Sites of Action of Gamma-Hydroxybutyrate (GHB)–A Neuroactive Drug with Abuse Potential

References

• Krnjevic K. Significance of GABA in brain function. GABA Mechanisms in Epilepsy, G. Tunnicliff, B. U. Reass. Wiley-Liss, New York 1991; 47–87
   Google Scholar
• Laborit H. Sodium 4-hydroxybutyrate. Int J Neuropharmacol 1964; 3: 433–452
   PubMedGoogle Scholar
• Laborit G., Larcan A., Kind A. Le gammahydroxybutyrate en anesthesie neuro-chirurgicale. Neuro-chirurgie 1962; 8: 104–107
   PubMed Web of Science ®Google Scholar
• Dyer T. E. γ-Hydroxybutyrate: A health-food product producing coma and seizurelike activity. Am J Emerg Med 1991; 9: 321–324
   PubMed Web of Science ®Google Scholar
• Stell J. M., Ryan J. M. Gamma-hydroxybutyrate is a new recreational drug that may lead to loss of consciousness. BMJ 1996; 313: 424
   PubMed Web of Science ®Google Scholar
• Chin M.-Y., Kreutzer R. A., Dyer J. E. Acute poisoning from γ-hydroxybutyrate in California. West J Med 1992; 156: 380–384
   PubMedGoogle Scholar
• Steele M. T., Watson W. A. Acute poisoning from gamma-hydroxybutyrate (GHB). Mo Med 1995; 92: 354–357
   PubMedGoogle Scholar
• Thomas G., Bonner S., Gascoigne A. Coma induced by abuse of γ-hydroxybutyrate (GHB or liquid ecstacy): A case report. BMJ 1997; 314: 35–36
   PubMed Web of Science ®Google Scholar
• Bessman S. P., Fishbein W. M. Gammahydroxybutyrate, a normal brain metabolite. Nature 1963; 200: 1207–1208
   PubMed Web of Science ®Google Scholar
• Snead O. C., Morley B. J. Ontogeny of γ-hydroxybutyric acid. I. Regional concentration in developing rat, monkey and human brain. Brain Res 1981; 227: 579–589
   PubMedGoogle Scholar
• Vayer P., Ehrhardt J.-D., Gobaille S., Mandel P., Maitre M. Gamma-hydroxybutyratedistribution and turnover rates in discrete brain regions of the rat. Neurochem Int 1988; 12: 53–59
   PubMed Web of Science ®Google Scholar
• Roth R. H., Giarman N. J. Conversion in vivo of y-aminobutyric acid to γ-hydroxybutyric acid in mammalian brain. Biochem Pharmacol 1969; 18: 247–250
   PubMed Web of Science ®Google Scholar
• Anderson R. A., Ritzmann R. F., Tabakoff B. Formation of gamma-hydroxybutyrate in brain. J Neurochem 1977; 28: 633–639
   PubMed Web of Science ®Google Scholar
• Tabakoff B., Von Wartburg J. P. Separation of aldehyde reductases and alcohol dehydrogenase from brain by affinity chromatography: Metabolism of succinic semialdehyde and ethanol. Biochem Biophys Res Commun 1975; 63: 957–966
   PubMed Web of Science ®Google Scholar
• Doherty J. D., Roth R. H. Metabolism of γ-hydroxy-[1-14C]butyrate by rat brain: Relationship to the Krebs cycle and metabolic compartmentation of amino acids. J Neurochem 1978; 30: 1305–1309
   PubMed Web of Science ®Google Scholar
• Weissmann-Nanopoulos D., Rumigny J. F., Mandel P., Vincendon G., Maitre M. Immunochemical localization in rat brain of the enzyme that synthesizes γ-hydroxybutyric acid. Neurochem Int 1982; 4: 523–529
   PubMed Web of Science ®Google Scholar
• Cash C. D., Maitre M., Mandel P. Purification from human brain and some properties of two NADPH-linked aldehyde reductases which reduce succinic semialdehyde to 4-hydroxybutyrate. J Neurochem 1979; 33: 1169–1175
   PubMed Web of Science ®Google Scholar
• Rumigny J. F., Maitre M., Cash C., Mandel P. Specific and nonspecific succinic semialdehyde reductases from rat brain: Isolation and properties. FEBS Letts 1980; 117: 111–116
