91
Views
3
CrossRef citations to date
0
Altmetric
Research Article

Relationships between cellular events and signaling pathways in various pesticide-affected neural cells

, , , , , , & show all
Pages 43-50 | Received 01 Mar 2010, Accepted 03 Apr 2010, Published online: 09 Jun 2010

References

  • Abdallah EA, Jett DA, Eldefrawi ME, Eldefrawi AT. (1992). Differential effects of paraoxon on the M3 muscarinic receptor and its effector system in rat submaxillary gland cells. J. Biochem Toxicol. 7:125–132.
  • Baldi I, Filleul L, Mohammed-Brahim B, Fabrigoule C, Dartigues JF, Schwall S, Drevet JP, Salamon R, Brochard P. (2001). Neuropsychologic effects of long-term exposure to pesticides: results from the French Phytoner study. Environ Health Perspect. 109:839–844.
  • Campbell CG, Seidler FJ, Slotkin TA. (1997). Chlorpyrifos interferes with cell development in rat brain regions. Brain Res Bull. 43:179–189.
  • Caughlan A, Newhouse K, Namgung U, Xia Z. (2004). Chlorpyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK/JNK MAP kinases. Toxicol Sci. 78:125–134.
  • Colborn T. (2006). A case for revisiting the safety of pesticides: a closer look at neurodevelopment. Environ Health Perspect. 114:10–17.
  • Colosio C, Tiramani M, Maroni M. (2003). Neurobehavioral effects of pesticides: state of the art. Neurotoxicology. 24:577–591.
  • Costa LG. (2006). Current issues in organophosphate toxicology. Clin Chim Acta. 366:1–13.
  • Cowley S, Paterson H, Kemp P, Marshall CJ. (1994). Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell. 77:841–852.
  • Crinnion WJ. (2000). Environmental medicine, part 4: pesticides-biologically persistent and ubiquitous toxins. Altern Med Rev. 5:432–447.
  • Crumpton TL, Seidler FJ, Slotkin TA. (2000). Developmental neurotoxicity of chlorpyrifos in vivo and in vitro: effects on nuclear transcription factors involved in cell replication and differentiation. Brain Res. 857:87–98.
  • Das KP, Barone S Jr. (1999). Neuronal differentiation in PC12 cells is inhibited by chlorpyrifos and its metabolites: Is acetylcholinesterase inhibition the site of action? Toxicol Appl Pharmacol. 160:217–230.
  • De Silva HJ, Samarawickrema NA, Wickremasinghe AR. (2006). Toxicity due to organophosphorus compounds: what about chronic exposure? Trans R Soc Trop Med Hyg. 100:803–806.
  • Dorea JG, Cruz-Granja AC, Lacayo-Romero ML, Cuadra-Leal J. (2001). Perinatal metabolism of dichlorodiphenyldichloroethylene in Nicaraguan mothers. Environ Res. 86:229–237.
  • Eckel-Mahan KL, Phan T, Han S, Wang H, Chan GC, Scheiner ZS, Storm DR. (2008). Circadian oscillation of hippocampal MAPK activity and cAMP: implications for memory persistence. Nat Neurosci. 11:1074–1082.
  • Garcia SJ, Seidler FJ, Crumptom TL, Slotkin TA. (2001). Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells. Brain Res. 891:54–68.
  • Grosse G, Thiele T, Heuckendorf E, Schopp E, Merder S, Pickert G, Ahnert-Hilger G. (2002). Deltamethrin differentially affects neuronal subtypes in hippocampal primary culture. Neuroscience. 112:233–341.
  • Guizzetti M, Pathak S, Giordano G, Costa LG. (2005). Effect of organophosphorus insecticides and their metabolites on astroglial cell proliferation. Toxicology. 215:182–190.
  • Gultekin F, Ozturk M, Akdogan M. (2000). The effect of organophosphate insecticide chlorpyrifos-ethyl on lipid peroxidation and antioxidant enzymes (in vitro). Arch Toxicol. 74:533–538.
