6
Views
11
CrossRef citations to date
0
Altmetric
Research Article

Metabolic Basis for Susceptibility and Resistance to Aflatoxin B1 Hepatocarcinogenesis in Rodents

Pages 97-109 | Published online: 28 Sep 2008

References

  • Wogan G.N. Dietary Factors and Special Epidemiological Situations of Liver Cancer in Thailand and Africa. Cancer Res. 1975; 35: 3499–3502
  • Harris Sun C.C. Multifactorial Etiology of Human Liver Cancer. Carcinogenesis (Lond.) 1984; 5: 697–701
  • van Rensburg S.J., Cook-Mozaffari P., van Schalkwyk D.J., Van Der Watt J.J., Vincent T.J., Purchase I.F. Hepatocellular Carcinoma and Dietary Aflatoxin in Mozambique and Transkei. Br. J. Cancer 1985; 51: 713–726
  • Rajagopalan M.S., Busch M.P., Blum H.F., Vyas G.N. Interaction of Aflatoxin and Hepatitis B Virus in the Pathogenesis of Hepatocellular Carcinoma. Life Sciences 1986; 39: 1287–1290
  • Campbell T.C., Hayes J.R. The Role of Aflatoxin Metabolism in its Toxic Lesion. Toxicol. Appl. Pharmacol. 1976; 35: 199–222
  • Miller J.A., Miller E.C. Ultimate Chemical Carcinogens as Reactive Mutagenic Electrophiles. Origins of Human Cancer, H.H. Hiatt, J.D. Watson, J.A. Winsten. Cold Spring Harbor. 1977; 605–627
  • Essigmann J.M., Croy R.G., Nadzan A.M., Busby W.F., Jr., Reinhold V.N., Büchi G., Wogan G.N. Structural Identification of the Major DNA Adduct Formed by Aflatoxin B1 In Vitro. Proc. Natl. Acad. Sci. USA 1977; 74: 1870–1874
  • Essigmann J.M., Croy R.G., Bennett R.A., Wogan G.N. Metabolic Activation of Aflatoxin B1: Patterns of DNA Adduct Formation, Removal and Excretion in Relation to Carcinogenesis. Drug Metab. Rev. 1982; 13: 581–602
  • Wong J.J., Hsieh D.P.H. Mutagenicity of Aflatoxins Related to their Metabolism and Carcinogenic Potential. Proc. Natl. Acad. Sci. USA 1976; 73: 2241–2244
  • Gurtoo H.L., Dahms R.P., Paigen B. Metabolic Activation of Aflatoxins Related to their Mutagenicity. Biochem. Biophys. Res. Commun. 1978; 81: 965–972
  • Lin J.K., Miller J.A., Miller E.C. 2,3-Dihydro-2(guan-7-yl)-3-hydroxy-aflatoxin B1, a Major Acid Hydrolysis Product of Aflatoxin B1-DNA or Ribosomal RNA Adducts Formed in Hepatic Microsome-Mediated Reactions and in Rat Liver In Vivo. Cancer Res. 1977; 37: 4430–4438
  • Degen G.H., Neumann H.G. The Major Metabolite of Aflatoxin B1 in the Rat is a Glutathione Conjugate. Chem. Biol. Interactions 1978; 22: 239–255
  • Moss E.J., Judah D.J., Przybylski M., Neal G.E. Some Mass Spectral and n.m.r. Analytical Studies of a Glutathione Conjugate of Aflatoxin B1. Biochem. J. 1983; 210: 227–233
  • Coles B., Meyer D.J., Ketterer B., Stanton C.A., Garner R. Studies on the Detoxication of Microsomally-Activated Aflatoxin B1 by Glutathione and Glutathione Transferases In Vitro. Carcinogenesis (Lond.) 1985; 6: 693–697
  • Newberne P.M., Butler W.H. Acute and Chronic Effects of Aflatoxin on the Liver of Domestic and Laboratory Animals: A review. Cancer Res. 1969; 29: 236–250
