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Research Article

The KCNH2 gene is associated with neurocognition and the risk of schizophrenia

, , , , , , , , & show all
Pages 114-120 | Received 22 Feb 2011, Accepted 07 Jul 2011, Published online: 22 Sep 2011

References

  • Atalar F, Acuner TT, Cine N, Oncu F, Yesilbursa D, Ozbek U, . 2010. Two four-marker haplotypes on 7q36.1 region indicate that the potassium channel gene HERG1 (KCNH2, Kv11.1) is related to schizophrenia: a case control study. Behav Brain Funct 6:27.
  • Berrettini WH. 2005. Genetic bases for endophenotypes in psychiatric disorders. Dialogues Clin Neurosci 7:95–101.
  • Cardno AG, and Gottesman, II. 2000. Twin studies of schizophrenia: from bow-and-arrow concordances to star wars Mx and functional genomics. Am J Med Genet 97:12–17.
  • Chen WJ, Liu SK, Chang CJ, Lien YJ, Chang YH, Hwu HG. 1998. Sustained attention deficit and schizotypal personality features in nonpsychotic relatives of schizophrenic patients. Am J Psychiatry 155:1214–1220.
  • Cornblatt BA, Risch NJ, Faris G, Friedman D, Erlenmeyer-Kimling L. 1988. The Continuous Performance Test, identical pairs version (CPT-IP): I. New findings about sustained attention in normal families. Psychiatry Res 26:223–238.
  • Green MF, Nuechterlein KH, Gold JM, Barch DM, Cohen J, Essock S, . 2004. Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteria. Biol Psychiatry 56:301–307.
  • Green MF. 2006. Cognitive impairment and functional outcome in schizophrenia and bipolar disorder. J Clin Psychiatry 67(Suppl 9):3–8; discussion 36–42.
  • Hashimoto R, Hashimoto H, Shintani N, Chiba S, Hattori S, Okada T, . 2007. Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia. Mol Psychiatry 12:1026–1032.
  • Huffaker SJ, Chen J, Nicodemus KK, Sambataro F, Yang F, Mattay V, . 2009. A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia. Nat Med 15:509–518.
  • Husted JA, Lim S, Chow EW, Greenwood C, Bassett AS. 2009. Heritability of neurocognitive traits in familial schizophrenia. Am J Med Genet B Neuropsychiatr Genet 150B:845–853.
  • Kongsamut S, Kang J, Chen XL, Roehr J, Rampe D. 2002. A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs. Eur J Pharmacol 450:37–41.
  • Lezak MD. 1995. Neuropyschological assessment. 3rd New York: Oxford University Press.
  • Meyer-Lindenberg A, Weinberger DR. 2006. Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat Rev Neurosci 7:818–827.
  • Nuechterlein KH, Barch DM, Gold JM, Goldberg TE, Green MF, Heaton RK. 2004. Identification of separable cognitive factors in schizophrenia. Schizophr Res 72:29–39.
  • Nuechterlein KH, Green MF, Kern RS, Baade LE, Barch DM, Cohen JD, . 2008. The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validity. Am J Psychiatry 165:203–213.
  • O'Donovan MC, Craddock N, Norton N, Williams H, Peirce T, Moskvina V, . 2008. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet 40:1053–1055.
  • Ohi K, Hashimoto R, Yasuda Y, Kiribayashi M, Iike N, Yoshida T, . 2009a. TATA box-binding protein gene is associated with risk for schizophrenia, age at onset and prefrontal function. Genes, Brain and Behavior 8:473–480.
  • Ohi K, Hashimoto R, Yasuda Y, Yoshida T, Takahashi H, Iike N, . 2009b. Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter study. Schizophr Res 109:80–85.
  • Ohi K, Hashimoto R, Yasuda Y, Yoshida T, Takahashi H, Iike N, . 2010. The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis. Schizophr Res 116:126–132.
  • Posthuma D, de Geus EJ, Boomsma DI. 2001. Perceptual speed and IQ are associated through common genetic factors. Behav Genet 31:593–602.
  • Sekiyama R, Iwase M, Takahashi H, Nakahachi T, Takahashi K, Ikezawa K, . 2008. Perception of emotional and neutral facial expression correlates with social functioning in chronic schizophrenia. Seishin Igaku 50:337–344.
  • Snitz BE, Macdonald AWr, Carter CS. 2006. Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of putative endophenotypes. Schizophr Bull 32:179–194.
  • Sugishita M. 2001. Japanese Wechsler Memory Scale-Revised. Tokyo: Nihonbunkakagakusha.
  • Sumiyoshi C, Sumiyoshi T, Matsui M, Nohara S, Yamashita I, Kurachi M, . 2004. Effect of orthography on the verbal fluency performance in schizophrenia: examination using Japanese patients. Schizophr Res 69:15–22.
  • Tan HY, Callicott JH, Weinberger DR. 2008a. Intermediate phenotypes in schizophrenia genetics redux: is it a no brainer? Mol Psychiatry 13:233–238.
  • Tan HY, Nicodemus KK, Chen Q, Li Z, Brooke JK, Honea R, . 2008b. Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans. J Clin Invest 118:2200–2208.
  • Tsuang M. 2000. Schizophrenia: genes and environment. Biol Psychiatry 47:210–220.
  • Wechsler D. 1997. Manual for the Wechsler Adult Intelligence Scale-III. San Antonio, TX: The Psychological Corporation.

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