19
Views
19
CrossRef citations to date
0
Altmetric
Research Article

Increased Matrix Proteins, Collagen and Transforming Growth Factor are Early Markers of Hepatotoxicity in Patients on Long-Term Methotrexate Therapy

, &
Pages 301-305 | Published online: 25 Sep 2008

References

  • Ashton R. E., Millward-Sadler G. H., White J. E. Complications in methotrexate treatment of psoriasis with particular reference to liver fibrosis. J Invest Dermatol 1982; 79: 229–232
  • Dahl M. G., Gregory M. M., Scheuer P. J. Methotrexate hepatotoxicity in psoriasis: comparison of different dose regimes. BMJ 1972; 1: 654–656
  • Podurgiel B. J., McGill D. B., Ludwig J., Taylor W. F., Muller S. A. liver injury associated with methotrexate therapy for psoriasis. Mayo Clin Proc 1973; 48: 787–792
  • Millward-Sadler G. H., Ryan T. J. Methotrexate induced liver disease in psoriasis. Br J Dermatol 1974; 90: 661–667
  • Kremer J. M., Lee R. G., Tolman K. G. Liver histology in rheumatoid arthritis patients receiving long‐term methotrexate therapy. A prospective study with baseline and sequential biopsy samples. Arthritis‐Rheum 1989; 32: 121–127
  • Mitchell D., Smith A., Rowan B., et al. Serum type HJ procollagen peptide, dynamic liver function tests and hepatic fibrosis in psoriatic patients receiving methotrexate. Br J Dermatol 1990; 122: 1–7
  • Arias J. M., Morton K. A., Albro J. E., et al. Comparison of methods for identifying early methotrexate‐induced hepatotoxicity in patients with rheumatoid arthritis. J Nucl Med 1993; 34: 1905–1909
  • Millward-Sadler G. H., Whorwell P. J. Liver biopsy: methods, diagnostic value and interpretation. Wright's Liver and Biliary Disease, Millward-Sadler, et al. Saunders Co, Philadelphia 1992; 476–497
  • Minocha A., Dean H. A., Pittsley R. A. Liver cirrhosis in rheumatoid arthritis patients treated with long‐term methotrexate. Vet Hum Toxicol 1993; 35: 45–48
  • Nohlgard C., Rubio C. A., Kock Y., Hammar H. Liver fibrosis quantified by image analysis in methotrexate‐treated patients with psoriasis. J Am Acad Dermatol 1993; 28: 40–45
  • Themido R., Loureiro M., Pecegueiro M., Brandao M., Campos M. C. Methotrexate hepatotoxicity in psoriatic patients submitted to long‐term therapy. Acta Derm Venereol 1992; 72: 361–364
  • Cash J. M., Swain M., Di Bisceglie A. M., Wilder R. L., Crofford L. J. Massive intrahepatic hemorrhage following routine liver biopsy in a patient with rheumatoid arthritis treated with methotrexate. J Rheumatol 1992; 19: 1466–1468
  • Scully C. J., Anderson C. J., Cannon G. W. Long‐term methotrexate therapy for rheumatoid arthritis. Semin Arthritis Rheum 1991; 20: 317–331
  • Friedman S. L., Millward-Sadler G. H., Arthur M. J. P. Liver fibrosis and cirrhosis. Wright's Liver and Biliary Diseases, Millward-Sadler, et al. Saunders, Philadelphia 1994; 822–881
  • Jaskiewicz K., Chasen M. R., Robson S. C. Differential expression of extracellular matrix proteins and integrins in hepatocellular carcinoma and chronic liver disease. Anticancer Res 1993; 13: 2229–2237
  • Drosos A. A., Psychos D., Andonopoulos A. P., et al. Methotrexate therapy in rheumatoid arthritis. A two year prospective follow‐up din Rheumatol 1990; 9: 333–341
  • Willkens R. F., Leonard P. A., Clegg D. O., et al. Liver histology in patients receiving low dose pulse methotrexate for the treatment of rheumatoid arthritis. Ann Rheum Dis 1990; 49: 591–593
  • Jaskiewicz K., Robson S. C., Banach L. Toxic hepatic injury is associated with proliferation of portal nerve fibers. Pathol Res Pract 1993; 189: 1191–1194
  • Jaskiewicz K., Voigt M. D., Robson S. C. Distribution of hepatic nerve fibers in liver diseases. Digestion 1994; 55: 247–252

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.