A preliminary study on methylphenidate-regulated gene expression in lymphoblastoid cells of ADHD patients

References

• Alberio T, Pippione AC, Comi C, Olgiati S, Cecconi D, Zibetti M, et al. 2012. Dopaminergic therapies modulate the T-CELL proteome of patients with Parkinson's disease. IUBMB Life 64:846–852.
   PubMed Web of Science ®Google Scholar
• Aoki M, Akiyama T, Miyoshi J, Toyoshima K. 1991. Identification and characterization of protein products of the cot oncogene with serine kinase activity. Oncogene 6:1515–1519.
   PubMed Web of Science ®Google Scholar
• Association AP. 2000. APA – American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders – DSM-IV-TR Washington, DC: American Psychiatric Association.
   Google Scholar
• Barbacioru CC, Wang Y, Canales RD, Sun YA, Keys DN, Chan F, et al. 2006. Effect of various normalization methods on Applied Biosystems expression array system data. BMC Bioinformatics 7:533.
   PubMed Web of Science ®Google Scholar
• Bartl J, Link P, Schlosser C, Gerlach M, Schmitt A, Walitza S, et al. 2010. Effects of methylphenidate: the cellular point of view. Attent Defic Hyperact Disord 2:225–232.
   PubMedGoogle Scholar
• Biederman J. 2005. Attention-deficit/hyperactivity disorder: a selective overview. Biol Psychiatry 57:1215–1220.
   PubMed Web of Science ®Google Scholar
• Bjorklund A, Dunnett SB. 2007. Dopamine neuron systems in the brain: an update. Trends Neurosci 30:194–202.
   PubMed Web of Science ®Google Scholar
• Brown RW, Hughes BA, Hughes AB, Sheppard AB, Perna MK, Ragsdale WL, et al. 2012. Sex and dose-related differences in methylphenidate adolescent locomotor sensitization and effects on brain-derived neurotrophic factor. J Psychopharmacol 26:1480–1488.
   PubMed Web of Science ®Google Scholar
• Chiariello M, Marinissen MJ, Gutkind JS. 2000. Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation. Mol Cell Biol 20:1747–1758.
   PubMed Web of Science ®Google Scholar
• Christiansen H, Kis B, Hirsch O, Matthies S, Hebebrand J, Uekermann J, et al. 2012. German validation of the Conners Adult ADHD Rating Scales (CAARS) II: reliability, validity, diagnostic sensitivity and specificity. Eur Psychiatry 27: 321–328.
   PubMed Web of Science ®Google Scholar
• Corominas-Roso M, Ramos-Quiroga JA, Ribases M, Sanchez-Mora C, Palomar G, Valero S, et al. 2013. Decreased serum levels of brain-derived neurotrophic factor in adults with attention-deficit hyperactivity disorder. Int J Neuropsychopharmacol 1–9.
   Google Scholar
• Crespo-Barreto J, Fryer JD, Shaw CA, Orr HT, Zoghbi HY. 2010. Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis. PLoS Genet 6:e1001021.
   PubMed Web of Science ®Google Scholar
• Faraone SV, Sergeant J, Gillberg C, Biederman J. 2003. The worldwide prevalence of ADHD: is it an American condition? World Psychiatry 2:104–113.
   PubMedGoogle Scholar
• Franke B, Faraone SV, Asherson P, Buitelaar J, Bau CH, Ramos-Quiroga JA, et al. 2012. The genetics of attention deficit/hyperactivity disorder in adults, a review. Mol Psychiatry 17:960–987.
   PubMed Web of Science ®Google Scholar
• Franke B, Neale BM, Faraone SV. 2009. Genome-wide association studies in ADHD. Hum Genet 126:13–50.
   PubMed Web of Science ®Google Scholar
• Fuke S, Minami N, Kokubo H, Yoshikawa A, Yasumatsu H, Sasagawa N, et al. 2006. Hesr1 knockout mice exhibit behavioral alterations through the dopaminergic nervous system. J Neurosci Res 84:1555–1563.
   PubMed Web of Science ®Google Scholar
• Fuke S, Sasagawa N, Ishiura S. 2005. Identification and characterization of the Hesr1/Hey1 as a candidate trans-acting factor on gene expression through the 3’ non-coding polymorphic region of the human dopamine transporter (DAT1) gene. J Biochem 137:205–216.
