601
Views
28
CrossRef citations to date
0
Altmetric
ORIGINAL INVESTIGATIONS

Hippocampal integrity and neurocognition in first-episode schizophrenia: A multidimensional study

, , , , , , , , , & show all
Pages 188-199 | Received 01 Feb 2011, Accepted 29 Aug 2011, Published online: 02 Nov 2011

References

  • Aleman A, Hijman R, de Haan EH, Kahn RS. 1999. Memory impairment in schizophrenia: a meta-analysis. Am J Psychiatry 156:1358–66.
  • Antonova E, Sharma T, Morris R, Kumari V. 2004. The relationship between brain structure and neurocognition in schizophrenia: a selective review. Schizophr Res 70:117–45.
  • Bassett AS, Collins EJ, Nuttall SE, Honer WG. 1993. Positive and negative symptoms in families with schizophrenia. Schizophr Res 11:9–19.
  • Bluml S, Seymour KJ, Ross BD. 1999. Developmental changes in choline- and ethanolamine-containing compounds measured with proton-decoupled (31)P MRS in in vivo human brain. Magn Reson Med 42:643–54.
  • DeLisi LE, Stritzke PH, Holan V, Anand A, Boccio A, Kuschner M, et al. 1991. Brain morphological changes in 1st episode cases of schizophrenia: are they progressive?. Schizophr Res 5:206–8.
  • Endicott J, Spitzer RL, Fleiss JL, Cohen J. 1976. The global assessment scale. A procedure for measuring overall severity of psychiatric disturbance. Arch Gen Psychiatry 33:766–71.
  • Gaffan D. 2005. Neuroscience. Widespread cortical networks underlie memory and attention. Science 309:2172–3.
  • Galderisi S, Davidson M, Kahn RS, Mucci A, Boter H, Gheorghe MD, et al. 2009. Correlates of cognitive impairment in first episode schizophrenia: the EUFEST study. Schizophr Res 115:104–14.
  • Green MF. 1996. What are the functional consequences of neurocognitive deficits in schizophrenia?. Am J Psychiatry 153:321–30.
  • Gruber O, Falkai P, Schneider-Axmann T, Schwab SG, Wagner M, Maier W. 2008. Neuregulin-1 haplotype HAP(ICE) is associated with lower hippocampal volumes in schizophrenic patients and in non-affected family members. J Psychiatr Res 43:1–6.
  • Gur RE, Turetsky BI, Cowell PE, Finkelman C, Maany V, Grossman RI, et al. 2000. Temporolimbic volume reductions in schizophrenia. Arch Gen Psychiatry 57:769–75.
  • Guy W BR. 1976. CGI: Clinical Global Impressions. Manual for the ECDEU Assessment Battery. 2nd Rev ed. Chevy chase, MD: National Institute of Mental Health. p. 12/1 12/6.
  • Harrison PJ. 2004. The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications. Psychopharmacology (Berlin) 174:151–62.
  • Heaton RK CG, Talley JL, Kay GG, Curtiss G. 1993. Wisconsin Card Sorting Test Manual – Revised and expanded. Lutz, FL: PAR.
  • Helmstaedter C, Wietzke J, Lutz MT. 2009. Unique and shared validity of the “Wechsler logical memory test”, the “California verbal learning test”, and the “verbal learning and memory test” in patients with epilepsy. Epilepsy Res 87:203–12.
  • Henseler I, Falkai P, Gruber O. 2009. A systematic fMRI investigation of the brain systems subserving different working memory components in schizophrenia. Eur J Neurosci 30:693–702.
  • Henseler I, Falkai P, Gruber O. 2010. Disturbed functional connectivity within brain networks subserving domain-specific subcomponents of working memory in schizophrenia: relation to performance and clinical symptoms. J Psychiatr Res 44: 364–72.
  • Hopfinger JB, Buonocore MH, Mangun GR. 2000. The neural mechanisms of top-down attentional control. Nat Neurosci 3:284–91.
  • Jamrozinski K, Gruber O, Kemmer C, Falkai P, Scherk H. 2009. Neurocognitive functions in euthymic bipolar patients. Acta Psychiatr Scand 119:365–74.
