16
Views
4
CrossRef citations to date
0
Altmetric
Research Article

Naturally-Derived Tumor Promoters and Inhibitors of Carcinogenesis

&
Pages 129-156 | Published online: 28 Sep 2008

References

  • Cardellina J. H., Marner F. J., Moore R. E. Seaweed Dermatitis: Structure of Lyngbyatoxin A. Science 1979; 204: 193
  • Fujiki H., Suganuma M., Hakii H., Bartolini G., Moore R. E., Takayama S., Sugimura T. A Two-Stage Mouse Skin Carcinogenesis Study of Lyngbyatoxin A. J. Cancer Res. Clin. Oncol. 1984; 108: 174
  • Fujiki H., Suganuma M., Sugimura T. Significance of New Environmental Tumor Promoters. Envir. Carcino. Revs. (J. Envir. Sci. Hlth.) 1989; C7(1)1
  • Kato Y., Scheuer P. J. Aplysiatoxin and Debromoaplysiatoxin, Constituents of The Marine Mollusk Stylocheilus Longicauda. J. Am. Chem. Soc. 1974; 96: 2245
  • Suganuma M., Fujiki H., Tahira T., Cheuk C., Moore R. E., Sugimura T. Estimation of Tumor Promoting Activity and Structure-Function Relationships of Aplysiatoxins. Carcinogenesis 1984; 5: 315
  • Fujiki H., Suganuma M., Yatsunami J., Komori A., Okabe S., Nishiwaki R. M., Ohta T. Significant Marine Natural Products in Cancer Research. Gazzetta Chimica Italiana 1993; 123: 309
  • Fujiki H., Suganuma M. Tumor Promotion by Inhibitors of Protein Phosphatases 1 and 2A: The Okadaic Acid Class of Compounds. Adv. Cancer Res. 1993; 61: 143
  • Fujiki H., Suganuma M., Komori A., Yatsunami J., Okabe S., Ohta T., Sueoka E. A New Tumor Promotion Pathway and Its Inhibitors. Cancer Detection and Prevention 1994; 18: 1
  • Komori A., Yatsunami J., Suganuma M., Okabe S., Abe S., Sakai A., Sasaki K., Fujiki H. Tumor Necrosis Factor Acts as a Tumor Promoter in BALB/3T3 Cell Transformation. Cancer Res. 1993; 53: 1982
  • Fujiki H., Suganuma M. Tumor Necrosis Factor-α, A New Tumor Promoter, Engendered by Biochemical Studies of Okadaic Acid. J. Biochem. 1994; 115: 1
  • Sporn M. B. Chemoprevention of Cancer. Lancet 1993; 342: 1211
  • Kobayashi M., Nakagawa T., Mitsuhashi H. Marine Terpenes and Terpenoids. I. Structures of Four Cembrane-type Diterpenes; Sarcophytol-A, Sarcophytol-A Acetate, Sarcophytol-B, and Sarcophytonin-A, from Soft Coral, Sarcophyton Glaucum. Chem. Pharm. Bull. (Tokyo) 1979; 27: 2382
  • Matsunaga S., Fusetani N., Konosu S. Bioactive Marine Metabolites VI. Structures Elucidation of Discodermia Kiiensis. Tetrahedron Lett. 1984; 255: 165
  • Yatsunami J., Fujiki H., Komori A., Suganuma M., Nishiwaki S., Okabe S., Nishiwaki R. M., Ohta T., Matsunaga S., Fusetani N., Sugimura T. Proceedings of The 1st International Congress on Vitamins and Biofactors in Life Science, T. Kobayashi. Center Acad. Pub., Japan 1992; 333
  • Suganuma M., Iguchi T., Okabe S., de Vries D. J., Murphy P. T., Baker J. T., Rao K. S., Willis R. H., Nakamura H., Fujiki H. Prodeedings of International Symposium on Ciguatera and Marine Natural Products, P. Scheuer, Y. Hokama, T. Yasumoto. 1995
  • Takashima M., Sakai H. A New Toxic Substance, Teleocidin, Produced by Streptomyces, I. Production, Isolation and Chemical Studies. Agr. Chem. Soc. Jpn. 1960; 4: 647
  • Fujiki H., Mori M., Nakayasu M., Terada M., Sugimura T., Moore R. E. Indole Alkaloids: Dihydro teleocidin B, Teleocidin, and Lyngbyatoxin A as Members of A New Class of Tumor Promoters. Proc. Natl. Acad. Sci. U.S.A. 1981; 78: 3872
  • Fujiki H., Suganuma M., Ninomiya M., Yoshizawa S., Yamashita K., Takayama S., Hitotsuyanagi Y., Sakai S., Shudo K., Sugimura T. Similar, Potent Tumor-Promoting Activity of All Isomers of Teleocidins A and B in A Two-Stage Carcinogenesis Experiment on The Skin of CD-1 Mice. Cancer Res. 1988; 48: 4211
  • Fujiki H., Sugimura T. New Classes of Tumor Promoters: Teleocidin, Aplysiatoxin, and Palytoxin. Adv. Cancer Res. 1987; 49: 223
