Identification of the N-acylsphingosine amidohydrolase 1 gene (ASAH1) for susceptibility to schizophrenia in a Han Chinese population

References

• Badner JA, Gershon ES. 2002. Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol Psychiatry 7: 405–411.
   PubMed Web of Science ®Google Scholar
• Bar J, Linke T, Ferlinz K, Neumann U, Schuchman EH, Sandhoff K. 2001. Molecular analysis of acid ceramidase deficiency in patients with Farber disease. Hum Mutat 17:199–209.
   PubMed Web of Science ®Google Scholar
• Barak Y, Achiron A, Mandel M, Mirecki I, Aizenberg D. 2005. Reduced cancer incidence among patients with schizophrenia. Cancer 104:2817–2821.
   PubMed Web of Science ®Google Scholar
• Barrett JC. 2009. Haploview: Visualization and analysis of SNP genotype data. Cold Spring Harb Protoc 2009:pdb ip71.
   PubMedGoogle Scholar
• Barrett JC, Fry B, Maller J, Daly MJ. 2005. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263–265.
   PubMed Web of Science ®Google Scholar
• Buccoliero R, Futerman AH. 2003. The roles of ceramide and complex sphingolipids in neuronal cell function. Pharmacol Res 47:409–419.
   PubMed Web of Science ®Google Scholar
• Buccoliero R, Bodennec J, Futerman AH. 2002. The role of sphingolipids in neuronal development: lessons from models of sphingolipid storage diseases. Neurochem Res 27:565–574.
   PubMed Web of Science ®Google Scholar
• Catts VS, Catts SV. 2000. Apoptosis and schizophrenia: is the tumour suppressor gene, p53, a candidate susceptibility gene? Schizophr Res 41:405–415.
   PubMed Web of Science ®Google Scholar
• Catts VS, Catts SV, O'Toole BI, Frost AD. 2008. Cancer incidence in patients with schizophrenia and their first-degree relatives – a meta-analysis. Acta Psychiatr Scand 117:323–336.
   PubMed Web of Science ®Google Scholar
• Cui DH, Jiang KD, Jiang SD, Xu YF, Yao H. 2005. The tumor suppressor adenomatous polyposis coli gene is associated with susceptibility to schizophrenia. Mol Psychiatry 10:669–677.
   PubMed Web of Science ®Google Scholar
• De La Vega FM. 2007. Selecting single-nucleotide polymorphisms for association studies with SNPbrowser software. Methods Mol Biol 376:177–193.
   PubMedGoogle Scholar
• De La Vega FM, Isaac HI, Scafe CR. 2006. A tool for selecting SNPs for association studies based on observed linkage disequilibrium patterns. Pac Symp Biocomput: 487–498.
   PubMedGoogle Scholar
• Devi AR, Gopikrishna M, Ratheesh R, Savithri G, Swarnalata G, Bashyam M. 2006. Farber lipogranulomatosis: clinical and molecular genetic analysis reveals a novel mutation in an Indian family. J Hum Genet 51:811–814.
   PubMed Web of Science ®Google Scholar
• Ehlert K, Frosch M, Fehse N, Zander A, Roth J, Vormoor J. 2007. Farber disease: clinical presentation, pathogenesis and a new approach to treatment. Pediatr Rheumatol Online J 5:15.
   PubMedGoogle Scholar
• Elojeimy S, Liu X, McKillop JC, El-Zawahry AM, Holman DH, Cheng JY, . 2007. Role of acid ceramidase in resistance to FasL: therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy. Mol Ther 15:1259–1263.
   PubMed Web of Science ®Google Scholar
• Grinshpoon A, Barchana M, Ponizovsky A, Lipshitz I, Nahon D, Tal O, . 2005. Cancer in schizophrenia: is the risk higher or lower? Schizophr Res 73:333–341.
   PubMed Web of Science ®Google Scholar
• Groden J, Thliveris A, Samowitz W, Carlson M, Gelbert L, Albertsen H, . 1991. Identification and characterization of the familial adenomatous polyposis coli gene. Cell 66: 589–600.
   PubMed Web of Science ®Google Scholar
• Holman DH, Turner LS, El-Zawahry A, Elojeimy S, Liu X, Bielawski J, . 2008. Lysosomotropic acid ceramidase inhibior induces apoptosis in prostate cancer cells. Cancer Chemother Pharmacol 61:231–242.