  • Herrold K.M. Aflatoxin Induced Lesions in Syrian Hamsters. Br. J. Cancer 1969; 23: 655–660
  • Moore M.R., Pitot H.C., Miller E.C., Miller J.A. Cholangiocellular Carcinomas Induced in Syrian Golden Hamsters Administered Aflatoxin B1 in Large Doses. J. Natl. Cancer Inst. 1982; 68: 271–278
  • Swenson D.H., Lin J.K., Miller E.C., Miller J.A. Aflatoxin B1-2,3-oxide as a Probable Intermediate in the Covalent Binding of Aflatoxin B1 and B2 to Rat Liver DNA and Ribosomal RNA In Vivo. Cancer Res. 1977; 37: 172–181
  • Garner R.C., Wright C.M. Binding of [14C]aflatoxin B1 to Cellular Macromolecules in the Rat and Hamster. Chem. Biol. Interactions 1975; 11: 123–131
  • Lotlikar P.D., Jhee E.C., Insetta S.M., Clearfield M.S. Modulation of Microsome-Mediated Aflatoxin B1 Binding to Exogenous and Endogenous DNA by Cytosolic Glutathione S-Transferases in Rat and Hamster Livers. Carcinogenesis (Lond.) 1984; 5: 269–276
  • Booth S.C., Bosenberg H., Garner R.C., Hertzog P.J., Norpoth K. The Activation of Aflatoxin B1 in Liver Slices and in Bacterial Mutagenicity Assays using Livers from Different Species Including Man. Carcinogenesis (Lond.) 1981; 2: 1063–1068
  • Lin J.K., Kennan K.A., Miller E.C., Miller J.A. Reduced Nicotinamide Adenine Dinucleotide Phosphate-Dependent Formation of 2,3-Dihydro-2,3-dihydroxy-aflatoxin B1 by Hepatic Microsomes. Cancer Res. 1978; 38: 2424–2428
  • Lotlikar P.D., Insetta S.M., Lyons P.R., Jhee E.C. Inhibition of Microsome Mediated Binding of Aflatoxin B1 to DNA by Glutathione S-Transferase. Cancer Lett. 1980; 9: 143–149
  • Raj H.G., Clearfield M.S., Lotlikar P.D. Comparative Kinetic Studies on Aflatoxin B1-DNA Binding and Aflatoxin B1-Glutathione Conjugation with Rat and Hamster Livers In Vitro. Carcinogenesis (Lond.) 1984; 5: 879–884
  • Degen G.H., Neumann H.G. Differences in Aflatoxin B1-Susceptibility of Rat and Mouse are Correlated with the Capability In Vitro to Inactivate Aflatoxin B1-Epoxide. Carcinogenesis (Lond.) 1981; 2: 299–306
  • O'Brien K., Moss E., Judah D., Neal G. Metabolic Basis of the Species Difference to Aflatoxin B1 Induced Hepatotoxicity. Biochem. Biophys. Res. Commun. 1983; 114: 813–821
  • McLean A.E.M., Marshall A. Reduced Carcinogenic Effects of Aflatoxin in Rats given Phenobarbitone. Br. J. Expt. Pathol. 1971; 52: 322–329
  • Williams G.M., Tanaka T., Maeura Y. Dose-Related Inhibition of Aflatoxin B1 Induced-Hepatocarcinogenesis by the Phenolic Antioxidants, Butylated Hydroxyanisole and Butylated Hydroxytoluene. Carcinogenesis (Lond.) 1986; 7: 1043–1050
  • Cabral J.R.P., Neal G.E. The Inhibitory Effects of Ethoxyquin on the Carcinogenic Action of Aflatoxin B1 in Rats. Cancer Lett. 1983; 19: 125–132
  • Gurtoo H.L., Koser P.L., Bansal S.K., Fox H.W., Sharma S.D., Mulhern A.I., Pavelic Z.P. Inhibition of Aflatoxin B1-Hepatocarcinogenesis in Rats by β-Naphthoflavone. Carcinogenesis (Lond.) 1985; 6: 675–678
