Association between genetic variants of serotonergic and glutamatergic pathways and the concentration of neurometabolites of the anterior cingulate cortex in paediatric patients with obsessive–compulsive disorder

References

• American Psychiatric Association. 2000. DSM-IV-TR, Diagnostic and Statistical Manual of Mental Disorders 4th edition, revised, Washington DC.
   Google Scholar
• American Psychiatric Association. 2013. DSM-V, Diagnostic and Statistical Manual of Mental Disorders 5th edition, Washington DC.
   Google Scholar
• Arnold PD, Macmaster FP, Richter MA, Hanna GL, Sicard T, Burroughs E, Mirza Y, Easter PC, Rose M, Kennedy JL, et al. 2009. Glutamate receptor gene (GRIN2B) associated with reduced anterior cingulate glutamatergic concentration in pediatric obsessive-compulsive disorder. Psychiatry Res. 172:136–139.
   PubMed Web of Science ®Google Scholar
• Ashburner J. 2007. A fast diffeomorphic image registration algorithm. Neuroimage. 38:95–113.
   PubMed Web of Science ®Google Scholar
• Ashburner J. 2009. Computational anatomy with the SPM software. Magn Reson Imaging. 27:1163–1174.
   PubMed Web of Science ®Google Scholar
• Atmaca M, Yildirim H, Ozdemir H, Koc M, Ozler S, Tezcan E. 2009. Neurochemistry of the hippocampus in patients with obsessive-compulsive disorder. Psychiatry Clin Neurosci. 63:486–490.
   PubMed Web of Science ®Google Scholar
• Bartha R, Stein MB, Williamson PC, Drost DJ, Neufeld RW, Carr TJ, Canaran G, Pensmore M, Anderson G, Siddiqui AR. 1998. A short echo 1H spectroscopy and volumetric MRI study of the corpus striatum in patients with obsessive-compulsive disorder and comparison subjects. Am J Psychiatry. 155:1584–1591.
   Google Scholar
• Birken DL, Oldendorf WH. 1989. N-acetyl-L-aspartic acid: a literature review of a compound prominent in 1H-NMR spectroscopic studies of brain. Neurosci Biobehav Rev. 13:23–31.
   PubMed Web of Science ®Google Scholar
• Bloch MH, Craiglow BG, Landeros-Weisenberger A, Dombrowski PA, Panza KE, Peterson BS, Leckman JF. 2009. Predictors of early adult outcomes in pediatric-onset obsessive-compulsive disorder. Pediatrics. 124:1085–1093.
   PubMed Web of Science ®Google Scholar
• Bly M. 2005. Mutation in the vesicular monoamine gene, SLC18A1, associated with schizophrenia. Schizophr Res. 78:337–338.
   PubMed Web of Science ®Google Scholar
• Brennan BP, Rauch SL, Jensen JE, Pope HG. 2013. A critical review of magnetic resonance spectroscopy studies of obsessive-compulsive disorder. Biol Psychiatry. 73:24–31.
   PubMed Web of Science ®Google Scholar
• Camarena B, Aguilar A, Loyzaga C, Nicolini H. 2004. A family-based association study of the 5-HT-1Dbeta receptor gene in obsessive-compulsive disorder. Int J Neuropsychopharmacol. 7:49–53.
   PubMed Web of Science ®Google Scholar
• Chen S-F, Chen C-H, Chen J-Y, Wang Y-C, Lai I-C, Liou Y-J, Liao D-L. 2007. Support for association of the A277C single nucleotide polymorphism in human vesicular monoamine transporter 1 gene with schizophrenia. Schizophr Res. 90:363–365.
   PubMed Web of Science ®Google Scholar
• Ciranna L. 2006. Serotonin as a modulator of glutamate- and GABA-mediated neurotransmission: implications in physiological functions and in pathology. Curr Neuropharmacol. 4:101–114.
