204
Views
29
CrossRef citations to date
0
Altmetric
ORIGINAL INVESTIGATIONS

Analysis of common genetic variants identifies RELN as a risk gene for schizophrenia in Chinese population

, , , , , , , , , , , & show all
Pages 91-99 | Received 10 Dec 2010, Accepted 04 May 2011, Published online: 11 Jul 2011

References

  • Abdolmaleky HM, Smith CL, Faraone SV, Shafa R, Stone W, Glatt SJ, . 2004. Methylomics in psychiatry: Modulation of gene-environment interactions may be through DNA methylation. Am J Med Genet B Neuropsychiatr Genet 127B: 51–59.
  • Barrett JC, Fry B, Maller J, Daly MJ. 2005. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263–265.
  • Ben-David E, Shifman S. 2010. Further investigation of the association between rs7341475 and rs17746501 and schizophrenia. Am J Med Genet B Neuropsychiatr Genet 153B: 1244–1247.
  • Bender RA, Zhou L, Wilkars W, Fester L, Lanowski JS, Paysen D, . 2010. Roles of 17ss-estradiol involve regulation of reelin expression and synaptogenesis in the dentate gyrus. Cereb Cortex 20:2985–2995.
  • Biamonte F, Assenza G, Marino R, D'Amelio M, Panteri R, Caruso D, . 2009. Interactions between neuroactive steroids and reelin haploinsufficiency in Purkinje cell survival. Neurobiol Dis 36:103–115.
  • Carter CJ. 2006. Schizophrenia susceptibility genes converge on interlinked pathways related to glutamatergic transmission and long-term potentiation, oxidative stress and oligodendrocyte viability. Schizophr Res 86(1–3):1–14.
  • Chen X, Lee G, Maher BS, Fanous AH, Chen J, Zhao Z, . 2010. GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia. Mol Psychiatry doi:10.1038/mp.2010.96.
  • Chen Y, Sharma RP, Costa RH, Costa E, Grayson DR. 2002. On the epigenetic regulation of the human reelin promoter. Nucleic Acids Res 30:2930–2939.
  • Cohen J. 1988. Statistical power analysis for the behavioral sciences. 2nd. Stockholm: Lawrence Erlbaum Associates.
  • DeSilva U, D'Arcangelo G, Braden VV, Chen J, Miao GG, Curran T, . 1997. The human reelin gene: isolation, sequencing, and mapping on chromosome 7. Genome Res 7:157–164.
  • Dickson SP, Wang K, Krantz I, Hakonarson H, Goldstein DB. 2010. Rare variants create synthetic genome-wide associations. PLoS Biol 8:e1000294.
  • Eastwood SL, Harrison PJ. 2003. Interstitial white matter neurons express less reelin and are abnormally distributed in schizophrenia: towards an integration of molecular and morphologic aspects of the neurodevelopmental hypothesis. Mol Psychiatry 8(9):769, 821–831.
  • Eastwood SL, Harrison PJ. 2006. Cellular basis of reduced cortical reelin expression in schizophrenia. Am J Psychiatry 163: 540–542.
  • Ekelund J, Lichtermann D, Hovatta I, Ellonen P, Suvisaari J, Terwilliger JD, . 2000. Genome-wide scan for schizophrenia in the Finnish population: evidence for a locus on chromosome 7q22. Hum Mol Genet 9:1049–1057.
  • Fatemi SH. 2005. Reelin glycoprotein: structure, biology and roles in health and disease. Mol Psychiatry 10:251–257.
  • Fatemi SH, Earle JA, McMenomy T. 2000. Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression. Mol Psychiatry 5:654–663, 571.
  • Fatemi SH, Snow AV, Stary JM, Araghi-Niknam M, Reutiman TJ, Lee S, . 2005. Reelin signaling is impaired in autism. Biol Psychiatry 57:777–787.
  • Faul F, Erdfelder E, Lang AG, Buchner A. 2007. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 39: 175–191.
  • Freedman R. 2003. Schizophrenia. New Engl J Med 349: 1738–1749.
  • Goes FS, Willour VL, Zandi PP, Belmonte PL, MacKinnon DF, Mondimore FM, . 2009. Sex-specific association of the Reelin gene with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 153B:549–553.
  • Goldberger C, Gourion D, Leroy S, Schurhoff F, Bourdel MC, Leboyer M, . 2005. Population-based and family-based association study of 5'UTR polymorphism of the reelin gene and schizophrenia. Am J Med Genet B Neuropsychiatr Genet 137B:51–55.
  • Grayson DR, Jia X, Chen Y, Sharma RP, Mitchell CP, Guidotti A, . 2005. Reelin promoter hypermethylation in schizophrenia. Proc Natl Acad Sci USA 102:9341–9346.
  • Guidotti A, Auta J, Davis JM, Di-Giorgi-Gerevini V, Dwivedi Y, Grayson DR, . 2000. Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study. Arch Gen Psychiatry 57:1061–1069.
  • Hadj-Sahraoui N, Frederic F, Delhaye-Bouchaud N, Mariani J. 1996. Gender effect on Purkinje cell loss in the cerebellum of the heterozygous reeler mouse. J Neurogenet 11(1–2):45–58.
  • Impagnatiello F, Guidotti AR, Pesold C, Dwivedi Y, Caruncho H, Pisu MG, . 1998. A decrease of reelin expression as a putative vulnerability factor in schizophrenia. Proc Natl Acad Sci USA 95:15718–15723.
  • Kahler AK, Djurovic S, Kulle B, Jonsson EG, Agartz I, Hall H, . 2008. Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene. Am J Med Genet B Neuropsychiatr Genet 147B: 1089–1100.
