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Research Article

The XS106 cell: a Langerhans’ cell surrogate with a selective type 2 phenotype

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Pages 303-312 | Received 02 Oct 2013, Accepted 02 Dec 2013, Published online: 18 Mar 2014

References

  • Romani N, Clausen BE,Stoitzner P. Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin. Immunol Rev 2010;234:120–141
  • Kimber I, Cumberbatch M, Dearman RJ, et al. Cytokines and chemokines in the initiation and regulation of epidermal Langerhans cell mobilization. Br J Dermatol 2000;142:401–412
  • Kaplan DH, Jenison MC, Saeland S, et al. Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity. Immunity 2005;23:611–620
  • Bobr A, Olvera-Gomez I, Igyarto BZ, et al. Acute ablation of Langerhans cells enhances skin immune responses. J Immunol 2010;185:4724–4728
  • Shklovskaya E, O’Sullivan BJ, Ng LG, et al. Langerhans cells are precommitted to immune tolerance induction. Proc Natl Acad Sci USA 2011;108:18049–18054
  • Igyarto BZ, Haley K, Ortner D, et al. Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses. Immunity 2011;35:260–272
  • Seneschal J, Clark RA, Gehad A, et al. Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells. Immunity 2012;36:873–884
  • van der Aar AM, Picavet DI, Muller FJ, et al. Langerhans cells favor skin flora tolerance through limited presentation of bacterial antigens and induction of regulatory T cells. J Invest Dermatol 2013;133:1240–1249
  • Trinchieri G, Sher A. Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol 2007;7:179–190
  • Flacher V, Bouschbacher M, Verronese E, et al. Human Langerhans cells express a specific TLR profile and differentially respond to viruses and Gram-positive bacteria. J Immunol 2006;177:7959–7967
  • Miller LS. Toll-like receptors in skin. Adv Dermatol 2008;24:71–87
  • Barton GM Medzhitov R. Control of adaptive immune responses by Toll-like receptors. Curr Opin Immunol 2002;14:380–383
  • Takeuchi J, Watari E, Shinya E, et al. Down-regulation of Toll-like receptor expression in monocyte-derived Langerhans cell-like cells: implications of low-responsiveness to bacterial components in the epidermal Langerhans cells. Biochem Biophys Res Commun 2003;306:674–679
  • Agrawal S. Agrawal A, Doughty B, et al. Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos. J Immunol 2003;171:4984–4989
  • Netea MG, Van der Meer JW, Sutmuller RP, et al. From the Th1/Th2 paradigm towards a Toll-like receptor/T-helper bias. Antimicrob Agents Chemother 2005;49:3991–3996
  • Mazzoni A, Segal DM. Controlling the Toll road to dendritic cell polarization. J Leukoc Biol 2004;75:721–730
  • Xu S, Ariizumi K, Caceres-Dittmar G, et al. Successive generation of antigen-presenting, dendritic cell lines from murine epidermis. J Immunol 1995;154:2697–2705
  • Matsue H, Matsue K, Walters M, et al. Induction of antigen-specific immunosuppression by CD95L cDNA-transfected ‘killer’ dendritic cells. Nat Med 1999;5:930–937
  • Dearman RJ, Cumberbatch M, Maxwell G, et al. Toll-like receptor ligand activation of murine bone marrow-derived dendritic cells. Immunology 2009;126:475–484
  • Barr TA, Brown S, Ryan G, et al. TLR-mediated stimulation of APC: distinct cytokine responses of B cells and dendritic cells. Eur J Immunol 2007;37:3040–3053
  • Hatse S, Princen K, Bridger G, et al. Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4. FEBS Lett 2002;527:255–262
  • Bennett CL, Noordegraaf M, Martina CA, Clausen BE. Langerhans cells are required for efficient presentation of topically applied hapten to T cells. J Immunol 2007;179:6830–6835
  • Merad M, Ginhoux F, Collin M. Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells. Nat Rev Immunol 2008;8:935–947
  • Wagner TL, Ahonen CL, Couture AM, et al. Modulation of TH1 and TH2 cytokine production with the immune response modifiers, R-848 and imiquimod. Cell Immunol 1999;191:10–19
  • Mitsui H, Watanabe T, Saeki H, et al. Differential expression and function of Toll-like receptors in Langerhans cells: comparison with splenic dendritic cells. J Invest Dermatol 2004;122:95–102
  • Neves BM, Cruz MT, Francisco V, et al. Differential roles of PI3-Kinase, MAPKs and NF-kappaB on the manipulation of dendritic cell T(h)1/T(h)2 cytokine/chemokine polarizing profile. Mol Immunol 2009;46:2481–2492
