Aflatoxin Detoxification in Humans Laboratory, Field and Clinical Perspectives

References

• Hu W.G., Tien C.C., Wang Y.H., Ting T.Y., Fong Y.C., Loung Y.T., Huang S.S. Urinary excretion of aflatoxin M1 in inhabitants of region with high liver cancer incidence in Guangxi. Hyg Invest. 1983; 27: 152
   Google Scholar
• Campbell T.C., Caedo J.P., Jr., Bulatao-Jaume L., Salamat L., Engel R.W. Aflatoxin M1 in human urine. Nature 1970; 227: 403
   PubMed Web of Science ®Google Scholar
• Lovelace C.E.A., Njapau H., Salter L.F., Bayley A.C. Screening method for the detection of aflatoxin and metabolites in human urine: aflatoxin B1, G1, M1, B2a, G2a, aflatoxicol I and II. J. of Chromatog. 1982; 227: 256
   PubMed Web of Science ®Google Scholar
• Bean T.A. Development of a high performance liquid chromatography method for aflatoxins in human urine and analysis of aflatoxin metabolite excretion in Nigerians. Ph.D. Thesis, University of Missouri, Kansas City 1988
   Google Scholar
• Nyathi C.B., Mutiro C.F., Hasler J.A., Chetsange C.J. A survey of urinary aflatoxin in Zimbabwe. Intl. J. Epidemiol. 1987; 16: 516
   PubMed Web of Science ®Google Scholar
• Zhu Jia-qi, Zhang Li-sheng, Hu X., Xiao Y., Chen Jun-shi, Xu Yi-chun, Fremy J., Chu F.S. Correlation of dietary aflatoxin B1 levels with excretion of aflatoxin M1 in human urine. Cancer Res. 1987; 47: 1848
   PubMed Web of Science ®Google Scholar
• Wild C.P., Umbenhauer D., Chapot B., Montesano R. Monitoring of individual human exposure to aflatoxins (AF) and N-nitrosamines (NNO) by inmunoassays. J. Cell. Biochem. 1986; 30: 171
   PubMed Web of Science ®Google Scholar
• Nelson B., Kimbrough R., Landrigan P.S., Hayes A.W., Yang G.C., Benanides J. Aflatoxin and Reye's syndrome: a case control study. Pediatrics 1980; 66: 865
   PubMed Web of Science ®Google Scholar
• Dragsted L.O., Bull J., Autrup H. Substances with affinity to a monoclonal aflatoxin B1 antibody in Danish urine samples. Fd. Chem. Toxicol. 1988; 26: 233
   PubMed Web of Science ®Google Scholar
• Coulter B.S., Hendrickse R.G., Lamplugh S.M., Macfarlane S.B.J., Moody J.B., Omer M.I.A., Suliman G.I., Williams T.E. Aflatoxins and kwashiorkor: clinical studies in Sudanese children. Trans. R. Soc. Trop. Med. Hyg. 1986; 80: 945
   PubMed Web of Science ®Google Scholar
• Gan L., Skipper P.L., Peng X., Groopman J.D., Chen J., Wogan G.n., Tannenbaum S.R. Serum albumin addutcs in the molecular epidemiology of aflatoxin carcinogenesis: Correlation with aflatoxin B1 intake and urinary excresion of aflatoxin M1. Carcinogen. 1988; 9: 1323
   PubMed Web of Science ®Google Scholar
• Denning D.W., Onwubalili J.K., Wilkinson A.P., Morgan M.R.A. Measurement of aflatoxin in Nigerian sera by enzyme-linked immunosorbent assay. Trans. R. Soc. Trop. Med. Hyg. 1988; 82: 169
   PubMed Web of Science ®Google Scholar
• Apeagyei P.C., Lamplugh S.M., Hendrickse R.G., Affram K., Lucas S. Aflatoxins in the livers of children with kwashiorkor in Ghana. Trop Geogr Med. 1985; 38: 273
   Google Scholar
• Wilkinson A.P., Denning D.W., Morgan R.A. Analysis of UK sera for aflatoxin by enzyme-linked immunosorbent assay. Human Toxicol. 1988; 7: 353
   PubMedGoogle Scholar
• Tsuboi S., Nagakawa T., Tomita M., Seo T., Ono H., Kawamira K., Iwamura N. Detection of Aflatoxin B1 in serum samples of male Japanese subjects by radioimmunoassay and high-performance liquid cromatography. Cancer Res. 1984; 44: 1231