  • Hargreaves AJ, Fowler MJ, Sachana M, Flaskos J, Bountouri M, Coutts IC, Glynn P, Harris W, Graham McLean, W. (2006). Inhibition of neurite outgrowth in differentiating mouse N2a neuroblastoma cells by phenyl saligenin phosphate: effects on MAP kinase (ERK 1/2) activation, neurofilament heavy chain phosphorylation and neuropathy target esterase activity. Biochem Pharmacol. 711240–711247.
  • He F. (1994). Synthetic pyrethroids. Toxicology. 91:43–49.
  • Hetman M, Xia Z. (2000). Signaling pathways mediating anti-apoptotic action of neurotrophins. Acta Neurobiol Exp (Wars). 60:531–545.
  • Huff RA, Corcoran JJ, Anderson JK, Abou-Donia MB. (1994). Chlorpyrifos oxon binds directly to muscarinic receptors and inhibits cAMP accumulation in rat striatum. J Pharmacol Exp Ther. 269:329–335.
  • Ishiyama M, Miyazono Y, Sasamoto K, Ohkura Y, Ueno K. (1997). A highly water-soluble disulfonated tetrazolium salt as a chromogenic indicator for NADH as well as cell viability. Talanta. 44:1299–1305.
  • Izrael M, Van der Zee EA, Slotkin TA, Yanai J. (2004). Cholinergic synaptic signaling mechanisms underlying behavioral teratogenicity: effects of nicotine, chlorpyrifos, and heroin converge on protein kinase C translocation in the intermedial part of the hyperstriatum ventrale and on imprinting behavior in an avian model. J Neurosci Res. 778:499–507.
  • Jett DA, Abdallah EA, El-Fakahany EE, Eldefrawi ME, Eldefrawi AT. (1991). The high affinity activation by paraoxon of a muscarinic receptor subtype in rat brain striatum. Pestic Biochem Physiol. 39:149–157.
  • Kaplan DR, Martin-Zanca D, Parada LF. (1991). Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF. Nature. 350:158–160.
  • Kozawa K, Aoyama Y, Mashimo S, Kimura H. (2009). Toxicity and actual regulation of organophosphate pesticides. Toxin Rev. 28:245–254.
  • Lassiter TL, Padilla S, Mortensen SR, Chanda SM, Moser VC, Barone S Jr. (1998). Gestational exposure to chlorpyrifos: apparent protection of the fetus? Toxicol Appl Pharmacol. 152:56–65.
  • Li T, Chalifour LE, Paudel HK. (2007). Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation. J Biol Chem. 282:6619–6628.
  • Matsuda K, Shimomura M, Ihara M, Akamatsu M, Sattelle DB. (2005). Neonicotinoids show selective and diverse actions on their nicotinic receptor targets: electrophysiology, molecular biology, and receptor modeling studies. Biosci Biotechnol Biochem. 69:1442–1452.
  • Nandi A, Chandil D, Lechesal R, Lechesal R, Pryor SC, McLaughlin A, Bonventre JA, Flynnx K, Weeks BS. (2006). Bifenthrin causes neurite retraction in the absence of cell death: a model for pesticide associated neurodegeneration. Med Sci Monit. 12:169–173.
  • Narahashi T. (2000). Neuroreceptors and ion channels as the basis for drug action: past, present, and future. J Pharmacol Exp Ther. 294:1–26.
  • Ostrea EM, Morales V, Ngoumgna E, Prescilla R, Tan E, Hernandez E, Ramirez GB, Cifra HL, Manlapaz ML. (2002). Prevalence of fetal exposure to environmental toxins as determined by meconium analysis. Neurotoxicology. 23:329–339.
  • Parran DK, Barone S Jr, Mundy WR. (2004). Methylmercury inhibits TrkA signaling through the ERK1/2 cascade after NGF stimulation of PC12 cells. Brain Res Dev Brain Res. 49:53–61.
  • Qiao D, Seidler FJ, Slotkin TA. (2001). Developmental neurotoxicity of chlorpyrifos modeled in vitro: comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells. Environ Health Perspect. 109:909–913.