   PubMed Web of Science ®Google Scholar
• Fung SJ, Sivagnanasundaram S, Weickert CS. 2011. Lack of change in markers of presynaptic terminal abundance alongside subtle reductions in markers of presynaptic terminal plasticity in prefrontal cortex of schizophrenia patients. Biol Psychiatry 69:71–79.
   PubMed Web of Science ®Google Scholar
• Gill KE, Pierre PJ, Daunais J, Bennett AJ, Martelle S, Gage HD, et al. 2012. Chronic treatment with extended release methylphenidate does not alter dopamine systems or increase vulnerability for cocaine self-administration: a study in nonhuman primates. Neuropsychopharmacology 37:2555–2565.
   PubMed Web of Science ®Google Scholar
• Giorgi FM, Bolger AM, Lohse M, Usadel B. 2010. Algorithm-driven artifacts in median Polish summarization of microarray data. BMC Bioinformatics 11:553.
   PubMed Web of Science ®Google Scholar
• Gong R, Ding C, Hu J, Lu Y, Liu F, Mann E, et al. 2011. Role for the membrane receptor guanylyl cyclase-C in attention deficiency and hyperactive behavior. Science 333:1642–1646.
   PubMed Web of Science ®Google Scholar
• Goold R, Hubank M, Hunt A, Holton J, Menon RP, Revesz T, et al. 2007. Down-regulation of the dopamine receptor D2 in mice lacking ataxin 1. Hum Mol Genet 16:2122–2134.
   PubMed Web of Science ®Google Scholar
• Greenhill LL, Pliszka S, Dulcan MK, Bernet W, Arnold V, Beitchman J, et al. 2002. Practice parameter for the use of stimulant medications in the treatment of children, adolescents, and adults. J Am Acad Child Adolesc Psychiatry 41:26S–49S.
   PubMed Web of Science ®Google Scholar
• Hearst SM, Lopez ME, Shao Q, Liu Y, Vig PJ. 2010. Dopamine D2 receptor signaling modulates mutant ataxin-1 S776 phosphorylation and aggregation. J Neurochem 114:706–716.
   PubMed Web of Science ®Google Scholar
• Hoogman M, Aarts E, Zwiers M, Slaats-Willemse D, Naber M, Onnink M, et al. 2011. Nitric oxide synthase genotype modulation of impulsivity and ventral striatal activity in adult ADHD patients and healthy comparison subjects. Am J Psychiatry 168:1099–1106.
   PubMed Web of Science ®Google Scholar
• Ishibashi M, Moriyoshi K, Sasai Y, Shiota K, Nakanishi S, Kageyama R. 1994. Persistent expression of helix-loop-helix factor HES-1 prevents mammalian neural differentiation in the central nervous system. EMBO J 13:1799–1805.
   PubMed Web of Science ®Google Scholar
• Iso T, Kedes L, Hamamori Y. 2003. HES and HERP families: multiple effectors of the Notch signaling pathway. J Cell Physiol 194:237–255.
   PubMed Web of Science ®Google Scholar
• Kanno K, Ishiura S. 2011. Differential effects of the HESR/HEY transcription factor family on dopamine transporter reporter gene expression via variable number of tandem repeats. J Neurosci Res 89:562–575.
   PubMed Web of Science ®Google Scholar
• Kim YW, Shin JC, An YS. 2009. Effects of methylphenidate on cerebral glucose metabolism in patients with impaired consciousness after acquired brain injury. Clin Neuropharmacol 32:335–339.
   PubMed Web of Science ®Google Scholar
• Korgun ET, Demir R, Sedlmayr P, Desoye G, Arikan GM, Puerstner P, et al. 2002. Sustained hypoglycemia affects glucose transporter expression of human blood leukocytes. Blood Cells Mol Dis 28:152–159.
   PubMed Web of Science ®Google Scholar
• Lee TH, Lee CH, Kim IH, Yan BC, Park JH, Kwon SH, et al. 2012. Effects of ADHD therapeutic agents, methylphenidate and atomoxetine, on hippocampal neurogenesis in the adolescent mouse dentate gyrus. Neurosci Lett 524:84–88.
   PubMed Web of Science ®Google Scholar
• Lesch KP, Selch S, Renner TJ, Jacob C, Nguyen TT, Hahn T, et al. 2011. Genome-wide copy number variation analysis in attention-deficit/hyperactivity disorder: association with neuropeptide Y gene dosage in an extended pedigree. Mol Psychiatry 16:491–503.
