Digoxin Specific Antibody (Fab) Fragments in 34 Cases of Severe Digitalis Intoxication

References

• Aeberhard P., Butler V. P., De1angenhagen B., Morin B. Le traitement ďune intoxication digitalique massive (20mg digitoxine) par les anticorps anti-digoxine fractiones (Fab). Arch mal Coer 1980; 73: 1471–1478
   PubMedGoogle Scholar
• Butler V. P., Chen J. P. Digoxin-specific antibodies. Proc Nat Acad Sci USA 1967; 57: 71
   PubMed Web of Science ®Google Scholar
• Butler V. P. Antibodies as specific antagonists of toxins, drugs and hormones. Pharmacological Reviews 1982; 34: 109–114
   PubMed Web of Science ®Google Scholar
• Butler V. P., Smith T. W., Schmidt D. H., Haber E. Immunological reversal of the effects of digoxin. Fed Proc 1977; 36: 2235–2241
   PubMedGoogle Scholar
• Caldwell J. H., Greenberger N. J. Interruption of the entero-hepatic circulation of digitoxin by cholestyramine. J Clin Invest 1971; 50: 2626
   PubMed Web of Science ®Google Scholar
• Cohen S. N. Antibody therapy of digoxin intoxication. Pediatrics 1982; 70: 3
   Google Scholar
• Curd J., Smith T. W., Jaton J. C., Haber E. The isolation of digoxin-specific antibody and its use in reversing the effects of digoxin. Proc Nat Acad Sci USA 1971; 10: 2401
   Google Scholar
• Cyran J., Smolarz A. Therapie der 1ebensbedrohlichen Digitalisintoxikation mit Schaf-Antidigoxin-Fab. Schweiz med Wschr, in press
   Google Scholar
• Ekins B. R., Watanabe A. S. Acute digoxin poisoning, Review of therapy. Am J Hosp Pharm 1978; 35: 268
   PubMedGoogle Scholar
• Ewy G. A., Marcus F. J., Fillmore S. J., Matthews N. P. Digitalis intoxication-diagnosis, management and prevention. Cardiovasc Clin 1974; 6: 153
   PubMedGoogle Scholar
• Gold H. K., Smith T. W. Reversal of ouabain and acetylstrophantidin effects in normal and failing cardiac muscle by specific antibody. J Clin Invest 1974; 53: 1655
   PubMed Web of Science ®Google Scholar
• Hall W. H., Shapell S. D., Doherty J. E. Effect of cholestyramine in digoxin absorption and excretion in man. Am J Cardiol 1977; 39: 213
   PubMed Web of Science ®Google Scholar
• Harenberg J., Staiger Ch., Wahl P., Smolarz A. Therapie einer schweren Digitalis-Lanata-Intoxikation mit Schaf-Antidigoxin-Fab. Therapiewoche 1983; 33: 6446–6452
   Google Scholar
• Hess P. Immunologische Hemmung der inotropen Herzglykosid-wirkung und Versuch der Lokalisation eines Digitalisrezeptors am Säugermyokard in vitro. Med Diss, Bern 1979
   Google Scholar
• Hess T. Ant ikörpertherapie der Digital isintoxikation. Thieme Copythek, Thieme, Stuttgart 1981
   Google Scholar
• Hess T., Riesen W., Scholtysik G., Stucki P. Digitoxin intixocation with severe thrombocytopenia: reversal by digoxin-specific antibodies. Eur J Clin Invest 1983; 13: 159–163
   PubMed Web of Science ®Google Scholar
• Jax W., Gevelmann M., Neubert P., Smolarz A. Behandlung einer schweren Glykosidintoxikation mit Schaf-Antidigoxin-Fab. Z Intensivmed 1983; 20: 250–254
   Google Scholar
• Larbig D., Raff U., Haasis R. Reversal of digitalis effects by specific antibodies. Pharmacology 1979; 18: 1–8
   PubMed Web of Science ®Google Scholar
• Lloyd B. L., Smith T. W. Contrasting rates of reversal of digoxin toxicity by digoxin-specific IgG and Fab fragments. Circulation 1978; 58: 280–283
   PubMed Web of Science ®Google Scholar
• Mandel W. J., Bigger J. T., Butler V. P. The electrophysiological effects of low and high digoxin concentrations on isolated mammalian cardiac tissue: reversal by digoxin specific antibody. J Clin Invest 1972; 51: 1378
   PubMed Web of Science ®Google Scholar
• Murphy D. J., Bremner W. F., Haber E., Butler V. P., Smith T. W., Gaum W. E. Massive digoxin poisoning treated with Fab fragments of digoxin-specific antibodies. Pediatrics 1982; 70: 472–473
