51
Views
6
CrossRef citations to date
0
Altmetric
Original

Mycotoxins as Causal Factors of Diseases in Humans

&
Pages 229-243 | Published online: 24 Sep 2010

References

  • Smith J. E., Henderson R. S. Mycotoxins and Animal Foods. CRC Press, Boston 1991
  • Miller J. D., Trenholm H. L. Mycotoxins in Grain; Compounds other than aflatoxin. Eagan Press, St. Paul, Mnnesota 1994
  • Hsieh D. P.H. Health risks posed by mycotoxins in foods. Korean J. Toxicol. 1990; 6(2)159–166
  • Steyn P. S., Stander M. A. Mycotoxins with special reference to rhe carcinogenic mycotoxins: aflatoxins, ochratoxins and fumonisins. General and Applied Toxicology2nd edition. 1989, in press
  • van Egmond H. P., Speijers G. J.A. Survey of data on the incidence and levels of ochratoxin A in food and animal feed worldwide. Journal of Natural Toxins 1994; 3(2)125–143
  • van Rensburg S. J. Role of mycotoxins in endemic liver and oesophageal cancer. Mycotoxins and phycotoxins, P. S. Steyn, R. Vleggaar. Elsevier, Amsterdam 1989; 483–494
  • Wang L-Y., Hatch M., Chen C-J., Levin B., You S-L., Lu S-N., Wu M-H., Wu W-P., Wang L-W., Wang Q., Huang G-Y., Yang P-M., Lee H-S., Santella R. M. Aflatoxin exposure and risk of hepatocellular carcinoma in Taiwan. International Journal of Cancer 1996; 67(5)620–625
  • Ishii K., Maeda K., Kamataki T., Kato R. Mutagenic activation of aflatoxin B1by several forms of purified cytochrome P450. Mutat. Res. 1986; 174: 85–88
  • Forrester L. M., Neal G. E., Judah D. J., Glancey M. J., Wolf C. R. Evidence for involvement of multiple forms of cytochrome P450 in aflatoxin B1metabolism in human liver. Proc. Natl. Acad. Sci. USA 1990; 87: 8306–8310
  • Raney K. D., Coles B., Guengrich F. P., Harris T. M. The errdo-8,9-epoxide of aflatoxin B1: a new metabolite. Chem. Res. Toxicol. 1992; 5: 333–335
  • Iyer R. S., Coles B. F., Thier K. D., Guengerich F. P., Harris T. M. DNA adduction by the potent carcinogen aflatoxin B1: Mechanistic studies. J. Am. Chem. Soc. 1994; 116: 1603–1609
  • Essigmann J. M., Croy R. G., Nadzan A. M., Busby W. F., Jr, Reinhold V. N., Büchi G., Wogan G. N. Structural identification of the major DNA adduct formed bv aflatoxin B1in vitro. Proc. Natl. Acad. Sci. USA 1977; 74: 1870–1874
  • Essigmann J. M., Green C. L., Croy R. G., Fowler K., Büchi G., Wogan G. N. Interactions of aflatoxin B1and alkylating agents with DNA: structural and functional studies. Cold Spring Harbor Sympos. Quant. Biol. 1982; 47: 327–337
  • Hsu I. C., Metcalf R. A., Sun T., Welsch J. A., Wang N. J., Hams C. C. Mutational hotspot in the p53 gene in human hepatocelluar carcinomas. Nature 1991; 350: 427–428
  • Bressac B., Kew M., Wands W, Ozturk M. Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature 1991; 350: 429–431
  • Fink-Gremmels. 1996, personnal communication
  • Rheeder J. P., Marasas W. F. O., Thiel P. G., Sydenham E. W., Shephard G. S., van Schalkwyk D. J. Fusarium moniliforme and fumonisins in corn in relation to human esophageal cancer in Transkei. Phytopathology 1992; 82(3)353–357
  • Yang C. S. Research on esophageal cancer in China: A review. Cancer Res. 1980; 40: 2633–2644
  • Chu F. S., Li G. Y. Simultaneous occurrence of fumonisin B, and other mycotoxins in moldy corn collected from the People's Republic of China in regions with high incidences of esophageal cancer. Appl. Environ. Microbiol. 1994; 60(3)847–852
  • Bezuidenhout G. C., Gelderblom W. C. A., Gorst-Allman C. P., Horak R. M., Marasas W. F. O., Spiteller G., Vleggaar R. Structure elucidation of the fumonisins, mycotoxins from Fusarium moniliforme. J. Chem. Soc., Chem. Commun. 1988; 743–745
