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Research Article

Beneficial effects of activated macrophages on sulfur mustard-induced cutaneous burns, an in vivo experience

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Pages 317-326 | Received 09 Sep 2013, Accepted 12 Dec 2013, Published online: 18 Mar 2014

References

  • Willems JL. Clinical management of mustard gas casual-ties. Ann Med Militaris 1989;3:1–61
  • Smith KJ, Hurst CG, Moeller RB, et al. Sulfur mustard: its continuing threat as a chemical warfare agent, the cutaneous lesions induced, progress in understanding its mechanism of action, its long-term health effects, and new developments for protection and therapy. J Am Acad Dermatol 1995;32:765–776
  • Dachir S, Cohen M, Fishbeine E, et al. Characterization of acute and long-term sulfur mustard-induced skin injuries in hairless guinea-pigs using non-invasive methods. Skin Res Technol 2010;16:114–124
  • Shohrati M, Davoudi M, Ghanei M. Cutaneous and ocular late complications of sulfur mustard in Iranian veterans. Cutan Ocul Toxicol 2007;26:73–81
  • Rowell M, Kehe K, Balszuweit F, Thiermann H. The chronic effects of sulfur mustard exposure. Toxicology 2009;263:9–11
  • Panahi Y, Sarayani A, Beiraghdar F, et al. Management of sulfur mustard-induced chronic pruritus: a review of clinical trials. Cutan Ocul Toxicol 2012;31:220–225
  • Balali-Mood M, Hefazi M, Mahmoudi M, et al. Lon-term complications of sulphur mustard poisoning in severely intoxicated Iranian veterans. Fundam Clin Pharmacol 2005;19:713–721
  • Poursaleh Z, Ghanei M, Babamahmoodi F, et al. Pathogenesis and treatment of skin lesions caused by sulfur mustard. Cutan Ocul Toxicol 2011;31:241–249
  • Emadi SN, Aslani J, Poursaleh Z, et al. Comparison late cutaneous complications between exposure to sulfur mustard and nerve agents. Cutan Ocul Toxicol 2012;3:214–219
  • Kehe K, Thiermann H, Balszuweit F, et al. Acute effects of sulfur mustard injury – Munich experiences. Toxicology 2009;263:3–8
  • Graham JS, Stevenson RS, Mitcheltree LW, et al. Medical management of cutaneous sulfur mustard injuries. Toxicology 2009;263:47–58
  • Dachir S, Fishbeine E, Meshulam Y, et al. Potential anti-inflammatory treatments against cutaneous sulfur mustard injury using the mouse ear vesicant model. Hum Exp Toxicol 2002;21:197–203
  • Dachir S, Fishbeine E, Meshulam Y, et al. Amelioration of sulfur mustard skin injury following a topical treatment with a mixture of a steroid and a NSAID. J Appl Toxicol 2004;24:107–113
  • Casillas RP, Kiser RC, Truxall JA, et al. Therapeutic approaches to dermatotoxicity by sulfur mustard I. Modulation of sulfur mustard-induced cutaneous injury in the mouse ear vesicant model. J Appl Toxicol 2000;20:S145–S151
  • Graham JS, Schomacker KT, Glatter RD, et al. Efficacy of laser debridement with autologous split-thickness skin grafting in promoting improved healing of deep cutaneous sulfur mustard burns. Burns 2002;2:719–730
  • Graham JS, Chilcott RP, Rice P, et al. Wound healing of cutaneous sulfur mustard injuries: strategies for the development of improved therapies. J Burns Wounds 2005;4:1–87
  • Singer AJ, Clark RAF. Cutaneous wound healing. New Engl J Med 1999;341:738–746
  • Russell L. Understanding physiology of wound healing and how dressings help. Br J Nursing 2000;9:10–21
  • Reinke JM, Sorg H. Wound repair and regeneration. Eur Surg Res 2012;49:35–43
  • Danon D, Frenkel O, Diamantshtein L, et al. A case report: macrophage treatment of pressure sores in paraplegia. J Wound Care 1998;7:281–283
  • Orenstein A, Kachel E, Zuloff-Shani A, et al. Treatment of deep sterna wound infections post-open heart surgery by application of activated macrophage suspension. Wound Rep Reg 2005;13:237–242
  • Leor J, Rozen L, Zuloff-Shani A, et al. Ex vivo activated human macrophages in improve healing, remodeling, and function of the infracted heart. Circulation 2006;114:I94–I100
  • Zuloff-Shani A, Adunsky A, Even-Zahav A, et al. Hard to heal pressure ulcers (stage III–IV): efficacy of injected activated macrophage suspension (AMS) as compared with standard of care (SOC) treatment controlled trial. Arch Gerontol Geriat 2010;51:268–272
  • Laskin DL, Sunil VR, Gardner CR, Laskin JD. Macrophages and tissue injury: agents of defense or destruction? Ann Rev Pharmacol Toxicol 2011;51:267–288
  • Hunt TK, Knighton DR. Studies on inflammation and wound healing: angiogenesis and collagen synthesis stimulated in vivo by resident and activated wound monocytes/macrophages. Surgery 1984;96:48–54
