Cardiovascular Changes and Plasma Drug Levels after Amitriptyline Overdose

References

• Bigger J. T., Jr., Kantor S. J., Glassman A. H., Perel J. M. Cardiovascular Effects of Tricyclic Antidepressant Drugs. Psychopharmacology: A Generation of Progress, M. A. Lipton, A. DiMascio, K. F. Killam. Raven, New York 1978; 1033
   Google Scholar
• Stimmel B. Cardiovascular Effects of Mood-Altering Drugs. Raven, New York 1979; 134
   Google Scholar
• Biggs J. T., Holland W. H., Chang S. S., Hipps P. P., Sherman W. R. The electron beam ionization mass fragmentographic analysis of tricyclic antidepressants in human plasma. J. Pharm. Sci. 1976; 65: 261
   PubMed Web of Science ®Google Scholar
• Ziegler V. E., Co B. T., Biggs J. T. Plasma nortriptyline levels and ECG findings. Am. J. Psychiatry 1977; 134: 441
   PubMed Web of Science ®Google Scholar
• Rudorfer M. V., Young R. C. Anticholinergic effects and plasma desipramine levels. Clin. Pharmacol. Ther. 1980; 28: 703
   PubMed Web of Science ®Google Scholar
• Spiker D. G., Weiss A. N., Chang S. S., Ruwitch J. F., Jr., Biggs J. T. Tricyclic antidepressant overdose: Clinical presentation and plasma levels. Clin. Pharmacol. Ther. 1975; 18: 539
   PubMed Web of Science ®Google Scholar
• Crome P., Newman B. Fatal tricyclic antidepressant poisoning. J. R. Soc. Med. 1979; 72: 649
   PubMed Web of Science ®Google Scholar
• Woodhead R. Cardiac rhythm in tricyclic antidepressant poisoning. Clin. Toxicol. 1979; 14: 499
   PubMed Web of Science ®Google Scholar
• Greenblatt D. J., Allen M. D., Noel B. J., Shader R. I. Acute overdosage with benzodiazepine derivatives. Clin. Pharmacol. Ther. 1977; 21: 497
   PubMed Web of Science ®Google Scholar
• Burckhardt D., Raeder E., Müller V., Imhoff P., Neubauer H. Cardiovascular effects of tricyclic and tetracyclic anti-depressants. J. Am. Med. Assoc. 1978; 239: 213
   PubMed Web of Science ®Google Scholar
• Ziegler V. E., Co B. T., Biggs J. T. Electrocardiographic findings in patients undergoing amitriptyline treatment. Dis. Nerv. Syst. 1977; 38: 697
   PubMedGoogle Scholar
• Rudorfer M. V., Young R. C. Desipramine: Cardiovascular effects and plasma levels. Am. J. Psychiatry 1980; 137: 984
   PubMed Web of Science ®Google Scholar
• Veith R. C., Friedel R. O., Bloom V., Bielski R. Electro-cardiogram changes and plasma desipramine levels during treatment of depression. Clin. Pharmacol. Ther. 1980; 27: 796
   PubMed Web of Science ®Google Scholar
• Davis J. M., Bartlett E., Termini B. A. Overdosage of psychotropic drugs: A review, Part II: Antidepressants and other psychotropic agents. Dis. Nerv. Syst. 1968; 29: 246
   PubMedGoogle Scholar
• Vohra J., Burrows G., Hunt D., Sloman G. The effect of toxic and therapeutic doses of tricyclic antidepressant drugs on intracardiac conduction. Eur. J. Cardiol. 1975; 3: 219
   PubMedGoogle Scholar
• Vohra J., Burrows G. D., Sloman G. Assessment of cardiovascular side effects of therapeutic doses of tricyclic antidepressant drugs. Aust. N. Z. J. Med. 1975; 5: 7
   PubMedGoogle Scholar
• Bailey D. N., Van Dyke C., Langou R. A., Jatlow P. L. Tricyclic antidepressants: Plasma levels and clinical findings in overdose. Am. J. Psychiatry 1978; 135: 1325
   PubMed Web of Science ®Google Scholar
• Braithwaite R. A., Crome P., Dawling S. Amitriptyline overdosage: Plasma concentrations and clinical features. Br. J. Clin. Pharmacol. 1979; 8: 388P
   PubMed Web of Science ®Google Scholar