  • Gelderblom W. C. A., Jaskiewicz K., Marasas W. F. O., Thiel P. G., Horak R. M., Vleggaar R., Kriek N. P.J. Fumonisins-novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme. Appl. Environ. Microbiol. 1988; 54(7)1806–1811
  • Ross P. F., Nelson P. E., Richard J. L., Osweiler G. D., Rice L. G., Plattner R. D., Wilson T. M. Production of fumonisins by Fusarium moniliforme and Fusarium proliferatum isolates associated with equine leukoencephalomalacia and a pulmonary endema in swine. Applied Environmental Biology 1990; 56: 3225–3226
  • Gelderblom W. C. A., Kriek N. J., Marasas W. F. O., Thiel P. G. Toxicity and carcinogenicity of the Fusarium moniliforme metabolite, fumonisin B1in rats. Carcinogenesis 1991; 12: 1247–1251
  • Lebepe-Mazur S., Bal H., Hopmans E., Murphy P., Henrich S. Fumonisin B1is fetotoxic in rats. Vet. Human Toxicol. 1995; 37(2)126–130
  • Gelderblom W. C. A., Snyman S. D., Abel S., Lebepe-Mazur S., Smuts C. M., van der Westhuizen L., Marasas W. F. O., Victor T. C., Knasmulle R. S., Huber W. Hepatotoxic - and carcinogenecity of the fumonisins in rats: a review regarding mechanistic implications for establishing risk in humans. Fumonisins in Food, L. S. Jackson, I. W. De Vries, L. D. Bulleman. Plenum Press, New York 1996; 279–296
  • Wang E., Norred W. P., Bacon C. W., Riley R. T., Merrill A. H. Inhibition of sphingolipid biosynthesis by fumonisins: implications for diseases associated with Fusarium moniliforme. J. Biol. Chem. 1991; 266: 14486–14490
  • Merrill A. H. Cell regulation by spingosine and more complex sphingolipids. J. Bioenerg. Biomembr. 1991; 23: 83–104
  • Gelderblom W. C. A., Smuts C. M., Abel S., Snyman S. D., Cawood M. E., van der Westhuizen L., Swanevelder S. Effects of Fumonisin B1on Protein and Lipid Synthesis in Primary Rat Hepatocytes. Fd. Chem. Toxic 1996; 34: 361–369
  • Cornwell D. G., Morisaki N. FA paradoxes in the control of cell proliferation: prostaglandins, lipid peroxides and cooxidation reactions. Free Radicals in Biology VI, W. A. Proyor. Academic Press, Orlando, FL 1984; 95–148
  • Gavino V. C., Miller J. S., Ikharebha S. O., Milo G. E., Maizewell D. G. Effect of polyunsaturated fatty acid and antioxidants on lipid peroxidarion in tissue cultures. J. Lipid Res. 1981; 22: 763–769
  • Krogh P. Mycoroxic porcine nephroparhy - a possible model for Balkan (endemic) nephropathy. Endemic nephroparhy, A. Puchlev. Balgarian Academy of Sciences, Sofia 1974; 266–270
  • Krogh P., Hald B., Plestina R., Ceovic S. Balkan (endemic) nephropathy and foodborne ochratoxin A: Preliminary results and foodstuffss. Acta Pathologica Microbiologica et Immunologica Scandinavica Section B 1977; 85: 238–240
  • Krogh P. Ochratoxin in foods. Mycotoxins in food, P. Krogh. Academic Press, London 1987; 97
  • Szczech G. M., Carlton W. W., Tuite J., Caldwell R. Ochratoxin A toxicosis in swine. Vet. Pathol. 1973; 10: 347
  • Pavlovic M., Plestina R., Krogh P. Ochratoxin A contamination of foodstuffs in an area with Balkan (endemic) nephropathy. Acta Pathologica Microbiologica et Immunologica Scandinavica Section B 1979; 87: 243–246
  • Petkova-Bocharova T, Castegnaro M. Ochraroxin contamination of cereals in an area of high incidence of Bulkiin endemic nephropathv in Bulgaria. Food. Addit. Contam. 1985; 2: 267–270