   PubMed Web of Science ®Google Scholar
• Drago A, Crisafulli C, Sidoti A, Serretti A. 2011. The molecular interaction between the glutamatergic, noradrenergic, dopaminergic and serotoninergic systems informs a detailed genetic perspective on depressive phenotypes. Prog Neurobiol. 94:418–460.
   PubMed Web of Science ®Google Scholar
• Ebert D, Speck O, König A, Berger M, Hennig J, Hohagen F. 1997. 1H-magnetic resonance spectroscopy in obsessive-compulsive disorder: evidence for neuronal loss in the cingulate gyrus and the right striatum. Psychiatry Res. 74:173–176.
   PubMed Web of Science ®Google Scholar
• Fux M, Benjamin J, Belmaker RH. 1999. Inositol versus placebo augmentation of serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder: a double-blind cross-over study. Int J Neuropsychopharmacol. 2:193–195.
   PubMed Web of Science ®Google Scholar
• Fux M, Levine J, Aviv A, Belmaker RH. 1996. Inositol treatment of obsessive-compulsive disorder. Am J Psychiatry. 153:1219–1221.
   PubMed Web of Science ®Google Scholar
• Gehring WJ, Himle J, Nisenson LG. 2000. Action-monitoring dysfunction in obsessive-compulsive disorder. Psychol Sci. 11:1–6.
   PubMed Web of Science ®Google Scholar
• González JR, Armengol L, Solé X, Guinó E, Mercader JM, Estivill X, Moreno V. 2007. SNPassoc: an R package to perform whole genome association studies. Bioinformatics. 23:644–645.
   PubMed Web of Science ®Google Scholar
• Govindaraju V, Young K, Maudsley AA. 2000. Proton NMR chemical shifts and coupling constants for brain metabolites. NMR Biomed. 13:129–153.
   PubMed Web of Science ®Google Scholar
• Greist JH, Jefferson JW, Kobak KA, Katzelnick DJ, Serlin RC. 1995. Efficacy and tolerability of serotonin transport inhibitors in obsessive-compulsive disorder. A meta-analysis. Arch Gen Psychiatry. 52:53–60.
   PubMed Web of Science ®Google Scholar
• Van Grootheest DS, Cath DC, Beekman AT, Boomsma DI. 2005. Twin studies on obsessive-compulsive disorder: a review. Twin Res Hum Genet. 8:450–458.
   PubMed Web of Science ®Google Scholar
• Grünblatt E, Hauser TU, Walitza S. 2014. Imaging genetics in obsessive-compulsive disorder: linking genetic variations to alterations in neuroimaging. Prog Neurobiol. 121:114–124.
   PubMed Web of Science ®Google Scholar
• Guerrini L, Belli G, Mazzoni L, Foresti S, Ginestroni A, Della Nave R, Diciotti S, Mascalchi M. 2009. Impact of cerebrospinal fluid contamination on brain metabolites evaluation with 1H-MR spectroscopy: a single voxel study of the cerebellar vermis in patients with degenerative ataxias. J Magn Reson Imaging. 30:11–17.
   PubMed Web of Science ®Google Scholar
• Heyman I, Fombonne E, Simmons H, Ford T, Meltzer H, Goodman R. 2001. Prevalence of obsessive-compulsive disorder in the British nationwide survey of child mental health. Br J Psychiatry. 179:324–329.
   PubMed Web of Science ®Google Scholar
• Jenkins BG, Koroshetz WJ, Beal MF, Rosen BR. 1993. Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy. Neurology. 43:2689–2695.
   PubMed Web of Science ®Google Scholar
• Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, Williamson D, Ryan N. 1997. Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry. 36:980–989.
   PubMed Web of Science ®Google Scholar
• Kim SJ, Namkoong K, Kang JI, Kim C-H. 2009. Association of a 5-HT1Dbeta receptor gene polymorphism with obsessive-compulsive disorder in Korean male subjects. Neuropsychobiology. 59:96–99.
