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Research Article

Benzidine Revisited: A Review of the Literature and Problems Associated with the Use of Benzidine and Its Congeners

Pages 13-42 | Published online: 25 Sep 2008

References

  • Federal Register Sept. 7, 1973; 38: 21375–21378
  • Federal Register Jan. 29, 1974; 39: 3756–3797
  • Chemistry and Engineering News Feb. 11, 1974; 12
  • Rehn L. Blasengeschwulste bei Fuchsin - Arbeitern. Arch Klin. Chirugie 1895; 50: 588
  • Ehrlicher H. Benzidin in arbeitsmedizinischer Sicht. Ztb. Arbeitsmed Arbeitsschutz 1958; 8: 201
  • Baker R. K., Deighton J. G. The metabolism of benzidine in the rat. Cancer Res. 1953; 13: 529
  • Butt L. T., Strafford N. Papilloma of the bladder in the chemical industry. Analytical methods for the determination of benzidine and β-naphthylamine, recommended by A.B.C.M. subcommittee. J. Appl. Chem. 1956; 6: 525
  • Elson L. A., Goulden F., Warren F. L. The metabolism of aromatic amines in relation to carcinogenesis. Brit. J. Cancer 1958; 12: 108
  • Sciarini L. J., Meigs J. W. The biotransformation of benzidine (4,4'-diaminobiphenyl). A.M.A. Arch. Ind. Health 1958; 18: 521
  • Akiyama T. The investigation of the manufacturing plant of organic pigment. Jikei, Med. J. 1970; 17: 1
  • Glassman J. M., Meigs J. W. Benzidine (4,4'-diaminobiphenyl) and substituted benzidines. A.M.A. Arch. Ind. Hyg. Occup. Med. 1951; 4: 519
  • Ghetti G. Excrezione urinaria di alcume ammine aromatiche in lavoratori addetti alla produzione ed all -impiego di benzidina, benzidine sostituite e loro sali. Med. Lavoro 1965; 51: 102
  • Troll W., Nelson N. Studies on aromatic amines. I. Preliminary observations on benzidine metabolism. Am. Ind. Hyg. Assoc. J. 1958; 19: 499
  • El-Dib M. A. Colorimetric determination of aniline derivatives in natural waters. J. Assoc. Org. Anal. Chemists 1971; 54: 1383
  • Troll W., Belman S., Rinde E. N-Hydroxy acetyl amino compounds, urinary metabolites of aromatic amines in man. Proc. Am. Assoc. Cancer Res. 1963; 4: 68
  • Clayson D. B., Ward E., Ward L. The fate of benzidine in various species. Acta Unio. Intern. Contra Cancerum 1959; 15: 581
  • Rinde E. Measurement of free aromatic amines in urine and application to the metabolism of 4-benzidine derived azo dyes. New York University. Feb., 1974, Thesis
  • Bowman M., personal communication
  • Gewin V. A. Rapid detection of benzidine and dianisidine by sodium hypochlorite. Gig. Tr. Prof. Zabol. 1971; 15: 59
  • Florea I. Spectrophotometric determination of benzidine with sodium hypochloride and hypochlorous acid. Rev. Roum. Chim. 1972; 17: 915–923
  • Sciarini L. J., Meigs J. W. The biotransformation of benzidine II. Studies in mouse and man. A.M.A. Arch. Environ. Health 1961; 2: 423
  • Oida S. Studies on acute and subacute benzidine poisoning. III. An experimental study (on subacute poisoning). J. Sci. Labor 1958; 34: 172
  • Oida O. Studies on acute and subacute benzidine poisoning. IV. Summary. J. Sci. Labor 1958; 34: 352
  • Weber H., Heidepriem C. Zur Kenntnis Des Verhaltens Aromatischer Amine Im Organismus. Zentr. Gewerbe-hygiene 1928; 5: 269
  • Sciarini L. J. 3-Hydroxybenzidine, a metabolite of benzidine. Arch. Biochem. Biophys. 1957; 71: 437
  • Sciarini L. J., Meigs J. W. The biotransformation of benzidine (4,4'-diaminobephenyl) an industrial carcinogen, in the dog I. A.M.A. Arch. Ind. Health 1958; 18: 521
