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Brief Communication

Guanfacine overdose resulting in initial hypertension and subsequent delayed, persistent orthostatic hypotension

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Pages 146-148 | Received 03 Nov 2009, Accepted 23 Nov 2009, Published online: 06 Feb 2010

References

  • Scahill L, Chappell PB, Kim YS, Schultz RT, Katsovich L, Shepherd E, Arnsten AF, Cohen DJ, Leckman JF. A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder. Am J Psychiatry 2001; 158:1067–1074.
  • Kisicki JC, Fiske K, Lyne A. Phase I, double-blind, placebo-controlled, dose-escalation study of the effects on blood pressure of abrupt cessation versus taper down of guanfacine extended-release tablets in adults aged 19–24 years. Clin Ther 2007; 29(9):1967–1979.
  • McGrath JC, Klein-Schwartz W. Epidemiology and toxicity of pediatric guanfacine exposures. Ann Pharmacother 2002; 36:1698–1703.
  • Van Dyke MW, Bonace AL, Ellenhorn MJ. Guanfacine overdose in a pediatric patient. Vet Hum Toxicol 1990; 32(1):46–47.
  • Granier P, Arsac P, Debru JL. Intoxication par la guanfacine. Nouv Presse Med 1982; 11:1636–1637.
  • Sorkin EM, Heel RC. Guanfacine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of hypertension. Drugs 1986; 31(4):301–336.
  • Keitel JR. Pharmacokinetics and metabolism of guanfacine in man: A review. Br J Pharmacol 1980; 10:25S–32S.
  • King A, Harris P, Fritzell J, Kurland R. Syncope in children with Toilette’s syndrome treated with guanfacine. Mov Disord 2006; 21(3):419–420.
  • Frisk-Holmberg M, Wibell L. Concentration-dependent blood pressure effects of guanfacine. Clin Pharmacol Ther 1986; 39(2):169–172.
  • Frye CB, Vance MA. Hypertensive crisis and myocardial infarction following massive clonidine overdose. Ann Pharmacother 2000; 34(5):611–615.
  • Barber ND, Reid JL. Comparison of the actions of centrally and peripherally administered clonidine and guanfacine in the rabbit: investigation of the differences. Br J Pharmacol 1982; 77:641–647.
  • Biederman J, Melmed RD, Patel A, McBurnett K, Konow J, Lyne A, Scherer N. A randomized, double-blind, placebo-controlled study of guanfacine extended release in children and adolescents with attention-deficit/hyperactivity disorder. Pediatrics 2008; 121:e73–e84.

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