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Clinical Toxicology Volume 5, 1972 - Issue 3
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Research Article

Adsorption of Propoxyphene Hydrochloride by Activated Charcoal

Stanley M. Chernish Senior Physician, Lilly Laboratory for Clinical Research and Visiting Staff and Attending Physician Gastro-Intestinal Clinic, Marion County General Hospital Assistant Professor of Medicine Indiana University School of Medicine, Indianapolis, Indiana
,
Robert L. Wolen Chief, Clinical Chemistry and Drug Metabolism, Lilly Laboratory for Clinical Research and Marion County General Hospital, Indianapolis, Indiana
&
Bruce E. Rodda Senior Statistician, Eli Lilly and Company, Indianapolis, Indiana
Pages 317-329 | Published online: 25 Sep 2008

References

  • Anderson A. H. Experimental studies on the pharmacology of activated charcoal. I. Adsorption power of charcoal from aqueous solutions. Acta. Pharmacol. Toxicol. 1946; 2: 69–78
  • Anderson A. H. Experimental studies on the pharmacology of activated charcoal. II. The effect of pH of the adsorption by charcoal from aqueous solutions. Acta Pharmacol. Toxicol. 1947; 3: 199–218
  • Anderson A. H. Experimental studies on the pharmacology of activated charcoal. III. Adsorption from gastrointestinal contents. Acta. Pharmacol. Toxicol. 1948; 4: 275–284
  • Anderson A. H. Experimental studies on the pharmacology of activated charcoal. IV. Adsorption of allypropynal (allylisopropyl-barbituric acid) in vivo. Acta. Pharmacol. Toxicol. 1948; 4: 379–388
  • Corby D. G., Decker W. J. An antidote for propoxyphene HCl. JAMA 1968; 203: 1074
  • Corby D. G., Decker W. J. Treatment of propoxyphene poisoning. JAMA 1968; 205: 250
  • Decker W. J., Combs H. F., Corby D. G. Adsorption of drugs and poisons by activated charcoal. Toxicol. Appl. Pharmacol. 1968; 13: 454–460
  • Draper N. R., Smith H. Applied Regression Analysis. Wiley, New York 1966
  • Fraser H. F. Propoxyphene antidotes. JAMA 1968; 204: 549
  • Gruber C. M., Jr., King E. P., Best M. M. Clinical bio-assay of oral analgesic activity of propoxyphene (Lilly), acetyl-salicylic acid, and codeine phosphate, and observations on placebo reactions. Arch. Int. Pharmacodyn. 1955; 114: 156–166
  • Holt L. E., Jr., Holtz P. H. The black bottle: A consideration of the role of charcoal in the treatment of poisoning in children. J. Pediat. 1963; 63: 306–314
  • Wagner J. G. Pharmacokinetics 7. Percent absorbed - time plots and absorption rate. Drug Intelligence 1968; 2: 332–338
  • Wolen R. L., Gruber C. M., Jr. Determination of propoxyphene in human plasma by gas chromatography. Anal. Chem. 1968; 40: 1243–1246

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