Voluntary exercise does not ameliorate context memory and hyperarousal in a mouse model for post-traumatic stress disorder (PTSD)

References

• Balogh SA, Wehner JM. 2003. Inbred mouse strain differences in the establishment of long-term fear memory. Behav Brain Res 140:97–106.
   Google Scholar
• Baruch DE, Swain RA, Helmstetter FJ. 2004. Effects of exercise on Pavlovian fear conditioning. Behav Neurosci 118:1123–1127.
   PubMed Web of Science ®Google Scholar
• Binder E, Droste SK, Ohl F, Reul JM. 2004. Regular voluntary exercise reduces anxiety-related behaviour and impulsiveness in mice. Behav Brain Res 155:197–206.
   PubMed Web of Science ®Google Scholar
• Burghardt PR, Fulk LJ, Hand GA, Wilson MA. 2004. The effects of chronic treadmill and wheel running on behavior in rats. Brain Res 1019:84–96.
   PubMed Web of Science ®Google Scholar
• Clark PJ, Brzezinska WJ, Thomas MW, Ryzhenko NA, Toshkov SA, Rhodes JS. 2008. Intact neurogenesis is required for benefits of exercise on spatial memory but not motor performance or contextual fear conditioning in C57BL/6J mice. Neuroscience 155:1048–1058.
   PubMed Web of Science ®Google Scholar
• Cotman CW, Berchtold NC. 2007. Physical activity and the maintenance of cognition: learning from animal models. Alzheimers Dement 3:S30–37.
   PubMed Web of Science ®Google Scholar
• Creer DJ, Romberg C, Saksida LM, van Praag H, Bussey TJ. 2010. Running enhances spatial pattern separation in mice. Proc Natl Acad Sci USA 107:2367–2372.
   Web of Science ®Google Scholar
• Duman CH, Schlesinger L, Russell DS, Duman RS. 2008. Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice. Brain Res 1199:148–158.
   PubMed Web of Science ®Google Scholar
• Farmer J, Zhao X, van Praag H, Wodtke K, Gage FH, Christie BR. 2004. Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo. Neuroscience 124:71–79.
   PubMed Web of Science ®Google Scholar
• Fuss J, Ben Abdallah NM, Hensley FW, Weber KJ, Hellweg R, Gass P. 2010a. Deletion of running-induced hippocampal neurogenesis by irradiation prevents development of an anxious phenotype in mice. PLoS One 5.
   Google Scholar
• Fuss J, Ben Abdallah NM, Vogt MA, Touma C, Pacifici PG, Palme R, et al. 2010b. Voluntary exercise induces anxiety-like behavior in adult C57BL/6J mice correlating with hippocampal neurogenesis. Hippocampus 20:364–376.
   PubMed Web of Science ®Google Scholar
• Golub Y, Mauch CP, Dahlhoff M, Wotjak CT. 2009. Consequences of extinction training on associative and non-associative fear in a mouse model of Posttraumatic Stress Disorder (PTSD). Behav Brain Res 205:544–549.
   PubMed Web of Science ®Google Scholar
• Greenwood BN, Foley TE, Day HE, Campisi J, Hammack SH, Campeau S, et al. 2003. Freewheel running prevents learned helplessness/behavioral depression: role of dorsal raphe serotonergic neurons. J Neurosci 23:2889–2898.
   PubMed Web of Science ®Google Scholar
• Greenwood BN, Strong PV, Foley TE, Fleshner M. 2009. A behavioral analysis of the impact of voluntary physical activity on hippocampus-dependent contextual conditioning. Hippocampus 19:988–1001.
   PubMed Web of Science ®Google Scholar
• Griesbach GS, Hovda DA, Molteni R, Wu A, Gomez-Pinilla F. 2004. Voluntary exercise following traumatic brain injury: brain-derived neurotrophic factor upregulation and recovery of function. Neuroscience 125:129–139.
   PubMed Web of Science ®Google Scholar
• Griesbach GS, Hovda DA, Gomez-Pinilla F. 2009. Exercise-induced improvement in cognitive performance after traumatic brain injury in rats is dependent on BDNF activation. Brain Res 1288:105–115.
   PubMed Web of Science ®Google Scholar
• Hernandez-Rabaza V, Llorens-Martin M, Velazquez-Sanchez C, Ferragud A, Arcusa A, Gumus HG, et al. 2009. Inhibition of adult hippocampal neurogenesis disrupts contextual learning but spares spatial working memory, long-term conditional rule retention and spatial reversal. Neuroscience 159:59–68.
   Google Scholar
• Hillman CH, Erickson KI, Kramer AF. 2008. Be smart, exercise your heart: exercise effects on brain and cognition. Nat Rev Neurosci 9:58–65.
   PubMed Web of Science ®Google Scholar
• Johnson RA, Rhodes JS, Jeffrey SL, Garland T Jr, Mitchell GS. 2003. Hippocampal brain-derived neurotrophic factor but not neurotrophin-3 increases more in mice selected for increased voluntary wheel running. Neuroscience 121:1–7.
   PubMed Web of Science ®Google Scholar
• Kamprath K, Wotjak CT. 2004. Nonassociative learning processes determine expression and extinction of conditioned fear in mice. Learn Mem 11:770–786.
   PubMedGoogle Scholar
• Khabour OF, Alzoubi KH, Alomari MA, Alzubi MA. 2010. Changes in spatial memory and BDNF expression to concurrent dietary restriction and voluntary exercise. Hippocampus 20:637–645.
   PubMed Web of Science ®Google Scholar
• Kim JJ, Jung MW. 2006. Neural circuits and mechanisms involved in Pavlovian fear conditioning: a critical review. Neurosci Biobehav Rev 30:188–202.