  • Kensler T.W., Egner P.A., Dolan P.M., Groopman J.D., Roebuck B.D. Mechanism of Protection Against Aflatoxin Tumorigenicity in Rats Fed 5-(2-Pyrazinyl)-4-methyl-1,2-dithiol-3-thione (Oltlpraz) and Related 1,2-Dithiol-3-thiones and 1,2-Dithiol-3-ones. Cancer Res. 1987; 47: 4271–4277
  • Garner R.C. Reduction in Binding of [14C] Aflatoxin B1 to Rat Liver Macromolecules by Phenobarbitone Pretreatment. Biochem. Pharmacol. 1975; 24: 1553–1556
  • Lotlikar P.D., Raj H.G., Bohm L.S., Ho L.L., Jhee E.C., Tsuji K., Gopalan P. A Mechanism of Inhibition of Aflatoxin B1-DNA Binding in the Liver by Phenobarbital Pretreatment of Rats. Cancer Res. 1989; 49: 951–957
  • Lotlikar P.D., Clearfield M.S., Jhee E.C. Effect of Butylated Hydroxyanisole on In Vivo and In Vitro Hepatic Aflatoxin B1-DNA Binding in Rats. Cancer Lett. 1984; 24: 241–250
  • Jhee E.C., Ho L.L., Tsuji K., Gopalan P., Lotlikar P.D. Effect of Butylated Hydroxyanisole Pretreatment on Aflatoxin B1-DNA Binding and Aflatoxin B1-Glutathione Conjugation in Isolated Hepatocytes from Rats. Cancer Res. 1989; 49: 1357–1360
  • Kensler T.W., Egner P.A., Trush M.A., Bueding E., Groopman J.D. Modification of Aflatoxin B1 Binding to DNA In Vivo in Rats Fed Phenolic Antioxidants, Ethoxyquin and Dithiothione. Carcinogenesis (Lond.) 1985; 6: 759–763
  • Monroe D.H., Holeski C.J., Eaton D.L. Effects of Single-Dose and Repeated-Dose Pretreatment with 2(3)-Tertbutyl-4-hydroxyanisole (BHA) on the Hepatobiliary Disposition and Covalent Binding to DNA of Aflatoxin B1 in the Rat. Food Chem. Toxicol. 1986; 24: 1273–1281
  • Kensler T.W., Egner P.A., Davidson N.E., Roebuck B.D., Pikul A., Groopman J.D. Modulation of Aflatoxin Metabolism, Aflatoxin-N7-guanine Formation and Hepatic Tumorigenesis in Rats Fed Ethoxyquin: Role of Induction of Glutathione S-Transferase. Cancer Res. 1986; 46: 3924–3931
  • Mandel H.G., Manson M.M., Judah D.J., Simpson J.L., Green J.A., Forrester L.M., Wolf C.R., Neal G.E. Metabolic Basis for the Protective Effect of the Antioxidant Ethoxyquin on Aflatoxin B1 Hepatocarcinogenesis in the Rat. Cancer Res. 1987; 47: 5218–5223
  • Fukuyama M.Y., Hsieh D.P.M. Effect of Butylated Hydroxytoluene Pretreatment on the Excretion, Tissue Distribution and DNA Binding of [14C]aflatoxin B1 in the Rat. Food Chem. Toxicol. 1985; 23: 567–573
  • Chang Y., Bjeldanes L.F. R-Goitrin and BHA-Induced Modulation of Aflatoxin B1 Binding to DNA and Biliary Excretion of Thiol Conjugates in Rats. Carcinogenesis (Lond.) 1987; 8: 585–590
  • Santhanam K., Ho L.L., Lotlikar P.D. 1989, unpublished data
  • Jhee E.C., Ho L.L., Lotlikar P.D. Effect of Butylated Hydroxyanisole Pretreatment on In Vitro Hepatic Aflatoxin B1-DNA Binding and Aflatoxin B1-Glutathione Conjugation in Rats. Cancer Res. 1988; 48: 2688–2692
  • Wattenberg L.W. Inhibitors of Chemical Carcinogenesis. Adv. Cancer Res. 1978; 26: 197–226

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.