  • Petkova-Bocharova T., Chernozemsky I. N., Castegnaro M. Ochraroxin A in human blood in relation to Balkan endemic nephropathy and urinary system tumours in Bulgaria. Food. Addit. Contam. 1988; 5(3)299–301
  • Bacha H., Maaroufi K., Achour A., Hamammi M., Ellouz F., Creppy E. E. Ochratoxins and ochratoxicoses in humans in Tunisia. Human ochratoxicosis and its pathologies, E. E. Creppy, M. Castegnaro, G. Dirheimer. John Libbey Eurotext Ltd. 1993; 111–121
  • Krogh P., Gyrd-Hnsen N., Hald B., Larsen S., Nieken JP., Smith M., Lvanoff C., Meisner H. Renal e nzyme activities in experimental ochratoxin A-induced porcine nephropathy: D iagnostic potential of phosphaenolpytuvate carboxykinase and gamma-glutamyl transpeptidase activity. J. Toxicol. Environ. Health 1988; 23: 1
  • Creppy E.-E., Röschenthaler R., Dirheimer G. Inhibition of protein synthesis in mice by ochraroxin A and its prevention by phenylalanine. Fd Chem. Toxic 1984; 22(11)883
  • Omar R. F., Rahimtula A. D., Bartsch H. Role of cytochrome P-450 in Ochratoxin A-stimulated lipid peroxidation. J. Biochem. Toxicol. 1991; 6: 203–209
  • Moore J. H., Truelove B. Ochratoxin A, inhibition of mitochondrial respiration. Science (Washington DC) 1970; 168: 1102
  • Meisner H., Chan S. Ochratoxin A an inhibitor of mitochondrial rransport. Biochem. 1974; 13: 2759
  • Wei Y.-H., Lu C.-Y., Lin T.-N., Wei R. D. Effect of ochratoxin A on rat liver mitochondrial respiration and oxidative phosphorylation. Toxicology 1985; 36: 119
  • Omar R. F., Hasinoff B. B., Mejilla F., Rahimtula A. D. Mechanism of ochratoxin A stimulated lipid peroxidation. Biochem. Pharmacol. 1990; 40(6)1183
  • Hasinoff B. B., Rahimtula A. D., Omar R. F. NADPH-cyrochronie-P-450 reductase promoted hydroxyl radical production by the iron(III)-ochratoxin A complex. Biochemica et Biophysica Acta 1990; 1036: 78
  • Hansen C. E., Dueland S., Drevon C. A., Størmer F. C. Metabolism of ochratoxin A by primary cultures of rat hepatocytes. Appl. Environ. Microbiol. 1982; 43(6)1267–1271
  • Størmer F. C., Støren O., Hansen C. E., Pederson J. I., Aasen A. J. Formation of (4R)-and (4S)-4-hydroxyochratoxin A and 10-hydroxvochratoxin A by rabbit liver microsomes. Appl. Environ. Microbiol. 1983; 45: 1183–1187
  • Størmer F. C., Hansen C. E., Pederson J. I., Hvistendahl G., Aasen A. J. Formation of (4R)- and (4S)-4-hydroxochratoxin A by liver microsomes from various species. Appl. Environ. Microbiol. 1981; 42: 1051–1056
  • Moroi K., Suzuki S., Kuga T., Yamazalu M., Kanisawa M. Reduction of ochratoxin A toxicity in mice treared with phenylalanine and phenobarbital. Toxicol. Lett. 1985; 25: 1–5
  • Stein A. F., Phillips T. D., Kubena L. F., Harvey R. B. Renal tubular secretion and readsorption as factors in ochratoxicosis: Effects of probenecid on nephrotoxicity. J. Toxicol. Environ. Health 1985; 16: 593
  • Beardall J. M., Miller J. D. Diseases in humans with mycotoxins as possible causes. Mycotoxins in grain; compounds other than aflatoxin, J. D. Miller, H. L. Trenholm. Eagan Press. 1994; 487–539, USAand references cited therein
  • Krishnamachari K. A. V. R., Bhat R. V. Poisoning by ergoty bajra (pearl millet) in man. Indian J. Med. Res. 1976; 64(11)1624–1628
  • Bhat R. V., Roy D. N., Tulpule P. G. The nature of alkaloids of ergoty pearl millet and its comparison with alkaloids of ergoty rye and ergoty wheat. Toxicol. Appl. Pharmacol. 1976; 36(1)11–17
  • van Rensburg S. J., Altcnkirk B. Claviceps purpurea - Ergotism. Mycotoxins, I. F.H. Purchase. Elsevier, Amsterdam 1974; 69–96
  • Pohland A. E. Mycotoxins in review. Food. Addit. Contam. 1993; 10(1)17–28