   PubMed Web of Science ®Google Scholar
• Liu L, Yuan G, Cheng Z, Zhang G, Liu X, Zhang H. 2013. Identification of the mRNA expression status of the dopamine d2 receptor and dopamine transporter in peripheral blood lymphocytes of schizophrenia patients. PLoS One 8:e75259.
   PubMed Web of Science ®Google Scholar
• Maratou E, Dimitriadis G, Kollias A, Boutati E, Lambadiari V, Mitrou P, et al. 2007. Glucose transporter expression on the plasma membrane of resting and activated white blood cells. Eur J Clin Invest 37:282–290.
   PubMed Web of Science ®Google Scholar
• Margraf J. 1994. Diagnostisches Kurzinterview bei psychischen Störungen: Mini-DIPS. Berlin, Heidelberg, New York: Springer Verlag
   Google Scholar
• Marzinke MA, Mavencamp T, Duratinsky J, Clagett-Dame M. 2013. 14-3-3epsilon and NAV2 interact to regulate neurite outgrowth and axon elongation. Arch Biochem Biophys 540:94–100.
   PubMed Web of Science ®Google Scholar
• Matilla A, Roberson ED, Banfi S, Morales J, Armstrong DL, Burright EN, et al. 1998. Mice lacking ataxin-1 display learning deficits and decreased hippocampal paired-pulse facilitation. J Neurosci 18:5508–5516.
   PubMed Web of Science ®Google Scholar
• McNeill EM, Klockner-Bormann M, Roesler EC, Talton LE, Moechars D, Clagett-Dame M. 2011. Nav2 hypomorphic mutant mice are ataxic and exhibit abnormalities in cerebellar development. Dev Biol 353:331–343.
   PubMed Web of Science ®Google Scholar
• Michaelides M, Pascau J, Gispert JD, Delis F, Grandy DK, Wang GJ, et al. 2010. Dopamine D4 receptors modulate brain metabolic activity in the prefrontal cortex and cerebellum at rest and in response to methylphenidate. Eur J Neurosci 32:668–676.
   PubMed Web of Science ®Google Scholar
• Momoi T, Fujita E, Senoo H, Momoi M. 2010. Genetic factors and epigenetic factors for autism: endoplasmic reticulum stress and impaired synaptic function. Cell Biol Int 34:13–19.
   Web of Science ®Google Scholar
• Muley PD, McNeill EM, Marzinke MA, Knobel KM, Barr MM, Clagett-Dame M. 2008. The atRA-responsive gene neuron navigator 2 functions in neurite outgrowth and axonal elongation. Dev Neurobiol 68:1441–1453.
   PubMed Web of Science ®Google Scholar
• Pascoli V, Valjent E, Corbille AG, Corvol JC, Tassin JP, Girault JA, et al. 2005. cAMP and extracellular signal-regulated kinase signaling in response to d-amphetamine and methylphenidate in the prefrontal cortex in vivo: role of beta 1-adrenoceptors. Mol Pharmacol 68:421–429.
   PubMed Web of Science ®Google Scholar
• Patriotis C, Makris A, Bear SE, Tsichlis PN. 1993. Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation. Proc Natl Acad Sci USA 90:2251–2255.
   PubMed Web of Science ®Google Scholar
• Piatkiewicz P, Czech A, Taton J, Gorski A. 2010. Investigations of cellular glucose transport and its regulation under the influence of insulin in human peripheral blood lymphocytes. Endokrynol Pol 61:182–187.
   PubMed Web of Science ®Google Scholar
• Reimold M, Globas C, Gleichmann M, Schulze M, Gerloff C, Bares R, et al. 2006. Spinocerebellar ataxia type 1, 2, and 3 and restless legs syndrome: striatal dopamine D2 receptor status investigated by [11C]raclopride positron emission tomography. Mov Disord 21:1667–1673.
   PubMed Web of Science ®Google Scholar
• Retz-Junginger P, Retz W, Blocher D, Weijers HG, Trott GE, Wender PH, et al. 2002. [Wender Utah rating scale. The short-version for the assessment of the attention-deficit hyperactivity disorder in adults]. Nervenarzt 73:830–838.
   PubMed Web of Science ®Google Scholar
• Retz W, Reif A, Freitag CM, Retz-Junginger P, Rosler M. 2010. Association of a functional variant of neuronal nitric oxide synthase gene with self-reported impulsiveness, venturesomeness and empathy in male offenders. J Neural Transm 117:321–324.