  • Rohlman DS, Lasarev M, Anger WK, Scherer J, Stupfel J, McCauley L. (2007). Neurobehavioral performance of adult and adolescent agricultural workers. Neurotoxicology. 28:374–380.
  • Roy TS, Seidler FJ, Slotkin TA. (2004). Morphologic effects of subtoxic neonatal chlorpyrifos exposure in developing rat brain: regionally selective alterations in neurons and glia. Brain Res Dev Brain Res. 148:197–206.
  • Schuh RA, Lein PJ, Beckles RA, Jett DA. (2002). Noncholinesterase mechanisms of chlorpyrifos neurotoxicity: altered phosphorylation of Ca2+/cAMP response element binding protein in cultured neurons. Toxicol Appl Pharmacol. 182:176–185.
  • Shafer TJ, Meyer DA, Crofton KM. (2005). Developmental neurotoxicity of pyrethroid insecticides: critical review and future research needs. Environ Health Perspect. 113:123–136.
  • Shaughnessy LW, Barone S Jr. (1997). Damage to the NBM leads to sustained lesion-induced increase in functional NGF in the cortex. Neuroreport. 8:2767–2774.
  • Slotkin TA. (2004). Guidelines for developmental neurotoxicity and their impact on organophosphate pesticides: a personal view from an academic perspective. Neurotoxicology. 25:631–640.
  • Socko R, Gralewicz S, Gorny R. (1999). Long term behavioral effects of a repeated exposure to chlorphenvinphos in rats. Int J Occup Med Environ Health. 12:105–117.
  • Song X, Seidler FJ, Saleh JL, Zhang J, Padilla, S, Slotkin TA. (1997). Cellular mechanisms for developmental toxicity of chlorpyrifos: Targeting the adenylyl cyclase signaling cascade. Toxicol Appl Pharmacol. 145:158–174.
  • Suzukawa, K, Miura K, Mitsushita J, Resau J, Hirose K, Crystal R, Kamata T. (2000). Nerve growth factor-induced neuronal differentiation requires generation of Rac1-regulated reactive oxygen species. J Biol Chem. 275:13175–13178.
  • Tan DH, Peng SQ, Wu YL, Wang YM, Lu CF, Ding W, Wang QX, Yan CH. (2009). Chlorpyrifos induces delayed cytotoxicity after withdrawal in primary hippocampal neurons through extracellular signal-regulated kinase inhibition. Biol Pharm Bull. 32:1649–1655.
  • Tomizawa M, Casida JE. (2000). Imidacloprid, thiacloprid, and their imine derivatives up-regulate the alpha 4 beta 2 nicotinic acetylcholine receptor in M10 cells. Toxicol Appl Pharmacol. 169:114–120.
  • Tran V, Hoffman N, Mofunanaya A, Pryor SC, Ojugbele O, McLaughlin A, Gibson L, Bonventre JA, Flynn K, Weeks BS. (2006). Bifenthrin inhibits neurite outgrowth in differentiating PC12 cells. Med Sci Monit. 12:BR57–BR62.
  • Verma SK, Raheja G, Gill KD. (2009). Role of muscarinic signal transduction and CREB phosphorylation in dichlorvos-induced memory deficits in rats: an acetylcholine independent mechanism. Toxicology. 256:175–182.
  • Ward TR, Mundy WR. (1996). Organophosphorus compounds preferentially affect second messenger systems coupled to M2/M4 receptors in rat frontal cortex. Brain Res Bull. 39:49–55.
  • Whyatt RM, Barr DB. (2001). Measurement of organophosphate metabolites in postpartum meconium as a potential biomarker of prenatal exposure: a validation study. Environ Health Perspect. 109:417–420.
  • Wu A, Li L, Liu Y. (2003). Deltamethrin induces apoptotic cell death in cultured cerebral cortical neurons. Toxicol Appl Pharmacol. 187:50–57.
  • Young JG, Eskenazi B, Gladstone EA, Bradman A, Pedersen L, Johnson C, Barr DB, Furlong CE, Holland N.T. (2005). Association between in utero organophosphate pesticide exposure and abnormal reflexes in neonates. Neurotoxicology. 26:199–209.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.