  • Englebertz P., Babel E. Nachweis von Benzidin und seinen Umwandlungsprodukten im Harn und in Organteilen. Zentr. Arbeitsmed. Arbeitsschutz 1953; 3: 161
  • Adler O. Die Wirkung und das Schicksal des Benzidins im Tierkorper. Arch. Exptl. Pathol. Pharmakol. 1908; 58: 167
  • Baker R. K. The carcinogenic activity of dihydroxy benzidine. Acta Unio Intern. Contra Cancer 1950; 7: 46
  • Sciarini L. J., Meigs J. W. Biotransformation of the benzidines. III. Studies on diorthotoluidine, dianisidine, and dichlorobenzidine 3,3' disubstituted congeners of benzidine (4,4'-diaminobiphenyl). A.M.A. Arch. Environ. Health 1961; 2: 584
  • Meigs J. W., Brown R. M., Sciarini L. J. A study of exposure to benzidine and substituted benzidines in a chemical plant. A.M.A. Arch. Ind. Hyg. 1951; 4: 533
  • Meigs J. W., Sciarini L. J., Van Sandt W. A. Skin penetration by diamines of the benzidine group. A.M.A. Arch. Ind. Hyg. 1954; 9: 122
  • Hirai K., Yasuhira K. Mitochondrial oxidation of 3,3'-diaminobenzidine and related compounds, and their possible relation to carcinogenesis. Gann 1972; 63: 665
  • Booth J., Boyland E. The biochemistry of aromatic amines. Biochem. J. 1964; 1964
  • Kellner H. M., Christ O. E., Lotzsch K. Animal studies on the kinetics of benzidine and 3,3'-dichlorobenzidine. Arch. Toxikol. 1973; 31: 61
  • Bonser G. M., Clayson D. B., Jull J. W. The induction of tumours of the subcutaneous tissues, liver and intestine in the mouse by certain dyestuffs and their intermediates. Brit. J. Cancer 1956; 10: 653
  • Prokofjeva O. G. Induction of hepatic tumors in mice by benzidine. Vop. Onkol. 1971; 17: 61
  • Berenblum I., Bonser G. M. Experimental investigation of “aniline cancer,”. J. Ind. Hyg. Toxicol. 1937; 19: 86
  • Spitz S., Maguigan W. H., Dobriner K. The carcinogenic action of benzidine. Cancer 1950; 3: 789
  • Boyland E., Harris J., Horning E. S. The induction of carcinoma of the bladder in rats with acetamidofluorene. Brit. J. Cancer 1954; 8: 647
  • Pliss G. B. On some regular relationships between carcinogenicity of aminodiphenyl derivatives and the structure of substance. Acta Unio Intern. Contra Cancerum 1963; 19: 499
  • Pliss G. B. Carcinogenic properties of benzidine. Vop. Onkol. 1964; 10: 529–532
  • Griswold D. P., Jr., Casey A. E., Weisburger E. K., Weisburger J. H. The carcinogenicity of multiple intragastric doses of aromatic and heterocyclic nitro or amino derivatives in young female Sprague-Dawley rats. Cancer Res. 1968; 28: 924
  • Baker R. K. The carcinogenic activity of dihydroxybenzidine. Further investigations. Cancer Res. 1953; 13: 137
  • Harman J. W. Chronic glomerulonephritis and the nephrotic syndrome induced in rats with N,N'-diacetylbenzidine. J. Pathol. 1971; 104: 119
  • Saffiotti U., Cefis F., Montesano R., Sellakumar A. R. Induction of Bladder Cancer in Hamsters Fed Aromatic Amines. Bladder Cancer, A Symposium, W. B. Deichmann, K. F. Lampe, R. A. Penalver, A. Soto. Aesculapius Publishing Co., Birmingham, Ala. 1967; 129–135
  • Bonser G. M. Ann. Rept. Brit. Empire Cancer Campaign 1959; 37: 417, Quote by Weisburger, E. K. in the NCTR Benzidine Symposium February 22, 1974
  • Bonser G. M., quoted in Spitz et al., Ref. [38]
  • Miller J. A., Miller E. C. The metabolic activation of carcinogenic aromatic amines and amides. Progr. Exptl. Tumor Res. 1969; 11: 273
  • Miller J. A., Miller E. C. Guest Editorial, Chemical Carcinogenesis: Mechanisms and approaches to its control. J. Natl. Cancer Inst. 1971; 47: V–XIV
