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Research Article

In Vitro Evaluation of Skin Absorption and Metabolism

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Pages 453-467 | Published online: 27 Sep 2008

References

  • Ainsworth M. Methods for measuring percutaneous absorption. J. Soc. Cosmet. Chem. 1960; 11: 69–78
  • Bronaugh R. L., Stewart R. F., Congdon E. R., Giles A. R., Jr. Methods for in vitro percutaneous absorption studies. I. Comparison with in vivo results. Toxicol. Appl. Pharmacol. 1982; 62: 474–480
  • Creasey N. H., Battensby J., Fletcher J. A. Factors affecting the permeability of skin. Curr. Probl. Dermatol. 1978; 7: 95–106
  • Franz T. J. Percutaneous absorption. On the relevance of in vitro data. J. Invest. Dermatol. 1975; 64: 190–195
  • Franz T. J. The finite dose technique as a valid in vitro model for the study of percutaneous absorption. Curr. Probl. Dermatol. 1978; 7: 58–68
  • Sekura D., Scala J. The percutaneous absorption of alkyl methyl sulfoxides. Pharmacology and the Skin, W. Montagna, E. Van Scott, R. Stoughton. Appleton-Century-Crofts, New York 1972; 257–269
  • Pannatier A., Jenner P., Testa B., Etter J. C. The skin as a drug metabolizing organ. Drug Metab. Rev. 1978; 8: 319–343
  • Kao J., Hall J., Shugart L. R., Holland J. M. An in vitro approach to studying cutaneous metabolism and disposition of topically applied xenobiotics. Toxicol. Appl. Pharmacol. 1984; 75: 289–298
  • Kao J., Patterson F. K., Hall J. Skin penetration and metabolism of topically applied chemicals in six mammalian species, including man: An in vitro study with benzo(a)pyrene and testosterone. Toxicol. Appl. Pharmacol. 1985; 81: 502–516
  • Kao J., Hall J. Skin absorption and cutaneous first pass metabolism of topical steroids: In vitro studies with mouse skin in organ culture. J. Pharmacol. Exp. Ther. 1987; 241: 482–487
  • Collier S. W., Sheikh N. M., Sakr A., Lichtin J. L., Stewart R. F., Bronaugh R. L. Maintenance of skin viability during in vitro percutaneous absorption metabolism studies. Toxicol. Appl. Pharmacol. 1989; 99: 522–533
  • Hanks J. H., Wallace R. D. Relation of oxygen and temperature in the preservation of tissues by refrigeration. Proc. Soc. Exp. Biol. Med. 1949; 71: 196–200
  • Dulbecco R., Freeman G. Plaque production by the polyoma virus. Virology 1959; 8: 396–397
  • Cohen B. E., Harmon C. S., Phizackerley P. J. R. Glucose metabolism in experimental skin flaps. Plast. Reconstr. Surg. 1983; 71: 79–85
  • Gutmann I., Wahlefeld A. W. Lactate determination with lactate dehydrogenase and NAD. Methods of Enzymatic Analysis, H. U. Bargmeyer. Academic Press, New York 1974; Vol. 3: 1464
  • Boone C. W. A surveillance procedure applied to sera. Tissue Culture: Methods and Applications, P. Kruze, M. Patterson. Academic Press, New York 1973; 677–682
  • Bronaugh R. L., Stewart R. F., Storm J. E. Extent of cutaneous metabolism during percutaneous absorption of xenobiotics. Toxicol. Appl. Pharmacol. 1989; 99: 534–543
  • Bronaugh R. L., Stewart R. F. Methods for in vitro percutaneous absorption studies. IV. The flow-through diffusion cell. J. Pharm. Sci. 1985; 74: 64–67
  • Bronaugh R. L., Stewart R. F. Methods for in vitro percutaneous absorption studies VI. Preparation of the barrier layer. J. Pharm. Sci. 1986; 75: 487–491
  • Bronaugh R. L., Stewart R. F. Methods for in vitro percutaneous absorption studies. III. Hydrophobic compounds. J. Pharm. Sci. 1984; 73: 1255–1258
  • Mukhtar H., Bickers D. R. Age related changes in benzo(a)pyrene metabolism and epoxide-metabolizing enzyme activities in rat skin. Drug Metab. Dispos. 1983; 11562–567
  • Rettie A. E., Williams F. M., Rawlins M. D., Mayer R. T., Burke M. D. Major differences between lung, skin, and liver in the microsomal metabolism of homologous series of resorufin and coumarin ethers. Biochem. Pharmacol. 1986; 35: 3495–3500
  • Bonati M., Latini R., Marzi E., Cantoni R., Belvedere G. [2-14C]Caffeine metabolism in control and 3-methylcholanthrene induced rat liver microsomes by high pressure liquid chromatography. Toxicol. Lett. 1980; 7: 1–7
  • Arnaud M. J. Comparative metabolic disposition of [l-Me14C]caffeine in rats, mice, and Chinese hamsters. Drug Metab. Dispos. 1985; 13: 471–478
  • Shaw Y.-S., Chen C. Ring hydroxylation of di-t-butylhydtoluene by rat liver microsomal preparations. Biochem. J. 1972; 128: 1285–1291
  • Matsuo M., Mihara K., Okuno M., Ohkawa H., Miyamoto J. Comparative metabolism of 3,5-di-tert-butyl-4-hydroxytoluene (BHT) in mice and rats. Food Chem. Toxicol. 1984; 22: 345–354
  • Yue T. L., Varma D. R. Pharmacokinetics, metabolism and disposition of salicylate in protein-deficient rats. Drug Metab. Dispos. 1982; 10: 147–152
  • Zaldi S. S. A., Banerjee B. D. Enzymatic detoxication of DDT to DDD by rat liver: Effects of some inducers and inhibitors of cytochrome P-450 enzyme system. Bull. Environ. Contam. Toxicol. 1987; 38: 1449–455
  • Fawcett S. C., King L. J., Bunyan P. J., Stanley P. I. The metabolism of 14C-DDT, 14C-DDD, 14C-DDE and 14C-DDMU in rats and Japanese quail. Xenobiotica 1987; 17: 525–538
  • Van Cantfort J., DeGraeve J., Gielen J. E. Radioactive assay for aryl hydrocarbon hydroxylase. Improved method and biological significance. Biochem. Biophys. Res. Commun. 1977; 79: 505–512
  • Bickers D. R., Mukhtar H., Yang S. K. Cutaneous metabolism of benzo(a)pyrene: Comparative studies in C57BL/6N and DBA/2N mice and neonatal Sprague-Dawley rats. Gem. Biol. Interact. 1983; 43: 1263–270
  • Cheng K.-C., Schenkman J. B. Testosterone metabolism by cytochrome P-450 isozymes RLM, and RLM5 and by microsomes. J. Biol. Chem. 1983; 258: 11738–11744
  • Davis B. P., Rampini E., Hsia S. L. 17-B-Hydroxysteroid dehydrogenase of rat skin. J. Biol. Chem. 1972; 247: 1407–1413
  • Cheng K.-C., Schenkman J. B. Metabolism of progesterone and estradiol by microsomes and purified cytochrome P-450 RLM, and RLM5Drug Metab. Dispos 1984; 12: 1222–234
  • Boobis A. R., Davies D. S. Human cytochromes P-450. Xenobiotica 1984; 14: 151–185

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