   PubMed Web of Science ®Google Scholar
• Innis MA, Gelfand DH, Sninsky JJ, White TJ. 1990. PCR Protocols: A guide to methods and applications. San Diedo, CA: Academic Press. 146–152.
   Google Scholar
• Jablensky A, Lawrence D. 2001. Schizophrenia and cancer: is there a need to invoke a protective gene? Arch Gen Psychiatry 58:579–580.
   PubMed Web of Science ®Google Scholar
• Jarskog LF, Glantz LA, Gilmore JH, Lieberman JA. 2005. Apoptotic mechanisms in the pathophysiology of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 29:846–858.
   PubMed Web of Science ®Google Scholar
• Kay SR, Fiszbein A, Opler LA. 1987. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13:261–276.
   PubMed Web of Science ®Google Scholar
• Kim HL, Satta Y. 2008. Population genetic analysis of the N-acylsphingosine amidohydrolase gene associated with mental activity in humans. Genetics 178:1505–1515.
   PubMed Web of Science ®Google Scholar
• Levav I, Lipshitz I, Novikov I, Pugachova I, Kohn R, Barchana M, . 2007. Cancer risk among parents and siblings of patients with schizophrenia. Br J Psychiatry 190:156–161.
   PubMed Web of Science ®Google Scholar
• Lewis CM, Levinson DF, Wise LH, DeLisi LE, Straub RE, Hovatta I, . 2003. Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia. Am J Hum Genet 73:34–48.
   PubMed Web of Science ®Google Scholar
• Li CM, Park JH, Simonaro CM, He X, Gordon RE, Friedman AH, . 2002. Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes. Genomics 79:218–224.
   PubMed Web of Science ®Google Scholar
• Lichtermann D, Karbe E, Maier W. 2000. The genetic epidemiology of schizophrenia and of schizophrenia spectrum disorders. Eur Arch Psychiatry Clin Neurosci 250:304–310.
   PubMed Web of Science ®Google Scholar
• Lichtermann D, Ekelund J, Pukkala E, Tanskanen A, Lonnqvist J. 2001. Incidence of cancer among persons with schizophrenia and their relatives. Arch Gen Psychiatry 58:573–578.
   PubMed Web of Science ®Google Scholar
• Liu X, Cheng JC, Turner LS, Elojeimy S, Beckham TH, Bielawska A, . 2009. Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy. Expert Opin Ther Targets 13:1449–1458.
   PubMed Web of Science ®Google Scholar
• Liu X, Elojeimy S, Turner LS, Mahdy AE, Zeidan YH, Bielawska A, . 2008. Acid ceramidase inhibition: a novel target for cancer therapy. Front Biosci 13:2293–2298.
   PubMed Web of Science ®Google Scholar
• Maeda I, Takano T, Matsuzuka F, Maruyama T, Higashiyama T, Liu G, . 1999. Rapid screening of specific changes in mRNA in thyroid carcinomas by sequence specific-differential display: decreased expression of acid ceramidase mRNA in malignant and benign thyroid tumors. Int J Cancer 81:700–704.
   PubMed Web of Science ®Google Scholar
• Mahdy AE, Cheng JC, Li J, Elojeimy S, Meacham WD, Turner LS, . 2009. Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer. Mol Ther 17:430–438.
   PubMed Web of Science ®Google Scholar
• Merrill AH Jr, Wang E. 1992. Enzymes of ceramide biosynthesis. Methods Enzymol 209:427–437.
   PubMed Web of Science ®Google Scholar
• Muramatsu T, Sakai N, Yanagihara I, Yamada M, Nishigaki T, Kokubu C, . 2002. Mutation analysis of the acid ceramidase gene in Japanese patients with Farber disease. J Inherit Metab Dis 25:585–592.
   PubMed Web of Science ®Google Scholar
• Narayan S, Head SR, Gilmartin TJ, Dean B, Thomas EA. 2009. Evidence for disruption of sphingolipid metabolism in schizophrenia. J Neurosci Res 87:278–288.
   PubMed Web of Science ®Google Scholar
• Numata S, Ueno S, Iga J, Yamauchi K, Hongwei S, Hashimoto R, . 2008. TGFBR2 gene expression and genetic association with schizophrenia. J Psychiatr Res 42:425–432.