  • Sakai S., Hitotsuyanagi Y., Aimi N., Fujiki H., Suganuma M., Sugimura T., Endo Y., Sudo K. Absolute Configuration of Lyngbyatoxin A (Teleocidin A-1) and Teleocidin A-2. Tetrahedron Lett. 1986; 27: 5219
  • Endo Y., Shudo K., Okamoto T. Molecular Requirements from Epigenetic Modulators, Synthesis of Active Fragments of Teleocidins and Lyngbyatoxin. Chem. Pharm. Bull. 1982; 30: 3457
  • Irie K., Hirota M., Hagiwara N., Koshimizu K., Hayashi H., Murao S., Tokuda H., Ito Y. The Epstein-Barr Virus Early Antigen Inducing Indole Alkaloids, (-)-Indolactam V and Its Related Compounds, Produced by Actinomycetes. Agr. Biol. Chem. 1984; 48: 1269
  • Aimi N., Odaka H., Sakai S., Fujiki H., Suganuma M., Moore R. E., Patterson G. M. L. Lyngbyatoxins B and C, Two New Irritants from Lyngbya Majuscula. J. Nat. Prod. 1990; 53: 1593
  • Moore R. E. Toxins, Anticancer Agents, and Tumor Promoters from Marine Prokaryotes. Pure Appl. Chem. 1982; 54: 1919
  • Fujiki H., Ikegami K., Hakii H., Suganuma M., Yamaizumi Z., Yamazato K., Moore R. E., Sugimura T. A Blue-Green Alga from OKINAWA Contains Aplysiatoxins, The Third Class of Tumor Promoters. Jpn. J. Cancer Res. (Gann) 1985; 76: 257
  • Ueyama H., Sasaki I., Shimomura K., Suganuma M. Specific Protein Interacting with A Tumor Promoter, Debromoaplysiatoxin, in Bovine Serum is I-Acid Glycoprotein. J. Cancer Res. Clin. Oncol. 1995, in press
  • Itai A., Kato Y., Tomioka N., Iitaka Y., Endo Y., Hasegawa M., Shudo K., Fujiki H., Sakai S. A Receptor Model for Tumor Promoters: Rational Superposition of Teleocidins and Phorbol Esters. Proc. Natl. Acad. Sci. U.S.A. 1988; 85: 3688
  • Fujiki H., Suganuma M., Nakayasu M., Hakii H., Horiuchi T., Takayama S., Sugimura T. Palytoxin Is A Non-12-O-Tetradecanoylphorbol-13-Acetate Type Tumor Promoter in Two-Stage Mouse Skin Carcinogenesis. Carcinogenesis 1986; 7: 707
  • Moore R. E., Bartolini G. Structure of Palytoxin. J. Am. Chem. Soc. 1981; 103: 2491
  • Uemura D., Ueda K., Hirata Y., Naoki H., Iwashita T. Further Studies on Palytoxin. Tetrahedron Lett. 1981; 22: 2781
  • Levine L., Fujiki H. Stimulation of Arachidonic Acid Metabolism by Different Types of Tumor Promoters. Carcinogenesis 1985; 6: 1631
  • Lazzaro M., Tashjian A. H., Fujiki H., Levine L. Palytoxin: An Extraordinarily Potent Stimulator of Prostaglandin Production and Bone Resorption in Cultured Mouse Calvariae. Encocrinology 1987; 120: 1338
  • Shibata S., Ishida Y., Kitano H., Ohizumi Y., Habon J., Tsukitani Y., Kikuchi H. Contractile Effect of Okadaic Acid, A Novel Ionophore-Like Substance from Black Sponge, on Isolated Smooth Muscles under The Condition of Ca Deficiency. J. Pharmacol. Exp. Ther. 1986; 223: 135
  • Tachibana K., Scheuer P. J., Tsukitani Y., Kikuchi H., Van Engen D., Clardy J., Gopichand Y., Schmitz F. J. Okadaic Acid, A Cytotoxic Polyether from Two Marine Sponges of The Genus Halichondria. J. Am. Chem. Soc. 1981; 103: 2469
  • Murata M., Shimatani M., Sugitani H., Oshima Y., Yasumoto T. Isolation and Structural Elucidation of The Causative Toxin of The Diarretic Shellfish Poisoning. Bull. Jpn. Soc. Sci. Fish. 1982; 48: 549
  • Fujiki H., Suganuma M., Suguri H., Yoshizawa S., Takagi K., Uda N., Wakamatsu K., Yamada K., Murata M., Yasumoto T., Sugimura T. Diarrhetic Shellfish Toxin, Dinophysistoxin-1, Is A Potent Tumor Promoter on Mouse Skin. Jpn. J. Cancer Res. (Gann) 1988; 79: 1089
  • Kato Y., Fusetani N., Matsunaga S., Hashimoto K., Fujita S., Furuya T. J. Calyculin A, A Novel Antitumor Metabolite from The Marine Sponge Discodermia Calyx. J. Am. Chem. Soc. 1986; 108: 2780
  • Matsunaga S., Fujiki H., Sakata D., Fusetani N. Calyculins E, F, G, and H, Additional Inhibitors of Protein Phosphatases 1 and 2A, from The Marine Sponge Discodermia Calyx. Tetrahedron 1991; 47: 2999