  • Jessen F, Block W, Traber F, Keller E, Flacke S, Papassotiropoulos A, et al. 2000. Proton MR spectroscopy detects a relative decrease of N-acetylaspartate in the medial temporal lobe of patients with AD. Neurology 55:684–8.
  • Jessen F, Block W, Traber F, Keller E, Flacke S, Lamerichs R, et al. 2001. Decrease of N-acetylaspartate in the MTL correlates with cognitive decline of AD patients. Neurology 57:930–2.
  • Kay SR, Fiszbein A, Opler LA. 1987. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13:261–76.
  • Klar AA, Ballmaier M, Leopold K, Hake I, Schaefer M, Bruhl R, et al. 2010. Interaction of hippocampal volume and N- acetylaspartate concentration deficits in schizophrenia: a combined MRI and 1H-MRS study. Neuroimage 53:51–7.
  • Konradi C, Heckers S. 2003. Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment. Pharmacol Ther 97:153–79.
  • Kubicki M, McCarley RW, Nestor PG, Huh T, Kikinis R, Shenton ME, et al. 2003. An fMRI study of semantic processing in men with schizophrenia. Neuroimage 20:1923–33.
  • Laws KR. 1999. A meta-analytic review of Wisconsin Card Sort studies in schizophrenia: general intellectual deficit in disguise?. Cogn Neuropsychiatry 4:1–30; discussion 31–5.
  • Maier M, Ron MA, Barker GJ, Tofts PS. 1995. Proton magnetic resonance spectroscopy: an in vivo method of estimating hippocampal neuronal depletion in schizophrenia. Psychol Med 25:1201–9.
  • Maudsley AA, Domenig C, Govind V, Darkazanli A, Studholme C, Arheart K, et al. 2009. Mapping of brain metabolite distributions by volumetric proton MR spectroscopic imaging (MRSI). Magn Reson Med 61:548–59.
  • Mesholam-Gately RI, Giuliano AJ, Goff KP, Faraone SV, Seidman LJ. 2009. Neurocognition in first-episode schizophrenia: a meta-analytic review. Neuropsychology 23:315–36.
  • Muller H, Hasse-Sander I, Horn R, Helmstaedter C, Elger CE. 1997. Rey Auditory-Verbal Learning Test: structure of a modified German version. J Clin Psychol 53:663–71.
  • Panenka WJ, Khorram B, Barr AM, Smith GN, Lang DJ, Kopala LC, et al. 2007. A longitudinal study on the effects of typical versus atypical antipsychotic drugs on hippocampal volume in schizophrenia. Schizophr Res 94:288–92.
  • Paz RD, Tardito S, Atzori M, Tseng KY. 2008. Glutamatergic dysfunction in schizophrenia: from basic neuroscience to clinical psychopharmacology. Eur Neuropsychopharmacol 18: 773–86.
  • Petrides M, Milner B. 1982. Deficits on subject-ordered tasks after frontal- and temporal-lobe lesions in man. Neuropsychologia 20:249–62.
  • Ragland JD, Gur RC, Valdez J, Turetsky BI, Elliott M, Kohler C, et al. 2004. Event-related fMRI of frontotemporal activity during word encoding and recognition in schizophrenia. Am J Psychiatry 161:1004–15.
  • Raz N, Rodrigue KM, Head D, Kennedy KM, Acker JD. 2004. Differential aging of the medial temporal lobe: a study of a five-year change. Neurology 62:433–8.
  • Remillard S, Pourcher E, Cohen H. 2005. The effect of neuroleptic treatments on executive function and symptomatology in schizophrenia: a 1-year follow up study. Schizophr Res 80: 99–106.
  • Rose SE, de Zubicaray GI, Wang D, Galloway GJ, Chalk JB, Eagle SC, et al. 1999. A 1H MRS study of probable Alzheimer's disease and normal aging: implications for longitudinal monitoring of dementia progression. Magn Reson Imaging 17:291–9.
  • Scherk H, Backens M, Zill P, Schneider-Axmann T, Wobrock T, Usher J, et al. 2008. SNAP-25 genotype influences NAA/Cho in left hippocampus. J Neural Transm 115:1513–8.
  • Schmidt KH, Metzler P. 1992. Wortschatztest WST. Weinheim: Beltz.