  • Di Pietro LA. Wound healing: the role of macrophage and other immune cells. Shock 1995;4:233–240
  • Fujiwara N, Kobayashi K. Macrophages in inflammation. Curr Drug Targets Inflamm Allergy 2005;4:281–286
  • Maruyama K, Asai J, Li M, et al. Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing. Am J Pathol 2007;1701:1178–1191
  • Brancato SK, Albina JE. Wound macrophages as key regulators of repair origin, phenotype, and function. Am J Pathol 2011;178:19–25
  • Delavary BM, van der Veer WM, van Egmond M, et al. Macrophages in skin injury and repair. Immunobiology 2011;216:753–762
  • Rappolee DA, Werb S. Macrophage-derived growth factors. Curr Top Microbiol Immunol 1992;181:87–140
  • Dovi JV, He LK, DiPietro LA. Accelerated wound closure in neutrophil-depleted mice. J Leukoc Biol 2003;73:448–455
  • Laskin DL. Macrophages and inflammatory mediators in chemical toxicity: a battle of forces. Chem Res Toxicol 2009;22:1376–1385
  • Rodero MP, Khosrotehrani K. Skin wound healing modulation by macrophages. Int J Clin Exp Pathol 2010;3:643–653
  • Gordon S, Unkeless JC, Cohn ZA. Induction of macrophage plasminogen activator by endotoxin stimulation and phagocytosis: evidence for a two stage process. J Exp Med 1974;140:995–1010
  • Lazarov-Spiegler O, Solomon AS, Zeev-Brann AB, et al. Transplantation of activated monocytes/macrophages overcomes central nervous system regrowth failure. FASEB J 1996;10:1296–1302
  • Danon D, Madjar J, Edinov E, et al. Treatment of human ulcers by application of macrophages prepared from a blood unit. Exp Gerontol 1997;32:633–641
  • Frenkel O, Shani E, Ben-Bassat I, et al. Activation of human monocytes/macrophages by hypo-osmotic shock. Clin Exp Immunol 2001;124:103–109
  • Dachir S, Cohen M, Kamus-Elimeleh D, et al. Characterization of acute and long-term pathologies of superficial and deep dermal sulfur mustard skin lesions in the hairless guinea pig model. Wound Rep Reg 2012;20:852–861
  • Graham JS, Schomacker KT, Glatter RD, et al. Bioengineering methods employed in the study of wound healing of sulphur mustard burns. Skin Res Technol 2002;8:57–69
  • Leibovich SJ, Ross R. The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum. Am J Pathol 1975;78:71–100
  • Goren I, Allmann N, Yogev N, et al. A transgenic mouse model of inducible macrophage depletion. Am J Pathol 2009;175:132–147
  • Mirza R, DiPietro LA, Koh TJ. Selective and specific macrophage ablation is detrimental to wound healing in mice. Am J Pathol 2009;175:2454–2462
  • Clark RAF. Basics of cutaneous wound repair. J Dermatol Surg Oncol 1993;19:693–706
  • Calvet JH, Planus E, Rouet P, et al. Matrix metalloproteinase gelatinases in sulfur mustard-induced acute airway injury in guinea pigs. Am J Physiol 1999;276:L762–L754
  • Koh TJ, DiPietro LA. Inflammation and wound healing: the role of the macrophage. Exp Rev Mol Med 2011;13:e23 . doi: 10.1017/S1462399411001943
  • Mol MA, van den Berg RM, Benscho HP. Involvement of caspases and transmembrane metalloproteases in sulphur mustard-induced microvesication in adult human skin in organ culture: directions for therapy. Toxicology 2009;258:39–46
  • Salo T, Makela M, Kylmaniemi M, et al. Expression of matrix metalloproteinase-2 and -9 during early human wound healing. Lab Invest 1994;70:176–182
  • Soo C, Shaw WW, Zhang X, et al. Differential expression of matrix metalloproteinases and their tissue-derived inhibitors in cutaneous wound repair. Plast Reconstr Surg 2000;105:638–647
  • Zuloff-Shani A, Kachel E, Frenkel O, et al. Macrophage suspensions prepared from a blood unit for treatment of refractory human ulcers. Transfus Apher Sci 2004;30:163–167
  • Ramli NA, Wong TW. Sodium carboxymethylcellulose scaffolds and their physicochemical effects on partial thickness wound healing. Int J Pharm 2011;403:73–82
  • Clery-Barraud C, Nguon N, Vallet V, et al. Sulfur mustard cutaneous injury characterization based on SKH-1 mouse model: relevance of non-invasive methods in terms of wound healing process analyses. Skin Res Technol 2013;19:e146–e156
  • Danon D, Kowatch MA, Rothe GS. Promotion of wound repair in old mice by local injection of macrophages. Proc Natl Acad Sci USA 1989; 86:2018–2020
  • Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 2008;8:958–969
  • Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol 2011;11:723–737

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