   PubMed Web of Science ®Google Scholar
• Hearl W. G., Churchich J. E. A mitrochondrial NADP+ -dependent reductase related to the 4-aminobutyrate shunt. J Biol Chem 1985; 260: 16361–16366
   PubMedGoogle Scholar
• Cho S.-W., Song M. S., Kim G.-Y., Kang W.-D., Choi E. Y., Choi S. Y. Kinetics and mechanism of an NADPH-dependent succinic semialdehyde reductase from bovine brain. Eur J Biochem 1993; 211: 757–762
   PubMedGoogle Scholar
• Kaufman E. E., Nelson T., Goochee C., Sokoloff L. The purification and characterization of an NADP+ -linked alcohol oxido-reductase which catalyzes the interconversion of γ-hydroxybutyrate and succinic semialdehyde. J Neurochem 1979; 32: 699–712
   PubMed Web of Science ®Google Scholar
• Nelson T., Kaufman E. E. Developmental time courses in the brain and kidney of two enzymes that oxidize γ-hydroxybutyrate. Dev Neurosci 1994; 16: 352–358
   PubMed Web of Science ®Google Scholar
• Kaufman E. E., Nelson T. Kinetics of coupled γ-hydroxybutyrate oxidation and D-glucuronate reduction by an NADP+ -dependent oxidoreductase. J Biol Chem 1981; 256: 6890–6894
   PubMed Web of Science ®Google Scholar
• Kaufman E. E., Nelson T. An overview of γ-hydroxybutyrate catabolism: The role of the cytosolic NADP+ -dependent oxidoreductase EC 1.1.1.19 and of a mitochondrial hydroxyacid-oxoacid transhydrogenase in the initial, rate-limiting step in this pathway. Neurochem Res 1991; 16: 965–974
   PubMed Web of Science ®Google Scholar
• Kaufman E. E., Nelson T., Fales H. M., Levin D. M. Isolation and characterization of a hydroxyacid-oxoacid transhydrogenase from rat kidney mitochondria. J Biol Chem 1988; 263: 16872–16879
   PubMed Web of Science ®Google Scholar
• Jacobs C., Bojasch M., Monch E., Rating D., Siemes H., Hanefeld F. Urinary excretion of gamma-hydroxy-butyric acid in a patient with neurological abnormalities. Clin Chim Acta 1981; 111: 169–178
   PubMed Web of Science ®Google Scholar
• Divry P., Baltassat P., Rolland M. O., Cotte I., Hermier M., Duran M., Wadman S. K. A new patient with 4-hydroxybutyric aciduria, a possible defect of 4-aminobutyrate metabolism. Clin Chim Acta 1983; 129: 303–309
   PubMed Web of Science ®Google Scholar
• Onkenhout W., Maaswinkel-Mooij P. D., Poorthuis B. J.H.M. 4-Hydroxybutyric acidura: Further clinical heterogeneity in a new case. Eur J Pediatrics 1989; 149: 194–196
   PubMed Web of Science ®Google Scholar
• Rating D., Hanefeld F., Siemes H., Kneer J., Jacobs C., Merimier M., Divry P. 4-Hydroxybutyric aciduria: A new inborn error of metabolism. I. Clinical review. J. Inherited Metab Dis 1984; 7: 90–92, (Suppl)
   PubMed Web of Science ®Google Scholar
• Rahbeeni Z., Ozand P. T., Rashed M., et al. 4-Hydroxybutryric aciduria. Brain Dev 1994; 84: 678–680
   Google Scholar
• Drakontides A. B., Schneider J. A., Funderburk W. H. Some effects of sodium gamma-hydroxybutyrate on the central nervous system. J Pharmacol Exp Ther 1962; 135: 275–284
   PubMed Web of Science ®Google Scholar
• Tunnicliff G. Significance of γ-hydroxibutryric acid in the brain. Gen Pharmacol 1992; 23: 1027–1034
   PubMedGoogle Scholar
• Winters W. D., Spooner C. E. Various seizure activities following gamma-hydroxybutyrate. Int J Neuropharmacol 1965; 4: 197–200
   PubMedGoogle Scholar