  • Porter J. K. Ergot alkaloids and alkaloids from other endophytes, responsible for causing toxic syndrome in cattle after eating contaminated grass. Prikl. Biokhim. Microbiol. 1993; 29(1)51–55
  • Schneider D. J., Miles C. O., Garthwaite I., Van Halderen A., Wessels J. C., Lategan H. J. First report of field outbreaks of ergot-alkaloid toxicity in South Africa. Ondcrstepoort J. Vet. Res. 1996; 63(2)97–108
  • Meylcr W. J. Side effects of ergotamine. Cephalalgia 1996; 16(1)5–10
  • Arafat W., Musa M. N. Patulin-induced inhibition of protein synthesis in hepatoma tissue culture. Res. Commun. Mol. Pathol. Pharmacol. 1995; 87(2)177–186
  • Grove J. F. Non-macrocyclic trichothecenes. Natural Products Report 1988; S187–209
  • Grove J. F. Non-macrocyclic trichothecenes, Part 2. Prog. Chem. Org. Nat. Prod. 1997; 69: 1–70, and references cited therein
  • van Egmond H. P. Aflatoxin M1: occurrence, toxicity. Regulation. Mycotoxins in Dairy Products, H. P. van Egmond. Elsevier Science Publishers LTD., England 1989; 11–55
  • Meloche J. L., Smith T. K. Altered tissue amino acid metabolism in acute T-2 toxicosis. Proc. Soc. Exp. Biol. Med. 1995; 210(3)260–265
  • Joffe A. Z. Fusarium poae and F. sporotrichioides as principal causal agents of alimentary toxic aleukia. Mycotoxic fungi, mycotoxins, mycotoxicoses - an encyclopedic handbook. Marcel Dekker, New York 1978; vol. 3: 21–86
  • Williams P. P. Effects of T-2 mycotoxiri on gastrointestinal tissues: a review of in vivo and in vitro models. Arch. Environ. Contam. Toxicol. 1989; 18(3)374–387
  • Lafarge-Frayssinet C., Decloitre F., Mousset S., Martin M., Frayssinet C. Induction of DNA single strand-breaks by T2-toxin. a trichothecene metabolite of Fusarium. Effect on lymphoid organs and liver. Mutat. Res. 1981; 88(2)115–123
  • Stob M., Baldwin R. S., Tuite J., Andrews F. N., Gilette K. G. Isolation of an anabolic uterotropic compound from corn infected with Gibberella zeae. Nature (London) 1962; 196: 1318
  • Pfohl-Leszkowicz A., Chekir-Ghedira L., Bacha H. Genotoxicity of zearalenone. an estrogenic mycotoxin: DNA adduct formation in female mouse tissues. Carcinogenesis 1995; 16(10)2315–2320
  • Riley R. T., Goeger D. E., Yoo H., Showker J. L. Comparison of three tetrameric acids and their ability to alter membrane function in cultured skeletal muscle cells and sarcoplasmic reticulum vesicles. Toxicology and Applied Pharmacology 1992; 114: 261–267
  • Porter J. K., Norred W. P., Cole R. J., Dorner J. W. Neurochemical effects of cyclopiazonic acid in chickens. Proc. Soc. Exp. Biol. Med. 1988; 187: 335–340
  • Agarwal S. S., Phadke S. R., Fredlund V., Viljoen D., Beighton P. Mseleni and Handigodu familial esteoarrhropathies: syndromic identity?. Am. J. Med. Genet. 1997; 72(4)435–439
  • Viljoen D., Fredlund V., Rarnesar R., Bieghton P. Brachydacrylous dwarfs of Mseleni. Am. J. Med. Genet. 1993; 46(6)636–640
  • Ballo R., Viljoen D., Machado M., Keene D., Horton W., Fredlund V., Jacobs M., Martell R., Beighton P., Rarnesar R. Mseleni joint disease - a molecular genetic approach to defining the aetiologv. S. Afr. Med. J. 1996; 86(8)956–958
  • Sokoloff L. Acquired chondronecrosis. Ann. Rheum. Dis. 1990; 11(2)262–264
  • Zhai S. S., Kimbrough R. D., Meng B., Han J. Y., LeVois M., Hou X., Yin X. N. Kashin-Beck disease a cross-sectional study in seven villages in the People's Republic of China. J. Toxicol. Environ. Health 1990; 30(4)239–259

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.