   PubMed Web of Science ®Google Scholar
• Stora C., Dvorackova I. Aflatoxin, viral hepatitis and primary liver cancer. J. Med. 1987; 18: 23
   PubMedGoogle Scholar
• Groopman J.D., Kensler T.W. The use of monoclonal antibody affinity columns for assessing DNA damage and repair following exposure to aflatoxin B1. Pharmac. Ther. 1987; 34: 321
   PubMed Web of Science ®Google Scholar
• Dragsted L.O., Larsen AI., Bull I., Autrup H. Aflatoksinudskillelse hos erhvervseksponerede havnearbejdere. Ugeskr. Laeger 1985; 147: 4148
   PubMedGoogle Scholar
• Coulter J.B.S., Lamplugh S.M., Suliman G.I., Omer M.I.A., Hendrickse G.E. Aflatoxins in human breast milk. Ann Trop Paediatr. 1984; 4: 61
   PubMedGoogle Scholar
• Groopman J.D., Donahue P.R., Zhu J., Chen J.S., Wogan G.N. Aflatoxin metabolism in humans: detection of metabolites and nucleic acid adducts in urine by affinity chromatography. Proc. Natl. Acad. Sci. USA 1985; 82: 6492
   PubMed Web of Science ®Google Scholar
• Lamplugh S.M., Hendrickse R.G., Apeagyei F., Mwanmut D.D. Aflatoxins in breast milk, neonatal cord blood and serum of pregnant women. Br. Med. J. 1988; 296: 968
   PubMed Web of Science ®Google Scholar
• Siraj M.Y., Hayes A.W., Unger P.D., Hogan G.R., Ryan N.J., Wray B.B. Analysis of aflatoxin B1 in human tissues with high-pressure liquid chromatography. Toxicol. Appl. Pharm. 1981; 589: 422
   Google Scholar
• Alpert M.E., Hutt M.S.R., Wogan G.N., Davidson C.S. Association between aflatoxin content of food and hepatoma frequency in Uganda. Cancer 1971; 28: 253
   PubMed Web of Science ®Google Scholar
• Keen P., Martin P. Is aflatoxin carcinogenic in man? The evidence in Swaziland. Trop. Geogr. Med. 1971; 23: 44
   PubMedGoogle Scholar
• Korobkin M., Williams E.H. Hepatoma and groundnuts in the West Nile District of Uganda. Yale J. Biol. Med. 1968; 41: 69
   PubMed Web of Science ®Google Scholar
• Alpert M.E., Wogan G., Davidson C.S. Aflatoxin and hepatoma in Uganda. Gastroentero. 1968; 54: 149
   Web of Science ®Google Scholar
• van Rensburg S.J., Van der Watt J.J., Purchase I.F.H., Coutinho L.P., Markham R. Primary liver cancer rate and aflatoxin intake in high cancer area. S. Afr. Med. J. 1974; 48: 2508a
   PubMed Web of Science ®Google Scholar
• van Rensburg S.J., Cook-Mozaffari P., van Schalkwyk D.J., Van der Watt J.J., Vincent T.J., Purchase I.F. Hepatocellular carcinoma and dietary aflatoxin in Mozambique and Transkei. Br. J. Cancer 1985; 51: 7
   Web of Science ®Google Scholar
• Shank R.C., Wogan G.N. Dietary aflatoxins and human liver cancer. I. Toxigenic molds in foods and foodstuffs of tropical South-east Asia. Fd. Cosmet. Toxicol. 1972; 10: 51
   Google Scholar
• Shank R.C., Wogan G.N. Dietary aflatoxins and human liver cancer. II. Aflatoxins in market foods and foodstuffs of Thailand and Hong Kong. Fd. Cosmet. Toxicol. 1972; 10: 61
   Google Scholar
• Shank R.C., Gordon J.E., Wogan G.N., Nondasuta A., Subhamani B. Dietary aflatoxins and human liver cancer III. Field survey of rural Thai families for ingested aflatoxins. Food Cosmet. Toxicol. 1972; 10: 71
   Google Scholar
• Shank R.C., Bhamarapravati N., Gordon J.E., Wogan G.N. Dietary aflatoxins and human liver cancer. IV. Incidence of primary liver cancer in two municipal populations of Thailand. Food Cosmet. Toxicol. 1972; 10: 171