• Godschalk M., Dzoljic M. R., Bonta I. L. Slow wave sleep and a state resembling absence epilepsy induced in the rat by γ-hydroxybutyrate. Eur J Pharmacol 1977; 44: 105–111
   PubMed Web of Science ®Google Scholar
• Snead O. C. γ-Hydroxybutyrate model of generalized absence seizures: Further characterization and comparison with other absence models. Epilepsia 1988; 29: 361–368
   PubMed Web of Science ®Google Scholar
• Bernasconi R., Lauber J., Marescaux C., et al. Experimental absence seizures: Potential role of γ-hydroxy-butyric acid and GABA, receptors. J Neural Transm 1992; 35: 155–177, (Suppl)
   Google Scholar
• Hosford D. A., Wang Y., Liu C. C., Snead O. C. Characterization of the anti-absence effects of SCH 50911, a GABAB receptor antagonist, in the lethargic mouse, gamma-hydroxybutyrate and pentylenetetrazole models. J Pharmacol Exp Ther 1995; 274: 1399–1403
   PubMed Web of Science ®Google Scholar
• Giarman N. J., Schmidt K. F. Some neurochemical aspects of the depressant action of γ-butyrolactone on the central nervous system. Brit J Pharmacol 1963; 20: 563–568
   Web of Science ®Google Scholar
• Waldeier P. C., Fehr B. Effects of baclofen and gamma-hydroxybutyrate on rat striatal and mesolimbic 5-HT metabolism. Eur J Pharmacol 1978; 49: 177–184
   PubMed Web of Science ®Google Scholar
• Anden N.-E., Magnusson T., Stock G. Effects of drugs influencing monoamine mechanisms on the increase in brain dopamine produced by axotomy or treatment with gamma-hydroxybutyric acid. NaunynSchmiedeberg's Arch Pharmacol 1973; 278: 363–372
   PubMed Web of Science ®Google Scholar
• Walters J. R., Rosh R. H., Aghajanian G. K. Dopaminergic neurons: Similar biochemical and histochemical effects of γ-hydroxybutyrate and acute lesions of the nigro-neostriatal pathway. J Pharmacol Exp Ther 1973; 186: 630–639
   PubMed Web of Science ®Google Scholar
• Bustos G., Roth R. H. Effect of γ-hydroxybutyrate on the release of monoamines from the rat striatum. Brit J Pharmacol 1972; 44: 817–820
   PubMed Web of Science ®Google Scholar
• Morgenroth V. H., Walters J. R., Rosh R. H. Dopaminergic neurons. Alteration in the kinetic properties of tyrosine hydroxylase after cessation of impulse flow. Biochem Pharmacol 1976; 25: 655–661
   PubMed Web of Science ®Google Scholar
• Spano P. F., Tagliamonte A., Tagliamonte P., Gessa G. L. Stimulation of brain dopamine synthesis by gamma-hydroxybutyrate. J Neurochem 1971; 18: 1831–1836
   PubMed Web of Science ®Google Scholar
• Cheramy A., Nieoullon A., Glowinski J. Stimulating effects of gamma-hydroxybutyrate on dopamine release from the caudate nucleus and the substantia nigra of the cat. J Pharmacol Exp Ther 1977; 203: 283–293
   PubMed Web of Science ®Google Scholar
• Godbout R., Jelenic P., Labrie C., Schmitt M., Bourguignon J.-J. Effect of gamma-hydroxybutyrate and its antagonist NCS-382 on spontaneous cell firing in the prefrontal cortex of the rat. Brain Res 1995; 673: 157–160
   PubMed Web of Science ®Google Scholar
• Hechler V., Gobaille S., Bourguignon J.-J., Maitre M. Extracellular events induced by γ-hydroxybutyrate in striatum: A microdialysis study. J Neurochem 1991; 56: 938–944
   PubMed Web of Science ®Google Scholar
• Howard S. G., Feigenbaum J. J. Effect of γ-hydroxy-butyrate on central dopamine release in vivo. Biochem Pharmacol 1997; 53: 103–110
