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Research Article

Massive Intoxication with Acetaminophen and Propoxyphene: Unexpected Survival and Unusual Pharmacokinetics of Acetaminophen

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Pages 1-16 | Published online: 25 Sep 2008

References

  • Zimmerman H. J. Effects of aspirin and acetaminophen on the liver. Arch. Intern. Med. 1981; 141: 333–342
  • Food and Drug Administration Department of Health, Education and Welfare, Propoxyphene. Fed. Reg. 1979; 44: 11837
  • Robinson A. E., Sattar H., McDowall R. D., Holder A. T., Powell R. Forensic toxicology of some deaths associated with the combined use of propoxyphene and acetaminophen (paracetamol). J. Forensic Sci. 1977; 22: 708–717
  • Young R. J., Lawson A. A. H. Distalgesic poisoning–Cause for concern. Br. Med. J. 1980; 280: 1045–1047
  • Lovejoy F. H., Mitchell A. A., Goldman P. The management of propoxyphene poisoning. J. Pediatr. 1974; 85: 98–100
  • Carson D. J. L., Carson E. D. Fatal dextropropoxyphene poisoning in Northern Ireland. Lancet 1977; 1: 894–897
  • Young D. J. Propoxyphene suicides. Arch. Intern. Med. 1972; 129: 62–66
  • Editorial. Treatment of dextropropoxyphene poisoning. Lancet 1977; 2: 542
  • Kleinman J. G., Breitenfield R. V., Roth D. A. Acute renal failure associated with acetaminophen ingestion: Report of a case and review of the literature. Clin. Nephrol. 1980; 14: 201–205
  • Prescott L. F. Treatment of severe acetaminophen poisoning with intravenous acetylcysteine. Arch. Intern. Med. 1981; 141: 386–389
  • Rumack B. H., Peterson R. G., Koch G. G., Amara I. A. Acetaminophen overdose. Arch. Intern. Med. 1981; 141: 380–385
  • Tjaden U. R., Kraak J. C., Huber J. F. K. Rapid trace analysis of barbiturates in blood and saliva by high-pressure liquid chromatography. J. Chromatogr. 1977; 143: 183–194
  • Galinsky R. E., Levy G. Effect of N-acetylcysteine on the pharmacokinetics of acetaminophen in rats. Life Sci. 1979; 25: 693–700
  • Verebely K., Inturrisi C. E. Disposition of propoxyphene and norpropoxyphene in man after a single oral dose. Clin. Pharmacol. Ther. 1974; 15: 302–309
  • Häkkinen I. P. T., Häkkinen L. M. Spectrophotometric determination of sulphate in serum and urine with barium chloranilate. Scand. J. Clin. Lab. Invest. 1959; 11: 294–297
  • Carmines E. L., Carchman R. A., Borzelleca J. F. A method for the evaluation of dose effect data utilizing a programmable calculator. J. Environ. Pathol. Toxicol. 1980; 4: 23–30
  • Rawlins M. D., Henderson D. B., Hijab A. R. Pharmacokinetics of paracetamol (acetaminophen) after intravenous and oral administration. Eur. J. Clin. Pharmacol. 1977; 11: 283–286
  • Gram L. F., Schou J., Way W. L., Heltberg J., Bodin N. O. d-Propoxyphene kinetics after single oral and intravenous doses in man. Clin. Pharmacol. Ther. 1979; 26: 473–482
  • Gibson T. P., Giacomini K. M., Briggs W. A., Whitman W., Levy G. Propoxyphene and norpropoxyphene plasma concentrations in the anephric patient. Clin. Pharmacol. Ther. 1980; 27: 665–670
  • Wolen R. L., Gruber C. M., Kiplinger G. F., Scholz N. E. Concentration of propoxyphene in human plasma following repeated oral doses. Toxicol. Appl. Pharmacol. 1971; 19: 493–497
  • Clark R., Thompson R. P. H., Borirakchanyavat V. Hepatic damage and death from overdose of paracetamol. Lancet 1973; 1: 66–69
  • Walker R. M., Massey T. E., McElligott T. F., Racz W. J. Acetaminophen-induced hypothermia, hepatic congestion, and modification by N-acetylcysteine in mice. Toxicol. Appl. Pharmacol. 1981; 59: 500–507
  • Moore R. A., Rumack B. H., Conner C. S., Peterson R. G. Naloxone underdosage after narcotic poisoning. Am. J. Dis. Child. 1980; 134: 156–158
  • Christensen H. Dextropropoxyphene and norpropoxyphene in blood, muscle, liver and urine in fatal poisoning. Acta Pharmacol. Toxicol. 1977; 40: 298–309
  • Wright N., Prescott L. F. Potentiation by previous drug therapy of hepatotoxicity following paracetamol overdosage. Scott. Med. J. 1973; 18: 56–58
  • Mitchell J. R., Thorgeirsson S. S., Potter W. Z., Jollow D. J., Keiser H. Acetaminophen-induced hepatic injury: Protective role of glutathione in man and rationale for therapy. Clin. Pharmacol. Ther. 1974; 16: 676–684