   PubMedGoogle Scholar
• Wogan G.N. Dietary factors and special epidemiological situations of liver cancer in Thailand and Africa. Cancer Res. 1975; 35: 3499
   PubMed Web of Science ®Google Scholar
• Bagshawe A.F., Gacengi D.M., Cameron C.H., Dorman J., Dane D.S. Hepatitis Bs antigen and liver cancer. A population based study in Kenya. J. Cancer 1975; 31: 581
   Web of Science ®Google Scholar
• Peers F.G., Linsell C.A. Dietary aflatoxins and liver cancer. A population based study in Kenya. Br. J. Cancer 1973; 27: 473
   PubMed Web of Science ®Google Scholar
• Peers F.G., Gilman G.A., Linsell C.A. Dietary aflatoxins and human liver cancer. A study in Swaziland. Int. J. Cancer 1976; 17: 167
   PubMed Web of Science ®Google Scholar
• Bulatso-Jayme J., Almero E.M., Castro Ma. C.T.R., Jardeleza Ma.T.R., Salamat L.A. A case-control dietary study of primary liver cancer risk from aflatoxin exposure. Inter. J. Epidemiol. 1982; 11: 112
   PubMed Web of Science ®Google Scholar
• Roebuck B.D. Ph.D. Thesis, Massachusetts Institute of Technology, Cambridge 1975
   Google Scholar
• Patterson D.S.P., Roberts B.A., Allcroft R. Aflatoxin metabolism. Food Cosmet. Toxicol. 1969; 7: 277
   PubMedGoogle Scholar
• Shank R.C. Metabolic activation of mycotoxins by animals and humans: an overview. J. Tox. Environ. Health 1977; 2: 1229
   PubMed Web of Science ®Google Scholar
• Gurtoo H.L. On the binding of aflatoxin B1 and its metabolites to hepatic microsomes. Biochem. Biophys. Res. Commun. 1973; 50: 649
   PubMed Web of Science ®Google Scholar
• Toxicology: Biochemistry and Pathology of Mycotoxins, K. Uraguchi, M. Yamazaki. Halsted Press, New York 1978
   Google Scholar
• Bártschi S.W., Rancy K.D., Stone M.P., Harris T.M. Preparation of the 8,9-epoxide of the mycotoxin aflatoxin B1: the ultimate carcinogenic species. J. Am. Chem. Soc. 1988; 110: 7929
   Web of Science ®Google Scholar
• Yourtee' D.M., Kirk-Yourtee' C.L., Searle S. Stereochemical effect in the mutagenicity of the aflatoxicols toward Salmonella typhimurium. Life sci. 1987; 41: 1795
   PubMed Web of Science ®Google Scholar
• Yourtee' D.M., Kirk-Yourtee' C.L. The direct mutagenicity of aflatoxin B1 and metabolites to Salmonella typhimurium: structure mutagenicity relationships and mechanisms of action. Res. Commun. Chem. Path. Pharm. 1987; 57: 55
   PubMedGoogle Scholar
• Yourtee' D.M., Kirk-Yourtee' C.L. The mutagenicity of aflatoxin Q1 to Salmonella typhimurium TA 100 with or without rat or human liver microsomal preparations. Res. Commun. in Chem. Path. Pharm. 1986; 54: 101
   PubMedGoogle Scholar
• Yourtee D.M., Bean Kirk- T.A., Yourtee C.L. Human aflatoxin B1 metabolism: An investigation of the importance of aflatoxin Q1 as a metabolite of hepatic post-mitochondrial fraction. Tox. Letters 1987; 38: 213
   PubMed Web of Science ®Google Scholar
• Rohrig T.P., Yourtee' D.M. In vitro metabolism of aflatoxin Q1 by rat liver post-mitochondrial homogenates. Res. Commun. Chem. Path. Pharm. 1983; 40: 457
   PubMedGoogle Scholar
• Yourtee' D.M., Rohrig T.P. The in vitro metabolism of aflatoxin Q1 by mouse and rabbit liver preparations. Res. Commun. Chem. Path. Pharm. 1985; 50: 103
   PubMedGoogle Scholar
• Stoloff L. Carcinogenicity of aflatoxins. Science 1987; 237: 1283
   PubMed Web of Science ®Google Scholar