   PubMedGoogle Scholar
• Diana M., Mereu G., Mura A., Fadda F., Passino N., Gessa G. Low doses of γ-hydroxybutyric acid stimulate the firing fate of dopaminergic neurons in unanesthetized rats. Brain Res 1991; 566: 208–211
   PubMed Web of Science ®Google Scholar
• Benavides J., Rumigny J. F., Bourguignon J. J., Cash C., Wermuth C. G., Mandel P., Vincendon G., Maitre M. High affinity binding site for γ-hydroxybutyric acid in rat brain. Life Sci 1982; 30: 953–961
   PubMed Web of Science ®Google Scholar
• Maitre M., Hechler V., Vayer P., Gobaille S., Cash C. D., Schmitt M., Bourguignon J.-J. A specific γ-hydroxy-butyrate receptor ligand possesses both antagonistic and anticonvulsant properties. J Pharmacol Exp Ther 1990; 255: 657–663
   PubMed Web of Science ®Google Scholar
• Cash C. D., Hechler V., Mersel M., Maitre M. Kinetic characterization and solubilization of γ-hydroxybutyrate from rat brain. Neurosci Lett 1996; 209: 25–28
   PubMedGoogle Scholar
• Maitre M., Rumigny J. F., Mandel P. Positive cooperativity in high affinity binding sites for γ-hydroxybutyric acid in rat brain. Neurochem Res 1983; 8: 113–120
   PubMed Web of Science ®Google Scholar
• Hechler V., Weissmann D., Mach E., Pujol J.-F., Maitre M. Regional distribution of high-affinity [3H]hydroxy-butyrate binding sites as determined by quantitative autoradiography. J Neurochem 1987; 49: 1025–1032
   PubMed Web of Science ®Google Scholar
• Ratomponirina C., Hode Y., Hechler V., Maitre M. γ-Hydroxybutyrate receptor binding in rat brain is inhibited by guanyl nucleotides and pertussis toxin. Neurosci Lett 1995; 189: 51–53
   PubMed Web of Science ®Google Scholar
• Snead O. C. Relation of the [3H]γ-hydroxybutyric acid (GHB) binding site to the y-aminobutyric acidb (GABAB) receptor in rat brain. Biochem Pharmacol 1996; 52: 1235–1243
   PubMed Web of Science ®Google Scholar
• Godbout R., Mantz J., Pirot S., Glowinski J., Thierry A.-M. Inhibitory influence of the mesocortical dopaminergic neurons on their target cells: Electrohysiological and pharmacological characterization. J Pharmacol Exp Ther 1991; 258: 728–738
   PubMed Web of Science ®Google Scholar
• Chrapusta S. J., Karoum F., Egan M. F., Wyatt R. J. γ-Butyrolactone-sensitive and -insensitive dopamine release, and their relationship to dopamine metabolism in three rat brain regions. Eur J Pharmacol 1992; 222: 129–135
   PubMed Web of Science ®Google Scholar
• Nissbrandt H., Engberg G. The GABAB-receptor antagonist, CGP 35348, antagonises γ-hydroxy-butyrate- and baclofen-induced alterations in locomotor activity and forebrain dopamine levels in mice. J Neural Transm 1996; 103: 1255–1263
   PubMed Web of Science ®Google Scholar
• Bowery N. G. GABAB receptors and their significance in mammalian pharmacology. Trends Pharmacol Sci 1989; 10: 401–407
   PubMed Web of Science ®Google Scholar
• Xie X., Smart T. G. γ-Hydroxybutyrate hyperpolarizes hippocampal neurones by activating GABAB receptors. Eur J Pharmacol 1992; 212: 291–294
   PubMed Web of Science ®Google Scholar
• Williams S. R., Turner J. P., Crunelli V. Gamma-hydroxybutyrate promotes oscillatory activity of rat and cat thalamocortical neurons by a tonic GABAB receptor-mediated hyperpolarization. Neuroscience 1995; 66: 133–141
   PubMed Web of Science ®Google Scholar