   PubMed Web of Science ®Google Scholar
• Kitamura H, Shioiri T, Kimura T, Ohkubo M, Nakada T, Someya T. 2006. Parietal white matter abnormalities in obsessive-compulsive disorder: a magnetic resonance spectroscopy study at 3-Tesla. Acta Psychiatr Scand. 114:101–108.
   PubMed Web of Science ®Google Scholar
• Lázaro L, Bargalló N, Andrés S, Falcón C, Morer A, Junqué C, Castro-Fornieles J. 2012. Proton magnetic resonance spectroscopy in pediatric obsessive-compulsive disorder: longitudinal study before and after treatment. Psychiatry Res. 201:17–24.
   PubMed Web of Science ®Google Scholar
• Lázaro L, Calvo A, Ortiz AG, Ortiz AE, Morer A, Moreno E, Calvo R, Bargalló N. 2014a. Microstructural brain abnormalities and symptom dimensions in child and adolescent patients with obsessive-compulsive disorder: A diffusion tensor imaging study. Depress and Anxiety. 31:1007–1017.
   PubMed Web of Science ®Google Scholar
• Lázaro L, Ortiz AG, Calvo A, Ortiz AE, Moreno E, Morer A, Calvo R, Bargalló N. 2014b. White matter structural alterations in pediatric obsessive-compulsive disorder: relation to symptom dimensions. Prog Neuropsychopharmacol Biol Psychiatry. 54:249–258.
   PubMed Web of Science ®Google Scholar
• Lohoff FW. 2010. Genetic variants in the vesicular monoamine transporter 1 (VMAT1/SLC18A1) and neuropsychiatric disorders. Methods Mol Biol. 637:165–180.
   PubMedGoogle Scholar
• Lohoff FW, Dahl JP, Ferraro TN, Arnold SE, Gallinat J, Sander T, Berrettini WH. 2006. Variations in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) are associated with bipolar I disorder. Neuropsychopharmacology. 31:2739–2747.
   PubMed Web of Science ®Google Scholar
• López-Gil X, Artigas F, Adell A. 2010. Unraveling monoamine receptors involved in the action of typical and atypical antipsychotics on glutamatergic and serotonergic transmission in prefrontal cortex. Curr Pharm Des. 16:502–515.
   PubMed Web of Science ®Google Scholar
• Magri C, Gardella R, Barlati SD, Podavini D, Iatropoulos P, Bonomi S, Valsecchi P, Sacchetti E, Barlati S. 2006. Glutamate AMPA receptor subunit 1 gene (GRIA1) and DSM-IV-TR schizophrenia: a pilot case-control association study in an Italian sample. Am J Med Genet B Neuropsychiatr Genet. 141B:287–293.
   PubMed Web of Science ®Google Scholar
• Marsh R, Maia TV, Peterson BS. 2009. Functional disturbances within frontostriatal circuits across multiple childhood psychopathologies. Am J Psychiatry. 166:664–674.
   PubMed Web of Science ®Google Scholar
• Mas S, Pagerols M, Gassó P, Ortiz A, Rodriguez N, Morer A, Plana MT, Lafuente A, Lázaro L. 2014. Role of GAD2 and HTR1B genes in early-onset obsessive-compulsive disorder: results from transmission disequilibrium study. Genes Brain Behav. 13:409–417.
   PubMed Web of Science ®Google Scholar
• Mas S, Plana MT, Castro-Fornieles J, Gassó P, Lafuente A, Moreno E, Martinez E, Milà M, Lázaro L. 2013. Common genetic background in anorexia nervosa and obsessive compulsive disorder: preliminary results from an association study. J Psychiatr Res. 47:747–754.
   PubMed Web of Science ®Google Scholar
• Mataix-Cols D, Rosario-Campos MC, do Leckman JF. 2005. A multidimensional model of obsessive-compulsive disorder. Am J Psychiatry. 162:228–238.