   PubMed Web of Science ®Google Scholar
• Park JH, Schuchman EH. 2006. Acid ceramidase and human disease. Biochim Biophys Acta 1758:2133–2138.
   PubMed Web of Science ®Google Scholar
• Park JK, Lee HJ, Kim JW, Park YH, Lee SS, Chang HI, . 2004. Differences in p53 gene polymorphisms between Korean schizophrenia and lung cancer patients. Schizophr Res 67:71–74.
   PubMed Web of Science ®Google Scholar
• Perry DK, Hannun YA. 1998. The role of ceramide in cell signaling. Biochim Biophys Acta 1436:233–243.
   PubMed Web of Science ®Google Scholar
• Pulver AE, Lasseter VK, Kasch L, Wolyniec P, Nestadt G, Blouin JL, . 1995. Schizophrenia: a genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes. Am J Med Genet 60:252–260.
   PubMed Web of Science ®Google Scholar
• Relative quantitation of gene expression. User Bulletin #2: ABI Prism 7700 Sequence Detection System. PE Applied Biosystems, 1997 (updated 10/2001).
   Google Scholar
• Ruckhaberle E, Rody A, Engels K, Gaetje R, von Minckwitz G, Schiffmann S, . 2008. Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer. Breast Cancer Res Treat 112: 41–52.
   PubMed Web of Science ®Google Scholar
• Ruckhaberle E, Holtrich U, Engels K, Hanker L, Gatje R, Metzler D, . 2009. Acid ceramidase 1 expression correlates with a better prognosis in ER-positive breast cancer. Climacteric 12:502–513.
   PubMed Web of Science ®Google Scholar
• Ruvolo PP. 2003. Intracellular signal transduction pathways activated by ceramide and its metabolites. Pharmacol Res 47:383–392.
   PubMed Web of Science ®Google Scholar
• Saad AF, Meacham WD, Bai A, Anelli V, Elojeimy S, Mahdy AE, . 2007. The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy. Cancer Biol Ther 6:1455–1460.
   PubMed Web of Science ®Google Scholar
• Savtchouk IA, Mattie FJ, Ollis AA. 2007. Ceramide: from embryos to tumors. Sci STKE 2007:jc1.
   PubMedGoogle Scholar
• Schwarz A, Futerman AH. 1997. Distinct roles for ceramide and glucosylceramide at different stages of neuronal growth. J Neurosci 17:2929–2938.
   PubMed Web of Science ®Google Scholar
• Seelan RS, Qian C, Yokomizo A, Bostwick DG, Smith DI, Liu W. 2000. Human acid ceramidase is overexpressed but not mutated in prostate cancer. Genes Chromosomes Cancer 29:137–146.
   PubMed Web of Science ®Google Scholar
• Spiegel S, Cuvillier O, Edsall L, Kohama T, Menzeleev R, Olivera A, . 1998. Roles of sphingosine-1-phosphate in cell growth, differentiation, and death. Biochemistry (Moscow) 63: 69–73.
   PubMed Web of Science ®Google Scholar
• Tabares-Seisdedos R, Rubenstein JL. 2009. Chromosome 8p as a potential hub for developmental neuropsychiatric disorders: implications for schizophrenia, autism and cancer. Mol Psychiatry 14:563–589.
   PubMed Web of Science ®Google Scholar
• Usadel H, Brabender J, Danenberg KD, Jeronimo C, Harden S, Engles J, . 2002. Quantitative adenomatous polyposis coli promoter methylation analysis in tumor tissue, serum, and plasma DNA of patients with lung cancer. Cancer Res 62: 371–375.
   PubMed Web of Science ®Google Scholar
• Zeidan YH, Jenkins RW, Korman JB, Liu X, Obeid LM, Norris JS, . 2008. Molecular targeting of acid ceramidase: implications to cancer therapy. Curr Drug Targets 9:653–661.
   PubMed Web of Science ®Google Scholar
• Zhang HH, Cui DH, Zhu ZQ, Jiang KD, Jiang SD. 2008. Association analysis between ASAH1 gene and symptom quantitative trait of schizophrenia in Chinese Han Population. Chin J Psychiatry 41:5–9.
   Google Scholar
• Zhang Z, Mandal AK, Mital A, Popescu N, Zimonjic D, Moser A, . 2000. Human acid ceramidase gene: novel mutations in Farber disease. Mol Genet Metab 70:301–309.
   PubMed Web of Science ®Google Scholar