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Clinical Toxicology Volume 16, 1980 - Issue 4
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Research Article

Lack of Toxicity of High Dose Propoxyphene Napsylate When Used for Maintenance Treatment of Addiction

George E. Woody University of Pennsylvania, Philadelphia, Pennsylvania, 19104
,
A. Thomas McLellan University of Pennsylvania, Philadelphia, Pennsylvania, 19104
,
Charles P. O'Brien Drug Dependence Treatment Service, Veterans Administration Medical Center, Philadelphia, Pennsylvania, 19104
,
Forest S. Tennant Community Health Project Inc, West Covina, California, 91790
&
Jim Mintz University of California at Los Angeles, Los Angeles, California, 90024; Veterans Administration Medical Center, Brentwood, California, 90073
Pages 473-478 | Published online: 25 Sep 2008

References

  • Tennant F. S. Propoxyphene napsylate (Darvon‐N) treatment of heroin addicts. J. Natl. Med. Assoc. 1974; 66: 23
  • Tennant F. S., et al. Outpatient withdrawal from methadone maintenance with propoxyphene napsylate (Darvon‐N). J. Psychedelic Drugs 1975; 7: 269
  • Inaba D. S., et al. The use of propoxyphene napsylate in the treatment of heroin and methadone addiction. West. J. Med. 1974; 121: 106
  • Jasinski D. R., et al. Therapeutic usefulness of propoxyphene napsylate in narcotic addiction. Arch. Gen. Psychiatry 1977; 34: 227
  • Tennant F. S. Propoxyphene napsylate for heroin addiction. J. Am. Med. Assoc. 1973; 226: 1012
  • Mattson R. H., Weisman G. K., Levy L. L. Dependence and central nervous system toxicity associated with the use of propoxyphene hydrochloride. Trans. Am. Neurol. Assoc. 1969; 94: 229
  • Woody G. E., et al. Usefulness of propoxyphene napsylate for maintenance treatment of narcotic addiction. 1979, Submitted for Publication
  • Tennant F. S., et al. Heroin detoxification: A comparison of propoxyphene and methadone. J. Am. Med. Assoc. 1975; 232: 1019
  • Fraser H. F., Isbell H. Pharmacology and addiction liability of dl‐ and d‐propoxyphene. Bull. Narc. 1960; 12: 9
  • Kiplinger G. F., Gruber C. M., Pierce E. C. A comparative study of the effects of chronic administration of propoxyphene salts to normal volunteers. Toxicol. Appl. Pharmacol. 1971; 19: 528
  • Emmerson J. L., et al. Short term toxicity of propoxyphene salts in rats and dogs. Toxicol. Appl. Pharmacol. 1971; 19: 452
  • Hudson P., Barringer M., McBay A. J. Fatal poisoning with propoxyphene: Report from 100 consecutive cases. South. Med. J. 1977; 70: 938
  • Rejent T. A., Michalek R. W., Lehotay J. M. Propoxyphene‐associated deaths: Methods, post‐mortem levels in blood and liver. Clin. Toxicol. 1977; 11: 43
  • McBay A. J., Hudson P. Propoxyphene overdose deaths. J. Am. Med. Associ 1975; 233: 1257
  • Sturner W. Q., Garriott J. C. Deaths involving propoxyphene. J. Am. Med. Assoc. 1973; 223: 1125
  • Carson D. L., Carson E. D. Fatal dextropoxyphene poisoning in Northern Ireland. Lancet 1977; 1: 894

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