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Research Article

The importance of metabolite identification in quantitative risk estimation

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Pages 781-805 | Published online: 25 Sep 2008

References

  • Wands R. C., Broome J. H. The Proceeding of the 5th Annual Conference on Environ. Toxicol. Wright Patterson AFB, Ohio 1974, USAF, AMRL-TR-74–125-237
  • 1977, Office of Pesticide Programs, Fed. Register, 42, 40009
  • Nachtomi E. The metabolism of ethylene dibromide in the rat. The enzymatic reaction with glutathione in vivo and in vitro. Biochem. Pharmacol. 1970; 19: 2853
  • Weisburger J. H. Toxicology, The Basic Science of Poisons, L. J. Casarett, J. Doull. MacMillan Publishing Co., Inc., New York 1975; 333
  • Weisburger J. H., Williams G. M. Casarett and Doull's Toxicology, The Basic Science of Poisons2nd Ed., J. Doull, C. D. Klaassen, M. O. Andur. MacMillan Publishing Co., Inc., New York 1980; 84
  • Baldwin R. W., Glaves D., Pimm M. V. Progress in Immunology, First International Congress in Immunology, B. Amos. Academic Press, New York 1975; 907
  • Kraybill H. F. (1982) The Toxicology Forum, 1982 Annual Winter Meeting. 1982. Bowers Reporting Co., Washington, 145
  • Krewski R. (1982) The Toxicology Forum, 1982 Annual Winter Meeting. 1982. Bowers Reporting Co., Washington, 212
  • Armitage P. One-Hit Theory of Infectivity Tritation for Self-Reproducing Particles. J. Natl. Cancer Inst. 1959; 23: 1313
  • Van Ryzin J., Rai K. The Scientific Basis of Toxicity Assessment, H. Witschi. Elsevier, New York 1979; 273
  • Crump K. S., Guess H. A., Deal K. L. Confidence Intervals and Tests of Hypothesis Concerning Dose Response Relations Inferred from Animal Carcinogenicity Data. Biometrics 1977; 33: 437
  • Hartley H. O., Sielken R. L. Estimation of “Safe Doses” in Carcinogenic Experiments. Biometrics 1977; 33: 1
  • Krewski D., Van Ryzin J. Current Topics in Probability and Statistics, M. Csorgo, D. Dawson, J. N. K. Ruo, E. Salek. North-Holland, New York 1981; 1
  • Druckrey H. Quantitative Aspects of Chemical Carcinogenesis, R. Truhaut. Springer-Derlag, New York 1967; 60
  • Hoel D. G., Gaylor D. W., Kirschstein R. L., Schneiderman M. A. Estimation of Risks of Irreversible, Delayed Toxicity. J. Toxicol. Environ. Hlth. 1975; 1: 133
  • Walker A. I. T., Thorpe E., Stevenson D. E. The Toxicology of Dieldrin I. Long-term Oral Toxicity Studies in Mice. Fd. Cosmet. Toxicol. 1972; 11: 415
  • Bruce R. D., Carlton W. W., Ferber K. H., Hughes D. H., Quast J. E., Salsburg D. S., Smith J. M. Reexamination of the ED01 Study. Fund. Appl. Toxicol. 1981; 1: 28
  • Bruce R. D., Carlton W. W., Ferber K. H., Hughes D. H., Quast J. E., Salsburg D. S., Smith J. M. Reexamination of the ED01 Study. Fund. Appl. Toxicol. 1981; 1: 119
  • Watanabe P. G., McGowan G. R., Madrid E. O., Gehring P. J. Fate of [14C] Vinyl Chloride following Inhalation Exposure in Rats. Toxicol. Appl. Pharmacol. 1976; 37: 49
  • Gehring P. J., Watanabe P. G., Park C. N. Risk of Angiosarcoma in Workers Exposed to Vinyl Chloride as Predicted from Studies in Rats. Toxicol. Appl. Pharmacol. 1979; 49: 15
  • Maltoni C., Lefemine G. Carcinogenicity Assays of Vinyl Chloride: Current Results. Ann. N. Y. Acad. Sci. 1975; 246: 195
  • Chandler J. L. R. The Chemical Dynamics of Mutagenesis and Carcinogenesis I. A Chemical-Kinetic Model of Dose-Response Relationships. Mutat. Res. 1974; 25: 169
  • Boutwell R. K. Carcinogenesis, T. J. Slaga, A. Swak, R. K. Boutwell, 1978; Vol. 2: 49
  • Yanysheva N. Y., Antomonov V. G. Predicting the Risk of Tumor Occurrence under the Effect of Small Doses of Carcinogens. Environ. Hlth. Perspectives 1976; 13: 95
  • Freireich E. J., Gehan E. A., Rall D. P., Schmidt L. M., Skipper H. E. Quantitative Comparison of Toxicity of Anti-Cancer Agents in Mouse, Rat, Dog, Monkey, and Man, Cancer Chemotherap. 1966; 219, Report, 50
  • Rall D. P. Difficulties in Extrapolating the Results of Toxicity Studies in Laboratory Animals to Man. Environ. Res. 1969; 2: 360
  • Mantel N., Schneiderman M. Estimating “Safe” Levels, A Hazardous Undertaking. Cancer Res. 1975; 35: 1379
  • Reitz R. H., Gehring P. J., Park C. N. Effects of Vinylidene Chloride on DNA Synthesis and DNA Repair, in the Rat and Mouse: A Comparative Study with Dimethylnitrosamine. Food Cosmetic. Toxicol. 1978; 16: 511
  • Cramner M. F. Estimation of Risks Due to Environmental Carcinogenesis. Med. and Pediatric Oncol. 1977; 3: 169
  • Crouch E., Wilson R. Interspecies Comparison of Carcinogenic Potency. J. Toxicol. Environ. Hlth. 1979; 5: 1095
  • Davidson I. W. F., Sumner D. D., Parker J. C. Chloroform: A Review of its Metabolic, Teratogenic, Mutagenic and Carcinogenic Potential. Drug and Chem. Toxicol. 1982; 5: 1
  • Weisburger J. H., Williams G. M. Carcinogen Testing: Current Problems and New Approaches. Science 1981; 214: 23
  • Ashby J., Styles J. A., Anderson D., Paton D. Saccharin: An Epigenetic Carcinogen/Mutagen?. Fd. Cosmet. Toxicol. 1978; 16: 95
  • Brusick D. Principles of Genetic Toxicology. Plenum Press, New York and London 1980

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