/ChemicalsPoisons/NationalPoisonsInformationServiceAnnualReports.
  • Bronstein AC, Spyker DA, Cantilena LR Jr, Jr et al. 2011 Annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 29th Annual Report. Clin Toxicol (Phila). 2012;50:911–1164.
  • Ostapowicz G, Fontana RJ, Schiødt FV, et al. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med. 2002;137:947–954.
  • Linden CH, Rumack BH. Acetaminophen overdose. Emerg Med Clin North Am. 1984;2:103–119.
  • Kerr F, Dawson A, Whyte IM, et al. The Australasian Clinical Toxicology Investigators Collaboration randomized trial of different loading infusion rates of N-acetylcysteine. Ann Emerg Med. 2005;45:402–408.
  • Sandilands EA, Bateman DN. Adverse reactions associated with acetylcysteine. Clin Tox. 2009;47:81–88.
  • Bateman DN, Dear JW, Thanacoody HK, et al. Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial. Lancet. 2014;383:697–704.
  • Graudins A. Paracetamol poisoning in adolescents in an Australian setting: not quite adults. Emerg Med Australasia. 2015;27:139–144.
  • Rumack BH. Acetaminophen heptatotoxicity: the first 35 years. J Toxicol Clin Toxicol. 2002;40:3–20.
  • Waring WS, Stephen AF, Robinson OD, et al. Lower incidence of anaphylactoid reactions to N-acetylcysteine in patients with high acetaminophen concentrations after overdose. Clin Tox. 2008;46:496–500.
  • Pakravan N, Waring WS, Sharma S, et al. Risk factors and mechanisms of anaphylactoid reactions to acetylcysteine in acetaminophen overdose. Clin Tox. 2008;46:697–702.
  • Daly S, Campbell DA, Cameron PA. Short-stay units and observation medicine: a systematic review. Med J Aust. 2003;178:599–563.
  • Westbrook JI, Gospodarevskaya E, Li L, et al. Cost-effectiveness analysis of a hospital electronic medication management system. J Am Med Inform Assoc. 2015;22:784–793.
  • McIntyre S, McD Taylor D, Greene S. Introduction of an N-acetylcysteine weight based dosing chart reduces prescription errors in the treatment of paracetamol poisoning. Emerg Med Australia. 2013;25:28–35.
  • Yip L, Dart RC, Hurlbut KM. Intravenous administration of oral N-acetylcysteine. Crit Care Med. 1998;26:40–43.
  • Mullins ME, Schmidt RU JrJr., Jang TB. What is the rate of adverse events with intravenous versus oral N-acetylcysteine in pediatric patients? Ann Emerg Med. 2004;44:547–548.

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