   PubMed Web of Science ®Google Scholar
• Rietz CS, Hasselhorn M, Labuhn AS. 2012. Are externalizing and internalizing difficulties of young children with spelling impairment related to their ADHD symptoms? Dyslexia 18:174–185.
   PubMed Web of Science ®Google Scholar
• Rizzi TS, Arias-Vasquez A, Rommelse N, Kuntsi J, Anney R, Asherson P, et al. 2011. The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: evidence from a large collaborative study totaling 4,963 subjects. Am J Med Genet B Neuropsychiatr Genet 156:145–157.
   PubMedGoogle Scholar
• Robinson JW, Potter LR. 2012. Guanylyl cyclases A and B are asymmetric dimers that are allosterically activated by ATP binding to the catalytic domain. Sci Signal 5: ra65.
   PubMed Web of Science ®Google Scholar
• Roeske D, Ludwig KU, Neuhoff N, Becker J, Bartling J, Bruder J, et al. 2011. First genome-wide association scan on neurophysiological endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic children. Mol Psychiatry 16:97–107.
   PubMed Web of Science ®Google Scholar
• Roget K, Ben-Addi A, Mambole-Dema A, Gantke T, Yang HT, Janzen J, et al. 2012. IkappaB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400. Mol Cell Biol 32: 4684–4690.
   PubMed Web of Science ®Google Scholar
• Sakamoto M, Hirata H, Ohtsuka T, Bessho Y, Kageyama R. 2003. The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain. J Biol Chem 278:44808–44815.
   PubMed Web of Science ®Google Scholar
• Selek S, Savas HA, Gergerlioglu HS, Bulut M, Yilmaz HR. 2008. Oxidative imbalance in adult attention deficit/hyperactivity disorder. Biol Psychol 79:256–259.
   PubMed Web of Science ®Google Scholar
• Shayevitz C, Cohen OS, Faraone SV, Glatt SJ. 2012. A re-review of the association between the NOTCH4 locus and schizophrenia. Am J Med Genet B Neuropsychiatr Genet 159B:477–483.
   PubMed Web of Science ®Google Scholar
• Simpson IA, Dwyer D, Malide D, Moley KH, Travis A, Vannucci SJ. 2008. The facilitative glucose transporter GLUT3: 20 years of distinction. Am J Physiol Endocrinol Metab 295:E242–253.
   PubMed Web of Science ®Google Scholar
• Van Waes V, Beverley J, Marinelli M, Steiner H. 2010. Selective serotonin reuptake inhibitor antidepressants potentiate methylphenidate (Ritalin)-induced gene regulation in the adolescent striatum. Eur J Neurosci 32:435–447.
   PubMed Web of Science ®Google Scholar
• Volkow ND, Fowler JS, Wang GJ, Telang F, Logan J, Wong C, et al. 2008. Methylphenidate decreased the amount of glucose needed by the brain to perform a cognitive task. PLoS One 3:e2017.
   PubMed Web of Science ®Google Scholar
• Vougioukalaki M, Kanellis DC, Gkouskou K, Eliopoulos AG. 2011. Tpl2 kinase signal transduction in inflammation and cancer. Cancer Lett 304:80–89.
   PubMed Web of Science ®Google Scholar
• Wanchoo SJ, Swann AC, Dafny N. 2009. Descending glutamatergic pathways of PFC are involved in acute and chronic action of methylphenidate. Brain Res 1301:68–79.
   PubMed Web of Science ®Google Scholar
• Wettenhall JM, Smyth GK. 2004. limmaGUI: a graphical user interface for linear modeling of microarray data. Bioinformatics 20:3705–3706.
   PubMed Web of Science ®Google Scholar
• Yang SR, Kim SJ, Byun KH, Hutchinson B, Lee BH, Michikawa M, et al. 2006. NPC1 gene deficiency leads to lack of neural stem cell self-renewal and abnormal differentiation through activation of p38 mitogen-activated protein kinase signaling. Stem Cells 24:292–298.
   PubMed Web of Science ®Google Scholar
• Zhang C, Browne A, Child D, Divito JR, Stevenson JA, Tanzi RE. 2010. Loss of function of ATXN1 increases amyloid beta-protein levels by potentiating beta-secretase processing of beta-amyloid precursor protein. J Biol Chem 285: 8515–8526.
   PubMed Web of Science ®Google Scholar