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Journal of Toxicology: Clinical Toxicology Volume 24, 1986 - Issue 2
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Research Article

Calcium Interferes with the Cardiodepressive Effects of Beta-Blocker Overdose in Isolated Rat Hearts

Johanna Langemeijer Department of Anaesthesiology, St. Antonius Hospital, P.O. Box 2500, 3430, EM Nieuwegein
,
Dick de Wildt Laboratory of Pharmacology, National Institute of Public Health and Environmental Hygiene
,
Gerard de Groot Unit for Pharmacokinetics, National Institute of Public Health and Environmental Hygiene
&
Bart Sangster Department of Reanimation and Clinical Toxicology, University Hospital, Utrecht; The Netherlands National Poison Control Center National Institute of Public Health and Environmental Hygiene, P.O.Box 1, 3720, BA Bilthoven, The Netherlands
Pages 111-133 | Published online: 25 Sep 2008

References

  • de Wildt D. J., Sangster B., Langemeijer J. J.M., de Groot G. Different toxicological profiles for various beta-blocking agents on cardiac function in isolated rat hearts. J. Toxicol; Clin. Toxicol. 1984; 22: 115–132
  • Langemeijer J. J.M., de Wildt D. J., de Groot G., Sangster B. Respiratory arrest as main determinant of toxicity due to overdose with different beta-blockers in rats. Acta Pharmacol. Toxicol. 1985; 57: 352–356
  • Hashimoto K., Satoh M., Imai S. Effects of etafenone and anti-arrhytmic drugs on Na and Ca channels of guinea-pig atrial muscle. J. Cardiovasc. Pharmacol. 1979; 1: 561–570
  • Rokuntanda M., Araki S., Sakanashi M. A pharmacological investigation on a possible calcium antagonistic action of propranolol. Arch. Int. Pharmacodyn. 1983; 262: 99–108
  • Akaike N., Nishi N., Oyama Y. Inhibitory effects of propranolol on the calcium current of Helix neurones. Brit. J. Pharmacol. 1981; 73: 431–434
  • Akaike N., Ito H., Nishi K., Oyama Y. Further analysis of inhibitory effects of propranolol and local anaesthetics on the calcium current in Helix neurones. Brit. J. Pharmacol. 1982; 76: 37–43
  • Dhalla N. L., Lee S. L. Comparison of the action of acebutolol, practolol and propranolol on calcium transport by hearts microsomes and mitochondria. Brit. J. Pharmacol. 1976; 57: 215–221
  • Noak E., Kurzmack M., Verjovski-Almeida S., Inesi G. The effects of propranolol and its analogs on Ca++ transport by sarcoplasmic reticulum vesicles. J. Pharmacol. Exp. Ther. 1978; 206: 218–288

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