Sexual dysfunction during treatment with serotonergic and noradrenergic antidepressants: Clinical description and the role of the 5-HTTLPR

References

• Ashton AK, Mahmood A, Iqbal F. 2005. Improvements in SSRI/SNRI-induced sexual dysfunction by switching to escitalopram. J Sex Marital Ther 31:257–262.
   PubMed Web of Science ®Google Scholar
• Baldessarini RJ, Marsh E. 1990. Fluoxetine and side effects. Arch Gen Psychiatry 47:191–192.
   PubMed Web of Science ®Google Scholar
• Baldwin DS, Cooper JA, Huusom AK, Hindmarch I. 2006. A double-blind, randomized, parallel-group, flexible-dose study to evaluate the tolerability, efficacy and effects of treatment discontinuation with escitalopram and paroxetine in patients with major depressive disorder. Int Clin Psychopharmacol 21:159–169.
   PubMed Web of Science ®Google Scholar
• Baldwin DS, Reines EH, Guiton C, Weiller E. 2007. Escitalopram therapy for major depression and anxiety disorders. Ann Pharmacother 41:1583–1592.
   PubMed Web of Science ®Google Scholar
• Bishop JR, Ellingrod VL, Akroush M, Moline J. 2009. The association of serotonin transporter genotypes and selective serotonin reuptake inhibitor (SSRI)-associated sexual side effects: possible relationship to oral contraceptives. Hum Psychopharmacol 24:207–215.
   PubMed Web of Science ®Google Scholar
• Bitran D, Hull EM, Holmes GM, Lookingland KJ. 1988. Regulation of male rat copulatory behavior by preoptic incertohypothalamic dopamine neurons. Brain Res Bull 20:323–331.
   PubMed Web of Science ®Google Scholar
• Christensen BS, Gronbaek M, Osler M, Pedersen BV, Graugaard C, Frisch M. 2010. Sexual dysfunctions and difficulties in Denmark: prevalence and associated sociodemographic factors. Arch Sex Behav 40:121 132.
   Google Scholar
• Clayton AH, Pradko JF, Croft HA, Montano CB, Leadbetter RA, Bolden-Watson C, . 2002. Prevalence of sexual dysfunction among newer antidepressants. J Clin Psychiatry 63:357–366.
   PubMed Web of Science ®Google Scholar
• Clayton AH, Keller A, McGarvey EL. 2006a. Burden of phase-specific sexual dysfunction with SSRIs. J Affect Disord 91: 27–32.
   PubMed Web of Science ®Google Scholar
• Clayton AH, Croft HA, Horrigan JP, Wightman DS, Krishen A, Richard NE . 2006b. Bupropion extended release compared with escitalopram: effects on sexual functioning and antidepressant efficacy in 2 randomized, double-blind, placebo-controlled studies. J Clin Psychiatry 67:736–746.
   PubMed Web of Science ®Google Scholar
• Clayton A, Kornstein S, Prakash A, Mallinckrodt C, Wohlreich M. 2007. Changes in sexual functioning associated with duloxetine, escitalopram, and placebo in the treatment of patients with major depressive disorder. J Sex Med 4:917–929.
   PubMed Web of Science ®Google Scholar
• Corona G, Ricca V, Bandini E, Mannucci E, Lotti F, Boddi V, . 2009. Selective serotonin reuptake inhibitor-induced sexual dysfunction. J Sex Med 6:1259–1269.
   PubMed Web of Science ®Google Scholar
• Corona G, Lee DM, Forti G, O'Connor DB, Maggi M, O'Neill TW, . 2010. Age-related changes in general and sexual health in middle-aged and older men: results from the European Male Ageing Study (EMAS). J Sex Med 7:1362–1380.
   PubMed Web of Science ®Google Scholar
• de Bakker PI, Yelensky R, Pe'er I, Gabriel SB, Daly MJ, Altshuler D. 2005. Efficiency and power in genetic association studies. Nat Genet 37:1217–1223.
   PubMed Web of Science ®Google Scholar
• Degner D, Grohmann R, Kropp S, R ther E, Bender S, Engel RR, . 2004. Severe adverse drug reactions of antidepressants: results of the German multicenter drug surveillance program AMSP. Pharmacopsychiatry 37(Suppl 1):39 45.
   Google Scholar
• Derogatis LR, Burnett AL. 2008. The epidemiology of sexual dysfunctions. J Sex Med 5:289–300.
   PubMed Web of Science ®Google Scholar
• Done CJ, Sharp T. 1992. Evidence that 5-HT2 receptor activation decreases noradrenaline release in rat hippocampus in vivo. Br J Pharmacol 107:240–245.
   PubMed Web of Science ®Google Scholar
• Drago A, De Ronchi D, Serretti A. 2009. Pharmacogenetics of antidepressant response: an update. Hum Genomics 3:257–274.
   PubMedGoogle Scholar
• Freeman B, Smith N, Curtis C, Huckett L, Mill J, Craig IW. 2003. DNA from buccal swabs recruited by mail: evaluation of storage effects on long-term stability and suitability for multiplex polymerase chain reaction genotyping. Behav Genet 33:67–72.