   PubMed Web of Science ®Google Scholar
• Meyerhoff DJ, MacKay S, Constans JM, Norman D, Van Dyke C, Fein G, Weiner MW. 1994. Axonal injury and membrane alterations in Alzheimer's disease suggested by in vivo proton magnetic resonance spectroscopic imaging. Ann Neurol. 36:40–47.
   PubMed Web of Science ®Google Scholar
• Meyer-Lindenberg A, Weinberger DR. 2006. Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat Rev Neurosci. 7:818–827.
   PubMed Web of Science ®Google Scholar
• Micali N, Heyman I, Perez M, Hilton K, Nakatani E, Turner C, Mataix-Cols D. 2010. Long-term outcomes of obsessive-compulsive disorder: follow-up of 142 children and adolescents. Br J Psychiatry. 197:128–134.
   PubMed Web of Science ®Google Scholar
• Mirza Y, O’Neill J, Smith EA, Russell A, Smith JM, Banerjee SP, Bhandari R, Boyd C, Rose M, Ivey J, et al. 2006. Increased medial thalamic creatine-phosphocreatine found by proton magnetic resonance spectroscopy in children with obsessive-compulsive disorder versus major depression and healthy controls. J Child Neurol. 21:106–111.
   PubMed Web of Science ®Google Scholar
• Mohamed MA, Smith MA, Schlund MW, Nestadt G, Barker PB, Hoehn-Saric R. 2007. Proton magnetic resonance spectroscopy in obsessive-compulsive disorder: a pilot investigation comparing treatment responders and non-responders. Psychiatry Res. 156:175–179.
   PubMed Web of Science ®Google Scholar
• Mundo E, Richter MA, Zai G, Sam F, McBride J, Macciardi F, Kennedy JL. 2002. 5HT1Dbeta Receptor gene implicated in the pathogenesis of Obsessive-Compulsive Disorder: further evidence from a family-based association study. Mol Psychiatry. 7:805–809.
   PubMed Web of Science ®Google Scholar
• O’Neill J, Piacentini JC, Chang S, Levitt JG, Rozenman M, Bergman L, Salamon N, Alger TR, McCracken JT. 2012. MRSI correlates of cognitive-behavioral therapy in pediatric obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 36:161–168.
   PubMed Web of Science ®Google Scholar
• Ortiz AE, Ortiz AG, Falcon C, Morer A, Plana MT, Bargalló N, Lázaro L. 2015. 1H-MRS of the anterior cingulate cortex in childhood and adolescent obsessive-compulsive disorder: a case-control study. Eur Neuropsychopharmacol. 25: 60–68.
   PubMed Web of Science ®Google Scholar
• Pauls DL. 2008. The genetics of obsessive compulsive disorder: a review of the evidence. Am J Med Genet C Semin Med Genet. 148C:133–139.
   PubMed Web of Science ®Google Scholar
• Pittenger C, Krystal JH, Coric V. 2006. Glutamate-modulating drugs as novel pharmacotherapeutic agents in the treatment of obsessive-compulsive disorder. NeuroRx. 3:69–81.
   PubMedGoogle Scholar
• Provencher SW. 2001. Automatic quantitation of localized in vivo 1H spectra with LCModel. NMR Biomed. 14:260–264.
   PubMed Web of Science ®Google Scholar
• Rosario-Campos MC, Leckman JF, Mercadante MT, Shavitt RG, Prado HS, Sada P, Zamignani D, Miguel EC. 2001. Adults with early-onset obsessive-compulsive disorder. Am J Psychiatry. 158:1899–1903.
   PubMed Web of Science ®Google Scholar
• Rosenberg DR, Amponsah A, Sullivan A, MacMillan S, Moore GJ. 2001. Increased medial thalamic choline in pediatric obsessive-compulsive disorder as detected by quantitative in vivo spectroscopic imaging. J Child Neurol. 16:636–641.