• Crome P., Braithwaite R. A. Relationship between clinical features of tricyclic antidepressant poisoning and plasma concentrations in children. Arch. Dis. Child. 1978; 53: 902
   PubMed Web of Science ®Google Scholar
• Petit J. M., Spiker D. G., Ruwitch J. F., Ziegler V. E., Weiss A. N., Biggs J. T. Tricyclic antidepressant plasma levels and adverse effects after overdose. Clin. Pharmacol. Ther. 1977; 21: 47
   PubMed Web of Science ®Google Scholar
• Thorstrand C. Clinical features in poisonings by tricyclic anti-depressants with special reference to the ECG. Acta Med. Scand. 1976; 199: 337
   PubMed Web of Science ®Google Scholar
• Langou R. A., Van Dyke C., Tahan S. R., Cohen L. S. Cardiovascular manifestations of tricyclic antidepressant overdose. Am. Heart J. 1980; 100: 458
   PubMed Web of Science ®Google Scholar
• Reed K., McKim H. R. ECG changes in pure imipramine overdose as function of plasma level. Can. Psychiatr. Assoc. J. 1978; 23: 573
   PubMedGoogle Scholar
• Rudorfer M. V. Tricyclic antidepressant plasma levels in overdose. J. Am. Med. Assoc. 1981; 245: 703
   Web of Science ®Google Scholar
• Zaks J. M., Ritter G. Multiple reversible ECG changes in amitriptyline intoxication. Cardiovasc. Med. 1978; 3: 828
   Google Scholar
• Taylor D. J. E., Braithwaite R. A. Cardiac effects of tricyclic antidepressant medication: A preliminary study of nortriptyline. Br. Heart J. 1978; 40: 1005
   PubMedGoogle Scholar
• Noble J., Matthew H. Acute poisoning by tricyclic antidepressants: Clinical features and management of 100 patients. Clin. Toxicol. 1969; 2: 403
   Web of Science ®Google Scholar
• Sedal L., Korman M. G., Williams P. O., Mushin G. Overdosage of tricyclic antidepressants: A report of two deaths and a prospective study of 24 patients. Med. J. Aust. 1972; 2: 74
   PubMed Web of Science ®Google Scholar
• Thorstrand C. Cardiovascular effects of poisoning with tricyclic antidepressants. Acta Med. Scand. 1974; 195: 505
   PubMed Web of Science ®Google Scholar
• Glassman A. H., Giardina E. V., Perel J. M., Bigger J. T., Jr., Kantor S. J., Davies M. Clinical characteristics of imipramine-induced orthostatic hypotension. Lancet 1979; 1: 468
   PubMed Web of Science ®Google Scholar
• Rudorfer M. V., Robins E. Fatal nortriptyline overdose, plasma levels, and in vivo methylation of tricyclic antidepressants. Am. J. Psychiatry 1981; 138: 982
   PubMed Web of Science ®Google Scholar
• Hurst H. E., Jarboe C. H. Clinical findings, elimination pharmacokinetics, and tissue drug concentrations following a fatal amitriptyline intoxication. Clin. Toxicol. 1981; 18: 119
   PubMed Web of Science ®Google Scholar
• Perel J. M. Pharmacokinetics of therapeutic and toxic reactions: II. Tricyclic antidepressants. Neurotoxicology, L. Roizin, H. Shiraki, N. Grcevic. Raven, New York 1977; 157
   Google Scholar
• Ziegler V. E., Fuller T. A., Biggs J. T. Nortriptyline and 10-hydroxynortriptyline plasma concentrations. J. Pharm. Pharmacol. 1976; 28: 849
   PubMed Web of Science ®Google Scholar
• Kantor S. J., Glassman A. H., Bigger J. T., Jr., Perel J. M., Giardini E. V. The cardiac effects of therapeutic plasma concentrations of imipramine. Am. J. Psychiatry 1978; 135: 534
   PubMed Web of Science ®Google Scholar
• Goulding R. Incidence, symptoms, treatment and outcome of antidepressant poisoning in Britain. Advances in Neurotoxicology, L. Manzo. Pergamon, Oxford 1980; 339
   Google Scholar
• Rudorfer M. V. Physostigmine for anticholinergic drug poisoning. Lancet 1980; 2: 589
   Google Scholar