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Journal of Toxicology: Clinical Toxicology Volume 28, 1990 - Issue 3
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Research Article

Clinical Course and Pharmacokinetics Following a Massive Overdose of Amphotericin B in a Neonate

Gideon Koren Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto
,
Alan Lau Division of Infectious Diseases, The Hospital for Sick Children, Toronto
,
Cynthia F. Kenyon Neonatal Perinatal Medicine, St. Joseph's Health Centre, London, Ontario
,
David Kroppert Neonatal Perinatal Medicine, St. Joseph's Health Centre, London, Ontario
&
Julia Klein Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto
Pages 371-378 | Published online: 25 Sep 2008

References

  • Lau A., Amphotericin B. Antimicrobial Drugs in Infants and Children, G Koren, C Prober, R Gold. Marcel Dekker, New York 1988; 517–534
  • Atkinson A J, Bennet J E. Amphotericin B pharmacokinetics in humans. Antimicrob Agents Chemother 1978; 13: 271–276
  • Golas C L, Prober C G, MacLeod S M, Soldin S J. Measurement of amphotericin B in serum or plasma by high performance liquid chromatography. J Chromatogr 1983; 278: 387–395
  • Koren G, Lau A, Klein J, et al. Pharmacokinetics and adverse effects of amphotericin B in infants and children. J Pediatr 1988; 113: 559–563
  • Brent J, Hunt M, Kulig K., Rumack B H. Amphotericin B overdoses in infants: Is there a role for exchange transfusion?. Vet Hum Toxicol 1989; 31: 347
  • Koren G, Klein J, MacLeod S M. Dissociation between aminoglycoside serum concentrations and nephrotoxicity. Life Sci 1988; 43: 1817–1823
  • Koren G, Long D, Klein J, et al. Comparison of the digitalis receptor in erythrocytes from preterm infants and adults. Pediatr Res 1988; 23: 414–417
  • Rieder M. Chloramphenicol. Antimicrobial Drugs in Infants and Children, G Koren, C Prober, R Gold. Marcel Dekker, New York 1988; 311–338
  • Koren G, Barzilay Z, Greenwald M. Ten-fold errors in drug dose administration: A neglected histogenic disease in children. Pediatrics 1985; 77: 848–849

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