   PubMed Web of Science ®Google Scholar
• Ochs H. R., Smith T. W. Reversal of digitoxin toxicity and modification of pharmacokinetics by specific antibodies. Cardiac Glycosides, Part II, G. Bodem, H. J. Dengler. Springer, Berlin-Heidelberg, New York 1978; 384–391
   Google Scholar
• Pall H. Einsatz der Haemocol-Haemoperfusion. Wiener Klin Wschr 1978; 90: 1
   PubMedGoogle Scholar
• Richter K., Singer H., Smolarz A. Die Behandlung der lebensbedrohlichen Digitalisvergif tung beim Kind mit Schaf-Digoxin-Antikorperfragmenten (Fab). Pëdiatrie und Intensivmedizin, H. Schachinger. Thieme, Stuttgart 1985, in press
   Google Scholar
• Risler T., Arnold G., Grabensee B. 1st die Hämoperf usion zur Behandlung der Digoxin-Intoxication geeignet. Z Kardiol 1979; 68: 313
   PubMedGoogle Scholar
• Rossi R., Leititis J. U., Hagel J., Smolarz A. Severe digoxin intioxication in a child treated by infusion of digoxin-specific Fab-antibody-fragments. Eur J Ped 1984; 142: 138–140
   PubMed Web of Science ®Google Scholar
• Semple P., Tilstone W. J., Cawson D. H. Furosemide and urinary digoxin clearance. New Engl J Med 1975; 293: 612
   PubMed Web of Science ®Google Scholar
• Schmidt D. H., Butler V. P. Immunological protection against digoxin toxicity. J Clin Invest 1971; 50: 866
   PubMed Web of Science ®Google Scholar
• Schmidt D. H., Butler V. P. Reversal of digoxin toxicity with specific antibodies. J Clin Invest 1971; 50: 1738
   PubMed Web of Science ®Google Scholar
• Smith T. W., Lloyd B. L., Spicer N., Haber E. Immunogenicity and kinetics of distribution and elimination of sheep digoxin-specific IgG and Fab-fragments in the rabbit and baboon. Clin Exp Immunol 1979; 36: 384–396
   PubMed Web of Science ®Google Scholar
• Smith T. W., Haber E., Yeatman L., Butler V. P. Reversal of advanced digoxin intoxication with Fab-fragments of digoxin-specific antibodies. New Engl J Med 1976; 294: 797
   PubMed Web of Science ®Google Scholar
• Smith T. W., Butler V. P., Haber E., Fozzard H., Marcus F. I., Bremner W. F., Schulman I. C., Phillipps A. Treatment of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments. New Engl J Med 1982; 307: 1357–1362
   PubMed Web of Science ®Google Scholar
• Smolarz A., Roesch E., Lenz H., Neubert P., Abshagen U. Erfahrungsbericht über die Behandlung von 16 schweren Glykosidvergiftungen mit Digitalis-Antikörper-Fragmenten (Fab). Z Kardiol 1984; 73: 113–119
   PubMedGoogle Scholar
• Wahl G., Bucking J., Hübner H., Schwartau M. Behandlungeinerlebensbedrohl ichen Digoxin-Intoxikationen mit heterologen digoxin-spezifischen Ant ikörperfragmenten. Dtsch med Wschr 1983; 108: 1441–1443
   PubMedGoogle Scholar
• Watson J. F., Butler V. P. Biologic activity of digoxin-specific antisera. J Clin Invest 1972; 51: 638
   PubMed Web of Science ®Google Scholar
• Weller P., Dickmans H. A., Hespe T. H., Adam M., Allolio B., Smolarz A., Grabensee B., Peters U. Kasuistik einer erfolgreichen Behandlung von rezidivierendem Kammerflimmern bei suizidaler Digoxinintoxikation mit spezifischen Antidigoxin-Fab-Fragmenten. Dtsch med Wschr 1983; 108: 1437–1440
   PubMed Web of Science ®Google Scholar
• Zilker T., Clarmann M. V., Felgenhauer N., Bihlmayr J., Smolarz A. Durchbruch in der Therapie der 1ebensbedrohlichen Digitalisintoxikation durch Einsatz von Schaf-Antidigoxin-Fragmenten. Intensivbehandlung 1983; 4: 149–157
   Google Scholar
• Zucker A. R., Lacina S. J., DasGupta D. S. Fab fragment of digoxin-specific antibodies used to reverse ventricular fibrillation induced by digoxin ingestion in a child. Pediatrics 1982; 70: 468–471
   PubMed Web of Science ®Google Scholar