  • Curschmann F. Statistische Erhebungen uber Blasentumoren bei Arbeitern in der chemischen Industrie. Zentr. Gewerbehygiene 1920; 8: 145
  • Curschmann F. Statistische Erhenbungern uber Blasentumoren bei Arbeitern in der chemischen Industrie. Zentr. Gewerbehygiene 1920; 8: 169
  • Oppenheimer R. Uber die bei Arbeitern Chemischer Betriebe beobachteten Erkrankyngen des Harnapparates. Ztg. Urologische Chirg. Gynaek. 1927; 21: 336
  • Simon L. XXII. Prognose und Behandlung der sogenannten Anilintumoren der Blase. Arch. Klin. Chirugie 1932; 173: 708
  • Goldblatt M. W. Vesical tumours induced by chemical compounds. Brit. J. Ind. Med. 1949; 6: 65
  • Scott T. S. The incidence of bladder tumours in a dyestuff factory. Brit. J. Ind. Med. 1952; 9: 127
  • Crabbe J. G. S. Exfoliative cytological control in occupational cancer of the bladder. Brit. Med. J. 1952; 2: 1072
  • Case R. A. M. Incidence of death from tumours of the urinary bladder. Brit. J. Soc. Prev. Med. 1935; 7: 14
  • Case R. A. M. The expected frequency of bladder tumour in works populations. Brit. J. Ind. Med. 1935; 10: 114
  • Case R. A. M., Hosker M. E., McDonald D. B., Pearson J. T. Tumours of the urinary bladder in workmen engaged in the manufacture and use of certain dyestuff intermediates in the British chemical industry. Part I. The role of aniline, benzidine, alpha-naphthylamine, and beta-naphthylamine. Brit. J. Ind. Med. 1954; 11: 75
  • Case R. A. M., Hosker M. E. Tumour of the urinary bladder as an occupational disease in the rubber industry in England and Wales. Brit. J. Soc. Prev. Med. 1954; 8: 39
  • Crabbe J. G. S., Cresdee W. C., Scott T. S., Williams M. H. C. The cytological diagnosis of bladder tumours amongst dyestuff workers. Brit. J. Ind. Med. 1956; 13: 270
  • Scott T. S., Williams M. H. C. The control of industrial bladder tumors. A code of working practice recommended by the British dyestuffs industry for the manufacture and use of products causing tumours of the bladder. Brit. J. Ind. Med. 1957; 14: 150
  • Goldblatt M. W. Occupational carcinogenesis. Brit. Med. Bull. 1958; 14: 136
  • Walpole A. L., Williams M. H. C. Aromatic amines as carcinogens in industry. Brit. Med. Bull. 1958; 14: 141
  • Scott T. S. Occupational bladder cancer. Brit. Med. J. 1964; 2: 302
  • Davies J. M. Bladder tumours in the electric-cable industry. Lancet 1965; 2: 143
  • Watts J. T. Hammersmith Coroners Court. Jan. 27, 1965, Transcript of evidence at inquest on George Lucy, deceased
  • Case R. A. M. Tumours of the urinary tract as occupational disease in several industries. Ann. Royal Coll. Surg. Eng. 1966; 39: 213
  • Boyland E. Occupational carcinogenesis. The Practitioner 1967; 199: 277
  • Veys C. A. Two epidemiological inquiries into the incidence of bladder tumors in industrial workers. J. Natl. Cancer Inst. 1969; 43: 219
  • Di Maio G. Tumori e Lesioni precancerose della vescica da amine o nitroderivati (detta da anilina). Arch. Ital. Urol. 1937; 14: 283
  • Barsotti M., Vigliani E. C. Bladder lesions from aromatic amines. Statistical considerations and prevention. A.M.A. Arch. Ind. Hyg. Occup. Med. 1952; 5: 234
  • Vigliani E. C., Barsotti M. Environmental tumors of the bladder in some Italian dye-stuff factories. Med del Lavoro 1961; 52: 241
  • Maltoni C., Ghetti G. Tumori della vie urinarie alte (reni ed ureteri) in operai di una fabrica di coloranti nord-italiana esposti a benzidina. Med Lavoro 1964; 55: 365