  • Seidman LJ, Faraone SV, Goldstein JM, Kremen WS, Horton NJ, Makris N, et al. 2002. Left hippocampal volume as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric study of nonpsychotic first-degree relatives. Arch Gen Psychiatry 59:839–49.
  • Steen RG, Hamer RM, Lieberman JA. 2005. Measurement of brain metabolites by 1H magnetic resonance spectroscopy in patients with schizophrenia: a systematic review and meta-analysis. Neuropsychopharmacology 30:1949–62.
  • Steen RG, Mull C, McClure R, Hamer RM, Lieberman JA. 2006. Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies. Br J Psychiatry 188:510–8.
  • Stern AJ, Savostyanova AA, Goldman A, Barnett AS, van der Veen JW, Callicott JH, et al. 2008. Impact of the brain-derived neurotrophic factor Val66Met polymorphism on levels of hippocampal N-acetyl-aspartate assessed by magnetic resonance spectroscopic imaging at 3 Tesla. Biol Psychiatry 64:856–62.
  • Szeszko PR, Goldberg E, Gunduz-Bruce H, Ashtari M, Robinson D, Malhotra AK, et al. 2003. Smaller anterior hippocampal formation volume in antipsychotic-naive patients with first-episode schizophrenia. Am J Psychiatry 160:2190–7.
  • Talairach J, Tournoux P. 1998. Coplanar sterotaxic atlas of the human brain. New York: Thieme Medical Publishers.
  • Tamminga CA, Stan AD, Wagner AD. 2010. The hippocampal formation in schizophrenia. Am J Psychiatry 167(10): 1178 93.
  • Thoma RJ, Monnig M, Hanlon FM, Miller GA, Petropoulos H, Mayer AR, et al. 2009. Hippocampus volume and episodic memory in schizophrenia. J Int Neuropsychol Soc 15:182–95.
  • Torres IJ, Flashman LA, O'Leary DS, , Swayze V 2ndAndreasen NC. 1997. Lack of an association between delayed memory and hippocampal and temporal lobe size in patients with schizophrenia and healthy controls. Biol Psychiatry 42: 1087–96.
  • Valenzuela MJ, Sachdev P. 2001. Magnetic resonance spectroscopy in AD. Neurology 56:592–8.
  • Velakoulis D, Wood SJ, Wong MT, McGorry PD, Yung A, Phillips L, et al. 2006. Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals. Arch Gen Psychiatry 63:139–49.
  • Watanabe T, Shiino A, Akiguchi I. 2010. Absolute quantification in proton magnetic resonance spectroscopy is useful to differentiate amnesic mild cognitive impairment from Alzheimer's disease and healthy aging. Dement Geriatr Cogn Disord 30:71–7.
  • Weiss AP, Zalesak M, DeWitt I, Goff D, Kunkel L, Heckers S. 2004. Impaired hippocampal function during the detection of novel words in schizophrenia. Biol Psychiatry 55: 668–75.
  • Wittchen HU, Wunderlich U, Gruschwitz S, Zaudig M. 1997. Strukturiertes Klinisches Interview für DSM-IV. Achse I: Psychische Störungen. A German, advanced adaptation of the original SCID version by Spitzer RL, Williams JB, Gibbon M, First MB. Göttingen: Hogrefe-Verlag.
  • Wobrock T, Ecker UK, Scherk H, Schneider-Axmann T, Falkai P, Gruber O. 2009. Cognitive impairment of executive function as a core symptom of schizophrenia. World J Biol Psychiatry 10:442–51.
  • Yildiz-Yesiloglu A, Ankerst DP. 2006. Neurochemical alterations of the brain in bipolar disorder and their implications for pathophysiology: a systematic review of the in vivo proton magnetic resonance spectroscopy findings. Prog Neuropsychopharmacol Biol Psychiatry 30:969–95.
  • Zierhut K, Bogerts B, Schott B, Fenker D, Walter M, Albrecht D, et al. 2010. The role of hippocampus dysfunction in deficient memory encoding and positive symptoms in schizophrenia. Psychiatry Res 183:187–94.
  • Zilles D, Burke S, Schneider-Axmann T, Falkai P, Gruber O. 2009. Diagnosis-specific effect of familial loading on verbal working memory in schizophrenia. Eur Arch Psychiatry Clin Neurosci 259:309–15.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.