• Fakunle Y.M., Ajdukiewicz A.B., Greenwood B.M., Edington G.M. Primary liver cell carcinoma (PLCC) in the Northern Guinea Savanna of Nigeria. Trans. Roy. Soc. Trop. Med. Hyg. 1977; 71: 335
   PubMed Web of Science ®Google Scholar
• Merrill A.H., Jr., Campbell T.C. Preliminary study of in vitro aflatoxin B1 metabolism by human liver. Toxicol. Appl. Pharmacol. 1974; 27: 210
   PubMed Web of Science ®Google Scholar
• Yourtee D.M., Phillips D.L. In vitro aflatoxin B1 metabolism by human liver across individuals. Biophys. J. 1976; 16: 234
   Web of Science ®Google Scholar
• Hsieh D.P.H., Dalezios J.I., Krieger R.I., Masri M.S., Haddon W.F. Use of monkey liver microsomes in production of aflatoxin Q1. J. Agr. Food Chem. 1974; 22: 515
   PubMed Web of Science ®Google Scholar
• Buchi G.H., Spitzner D., Paglialunga S., Wogan G.N. Aflatoxin Q1: A major metabolite of aflatoxin B1 produced by human liver. Res. Commun. Chem. Pathol. Pharmacol. 1974; 8: 585
   PubMedGoogle Scholar
• Masri M.S., Haddon W.F., Lundin R.E., Hsieh P.H. Aflatoxin Q1: A newly identified major metabolite of aflatoxin B1 in monkey liver. J. Agr. Food Chem. 1974; 22: 512
   PubMed Web of Science ®Google Scholar
• Patterson D.S.P., Roberts B.A. The in vitro reduction of aflatoxin B1 and B2 by soluble avian liver enzymes. Food Cosmet. Toxicol. 1971; 9: 829
   PubMedGoogle Scholar
• Schoeenhard G.L., Lee D.L., Sinnhuber R.O. Aflatoxin B1 activation and aflatoxicol toxicity in rainbow Salmo gairdneri. Fed. Proc. 1974; 33: 247
   Google Scholar
• Edwards G.S., Rintel T.D., Parker C.M. Aflatoxicol as a possible predictor for species sensitivity to aflatoxin B1 (AFB1). Proc. Am. Assoc. Cancer Res. 1975; 16: 133, abstr. 531
   Google Scholar
• Patterson D.S.P., Roberts B.A. Aflatoxin metabolism in duck-liver homogenates: The relative importance of reversible cyclopentenone reduction and hemiacetal formation. Food Cosmet. Toxicol. 1972; 20: 3377
   Google Scholar
• Schabort J.C., Steyn M. Substrate and phenobarbital inducible aflatoxin-4-hydroxylation and aflatoxin metabolism by rat liver microsomes. Biochem. Pharmacol. 1969; 18: 2241
   PubMed Web of Science ®Google Scholar
• Patterson D.S.P., Roberts B.A. The formation of aflatoxin B2a and G2a and their degradation products during the in vitro detoxification of aflatoxin by livers of certain avian and mammalian species. Food Cosmet. Toxicol. 1970; 8: 527
   PubMedGoogle Scholar
• Gurtoo H.L., Campbell T.C. Metabolism of aflatoxin B1 and its metabolism-dependent and independent binding to rat hepatic microsomes. Mol. Pharmacol. 1974; 10: 776
   Web of Science ®Google Scholar
• Raj H.G., Prasanna H.R., Magee P.N., Lotlikar P.D. Effect of purified rat and hamster hepatic glutathione S-transferases on the microsome mediated binding of aflatoxin B1 to DNA. Cancer Letters 1986; 33: 1
   PubMed Web of Science ®Google Scholar
• Jorgensen K.V., Clayton J.W., Price R.L. Evaluation of aflatoxin B1 mutagenesis: Addition of glutathione and glutathione S-transferase to the Salmonelia mutagenicity assay. Environ Mutagen. 1987; 9: 411
   PubMedGoogle Scholar
• Raj H.G., Clearfield M.S., Lotlikar P.D. Comparative kinetic studies on aflatoxin B1-DNA binding and aflatoxin B1-glutathione conjugation with rat and hamster livers in vitro. Carcinogen. 1984; 5: 879
   PubMed Web of Science ®Google Scholar