   PubMed Web of Science ®Google Scholar
• Grohmann R, Rüther E, Engel RR, Hippius H. 1999. Assessment of adverse drug reactions in psychiatric inpatients with the AMSP drug safety program: methods and first results for tricyclic antidepressants and SSRI. Pharmacopsychiatry 32:21–28.
   PubMed Web of Science ®Google Scholar
• Haberfellner EM. 2007. A review of the assessment of antidepressant-induced sexual dysfunction used in randomized, controlled clinical trials. Pharmacopsychiatry 40:173–182.
   PubMed Web of Science ®Google Scholar
• Hirschfeld RM, Vornik LA. 2004. Newer antidepressants: review of efficacy and safety of escitalopram and duloxetine. J Clin Psychiatry 65 Suppl 4:46–52.
   Google Scholar
• Hsu JH, Shen WW. 1995. Male sexual side effects associated with antidepressants: a descriptive clinical study of 32 patients. Int J Psychiatry Med 25:191–201.
   PubMed Web of Science ®Google Scholar
• Huezo-Diaz P, Uher R, Smith R, Rietschel M, Henigsberg N, Marusic A, . 2009. Moderation of antidepressant response by the serotonin transporter gene. Br J Psychiatry 195:30–38.
   PubMed Web of Science ®Google Scholar
• Hull EM, Lorrain DS, Du J, Matuszewich L, Lumley LA, Putnam SK, . 1999. Hormone-neurotransmitter interactions in the control of sexual behavior. Behav Brain Res 105:105–116.
   PubMed Web of Science ®Google Scholar
• Ising M, Lucae S, Binder EB, Bettecken T, Uhr M, Ripke S, . 2009. A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression. Arch Gen Psychiatry 66:966–975.
   PubMed Web of Science ®Google Scholar
• Janssen PK, Bakker SC, Rethelyi J, Zwinderman AH, Touw DJ, Olivier B, . 2009. Serotonin transporter promoter region (5-HTTLPR) polymorphism is associated with the intravaginal ejaculation latency time in Dutch men with lifelong premature ejaculation. J Sex Med 6:276–284.
   PubMed Web of Science ®Google Scholar
• Kato M, Serretti A. 2010. Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder. Mol Psychiatry 15:473–500.
   PubMed Web of Science ®Google Scholar
• Lanza di Scalea T, Hanusa BH, Wisner KL. 2009. Sexual function in postpartum women treated for depression: results from a randomized trial of nortriptyline versus sertraline. J Clin Psychiatry 70:423–428.
   PubMed Web of Science ®Google Scholar
• Laumann EO, Paik A, Rosen RC. 1999. Sexual dysfunction in the United States: prevalence and predictors. J Am Med Assoc 281:537–544.
   PubMed Web of Science ®Google Scholar
• Laumann EO, Glasser DB, Neves RC, Moreira ED Jr. 2009. A population-based survey of sexual activity, sexual problems and associated help-seeking behavior patterns in mature adults in the United States of America. Int J Impot Res 21:171–178.
   PubMed Web of Science ®Google Scholar
• Lee AW, Pfaff DW. 2008. Hormone effects on specific and global brain functions. J Physiol Sci 58:213–220.
   PubMed Web of Science ®Google Scholar
• Lin E, Chen PS. 2008. Pharmacogenomics with antidepressants in the STAR*D study. Pharmacogenomics 9:935–946.
   PubMed Web of Science ®Google Scholar
• Lingjaerde O, Ahlfors UG, Bech P, Dencker SJ, Elgen K. 1987. The UKU side effect rating scale. A new comprehensive rating scale for psychotropic drugs and a cross-sectional study of side effects in neuroleptic-treated patients. Acta Psychiatr Scand 76(Suppl 334):1–100.
   PubMedGoogle Scholar
• Meltzer HY, Young M, Metz J, Fang VS, Schyve PM, Arora RC. 1979. Extrapyramidal side effects and increased serum prolactin following fluoxetine, a new antidepressant. J Neural Transm 45:165–175.
   PubMed Web of Science ®Google Scholar
• Montejo AL, Llorca G, Izquierdo JA, Rico-Villademoros F. 2001. Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients. Spanish Working Group for the Study of Psychotropic-Related Sexual Dysfunction. J Clin Psychiatry 62(Suppl 3):10–21.
   PubMed Web of Science ®Google Scholar
• Montgomery SA, Baldwin DS, Riley A. 2002. Antidepressant medications: a review of the evidence for drug-induced sexual dysfunction. J Affect Disord 69:119–140.
   PubMed Web of Science ®Google Scholar
• Ozbek E, Tasci AI, Tugcu V, Ilbey YO, Simsek A, Ozcan L, . 2009. Possible association of the 5-HTTLPR serotonin transporter promoter gene polymorphism with premature ejaculation in a Turkish population. Asian J Androl 11:351–355.
   PubMed Web of Science ®Google Scholar
• Perlis RH, Laje G, Smoller JW, Fava M, Rush AJ, McMahon FJ. 2009. Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients. Neuropsychopharmacology 34:1819–1828.