  • Kushima I, Nakamura Y, Aleksic B, Ikeda M, Ito Y, Shiino T, . 2010. Resequencing and association analysis of the KALRN and EPHB1 genes and their contribution to schizophrenia susceptibility. Schizophr Bull doi: 10.1093/schbul/sbq118.
  • Levinson DF, Duan J, Oh S, Wang K, Sanders AR, Shi J, . 2011. Copy number variants in schizophrenia: confirmation of five previous findings and new evidence for 3q29 microdeletions and VIPR2 duplications. Am J Psychiatry 168: 302–316.
  • Li J, Zhou G, Ji W, Feng G, Zhao Q, Liu J, . 2011. Common variants in the BCL9 gene conferring risk of schizophrenia. Arch Gen Psychiatry 68:232–240.
  • Li T, Li Z, Chen P, Zhao Q, Wang T, Huang K, . 2010. Common variants in major histocompatibility complex region and TCF4 gene are significantly associated with schizophrenia in Han Chinese. Biol Psychiatry 68:671–673.
  • Lichtenstein P, Yip BH, Bjork C, Pawitan Y, Cannon TD, Sullivan PF, . 2009. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet 373:234–239.
  • Lipska BK, Peters T, Hyde TM, Halim N, Horowitz C, Mitkus S, . 2006. Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs. Hum Mol Genet 15:1245–1258.
  • Liu Y, Chen PL, McGrath J, Wolyniec P, Fallin D, Nestadt G, . 2010. Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish women. Psychiatr Genet 20:184–186.
  • Luo XJ, Diao HB, Wang JK, Zhang H, Zhao ZM, Su B. 2008. Association of haplotypes spanning PDZ-GEF2, LOC728637 and ACSL6 with schizophrenia in Han Chinese. J Med Genet 45:818–826.
  • Need AC, Ge D, Weale ME, Maia J, Feng S, Heinzen EL, . 2009. A genome-wide investigation of SNPs and CNVs in schizophrenia. PLoS Genet 5:e1000373.
  • O'Donovan MC, Craddock N, Norton N, Williams H, Peirce T, Moskvina V, . 2008. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet 40:1053–1055.
  • Pisante A, Bronstein M, Yakir B, Darvasi A. 2009. A variant in the reelin gene increases the risk of schizophrenia and schizoaffective disorder but not bipolar disorder. Psychiatr Genet 19:212.
  • Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, . 2007. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81:559–575.
  • Quattrocchi CC, Wannenes F, Persico AM, Ciafre SA, D'Arcangelo G, Farace MG, . 2002. Reelin is a serine protease of the extracellular matrix. J Biol Chem 277:303–309.
  • Riley B, Thiselton D, Maher BS, Bigdeli T, Wormley B, McMichael GO, . 2010. Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample. Mol Psychiatry 15:29–37.
  • Schaid DJ, Rowland CM, Tines DE, Jacobson RM, Poland GA. 2002. Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet 70: 425–434.
  • Seripa D, Matera MG, Franceschi M, Daniele A, Bizzarro A, Rinaldi M, . 2008. The RELN locus in Alzheimer's disease. J Alzheimers Dis 14:335–344.
  • Shen YC, Liao DL, Chen JY, Wang YC, Lai IC, Liou YJ, . 2009. Resequencing and association study of vesicular glutamate transporter 1 gene (VGLUT1) with schizophrenia. Schizophr Res 115(2–3):254–260.
  • Shifman S, Johannesson M, Bronstein M, Chen SX, Collier DA, Craddock NJ, . 2008. Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women. PLoS Genet 4:e28.
  • Stefansson H, Ophoff RA, Steinberg S, Andreassen OA, Cichon S, Rujescu D, . 2009. Common variants conferring risk of schizophrenia. Nature 460:744–747.
  • Tamura Y, Kunugi H, Ohashi J, Hohjoh H. 2007. Epigenetic aberration of the human REELIN gene in psychiatric disorders. Mol Psychiatry 12(6):519, 593–600.
  • Tissir F, Goffinet AM. 2003. Reelin and brain development. Nat Rev Neurosci 4:496–505.
  • Tochigi M, Iwamoto K, Bundo M, Komori A, Sasaki T, Kato N, . 2008. Methylation status of the reelin promoter region in the brain of schizophrenic patients. Biol Psychiatry 63:530–533.
  • Tost H, Lipska BK, Vakkalanka R, Lemaitre H, Callicott JH, Mattay VS, . 2010. No effect of a common allelic variant in the reelin gene on intermediate phenotype measures of brain structure, brain function, and gene expression. Biol Psychiatry 68:105–107.
  • Vacic V, McCarthy S, Malhotra D, Murray F, Chou HH, Peoples A, . 2011. Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia. Nature 471(7339):499 503.
  • Wedenoja J, Loukola A, Tuulio-Henriksson A, Paunio T, Ekelund J, Silander K, . 2008. Replication of linkage on chromosome 7q22 and association of the regional Reelin gene with working memory in schizophrenia families. Mol Psychiatry 13: 673–684.
  • Wedenoja J, Tuulio-Henriksson A, Suvisaari J, Loukola A, Paunio T, Partonen T, . 2010. Replication of association between working memory and Reelin, a potential modifier gene in schizophrenia. Biol Psychiatry 67:983–991.
  • Williams HJ, Norton N, Dwyer S, Moskvina V, Nikolov I, Carroll L, . 2011. Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder. Mol Psychiatry 16(4):429 441.
  • Zhang R, Lu SM, Qiu C, Liu XG, Gao CG, Guo TW, . 2011. Population-based and family-based association studies of ZNF804A locus and schizophrenia. Mol Psychiatry 16(4):360 361.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.