   PubMed Web of Science ®Google Scholar
• Kramer AF, Erickson KI. 2007. Capitalizing on cortical plasticity: influence of physical activity on cognition and brain function. Trends Cogn Sci 11:342–348.
   PubMed Web of Science ®Google Scholar
• Leasure JL, Jones M. 2008. Forced and voluntary exercise differentially affect brain and behavior. Neuroscience 156: 456–465.
   PubMed Web of Science ®Google Scholar
• Leggio MG, Mandolesi L, Federico F, Spirito F, Ricci B, Gelfo F, Petrosini L. 2005. Environmental enrichment promotes improved spatial abilities and enhanced dendritic growth in the rat. Behav Brain Res 163:78–90.
   PubMed Web of Science ®Google Scholar
• Liu YF, Chen HI, Wu CL, Kuo YM, Yu L, Huang AM, et al. 2009. Differential effects of treadmill running and wheel running on spatial or aversive learning and memory: roles of amygdalar brain-derived neurotrophic factor and synaptotagmin I. J Physiol 587:3221–3231.
   PubMed Web of Science ®Google Scholar
• Loh DH, Navarro J, Hagopian A, Wang LM, Deboer T, Colwell CS. 2010. Rapid changes in the light/dark cycle disrupt memory of conditioned fear in mice. PLoS One 5.
   Google Scholar
• Nichol KE, Parachikova AI, Cotman CW. 2007. Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse. Behav Brain Res 184:124–132.
   PubMed Web of Science ®Google Scholar
• O'Callaghan RM, Ohle R, Kelly AM. 2007. The effects of forced exercise on hippocampal plasticity in the rat: A comparison of LTP, spatial- and non-spatial learning. Behav Brain Res 176:362–366.
   PubMed Web of Science ®Google Scholar
• Orr SP, Metzger LJ, Pitman RK. 2002. Psychophysiology of post-traumatic stress disorder. Psychiatr Clin North Am 25: 271–293.
   PubMed Web of Science ®Google Scholar
• Phillips RG, LeDoux JE. 1992. Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav Neurosci 106:274–285.
   PubMed Web of Science ®Google Scholar
• Rau V, DeCola JP, Fanselow MS. 2005. Stress-induced enhancement of fear learning: an animal model of posttraumatic stress disorder. Neurosci Biobehav Rev 29:1207–1223.
   PubMed Web of Science ®Google Scholar
• Remington G. 2009. From mice to men: What can animal models tell us about the relationship between mental health and physical activity?. Ment Health Phys Activity 2:10–15.
   Google Scholar
• Siegmund A, Wotjak CT. 2006. Toward an animal model of posttraumatic stress disorder. Ann NY Acad Sci 1071: 324–334.
   PubMed Web of Science ®Google Scholar
• Siegmund A, Wotjak CT. 2007. A mouse model of posttraumatic stress disorder that distinguishes between conditioned and sensitised fear. J Psychiatr Res 41:848–860.
   PubMed Web of Science ®Google Scholar
• Van der Borght K, Havekes R, Bos T, Eggen BJ, Van der Zee EA. 2007. Exercise improves memory acquisition and retrieval in the Y-maze task: relationship with hippocampal neurogenesis. Behav Neurosci 121:324–334.
   PubMed Web of Science ®Google Scholar
• Van Hoomissen JD, Holmes PV, Zellner AS, Poudevigne A, Dishman RK. 2004. Effects of beta-adrenoreceptor blockade during chronic exercise on contextual fear conditioning and mRNA for galanin and brain-derived neurotrophic factor. Behav Neurosci 118:1378–1390.
   PubMed Web of Science ®Google Scholar
• van Praag H. 2008. Neurogenesis and exercise: past and future directions. Neuromolecular Med 10:128–140.
   PubMed Web of Science ®Google Scholar
• van Praag H. 2009. Exercise and the brain: something to chew on. Trends Neurosci 32:283–290.
   PubMed Web of Science ®Google Scholar
• van Praag H, Christie BR, Sejnowski TJ, Gage FH. 1999a. Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc Natl Acad Sci USA 96:13427–13431.
   PubMed Web of Science ®Google Scholar
• van Praag H, Kempermann G, Gage FH. 1999b. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci 2:266–270.
   PubMed Web of Science ®Google Scholar
• van Praag H, Shubert T, Zhao C, Gage FH. 2005. Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci 25:8680–8685.
   PubMed Web of Science ®Google Scholar
• Vansteenwegen D, Hermans D, Vervliet B, Francken G, Beckers T, Baeyens F, Eelen P. 2005. Return of fear in a human differential conditioning paradigm caused by a return to the original acquistion context. Behav Res Ther 43:323–336.
   PubMed Web of Science ®Google Scholar
• Vaynman S, Ying Z, Gomez-Pinilla F. 2004a. Exercise induces BDNF and synapsin I to specific hippocampal subfields. J Neurosci Res 76:356–362.
   PubMedGoogle Scholar
• Vaynman S, Ying Z, Gomez-Pinilla F. 2004b. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur J Neurosci 20:2580–2590.
   PubMed Web of Science ®Google Scholar
• Wojtowicz JM, Askew ML, Winocur G. 2008. The effects of running and of inhibiting adult neurogenesis on learning and memory in rats. Eur J Neurosci 27:1494–502.
   PubMed Web of Science ®Google Scholar
• Yehuda R. 2002. Post-traumatic stress disorder. New Engl J Med 346:108–114.
   PubMed Web of Science ®Google Scholar