   PubMed Web of Science ®Google Scholar
• Rosenberg DR, MacMaster FP, Keshavan MS, Fitzgerald KD, Stewart CM, Moore GJ. 2000. Decrease in caudate glutamatergic concentrations in pediatric obsessive-compulsive disorder patients taking paroxetine. J Am Acad Child Adolesc Psychiatry. 39:1096–1103.
   PubMed Web of Science ®Google Scholar
• Rosenberg DR, Mirza Y, Russell A, Tang J, Smith JM, Banerjee SP, Bhandari R, Rose M, Ivey J, Boyd C, Moore GJ. 2004. Reduced anterior cingulate glutamatergic concentrations in childhood OCD and major depression versus healthy controls. J Am Acad Child Adolesc Psychiatry. 43:1146–1153.
   PubMed Web of Science ®Google Scholar
• Saxena S, Rauch SL. 2000. Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder. Psychiatr Clin North Am. 23:563–586.
   PubMed Web of Science ®Google Scholar
• Scahill L, Riddle MA, McSwiggin-Hardin M, Ort SI, King RA, Goodman WK, et al. 1997. Children's Yale-Brown Obsessive Compulsive Scale: reliability and validity. J Am Acad Child Adolesc Psychiatry. 36:844–852.
   PubMed Web of Science ®Google Scholar
• Smith EA, Russell A, Lorch E, Banerjee SP, Rose M, Ivey J, Bandari R, Moore GJ, Rosenberg DR. 2003. Increased medial thalamic choline found in pediatric patients with obsessive-compulsive disorder versus major depression or healthy control subjects: a magnetic resonance spectroscopy study. Biol Psychiatry. 54:1399–1405.
   PubMed Web of Science ®Google Scholar
• Starck G, Ljungberg M, Nilsson M, Jönsson L, Lundberg S, Ivarsson T, Ribbelin S, Ekholm S, Carlsson A, Forssell-Aronsson E, et al. 2008. A 1H magnetic resonance spectroscopy study in adults with obsessive compulsive disorder: relationship between metabolite concentrations and symptom severity. J Neural Transm. 115:1051–1062.
   PubMed Web of Science ®Google Scholar
• Stewart SE, Geller DA, Jenike M, Pauls D, Shaw D, Mullin B, Faraone SV. 2004. Long-term outcome of pediatric obsessive-compulsive disorder: a meta-analysis and qualitative review of the literature. Acta Psychiatr Scand. 110:4–13.
   PubMed Web of Science ®Google Scholar
• Stewart SE, Platko J, Fagerness J, Birns J, Jenike E, Smoller JW, Perlis R, Leboyer M, Delorme R, Chabane N, et al. 2007. A genetic family-based association study of OLIG2 in obsessive-compulsive disorder. Arch Gen Psychiatry. 64:209–214.
   PubMed Web of Science ®Google Scholar
• Szeszko PR, Ardekani BA, Ashtari M, Malhotra AK, Robinson DG, Bilder RM, Lim KO. 2005. White matter abnormalities in obsessive-compulsive disorder: a diffusion tensor imaging study. Arch Gen Psychiatry. 62:782–790.
   PubMed Web of Science ®Google Scholar
• Taylor S, Jang KL, Asmundson GJG. 2010. Etiology of obsessions and compulsions: a behavioral-genetic analysis. J Abnorm Psychol. 119:672–682.
   PubMed Web of Science ®Google Scholar
• Taylor S. 2013. Molecular genetics of obsessive-compulsive disorder: a comprehensive meta-analysis of genetic association studies. Mol Psychiatr. 18:799–805.
   PubMed Web of Science ®Google Scholar
• Ting JT, Feng G. 2008. Glutamatergic synaptic dysfunction and obsessive-compulsive disorder. Curr Chem Genomics. 2:62–75.