• Mathivet P., Bernasconi R., De Barry J., Marescaux C., Bittiger H. Binding characteristics of γ-hydroxy-butyric acid as a weak but selective GABAB receptor agonist. Eur J Pharmacol 1997; 321: 67–75
   PubMed Web of Science ®Google Scholar
• Benavides J., Rumigny J. F., Bourguignon J. J., Wermuth C. G., Mandel P., Maitre M. A high-affinity, Na+ -dependent uptake system for γ-hydroxybutyrate in membrane vesicles prepared from rat brain. J Neurochem 1982; 38: 1570–1575
   PubMed Web of Science ®Google Scholar
• Tunnicliff G. Stimulation of mouse brain γ-hydroxybutyric acid transport by pyridoxal 5′-phosphate. Pharmacology 1994; 49: 271–277
   PubMed Web of Science ®Google Scholar
• Blumenfeld M., Suntay R. G., Harmel M. H. Sodium gamma-hydroxybutyric acid: A new anesthetic adjuvant. Anesth Analg Curr Res 1962; 41: 721–726
   Web of Science ®Google Scholar
• Solway J., Sadove M. S. 4-Hydroxybutyrate: A clinical study. Anesth Analg Curr Res 1965; 44: 532–539
   PubMed Web of Science ®Google Scholar
• Aldrete J. A., Barnes D. P. 4-Hydroxybutyrate anesthesia for cardiovascular surgery. Anesthesia 1968; 23: 558–565
   PubMed Web of Science ®Google Scholar
• Vickers M. D. Gamma-hydroxybutyric acid. Int Anaesth Clin 1969; 7: 75–89
   PubMedGoogle Scholar
• Brown T. C. Gamma-hydroxybutyrate in paediatric anaesthesia. Aust NZ J Surg 1970; 40: 94–99
   PubMedGoogle Scholar
• Entholzner E., Mielke L., Pichlmeier R., Weber F., Schneck H. EEG changes during sedation with gamma-hydroxybutyric acid. Anaestksist 1995; 44: 345–350
   PubMed Web of Science ®Google Scholar
• Mamelak M., Escruiu J. M., Stokan O. The effects of EEG-behavioral study of sodium hydroxybutyrate in gamma-hydroxybutyrate on sleep. Biol Psychiatry 1977; 12: 273–288
   PubMed Web of Science ®Google Scholar
• Metcalf D. R., Emde R. N., Stripe J. T. An EEG-behavioral study of sodium hydroxybutyrate in humans. Electroenceph Clin Neurophysiol 1966; 20: 506–512
   PubMedGoogle Scholar
• Lapierre O., Montplaisir J., Lamarre M., Bedard M. A. The effect of gamma-hydroxybutyrate on nocturnal and diurnal sleep of normal subjects: Further considerations on REM sleep-triggering mechanisms. Sleep 1990; 13: 24–30
   PubMed Web of Science ®Google Scholar
• Broughton R., Mamelak M. The treatment of narcolepsy-catalepsy with nocturnal gamma-hydroxybutyrate. Can J Neurol Sci 1979; 6: 1–6
   PubMed Web of Science ®Google Scholar
• Scharf M. B., Brown D., Woods M., Brown L., Hirschowitz J. The effects and effectiveness of γ-hydroxybutyrate in patients with narcolepsy. J Clin Psychiatr 1985; 46: 222–225
   PubMed Web of Science ®Google Scholar
• Mamelak M., Scharf M. B., Woods M. Treatment of narcolepsy with γ-hydroxybutyrate. A review of clinical and sleep laboratory findings. Sleep 1993; 16: 216–220
   PubMedGoogle Scholar
• Lammers G. J., Arends J., Declerck A. C., Ferrari M. D., Schouwink G., Troost J. Gamma-hydroxybutyrate and narcolepsy: A double-blind placebo-controlled study. Sleep 1993; 16: 216–220
   PubMed Web of Science ®Google Scholar
• Scrima L., Hartman P. G., Johnson F. H., Thomas E. E., Hiller F. C. The effects of γ-hydroxybutyrate on the sleep of narcolepsy patients: A double-blind study. Sleep 1990; 13: 479–490
   PubMed Web of Science ®Google Scholar
• Snead O. C., Bearden L. J. Naloxone overcomes the dopaminergic, EEG and behavioral effects of γ-hydroxybutyrate. Neurology 1980; 30: 832–838