  • Wilson J. T., Kasantikul V., Harbison R., Martin D. Death in an adolescent following an overdose of acetaminophen and phenobarbital. Am. J. Dis. Child. 1978; 132: 466–473
  • Slattery J. T., Levy G. Acetaminophen kinetics in acutely poisoned patients. Clin. Pharmacol. Ther. 1979; 25: 185–195
  • Prescott L. F., Wright N., Roscoe P., Brown S. S. Plasma paracetamol half-life and hepatic necrosis in patients with paracetamol overdosage. Lancet 1971; 1: 519–522
  • Forrest J. A. H., Roscoe P., Prescott L. F., Stevenson I. H. Abnormal drug metabolism after barbiturate and paracetamol overdose. Br. Med. J. 1974; 4: 499–502
  • Saunders J. B., Wright N., Lewis K. O. Predicting outcome of paracetamol poisoning by using 14C-aminopyrine breath test. Br. Med. J. 1980; 280: 279–280
  • Büch H., Rummel W., Pfelger K., Eschrich C. H., Texter N. Ausscheidung freien und konjugierten Sulfates bei Ratte und Menschen nach Verabreichung von N-acetyl-p-aminophenol. Naunyn-Schmiedebergs Arch. Pharmakol. Exp. Pathol. 1968; 259: 276–289
  • Galinsky R. E., Slattery J. T., Levy G. Effect of sodium sulfate on acetaminophen elimination by rats. J. Pharm. Sci. 1979; 68: 803–805
  • Galinsky R. E., Levy G. Dose- and time-dependent elimination of acetaminophen in rats-Pharmacokinetic implications of cosubstrate depletion. J. Pharmacol. Exp. Ther. 1981; 219: 14–20
  • Osie S., Lowenthal D. T., Briggs W. A., Levy G. Effect of hemodialysis on kinetics of acetaminophen elimination by anephric patients. Clin. Pharmacol. Ther. 1975; 18: 680–686
  • Giacomini K. M., Gibson T. P., Levy G. Effect of hemodialysis on propoxyphene and norpropoxyphene concentrations in blood of anephric patients. Clin. Pharmacol. Ther. 1980; 27: 508–514
  • Chaignon M., Chen W. T., Tarazi R. C., Bravo E. L., Nakamoto S. Effect of hemodialysis on blood volume distribution and cardiac output. Hypertension 1981; 3: 327–332
  • Prescott L. F., Wright N. The effects of hepatic and renal damage on paracetamol metabolism and excretion following overdosage. A pharmacokinetic study. Br. J. Pharmacol. 1973; 49: 602–613
  • Winchester J. F., Gelfand M. C., Helliwell M., Vale J. A., Goulding R., Schreiner G. E. Extracorporeal treatment of salicylate or acetaminophen poisoning–Is there a role. Arch. Intern. Med. 1981; 141: 370–374
  • Canalese J., Gimson A. E. S., Davis M., Williams R. Factors contributing to mortality in paracetamol-induced hepatic failure. Br. Med. J. 1981; 282: 199–201
  • Cocchetto D. M., Levy G. Absorption of orally administered sodium sulfate in man. J. Pharm. Sci. 1981; 70: 331–333
  • Levy G., Galinsky R. E., Lin J. H. Pharmacokinetic consequences and toxicologic implications of endogenous cosubstrate depletion. Drug Metab. Dispos.
  • Prescott L. F. Kinetics and metabolism of paracetamol and phenacetin. Br. J. Clin. Pharmacol. 1980; 10: 291S–298S
  • Prescott L. F. The nephrotoxicity and hepatotoxicity of antipyretic analgesics. Br. J. Clin. Pharmacol. 1979; 7: 453–462
  • Caldwell J., Davies S., Smith R. L. Inter-individual differences in the conjugation of paracetamol with glucuronic acid and sulfate. Br. J. Pharmacol. 1980; 70: 112P–113P
  • Franklin M. R. Inhibition of mixed function oxidations by substrates forming reduced cytochrome P-450 metabolic intermediate complexes. Pharmacol. Ther. 1977; 2: 227–245
  • Dam M., Christiansen J. Interaction of propoxyphene with carbamazepine. Lancet 1977; 2: 509
  • Pelkonen O., Puurunen J. The effect of cimetidine on in vitro and in vivo microsomal drug metabolism in the rat. Biochem. Pharmacol. 1980; 29: 3075–3080
  • Hicks R., Hulbert P. B., Kwizera E. N. Inhibition or induction of drug-metabolism in relation to dextropropoxyphene-induced glutathione depletion in isolated hepatocytes. Br. J. Pharmacol. 1981; 74: 302P–303P
  • Jacob P., Rigod J. F., Pond S. M., Benowitz N. L., To Be Published
  • Mitchell M. C., Schenker S., Avant G. R., Speeg K. V., Jr. Cimetidine protects against acetaminophen hepatotoxicity in rats. Gastroenterology 1981; 81: 1052–1060
  • Galinsky R. E., Levy G. Effect of cimetidine on acetaminophen pharmacokinetics in rats. Int. J. Pharm.

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