  • Clemmesen J., Nielsen A., Lockwood K. On the aetiology of bladder tumors. Acta Unio Intern. Contra Cancrum 1960; 16: 280
  • Billiard-Duchesne J. L. Les amino-tumeurs de la vessie: 17 observations francaise. J. Urol. Med. Chir. 1947; 53: 401
  • Billiard-Duchesne J. L. Les amino-tumeurs de la vessie: Notes d'etiologie et de prophylaxie. Arch. Mal. Prof. 1948; 9: 109
  • Desoille H., Hochfeld N., Aboulker P. Le depistage des tumeurs vesicales chez les travailleurs des produits colorants. Arch. Mal. Prof. 1948; 9: 149
  • Billiard-Duchesne J. L. Les amino-tumeurs de la vessie. J. Urol. Med. Chir. 1959; 65: 748
  • Muller A. Ruchblick auf gewerblichen Blasen- und Nieren-schadigungen in der Basler Farbstoffindustrie. Schweiz. Med. Wochschr. 1949; 79: 445–449
  • Uebelin F., Pletscher A. Atiologie und Prophylaxe gewerblicher Tumoren in der Farbstoffindustrie. Schweiz. Med. Wochschr. 1954; 84: 917
  • Muller A. Erfahrungen uber die Behandlung von Anilintumoren der Blase. Z. Urol. 1931; 25: 411
  • Muller A. Uber Blasen- und Nierenschadigungen in der Farbstoffindustrie. Helv. Chir. Acta 1951; 18: 1
  • Nishimura I. On aniline tumors of the bladder (case report). Japan. J. Urol. 1940; 29: 733
  • Yoshida M. A case of occupational bladder cancer. Dermatol. Urol. (Fukuoka) 1935; 15: 95
  • Oida O. Studies on acute and subacute benzidine poisoning. J. Sci. Labor 1957; 33: 939
  • Tomoyoshi T. Aniline tumor of the bladder, report of a case. Acta Urol. Japon. 1958; 4: 520
  • Yamamoto C., Tadokoro M., Hayashi T., Nakaoka H. Acute hemorrhagic cystitis which is found in employees of benzidine manufacturing factories. Japan Sci. Rev. Med. Sci. 1959; 7: 546
  • Troll W. February 22, 1974, quoted in NCTR Benzidine Symposium
  • Ferguson R. S. Symposium on anilin tumors of the bladder. J. Urol. 1934; 31: 121
  • Gehrmann G. H. The carcinogenic agent - chemistry and industrial aspects. J. Urol. 1934; 31: 126
  • Gay D. M. Pathology of anilin tumors of the bladder. J. Urol. 1934; 31: 137
  • Anderson L. W. Incidence, symptoms and signs, results of survey. J. Urol. 1934; 31: 148
  • Washburn V. D. The treatment of anilin tumor of the urinary bladder. J. Urol. 1934; 31: 155
  • Gehrmann G. H. Papilloma and carcinoma of the bladder in dye workers. JAMA 1936; 107: 1436
  • Ferguson R. S. Clinical significance of the anilin tumor of the bladder. J. Urol. 1937; 38: 243
  • Hueper W. C. “Aniline tumors” of the bladder. Arch. Pathol. 1938; 25: 856
  • Maguigan W. H. Occupational bladder tumors. Acta Unio Intern. Contra Cancerum 1950; 6: 1359
  • Hueper W. C. Recent developments in environmental cancer. A.M.A. Arch. Pathol. 1954; 58: 475
  • Dorn H. F. Cancer mortality trends in the United States of America. Cancer 1957; 3: 208
  • Hueper W. C. Environmental carcinogenesis and cancer. Cancer Res. 1961; 21: 842
  • Goldwater L. J., Rosso A. J., Kleinfeld M. Bladder tumors in a coal tar dye plant. Arch. Environ. Health 1965; 11: 814
  • Mancuso T. F., El-Attar A. A. Cohort study of workers exposed to betanaphthylamine and benzidine. J. Occup. Med. 1967; 9: 277
  • Rye W. A., Woolrich P. F., Zanes R. P. Facts and myths concerning aromatic diamine curing agents. J. Occup. Med. 1970; 12: 211
  • Zavon M. R., Hoegg U., Bingham E. Benzidine exposure as a cause of bladder tumors. Arch. Environ. Health 1973; 27

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