   PubMed Web of Science ®Google Scholar
• Phanjoo AL. 2000. Sexual dysfunction in old age. Adv Psychiatr Treat 6:270–277.
   Google Scholar
• Rosen RC, Lane RM, Menza M. 1999. Effects of SSRIs on sexual function: a critical review. J Clin Psychopharmacol 19:67–85.
   PubMed Web of Science ®Google Scholar
• Rothschild AJ. 2000. Sexual side effects of antidepressants. J Clin Psychiatry 61(Suppl 11):28–36.
   PubMedGoogle Scholar
• Safarinejad MR. 2010a. Analysis of association between the 5-HTTLPR and STin2 polymorphisms in the serotonin-transporter gene and clinical response to a selective serotonin reuptake inhibitor (sertraline) in patients with premature ejaculation. BJU Int 105:73–78.
   PubMed Web of Science ®Google Scholar
• Safarinejad MR. 2010b. The effects of the adjunctive bupropion on male sexual dysfunction induced by a selective serotonin reuptake inhibitor: a double-blind placebo-controlled and randomized study. BJU Int 106:840–847.
   PubMed Web of Science ®Google Scholar
• Safarinejad MR. 2010c. Reversal of SSRI-induced female sexual dysfunction by adjunctive bupropion in menstruating women: a double-blind, placebo-controlled and randomized study. J Psychopharmacol in press.
   Google Scholar
• Schosser A, Kasper S. 2009. The role of pharmacogenetics in the treatment of depression and anxiety disorders. Int Clin Psychopharmacol 24:277–288.
   PubMed Web of Science ®Google Scholar
• Schweitzer I, Maguire K, Ng C. 2009. Sexual side-effects of contemporary antidepressants: review. Aust NZ J Psychiatry 43:795–808.
   PubMed Web of Science ®Google Scholar
• Segraves RT. 1989. Effects of psychotropic drugs on human erection and ejaculation. Arch Gen Psychiatry 46:275–284.
   PubMed Web of Science ®Google Scholar
• Segraves RT. 2007. Sexual dysfunction associated with antidepressant therapy. Urol Clin North Am 34:575–579.
   PubMed Web of Science ®Google Scholar
• Serretti A, Chiesa A. 2009. Treatment-emergent sexual dysfunction related to antidepressants: a meta-analysis. J Clin Psychopharmacol 29:259–266.
   PubMed Web of Science ®Google Scholar
• Serretti A, Kato M, De Ronchi D, Kinoshita T. 2007. Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with selective serotonin reuptake inhibitor efficacy in depressed patients. Mol Psychiatry 12:247–257.
   PubMed Web of Science ®Google Scholar
• Smith SM, O'Keane V, Murray R. 2002. Sexual dysfunction in patients taking conventional antipsychotic medication. Br J Psychiatry 181:49–55.
   PubMed Web of Science ®Google Scholar
• Stahl SM. 1998. Mechanism of action of serotonin selective reuptake inhibitors. Serotonin receptors and pathways mediate therapeutic effects and side effects. J Affect Disord 51:215–235.
   PubMed Web of Science ®Google Scholar
• Uher R, Farmer A, Maier W, Rietschel M, Hauser J, Marusic A, . 2008. Measuring depression: comparison and integration of three scales in the GENDEP study. Psychol Med 38: 289–300.
   PubMed Web of Science ®Google Scholar
• Uher R, Farmer A, Henigsberg N, Rietschel M, Mors O, Maier W, . 2009a. Adverse reactions to antidepressants. Br J Psychiatry 195:202–210.
   PubMed Web of Science ®Google Scholar
• Uher R, Huezo-Diaz P, Perroud N, Smith R, Rietschel M, Mors O, . 2009b. Genetic predictors of response to antidepressants in the GENDEP project. Pharmacogenomics J 9: 225–233.
   PubMed Web of Science ®Google Scholar
• Uher R, Maier W, Hauser J, Marusic A, Schmael C, Mors O, . 2009c. Differential efficacy of escitalopram and nortriptyline on dimensional measures of depression. Br J Psychiatry 194:252–259.
   PubMed Web of Science ®Google Scholar
• Uher R, Perroud N, Ng MY, Hauser J, Henigsberg N, Maier W, . 2010. Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. Am J Psychiatry 167: 555–564.
   PubMed Web of Science ®Google Scholar
• Werneke U, Northey S, Bhugra D. 2006. Antidepressants and sexual dysfunction. Acta Psychiatr Scand 114:384–397.
   PubMed Web of Science ®Google Scholar
• Williams V, Edin H, Hogue S, Fehnel S, Baldwin D. 2010. Prevalence and impact of antidepressant-associated sexual dysfunction in three European countries: replication in a cross-sectional patient survey. J Psychopharmacol 24:489–496.
   PubMed Web of Science ®Google Scholar
• Zisook S, Rush AJ, Haight BR, Clines DC, Rockett CB. 2006. Use of bupropion in combination with serotonin reuptake inhibitors. Biol Psychiatry 59:203–210.
   PubMed Web of Science ®Google Scholar