  • Fujiki H., Suganuma M., Yoshizawa S., Kanazawa H., Sugimura T., Manam S., Kahn S. M., Jiang W., Hoshina S., Weinstein I. B. Codon 61 Mutations in The c-Harvey-ras Gene in Mouse Skin Tumors Induced by 7,12-Dimethylbenz(a)anthracene Plus Okadaic Acid Class Tumor Promoters. Mol. Carcinogen. 1989; 2: 184
  • Carmichael W. W., Mahmood N. A. Seafood Toxins, E. P. Ragelis. American Chemical Society, Washington 1984; 377
  • Suganuma M., Fujiki H., Okabe S., Nishiwaki S., Brautigan D., Ingebritsen T. S., Rosner M. R. Structurally Different Members of The Okadaic Acid Class Selectively Inhibit Protein Serine/Threonine but not Tyrosine Phosphatase Activity. Toxicon 1992; 30: 873
  • Suganuma M., Tatematsu M., Yatsunami J., Yoshizawa S., Okabe S., Uemura D., Fujiki H. An Alternative Theory of Tissue Specificity by Tumor Promotion of Okadaic Acid in Glandular Stomach of SD Rats. Carcinogenesis 1992; 13: 1841
  • Namikoshi M., Rinehart K. L., Sakai R., Stotts R., Dahlem A. M., Beasley V. R., Carmichael W. W., Evans W. R. Identification of 12 Hepatotoxins from A Homer Lake Bloom of The Cyanobacteria Microcystis Aeruginosa, Microcystis Viridis, and Microcystis Wesenbergii: Nine New Microcystins. J. Org. Chem. 1992; 57: 866
  • Rinehart K. L., Harada K-I., Namikoshi M., Chen C., Harvis C. A., Munro M. H. G., Blunt J. W., Mulligan P. E., Beasley V. R., Dahlem A. M., Carmichael W. W. Nodularin, Microcystin, and The Configuration of Adda. J. Am. Chem. Soc. 1988; 110: 8557
  • Nishiwaki R., Ohta T., Sueoka E, Suganuma M., Harada K-I., Watanabe M. F., Fujiki H. Two Significant Aspects of Microcystin-LR: Specific Binding and Liver Specficity. Cancer Lett. 1994; 83: 283
  • Ohta T., Sueoka E., Iida N., Komori A., Suganuma M., Nishiwaki R., Tatematsu M., Kim S. J., Carmichael W. W., Fujiki H. Nodularin, A Potent Inhibitor of Protein Phosphatases 1 and 2A, Is A New Environmental Carcinogen in Male F344 Rat Liver. Cancer Res. 1994; 54: 6402
  • de Silva E. D., Williams D. E., Andersen R. J., Klix H., Holmes C. F. B., Allen T. M. Motuporin, A Potent Protein Phosphatase Inhibitor Isolated from The Papua New Guinea Sponge Theonella Swinhoei Gray. Tetrahedron Lett. 1992; 33: 1561
  • Yu S. Z. Primary Liver Cancer, Z. Y. Tang, M. C. Wu, S. S. Xia. China Academic Publishers, Beijing, Springer-Verlag, Berlin 1989; 30
  • Guy G. R., Cao X., Chua S. P., Tan Y. H. Okadaic Acid Mimics Multiple Changes in Early Protein Phosphorylation and Gene Expression Induced by Tumor Necrosis Factor or Interleukin-1. J. Biol. Chem. 1992; 267: 1846
  • Thevenin C., Kim S. J., Rieckmann P., Fujiki H., Norcross M. A., Sporn M. B., Fauci A. S., Kehrl J. H. Induction of Nuclear Factor-kB and The Human Immunodeficiency Virus Long Terminal Repeat by Okadaic Acid, A Specific Inhibitor of Phosphatases 1 and 2A. New Biologist 1990; 2: 793
  • Old L. J. Tumor Necrosis Factor (TNF). Science 1985; 230: 630
  • Fujiki H., Suganuma M., Takagi K., Nishiwaki S., Yoshizawa S., Okabe S., Yatsunami J., Frenkel K., Troll W., Marshall J. A., Tius M. A. Phenolic Compounds in Food and Their Effects on Health II, M-T Huang, T. C Ho, C. Y. Lee. American Chemical Society, Washington, DC 1992; 380
  • Komori A., Suganuma M., Okabe S., Zou X., Tius M. A., Fujiki H. Canventol Inhibits Tumor Promotion in CD-1 Mouse Skin through Inhibition of Tumor Necrosis Factor α Release and of Protein Isoprenylation. Cancer Res. 1993; 53: 3462
  • Nakamura H., Wu H., Ohizumi Y., Hirata Y. Agelasine-A, -B, -C and -D, Novel Bicyclic Diterpenoids with A 9-Methyladenium Unit Possessing Inhibitory Effects on Na, K-ATPase from The Okinawan Sea Sponge Agelas Sp. Tetrahedron Lett. 1984; 25: 2989

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.