   PubMedGoogle Scholar
• Tükel R, Aydın K, Ertekin E, Ozyıldırım SŞ, Taravari V. 2014. Proton magnetic resonance spectroscopy in obsessive-compulsive disorder: Evidence for reduced neuronal integrity in the anterior cingulate. Psychiatry Res. 224:275–280.
   PubMed Web of Science ®Google Scholar
• Ulloa RE, Ortiz S, Higuera F, Nogales I, Fresan A, Apiquian R, Cortés J, Arechavaleta B, Foulilux C, Martínez P, et al. 2006. Interrater reability of the Spanish version of Schedule for Affective Disorders and Schizophrenia for School-Age Children Present and Lifetime Disorder (KL-SADS-PL). Actas Esp Psychiatr. 34:36–40.
   PubMed Web of Science ®Google Scholar
• Van Veen V, Carter CS. 2002. The anterior cingulate as a conflict monitor: fMRI and ERP studies. Physiol Behav. 77:477–482.
   PubMed Web of Science ®Google Scholar
• Villafuerte SM, Vallabhaneni K, Sliwerska E, McMahon FJ, Young EA, Burmeister M. 2009. SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A. Psychiatr Genet. 19:281–291.
   PubMed Web of Science ®Google Scholar
• Walitza S, Wendland JR, Gruenblatt E, Warnke A, Sontag TA, Tucha O, Lange KW. 2010. Genetics of early-onset obsessive-compulsive disorder. Eur Child Adolesc Psychiatry. 19:227–235.
   PubMed Web of Science ®Google Scholar
• Whiteside SP, Port JD, Deacon BJ, Abramowitz JS. 2006. A magnetic resonance spectroscopy investigation of obsessive-compulsive disorder and anxiety. Psychiatry Res. 146:137–147.
   PubMed Web of Science ®Google Scholar
• Whiteside SP, Abramowitz JS, Port JD. 2012. Decreased caudate N-acetyl-l-aspartic acid in pediatric obsessive-compulsive disorder and the effects of behavior therapy. Psychiatry Res. 202:53–59.
   PubMed Web of Science ®Google Scholar
• Wu K, Hanna GL, Rosenberg DR, Arnold PD. 2012. The role of glutamate signaling in the pathogenesis and treatment of obsessive-compulsive disorder. Pharmacol Biochem Behav. 100:726–735.
   PubMed Web of Science ®Google Scholar
• Xu Z, Zhang Z, Shi Y, Pu M, Yuan Y, Zhang X, Li L, Reynolds GP. 2012. Influence and interaction of genetic polymorphisms in the serotonin system and life stress on antidepressant drug response. J Psychopharmacol. 26:349–359.
   PubMed Web of Science ®Google Scholar
• Yücel M, Harrison BJ, Wood SJ, Fornito A, Wellard RM, Pujol J, Clarke K, Philips ML, Kyrios M, Velakoulis D, et al. 2007. Functional and biochemical alterations of the medial frontal cortex in obsessive-compulsive disorder. Arch Gen Psychiatry. 64:946–955.
   PubMed Web of Science ®Google Scholar
• Yücel M, Wood SJ, Wellard RM, Harrison BJ, Fornito A, Pujol J, Velakoulis D, Pantelis C. 2008. Anterior cingulate glutamate-glutamine levels predict symptom severity in women with obsessive-compulsive disorder. Aust N Z J Psychiatry. 42:467–477.
   PubMed Web of Science ®Google Scholar
• Zurowski B, Kordon A, Weber-Fahr W, Voderholzer U, Kuelz AK, Freyer T, Wahl K, Büchel C, Hohagen F. 2012. Relevance of orbitofrontal neurochemistry for the outcome of cognitive-behavioural therapy in patients with obsessive-compulsive disorder. Eur Arch Psychiatry Clin Neurosci. 262:617–624.
   PubMed Web of Science ®Google Scholar