Advanced search
Publication Cover
Clinical Toxicology Volume 54, 2016 - Issue 3
Submit an article Journal homepage
331
Views
9
CrossRef citations to date
0
Altmetric
Critical Care

Towards rationalisation of antivenom use in funnel-web spider envenoming: enzyme immunoassays for venom concentrations

Mark MillerEmergency Department, John Hunter Hospital, Newcastle, NSW, Australia;
,
Margaret A. O’LearyClinical Toxicology Research Group, University of Newcastle, Newcastle, NSW, Australia;
&
Geoffrey K. IsbisterClinical Toxicology Research Group, University of Newcastle, Newcastle, NSW, Australia; ;Department of Clinical Toxicology and Pharmacology, Calvary Mater Hospital, Newcastle, NSW, AustraliaCorrespondence[email protected]
Pages 245-251 | Received 09 Sep 2015, Accepted 16 Nov 2015, Published online: 17 Dec 2015

References

  • Isbister GK, Gray MR, Balit CR, et al. Funnel-web spider bite: a systematic review of recorded clinical cases. Med J Aust. 2005;182:407–411.
  • Hartman LJ, Sutherland SK. Funnel-web spider (Atrax robustus) antivenom in the treatment of human envenomation. Med J Aust. 1984;141:796–799.
  • Isbister GK, Bawaskar HS. Scorpion envenomation. N Engl J Med. 2014;371:457–463.
  • Nicholson GM, Walsh R, Little MJ, et al. Characterisation of the effects of robustoxin, the lethal neurotoxin from the Sydney funnel-web spider Atrax robustus, on sodium channel activation and inactivation. Pflugers Arch. 1998;436:117–126.
  • White J. CSL Antivenom handbook. Melbourne: CSL Ltd; 2001.
  • Theakston RD. The application of immunoassay techniques, including enzyme-linked immunosorbent assay (ELISA), to snake venom research. Toxicon. 1983;21:341–352.
  • Kulawickrama S, O'Leary MA, Hodgson WC, et al. Development of a sensitive enzyme immunoassay for measuring taipan venom in serum. Toxicon. 2010;55:1510–1518.
  • Isbister GK, Brown SG, Page CB, et al. Snakebite in Australia: a practical approach to diagnosis and treatment. Med J Aust. 2013;199:763–768.
  • O'Leary MA, Kornhauser RS, Hodgson WC, et al. An examination of the activity of expired and mistreated commercial Australian antivenoms. Trans Roy Soc Trop Med H. 2009;103:937–942.
  • O'Leary MA, Isbister GK, Schneider JJ, et al. Enzyme immunoassays in brown snake (Pseudonaja spp.) envenoming: detecting venom, antivenom and venom-antivenom complexes. Toxicon. 2006;48:4–11.
  • O'Leary MA, Maduwage K, Isbister GK. Detection of venom after antivenom administration is largely due to bound venom. Toxicon. 2015;93:112–118.
  • Isbister GK, Warner G. Acute myocardial injury caused by Sydney funnel-web spider (Atrax robustus) envenoming. Anaesth Intensive Care. 2003;31:672–674.
  • Allen GE, Brown SG, Buckley NA, et al. Clinical effects and antivenom dosing in brown snake (Pseudonaja spp.) envenoming – Australian Snakebite Project (ASP-14). PLoS One. 2012;7:e53188.
  • Little MJ, Zappia C, Gilles N, et al. delta-Atracotoxins from Australian funnel-web spiders compete with scorpion alpha-toxin binding but differentially modulate alkaloid toxin activation of voltage-gated sodium channels. J Biol Chem. 1998;273:27076–27083.
  • Ghalim N, El-Hafny B, Sebti F, et al. Scorpion envenomation and serotherapy in Morocco. Am J Trop Med Hyg. 2000;62:277–283.
  • Abroug F, Ouanes-Besbes L, Ouanes I, et al. Meta-analysis of controlled studies on immunotherapy in severe scorpion envenomation. Emerg Med J. 2011;28:963–969.
  • Ramasamy S, Isbister GK, Seymour JE, et al. The in vivo cardiovascular effects of box jellyfish Chironex fleckeri venom in rats: efficacy of pre-treatment with antivenom, verapamil and magnesium sulphate. Toxicon. 2004;43:685–690.
  • Chavez-Olortegui C, Bohorquez K, Alvarenga LM, et al. Sandwich-ELISA detection of venom antigens in envenoming by Phoneutria nigriventer spider. Toxicon. 2001;39:909–911.
  • Bucaretchi F, Mello SM, Vieira RJ, et al. Systemic envenomation caused by the wandering spider Phoneutria nigriventer, with quantification of circulating venom. Clin Toxicol (Phila). 2008;46:885–889.
  • Richardson M, Pimenta AM, Bemquerer MP, et al. Comparison of the partial proteomes of the venoms of Brazilian spiders of the genus Phoneutria. Comp Biochem Physiol C Toxicol Pharmacol. 2006;142:173–187.
  • Stoecker WV, Green JA, Gomez HF. Diagnosis of loxoscelism in a child confirmed with an enzyme-linked immunosorbent assay and noninvasive tissue sampling. J Am Acad Dermatol. 2006;55: 888–890.
  • Isbister GK, Gray MR. Bites by Australian mygalomorph spiders (Araneae, Mygalomorphae), including funnel-web spiders (Atracinae) and mouse spiders (Actinopodidae: Missulena spp). Toxicon. 2004;43:133–140.
  • Isbister GK. Mouse spider bites (Missulena spp.) and their medical importance. A systematic review. Med J Aust. 2004;180:225–227.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.