  • Fujita H, Asahina A, Sugaya M, et al. Differential production of Th1- and Th2-type chemokines by mouse Langerhans cells and splenic dendritic cells. J Invest Dermatol 2005;124:343–350
  • Mori T, Kabashima K, Yoshiki R, et al. Cutaneous hypersensitivities to hapten are controlled by IFN-gamma-upregulated keratinocyte Th1 chemokines and IFN-gamma-downregulated langerhans cell Th2 chemokines. J Invest Dermatol 2008;128:1719–1727
  • Matsui K, Nishikawa A. Percutaneous application of peptidoglycan from Staphylococcus aureus induces infiltration of CCR4+ cells into mouse skin. J Investig Allergol Clin Immunol 2011;21:354–362
  • Lebre MC, van der Aar AM, van Baarsen L, et al. Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9. J Invest Dermatol 2007;127:331–341
  • Baker BS, Ovigne JM, Powles AV, et al. Normal keratinocytes express Toll-like receptors (TLRs) 1, 2 and 5: modulation of TLR expression in chronic plaque psoriasis. Br J Dermatol 2003;148:670–679
  • Kollisch G, Kalali BN, Voelcker V, et al. Various members of the Toll-like receptor family contribute to the innate immune response of human epidermal keratinocytes. Immunology 2005;114:531–541
  • Boyd A, Bennuru S, Wang Y, et al. Quiescent innate response to infective filariae by human Langerhans cells suggests a strategy of immune evasion. Infect Immun 2013;81:1420–1429
  • Sugita K, Kabashima K, Atarashi K, et al. Innate immunity mediated by epidermal keratinocytes promotes acquired immunity involving Langerhans cells and T cells in the skin. Clin Exp Immunol 2007;147:176–183
  • Cumberbatch M, Clelland K, Dearman RJ, Kimber I. Impact of cutaneous IL-10 on resident epidermal Langerhans’ cells and the development of polarized immune responses. J Immunol 2005;175:43–50
  • Strid J, Hourihane J, Kimber I, et al. Disruption of the stratum corneum allows potent epicutaneous immunization with protein antigens resulting in a dominant systemic Th2 response. Eur J Immunol 2004;34:2100–2109
  • Gomez de Aguero M, Vocanson M, Hacini-Rachinel F, et al. Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8+ T cells and activating Foxp3+ regulatory T cells. J Clin Invest 2012;122:1700–1711
  • McClellan SA, Huang X, Barrett RP, et al. Matrix metalloproteinase-9 amplifies the immune response to Pseudomonas aeruginosa corneal infection. Invest Ophthalmol Vis Sci 2006;47:256–264
  • Ouwehand K, Spiekstra SW, Reinders J, et al. Comparison of a novel CXCL12/CCL5 dependent migration assay with CXCL8 secretion and CD86 expression for distinguishing sensitizers from non-sensitizers using MUTZ-3 Langerhans cells. Toxicol In Vitro 2010;24:578–585
  • Vecchi A, Massimiliano L, Ramponi S, et al. Differential responsiveness to constitutive vs. inducible chemokines of immature and mature mouse dendritic cells. J Leukoc Biol 1999;66:489–494
  • Sallusto F, Schaerli P, Loetscher P, et al. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation. Eur J Immunol 1998;28:2760–2769
  • Timares L, Takashima A, Johnston SA. Quantitative analysis of the immunopotency of genetically transfected dendritic cells. Proc Natl Acad Sci USA 1998;95:13147–13152
  • Kabashima K, Shiraishi N, Sugita K, et al. CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells. Am J Pathol 2007;171:1249–1257
  • Ouwehand K, Santegoets SJ, Bruynzeel DP, et al. CXCL12 is essential for migration of activated Langerhans cells from epidermis to dermis. Eur J Immunol 2008;38:3050–3059
  • Ouwehand K, Scheper RJ, de Gruijl TD, Gibbs S. Epidermis-to-dermis migration of immature Langerhans cells upon topical irritant exposure is dependent on CCL2 and CCL5. Eur J Immunol 2010;40:2026–2034
  • Kobayashi Y, Staquet MJ, Dezutter-Dambuyant C, Schmitt D. Development of motility of Langerhans cell through extracellular matrix by in vitro hapten contact. Eur J Immunol 1994;24:2254–2257
  • Forster R, Schubel A, Breitfeld D, et al. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 1999;99:23–33
  • Ohl L, Mohaupt M, Czeloth N, et al. CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity 2004;21:279–288
  • Saeki H, Moore AM, Brown MJ, Hwang ST. Cutting edge: secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes. J Immunol 1999;162:2472–2475

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