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Clinical Toxicology Volume 14, 1979 - Issue 2
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Research Article

Comparison of Spectrofluorometric and GC/MS Procedures for the Quantitation of Morphine in Blood and Brain

Dwight Reed Office of the Sheriff/Coroner, Santa Ana, California, 92702; Forensic Science Services, 550 N. Flower St., Room 201, P. O. Box 449, Santa Ana, California, 92702
Pages 169-180 | Published online: 25 Sep 2008

References

  • Wallace J. E., Biggs J. D., Blum K. Gas-liquid and thinlayer chromatographic determination of morphine in biologic specimens. Clin. Chim. Acta 1972; 36: 85
  • Robinson A. E., Williams F. M. Post mortem distribution of morphine in heroin addicts. Med. Sci. Law July, 1971; 135
  • Kupferberg H., Burkhalta A., Way E. L. A sensitive fluorometric assay for morphine in plasma and brain. J. Pharmacol. Exp. Therap. 1964; 145: 247
  • Goldbaum L. R., Santinga P. H., Dominguez A. M. A procedure for rapid analysis of large numbers of urine samples for drugs. Clin. Toxicol. 1972; 5: 367
  • Reynolds P. C. Morphine free in blood, urine and tissue; morphine total in bile. Traces 1972; 10: 1
  • Spector S., Parker C. W. Morphine radioimmunoassay. Science 1970; 168: 1347
  • Spector S. Quantitative determination of morphine in serum by radioimmunoassay. J. Pharmacol. Exp. Therap. 1971; 178: 253
  • Schneider R. S., Lindquist P., Tong-in Wong E., Rubenstein K. E., Ullman E. F. Homogeneous enzyme immunoassay for opiates in urine. Clin. Chem. 1973; 19: 821
  • Leute R. K., Ullman E. F., Goldstein A. Spin immunoassay techniques of opiate narcotics in urine and saliva. JAMA 1972; 221: 1231
  • Adler F. L., Liu C. T. Detection of morphine by hemagglutination inhibition. J. Immunol. 1971; 106: 1684
  • Ebbighausen W. O. R., Mowat J. H., Vestergaard P., Kline N. S. Stable isotope method for the assay of codeine and morphine by gas chromatography mass spectrometry. A feasibility study. Advan. Biochem. Psychopharmacol. 1973; 7: 135
  • Hipp P. P., Eveland M. R., Meyer E. R., Sherman W. R., Cicero T. J. Mass fragmentography of morphine: relationship between brain levels and analgesic activity. J. Pharmacol. Exp. Therap. 1976; 196: 642
  • Spiehler V. R., Reed D., Cravey R. H., Wilcox W. P., Shaw R. F., Holland S. Comparison of results for quantitative determination of morphine by radioimmunoassay, enzyme immunoassay and spectrofluorometry. J. Forensic Sci. 1975; 20: 647
  • Pearce D. S., Wiersema S., Kuo M. C., Emery C. Simultaneous determination of morphine and codeine in blood by use of select ion monitoring and deuterated internal standards. Clin. Toxicol. 1979; 14: 161

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