   PubMed Web of Science ®Google Scholar
• Schmidt C., Gobaille S., Hechler V., Schmidt M., Bourguignon J.-J., Maitre M. Anti-sedative and anti-cataleptic properties of NCS-382, a γ-hydroxybutyrate receptor antagonist. Eur J Pharmacol 1991; 203: 393–397
   PubMed Web of Science ®Google Scholar
• Fadda F., Argiolas A., Melis M. R., De montis G., Gessa G. L. Suppression of voluntary ethanol consumption in rats by gamma-butyrolactone. Life Sci 1989; 32: 1471–1477
   Google Scholar
• Fadda F., Mosca E., Colombo G., Gessa G. L. Suppression by gamma-hydroxybutyric acid of ethanol withdrawal syndrome in rats. Alcohol Alcoholism 1989; 24: 447–451
   PubMed Web of Science ®Google Scholar
• Gallimberti L., Ferri M., Ferrara S. D., Fadda F., Gessa G. L. Gamma-hydroxybutyric acid in the treatment of alcohol dependence: A double blind study. Alcohol Clin Exp Res 1992; 16: 673–676
   PubMed Web of Science ®Google Scholar
• Gallimberti L., Canton G., Gentile N., Ferri M., Cibin M., Ferrara S. D., Fadda F., Gessa G. L. Gamma-hydroxybutyric acid for the treatment of alcohol withdrawal syndrome. Lancet 1989; 2: 787–789
   PubMed Web of Science ®Google Scholar
• Gallimberti L., Cibin M., Pagnin P., Sabbion R., Pani P. P., Pirastu R., Ferrara S. D., Gessa G. L. Gamma-hydroxybutyricacid for treatment of opiate withdrawal syndrome. Neuropsychophannacology 1993; 9: 77–81
   PubMed Web of Science ®Google Scholar
• Gessa G. L., Dianna M., Fadda F., Colombo G. Gamma-hydroxybutyric acid (GHB) for treatment of ethanol dependence. Eur Neuropsychophrmacol 1993; 3: 224–225
   Google Scholar
• Takahara J., Yunoki S., Yakushiji W., Yamane Ofuji T. Stimulatory effects of gamma-hydroxybutyric acid on growth hormone and prolactin release in humans. J Clin Endocrinol Metab 1977; 44: 1014–1017
   PubMed Web of Science ®Google Scholar
• Gerra G., Marcato A., Fertonani Affini G., et al. Gamma-hydroxybutyric acid (GHB) and neuro-endocrine function in humans. Neuroendocrinol Lett 1994; 16: 55–63
   Web of Science ®Google Scholar
• Ross T. M. Gamma-hydroxybutyrate overdose: Two cases illustrate the unique aspects of this dangerous recreational drug. J Em Nursing 1995; 21: 374–376
   PubMedGoogle Scholar
• Louagie H. K., Verstraete A. G., De Soete C. J., Beatens D. G., Calle P. A. A sudden awakening from a near coma after combined intake of gamma-hydroxybutyric acid and ethanol. J Toxicoi Clin Toxicol 1997; 35: 591–594
   PubMed Web of Science ®Google Scholar
• Carter J., Mofenson H., Caraccio T., et al. Gamma-hydroxybutrate use-New York and Texas, 1995–1996. Morb Mortai Wkly Rep 1997; 46: 281–283
   PubMedGoogle Scholar
• Marwick C. Coma-inducing drug GHB may be reclassified. JAMA 1997; 277: 1505–1506
   PubMed Web of Science ®Google Scholar
• Galloway G. P., Frederick S. L., Staggers F. Physical dependence on sodium oxybate. Lancet 1994; 343: 57
   PubMed Web of Science ®Google Scholar
• Galloway G. P., Frederick S. L., Staggers F. E., Gonzales M., Stalcup S. A., Smith D. E. Gamma-hydroxybutyrate: An emerging drug of abuse that causes physical dependence. Addiction 1997; 92: 89–96
   PubMed Web of Science ®Google Scholar
• Friedman J., Westlake R., Furman M. “Grievous bodily harm”: Gamma-hydroxybutyrate abuse leading to a Wernicke-Korsakoff syndrome. Neurology 1997; 35: 591–594
   Google Scholar